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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: BC015725 is the fusion of parental proteins PLD6, IFNAR1 (from a repository: Sun May 21 07:28:26 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)4
The number (and %) of the onco-proteins2 (50.00 %)
The number (and %) of the tumor suppressors1 (25.00 %)
Total number of binary PPIs (saturation %)7 (116.67 %)
The number (and %) of affected PPIs3 (42.86 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.3333
The network average Clustering coefficient0.583
The number (and %) of a zero Clustering coefficients1 (25.00 %)
The number (and %) of a zero Betweenness Centrality3 (75.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FLCN,IFNAR1 All fusions
: BC015725;
Proteins found in more fusions RACK1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 BC015725chimera30.3334.000Folliculin_C (PF16692, IPR032035): Folliculin C-terminal domain
2 BTRConcoprotein31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
3 FBXW11interactor31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
4 RACK1suppressor200WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AP2M1interactorAdap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
2 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
3 IFNAR1parental proteinInterfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
4 IFNAR2interactorInterfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
Tissue_fac (PF01108, IPR003961): Tissue factor
5 P2RX4interactorP2X_receptor (PF00864, IPR001429): ATP P2X receptor
6 PEX19interactorPex19 (PF04614, IPR006708): Pex19 protein family
Rod-binding (PF10135, IPR019301): Rod binding protein
7 PIK3R1oncoproteinRhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
8 PLD6parental proteinAPOBEC_C (PF05240, IPR007904): APOBEC-like C-terminal domain
PLDc_2 (PF13091, IPR025202): PLD-like domain
9 PRKD2interactorABC1 (PF03109, IPR004147): ABC1 family
Pkinase (PF00069, IPR000719): Protein kinase domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
10 PRMT1interactorMethyltransf_25 (PF13649): Methyltransferase domain
11 SFNsuppressor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
12 SOCS1suppressorSH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
13 STAT2oncoproteinSH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT2_C (PF12188, IPR022756): Signal transducer and activator of transcription 2 C terminal
14 STAT3suppressorSH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
15 STAT6oncoproteinSH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT6_C (PF14596, IPR028187): STAT6 C-terminal
16 TYK2interactorPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase

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