Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	41
The number (and %) of the onco-proteins	8 (19.51 %)
The number (and %) of the tumor suppressors	17 (41.46 %)
Total number of binary PPIs (saturation %)	242 (29.51 %)
The number (and %) of affected PPIs	40 (16.53 %)
The number of possible different fusions	8
PPI diameter	2
PPI radius	1
The average degree of PPI	11.073
Assortativity coefficient	-0.1743
The network average Clustering coefficient	0.655
The number (and %) of a zero Clustering coefficients	4 (9.76 %)
The number (and %) of a zero Betweenness Centrality	11 (26.83 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: SSX2,SS18	All fusions : AY138490;
Proteins found in more fusions	SMARCC1 (see 2 fusions); EZH2 (see 1 fusions); CUL3 (see 1 fusions); EP300 (see 1 fusions); GRB2 (see 1 fusions); SMARCB1 (see 12 fusions); SUZ12 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AY138490	chimera	40	0.240	784.279	SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
2	AKAP9	oncoprotein	3	1.000	0	ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11 FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Hema_stalk (PF08720, IPR014831): Influenza C hemagglutinin stalk IncA (PF04156, IPR007285): IncA protein Laminin_II (PF06009, IPR010307): Laminin Domain II Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP) Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region ApoO (PF09769, IPR019166): Apolipoprotein O Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Macoilin (PF09726, IPR019130): Transmembrane protein PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) FlxA (PF14282, IPR025577): FlxA-like protein DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407) UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain FAM76 (PF16046, IPR032017): FAM76 protein ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
3	ARID1A	suppressor	17	0.772	8.031	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
4	ARID1B	oncoprotein	14	0.923	1.325	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin (PF01080, IPR001108): Presenilin DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235) DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa Spt20 (PF12090, IPR021950): Spt20 family
5	ARID2	suppressor	9	1.000	0	ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
6	ATF2	oncoprotein	5	0.500	2.000	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
7	BCL7A	suppressor	12	0.924	1.071	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
8	BCL7B	suppressor	10	0.978	0.154	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
9	BCL7C	suppressor	13	0.936	1.071	BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
10	BRD9	interactor	2	1.000	0	TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3 Bromodomain (PF00439, IPR001487, SM00297): Bromodomain DUF3512 (PF12024, IPR021900): Domain of unknown function (DUF3512)
11	CDKN1A	suppressor	5	0.700	1.500	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
12	CST11	interactor	1	0	0	Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
13	CUL3	protein found in more fusions	14	0.526	28.733	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14	DPF1	interactor	7	1.000	0	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PHD_4 (PF16866, IPR019787): PHD-finger
15	DPF2	interactor	15	0.810	5.281	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
16	DPF3	interactor	14	0.879	2.456	PHD (PF00628, IPR019787, SM00249): PHD-finger zf-C2H2_4 (PF13894): C2H2-type zinc finger Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ. Lar_restr_allev (PF14354): Restriction alleviation protein Lar
17	EED	suppressor	15	0.593	18.256	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18	EP300	oncoprotein	8	0.381	9.583	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
19	EZH2	suppressor	8	0.714	3.369	CDC45 (PF02724, IPR003874): CDC45-like protein TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain SET (PF00856, IPR001214, SM00317): SET domain EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2 Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
20	GLTSCR1	suppressor	2	1.000	0	SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
21	GRB2	oncoprotein	5	0.667	1.500	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
22	HDAC1	suppressor	18	0.515	39.840	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23	HDAC2	suppressor	14	0.615	14.383	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
24	MLLT10	oncoprotein	3	1.000	0	SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal PHD_2 (PF13831): PHD-finger zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain Tnp_zf-ribbon_2 (PF13842, IPR032718): DDE_Tnp_1-like zinc-ribbon CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106 DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718) DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887) AP3D1 (PF06375): AP-3 complex subunit delta-1
25	NEFM	interactor	1	0	0	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886) DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
26	NFKBID	interactor	1	0	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
27	PHF10	interactor	9	1.000	0	Herpes_MCP (PF03122, IPR000912): Herpes virus major capsid protein PHD (PF00628, IPR019787, SM00249): PHD-finger MRI (PF15325, IPR028278): Modulator of retrovirus infection
28	RBM14	suppressor	9	0.556	8.555	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
29	RNF2	interactor	15	0.560	22.523	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
30	SMARCA2	suppressor	20	0.632	28.899	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
31	SMARCA4	suppressor	22	0.615	26.505	DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain BRK (PF07533, IPR006576, SM00592): BRK domain Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065) SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
32	SMARCA5	interactor	10	0.833	1.755	HAND (PF09110, IPR015194): HAND SLIDE (PF09111, IPR015195): SLIDE SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DBINO (PF13892, IPR020838): DNA-binding domain RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
33	SMARCB1	suppressor	22	0.610	36.448	SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
34	SMARCC1	suppressor	22	0.619	27.025	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
35	SMARCC2	interactor	22	0.597	35.866	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
36	SMARCD1	interactor	20	0.605	45.206	ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit DivIC (PF04977, IPR007060): Septum formation initiator SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
37	SMARCE1	interactor	20	0.647	19.483	DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1) Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
38	SUZ12	suppressor	10	0.722	5.536	DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070) VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
39	SYNCRIP	interactor	5	0.600	2.536	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
40	TAX1BP1	interactor	1	0	0	CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80 zf-C2H2_4 (PF13894): C2H2-type zinc finger PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
41	TLE1	interactor	6	0.600	2.833	TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ACTL6A	interactor	Actin (PF00022, IPR004000, SM00268): Actin
2	ACTL6B	interactor	Actin (PF00022, IPR004000, SM00268): Actin
3	BLZF1	interactor	DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178) ZapB (PF06005, IPR009252): Cell division protein ZapB JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
4	ELAVL1	oncoprotein	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5	KRT40	interactor	Filament (PF00038, IPR001664): Intermediate filament protein UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
6	MAGEC2	interactor	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal APOC4 (PF15119, IPR028120): Apolipoprotein C4
7	RAB3IP	interactor	Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
8	RAB5C	oncoprotein	Ras (PF00071, IPR001806, SM00173): Ras family
9	SMARCD2	interactor	SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
10	SMARCD3	interactor	SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
11	SS18	parental protein	SSXT (PF05030, IPR007726): SSXT protein (N-terminal region) Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
12	SSX2	parental protein	KRAB (PF01352, IPR001909, SM00349): KRAB box
13	SSX2B	interactor	KRAB (PF01352, IPR001909, SM00349): KRAB box
14	SSX2IP	interactor	ZapB (PF06005, IPR009252): Cell division protein ZapB ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding YqzH (PF14164, IPR025546): YqzH-like protein
15	SSX3	interactor	KRAB (PF01352, IPR001909, SM00349): KRAB box
16	SYCE1	interactor	CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
17	YWHAG	interactor	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
18	ZBED1	interactor	Dimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region zf-BED (PF02892, IPR003656, SM00614): BED zinc finger DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)
19	ZMIZ2	interactor	zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger

B a c k t o T o p ⇑

Fusion ID: Protein names:	AY138490
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

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