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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AY187921 is the fusion of parental proteins MLLT1, KMT2A (from a repository: Sun Nov 13 16:24:43 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)107
The number (and %) of the onco-proteins46 (42.99 %)
The number (and %) of the tumor suppressors18 (16.82 %)
Total number of binary PPIs (saturation %)721 (12.71 %)
The number (and %) of affected PPIs106 (14.70 %)
The number of possible different fusions21
PPI diameter2
PPI radius1
The average degree of PPI12.710
Assortativity coefficient-0.2576
The network average Clustering coefficient0.514
The number (and %) of a zero Clustering coefficients4 (3.74 %)
The number (and %) of a zero Betweenness Centrality12 (11.21 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: KMT2A,MLLT1 All fusions
: AY187921;
Proteins found in more fusions AFF1 (see 1 fusions); CTBP1 (see 2 fusions); MRPL12 (see 1 fusions); SMARCB1 (see 12 fusions); RUNX1 (see 1 fusions); CREBBP (see 5 fusions); CREBBP/KAT6A (see 10 fusions); EWSR1 (see 2 fusions); KIF11 (see 1 fusions); KAT8 (see 1 fusions); POLR2A (see 2 fusions); CSNK2A1 (see 1 fusions); CHD3 (see 1 fusions); SMARCC1 (see 2 fusions); HCFC1 (see 2 fusions); MAP3K5 (see 1 fusions); NCL (see 3 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AY187921chimera1060.1036736.761AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
YEATS (PF03366, IPR005033): YEATS family
YL1 (PF05764, IPR008895): YL1 nuclear protein
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
2 ACACAinteractor60.5332.737ACC_central (PF08326, IPR013537): Acetyl-CoA carboxylase, central region
Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Carboxyl_trans (PF01039, IPR000022): Carboxyl transferase domain
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
DUF445 (PF04286, IPR007383): Protein of unknown function (DUF445)
3 AFDNoncoprotein40.5001.583DIL (PF01843, IPR018444, SM01132): DIL domain
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FHA (PF00498, IPR000253, SM00240): FHA domain
MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
Pap_E4 (PF02711, IPR003861): E4 protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
ARGLU (PF15346): Arginine and glutamate-rich 1
4 AFF1oncoprotein160.45735.302AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
5 AFF4oncoprotein120.68210.181AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
6 ASB2interactor70.4677.333Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
7 AVPinteractor200Protamine_P1 (PF00260, IPR000221): Protamine P1
8 BCORoncoprotein80.4299.050Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
9 BMI1oncoprotein210.36858.827zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
10 BRD4oncoprotein100.37817.417Caldesmon (PF02029, IPR006018): Caldesmon
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Stm1_N (PF09598, IPR019084): Stm1
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
NAM-associated (PF14303, IPR029466): No apical meristem-associated C-terminal domain
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
BRD4_CDT (PF17105, IPR031354): C-terminal domain of bromodomain protein 4
11 CBX4oncoprotein130.47017.749Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
CBX7_C (PF17218): CBX family C-terminal motif
12 CBX8interactor120.52715.959Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
13 CCNT1oncoprotein150.48424.326Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
MDFI (PF15316, IPR026134): MyoD family inhibitor
14 CDK9protein found in more fusions180.41948.400Pkinase (PF00069, IPR000719): Protein kinase domain
15 CHD1suppressor70.5714.374CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Serglycin (PF04360, IPR007455): Serglycin
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4208 (PF13907, IPR025260): Domain of unknown function (DUF4208)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
16 CHD3oncoprotein210.49541.674CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
17 CREBBPsuppressor270.345102.070Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
18 CSNK2A1oncoprotein260.330105.371Pkinase (PF00069, IPR000719): Protein kinase domain
19 CSNK2A2interactor120.42413.784Pkinase (PF00069, IPR000719): Protein kinase domain
20 CTBP1protein found in more fusions140.48718.1872-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
21 CTNNB1oncoprotein80.4646.545Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
22 CTR9interactor170.32471.181DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
Pap_E4 (PF02711, IPR003861): E4 protein
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175)
TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat
TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
23 CXXC1interactor90.5836.494ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLATZ (PF04640, IPR006734): PLATZ transcription factor
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116)
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347)
zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
24 DOT1Loncoprotein90.38915.362AT_hook (PF02178, IPR017956, SM00384): AT hook motif
DivIC (PF04977, IPR007060): Septum formation initiator
DOT1 (PF08123, IPR013110): Histone methylation protein DOT1
ZapB (PF06005, IPR009252): Cell division protein ZapB
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
25 DYNLT1interactor30.6671.000Tctex-1 (PF03645, IPR005334): Tctex-1 family
26 E2F2suppressor100E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
27 E2F4suppressor41.0000E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
SPX (PF03105, IPR004331): SPX domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
28 E2F6oncoprotein60.8000.933BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
29 EAF1suppressor100.7117.774Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Peroxin-3 (PF04882, IPR006966): Peroxin-3
