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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AY138489 is the fusion of parental proteins SSX2, SS18 (from a repository: Tue Feb 7 03:21:36 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins8 (19.51 %)
The number (and %) of the tumor suppressors17 (41.46 %)
Total number of binary PPIs (saturation %)242 (29.51 %)
The number (and %) of affected PPIs40 (16.53 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI11.073
Assortativity coefficient-0.1743
The network average Clustering coefficient0.655
The number (and %) of a zero Clustering coefficients4 (9.76 %)
The number (and %) of a zero Betweenness Centrality11 (26.83 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SSX2,SS18 All fusions
: AY138489;
Proteins found in more fusions SMARCC1 (see 2 fusions); EZH2 (see 1 fusions); CUL3 (see 1 fusions); EP300 (see 1 fusions); GRB2 (see 1 fusions); SMARCB1 (see 12 fusions); SUZ12 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AY138489chimera400.240784.279SSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
2 AKAP9oncoprotein31.0000ACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
ZYG-11_interact (PF05884, IPR008574): Interactor of ZYG-11
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
Hema_stalk (PF08720, IPR014831): Influenza C hemagglutinin stalk
IncA (PF04156, IPR007285): IncA protein
Laminin_II (PF06009, IPR010307): Laminin Domain II
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
ApoO (PF09769, IPR019166): Apolipoprotein O
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Macoilin (PF09726, IPR019130): Transmembrane protein
PACT_coil_coil (PF10495, IPR019528): Pericentrin-AKAP-450 domain of centrosomal targeting protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
FlxA (PF14282, IPR025577): FlxA-like protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
FAM76 (PF16046, IPR032017): FAM76 protein
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
3 ARID1Asuppressor170.7728.031ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
YscJ_FliF_C (PF08345, IPR013556): Flagellar M-ring protein C-terminal
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
4 ARID1Boncoprotein140.9231.325ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908)
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Presenilin (PF01080, IPR001108): Presenilin
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
DUF2235 (PF09994, IPR018712): Uncharacterized alpha/beta hydrolase domain (DUF2235)
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
Spt20 (PF12090, IPR021950): Spt20 family
5 ARID2suppressor91.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
BAF250_C (PF12031, IPR021906): SWI/SNF-like complex subunit BAF250/Osa
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
6 ATF2oncoprotein50.5002.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
7 BCL7Asuppressor120.9241.071BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754)
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
UPF0561 (PF10573, IPR018888): Uncharacterised protein family UPF0561
8 BCL7Bsuppressor100.9780.154BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
9 BCL7Csuppressor130.9361.071BCL_N (PF04714, IPR006804): BCL7, N-terminal conserver region
10 BRD9interactor21.0000TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
NPR3 (PF03666, IPR005365): Nitrogen Permease regulator of amino acid transport activity 3
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
DUF3512 (PF12024, IPR021900): Domain of unknown function (DUF3512)
11 CDKN1Asuppressor50.7001.500CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
12 CST11interactor100Cystatin (PF00031, IPR000010, SM00043): Cystatin domain
13 CUL3protein found in more fusions140.52628.733Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14 DPF1interactor71.0000PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ.
PHD_4 (PF16866, IPR019787): PHD-finger
15 DPF2interactor150.8105.281PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ.
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
Zf_RING (PF16744, IPR031946): KIAA1045 RING finger
16 DPF3interactor140.8792.456PHD (PF00628, IPR019787, SM00249): PHD-finger
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Requiem_N (PF14051, IPR025750): N-terminal domain of DPF2/REQ.