EAF (PF09816, IPR019194): RNA polymerase II transcription elongation factor
30 ELLoncoprotein90.6943.676Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
31 ELL2interactor90.8611.555Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Wbp11 (PF09429, IPR019007): WW domain binding protein 11
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
32 ELL3interactor90.6395.340Occludin_ELL (PF07303, IPR010844): Occludin homology domain
ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
TEX19 (PF15553, IPR029093): Testis-expressed protein 19
33 EWSR1oncoprotein170.34244.824RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
34 H2AFXsuppressor160.44228.232Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
35 H3F3Aoncoprotein140.30842.791Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
36 HCFC1protein found in more fusions160.41936.494fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
37 HCFC2interactor51.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
38 HDAC1suppressor340.339180.532FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
39 HDAC2suppressor310.414103.024Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
40 HECW2interactor100.5289.005C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
41 HIST1H1Boncoprotein40.5001.667Pneumo_att_G (PF05539, IPR008781): Pneumovirinae attachment membrane glycoprotein G
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
42 HIST1H2BGoncoprotein60.4005.619Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
43 HIST1H3Ainteractor300.246194.613Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
44 HIST1H4Ainteractor160.47525.283CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
45 HIST2H2ACinteractor120.6526.374Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
46 HIST2H2BEinteractor120.48515.912Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
47 HIST2H3Cinteractor90.27815.867Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
48 HIST3H3interactor280.288143.645Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
49 HIST4H4interactor160.40031.827CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
50 ING4suppressor70.3333.915PHD (PF00628, IPR019787, SM00249): PHD-finger
SOGA (PF11365, IPR027881): Protein SOGA
ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
51 KAT6Aoncoprotein110.41816.120BUD22 (PF09073, IPR015158): BUD22
MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
PHD (PF00628, IPR019787, SM00249): PHD-finger
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
zf-met (PF12874): Zinc-finger of C2H2 type
52 KAT8protein found in more fusions150.37431.716MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
53 KIF11protein found in more fusions50.5001.056Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2
DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510)
Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
54 KRASoncoprotein60.4004.019Ras (PF00071, IPR001806, SM00173): Ras family
55 LEO1interactor90.5838.409Leo1 (PF04004, IPR007149): Leo1-like protein
PPP4R2 (PF09184, IPR015267): PPP4R2
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
56 LGR4interactor50.5002.0007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
57 MAP3K5oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
58 MBD3interactor120.8182.629DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
59 MED26interactor150.47636.212Med26 (PF08711, IPR017923): TFIIS helical bundle-like domain
Med26_C (PF15693, IPR031416): Mediator complex subunit 26 C-terminal
Med26_M (PF15694, IPR031417): Mediator complex subunit 26 middle domain
60 MEN1suppressor210.31483.804Menin (PF05053, IPR007747): Menin
61 MLLT10oncoprotein60.7002.167SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
Tnp_zf-ribbon_2 (PF13842, IPR032718): DDE_Tnp_1-like zinc-ribbon
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
AP3D1 (PF06375): AP-3 complex subunit delta-1
62 MLLT3oncoprotein180.36670.658Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446)
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
NKAP (PF15692): NF-kappa-B-activating protein
BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
63 MLLT6oncoprotein21.0000DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
64 MRPL12protein found in more fusions31.0000Ribosomal_L12 (PF00542, IPR013823): Ribosomal protein L7/L12 C-terminal domain
Ribosomal_L12_N (PF16320, IPR008932): Ribosomal protein L7/L12 dimerisation domain
65 MTM1interactor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
3-PAP (PF12578, IPR022587): Myotubularin-associated protein
66 MYBoncoprotein90.4726.002Cmyb_C (PF09316, IPR015395): C-myb, C-terminal
LMSTEN (PF07988, IPR012642): LMSTEN motif
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
67 NCLprotein found in more fusions180.38250.286DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
Myc_N (PF01056, IPR012682): Myc amino-terminal region
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
YL1 (PF05764, IPR008895): YL1 nuclear protein
Limkain-b1 (PF11608, IPR024582): Limkain b1
68 OXTinteractor100Hormone_4 (PF00220, IPR022423): Neurohypophysial hormones, N-terminal Domain
Hormone_5 (PF00184, IPR000981, SM00003): Neurohypophysial hormones, C-terminal Domain
69 PAF1oncoprotein120.43919.947Paf1 (PF03985, IPR007133): Paf1
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
70 PKN1interactor50.8330.400C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
71 POLR2Aprotein found in more fusions200.31071.475RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
72 PPIEinteractor31.0000Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
73 PPP1R15Ainteractor21.0000FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region
SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1
CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
74 PSIP1oncoprotein40.5000.850AT_hook (PF02178, IPR017956, SM00384): AT hook motif
BEX (PF04538, IPR021156): Brain expressed X-linked like family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