Lar_restr_allev (PF14354): Restriction alleviation protein Lar
17 EEDsuppressor150.59318.256WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
18 EP300oncoprotein80.3819.583Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
19 EZH2suppressor80.7143.369CDC45 (PF02724, IPR003874): CDC45-like protein
TCR (PF03638, IPR005172, SM01114): Tesmin/TSO1-like CXC domain, cysteine-rich domain
SET (PF00856, IPR001214, SM00317): SET domain
EZH2_WD-Binding (PF11616, IPR021654): WD repeat binding protein EZH2
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
20 GLTSCR1suppressor21.0000SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
GLTSCR1 (PF15249, IPR015671): Conserved region of unknown function on GLTSCR protein
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
21 GRB2oncoprotein50.6671.500SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
22 HDAC1suppressor180.51539.840FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
23 HDAC2suppressor140.61514.383Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
24 MLLT10oncoprotein31.0000SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
Tnp_zf-ribbon_2 (PF13842, IPR032718): DDE_Tnp_1-like zinc-ribbon
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
AP3D1 (PF06375): AP-3 complex subunit delta-1
25 NEFMinteractor100ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
DUF4637 (PF15470, IPR029174): Domain of unknown function (DUF4637)
26 NFKBIDinteractor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
27 PHF10interactor91.0000Herpes_MCP (PF03122, IPR000912): Herpes virus major capsid protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
MRI (PF15325, IPR028278): Modulator of retrovirus infection
28 RBM14suppressor90.5568.555RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
29 RNF2interactor150.56022.523zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
30 SMARCA2suppressor200.63228.899DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168)
DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
BRK (PF07533, IPR006576, SM00592): BRK domain
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
31 SMARCA4suppressor220.61526.505DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840)
HSA (PF07529, IPR014012, SM00573): HSA
QLQ (PF08880, IPR014978, SM00951): QLQ
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
BRK (PF07533, IPR006576, SM00592): BRK domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4065 (PF13274, IPR025272): Protein of unknown function (DUF4065)
SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
32 SMARCA5interactor100.8331.755HAND (PF09110, IPR015194): HAND
SLIDE (PF09111, IPR015195): SLIDE
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DBINO (PF13892, IPR020838): DNA-binding domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
33 SMARCB1suppressor220.61036.448SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
34 SMARCC1suppressor220.61927.025SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
35 SMARCC2interactor220.59735.866GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1
SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal
SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
36 SMARCD1interactor200.60545.206ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
DivIC (PF04977, IPR007060): Septum formation initiator
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
37 SMARCE1interactor200.64719.483DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
38 SUZ12suppressor100.7225.536DUF2070 (PF09843, IPR019204): Predicted membrane protein (DUF2070)
VEFS-Box (PF09733, IPR019135): VEFS-Box of polycomb protein
39 SYNCRIPinteractor50.6002.536RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
40 TAX1BP1interactor100CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
41 TLE1interactor60.6002.833TLE_N (PF03920, IPR005617): Groucho/TLE N-terminal Q-rich domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACTL6AinteractorActin (PF00022, IPR004000, SM00268): Actin
2 ACTL6BinteractorActin (PF00022, IPR004000, SM00268): Actin
3 BLZF1interactorDASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF1178 (PF06676, IPR009562): Protein of unknown function (DUF1178)
ZapB (PF06005, IPR009252): Cell division protein ZapB
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
4 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
5 KRT40interactorFilament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
6 MAGEC2interactorMAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
APOC4 (PF15119, IPR028120): Apolipoprotein C4
7 RAB3IPinteractorSec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
8 RAB5ConcoproteinRas (PF00071, IPR001806, SM00173): Ras family
9 SMARCD2interactorSWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
10 SMARCD3interactorSWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
11 SS18parental proteinSSXT (PF05030, IPR007726): SSXT protein (N-terminal region)
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
12 SSX2parental proteinKRAB (PF01352, IPR001909, SM00349): KRAB box
13 SSX2BinteractorKRAB (PF01352, IPR001909, SM00349): KRAB box
14 SSX2IPinteractorZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
15 SSX3interactorKRAB (PF01352, IPR001909, SM00349): KRAB box
16 SYCE1interactorCENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
17 YWHAGinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
18 ZBED1interactorDimer_Tnp_hAT (PF05699, IPR008906): hAT family C-terminal dimerisation region
zf-BED (PF02892, IPR003656, SM00614): BED zinc finger
DUF4413 (PF14372, IPR025525): Domain of unknown function (DUF4413)
19 ZMIZ2interactorzf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger

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