PGA2 (PF07543, IPR011431): Protein trafficking PGA2
PWWP (PF00855, IPR000313, SM00293): PWWP domain
LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF)
TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
75 RANoncoprotein70.5715.471Ras (PF00071, IPR001806, SM00173): Ras family
76 RBBP4oncoprotein230.51438.331eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
77 RBBP5oncoprotein170.37540.088WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
78 RBBP7suppressor200.55824.623WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein
CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
79 RFX5oncoprotein60.4676.500RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
RFX5_DNA_bdg (PF14621, IPR029298): RFX5 DNA-binding domain
80 RFXAPinteractor30.6671.000RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
81 RNF2interactor320.290175.502zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
82 RPL12interactor50.5004.000Ribosomal_L11 (PF00298, IPR020783): Ribosomal protein L11, RNA binding domain
Ribosomal_L11_N (PF03946, IPR020784): Ribosomal protein L11, N-terminal domain
83 RUNX1suppressor100.6674.145Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
84 SAP30interactor90.8332.488Titin_Z (PF09042, IPR015129): Titin Z
zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger
SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
85 SBF1interactor21.0000dDENN (PF03455, IPR005112, SM00801): dDENN domain
DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain
GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
PH (PF00169, IPR001849, SM00233): PH domain
uDENN (PF03456, IPR005113, SM00800): uDENN domain
T2SSJ (PF11612, IPR010055): Type II secretion system (T2SS), protein J
SBF2 (PF12335, IPR022096): Myotubularin protein
86 SEToncoprotein60.5000.744NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
Nop14 (PF04147, IPR007276): Nop14-like family
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
87 SIN3Aoncoprotein270.40291.511Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor
PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat
Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
88 SIRT1suppressor170.31745.363DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
89 SIRT7interactor260.295135.504DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
90 SKP2suppressor40.6671.667LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_2 (PF07723, IPR013101): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
91 SMARCA2suppressor240.43160.544DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
92 SMARCB1suppressor170.50836.447SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
93 SMARCC1suppressor150.54914.302SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
94 SMARCC2interactor130.6925.293GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
95 SNW1protein found in more fusions220.29594.287SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
96 SVILinteractor30.6671.000Gelsolin (PF00626, IPR007123): Gelsolin repeat
VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
97 SYMPKinteractor50.7001.567HEAT (PF02985, IPR000357): HEAT repeat
DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453)
Symplekin_C (PF12295, IPR022075): Symplekin tight junction protein C terminal
Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
98 TAF1oncoprotein150.41930.251Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
LcrG (PF07216, IPR009863): LcrG protein
Opi1 (PF08618, IPR013927): Transcription factor Opi1
Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal
TBP-binding (PF09247, IPR009067): TATA box-binding protein binding
U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591)
zf-CCHC_6 (PF15288): Zinc knuckle
99 TAF6interactor200.55332.537CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal
TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
100 TAF9interactor90.8061.679TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
101 TBPinteractor150.56016.563TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
102 TCEB1oncoprotein60.5336.000Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
103 TCEB2interactor40.8330.667ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
104 TOP1oncoprotein110.54514.424DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core
Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment
MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
TonB_N (PF16031): TonB N-terminal region
105 TP53suppressor400.244317.713DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
106 WDR5interactor220.35981.736WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
107 WDR61interactor60.8001.733WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ASH2LinteractorSPRY (PF00622, IPR003877, SM00449): SPRY domain
PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
2 CBFBsuppressorCBF_beta (PF02312, IPR003417): Core binding factor beta subunit
3 CDC73suppressorCDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal
CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
4 INSinteractorInsulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
5 KMT2Aparental proteinAT_hook (PF02178, IPR017956, SM00384): AT hook motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus
FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
SET (PF00856, IPR001214, SM00317): SET domain
zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
6 MLLT1parental proteinDUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Peptidase_S64 (PF08192, IPR012985): Peptidase family S64
YEATS (PF03366, IPR005033): YEATS family
DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
7 PIH1D1interactorPIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
8 SENP3interactorNop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
9 TASP1interactorAsparaginase_2 (PF01112, IPR000246): Asparaginase

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