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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW993608 is the fusion of parental proteins CASP2 (from a repository: Mon Dec 5 21:52:10 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)26
The number (and %) of the onco-proteins13 (50.00 %)
The number (and %) of the tumor suppressors2 (7.69 %)
Total number of binary PPIs (saturation %)96 (29.54 %)
The number (and %) of affected PPIs25 (26.04 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI6.077
Assortativity coefficient-0.3097
The network average Clustering coefficient0.608
The number (and %) of a zero Clustering coefficients5 (19.23 %)
The number (and %) of a zero Betweenness Centrality11 (42.31 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CASP2 All fusions
: AW993608;
Proteins found in more fusions RXRA (see 2 fusions); BCL2L1 (see 1 fusions); NOD1 (see 1 fusions); EEF1A1 (see 1 fusions); NOL3 (see 2 fusions); GRB2 (see 1 fusions); TNFRSF1A (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW993608chimera250.180381.333Peptidase_C14 (PF00656, IPR011600): Caspase domain
2 BBOX1interactor200DUF971 (PF06155, IPR010376): Protein of unknown function (DUF971)
TauD (PF02668, IPR003819): Taurine catabolism dioxygenase TauD, TfdA family
3 BCL2oncoprotein60.9000.400Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
4 BCL2L1oncoprotein60.9000.400Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
5 BIRC2oncoprotein90.8931.200BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 CASP10interactor100.7505.200DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
7 CASP14interactor31.0000Peptidase_C14 (PF00656, IPR011600): Caspase domain
8 CASP3interactor110.6898.400Peptidase_C14 (PF00656, IPR011600): Caspase domain
9 CASP7interactor100.8332.367Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
10 CASP8suppressor150.48433.000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
11 CASP9oncoprotein110.60015.567CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
12 CCND3oncoprotein100Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
13 CRADDinteractor50.5004.500CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Death (PF00531, IPR000488, SM00005): Death domain
14 CRYABoncoprotein110.55616.133Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
15 EEF1A1suppressor40.6671.000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
16 EPN3interactor100ENTH (PF01417, IPR001026, SM00273): ENTH domain
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
17 GRB2oncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
18 MDM2oncoprotein50.6672.000Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
19 NLRP1interactor21.0000Birna_VP5 (PF03042, IPR004284): Birnavirus VP5 protein
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Herpes_U30 (PF04523, IPR007611): Herpes virus tegument protein U30
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
FIIND (PF13553, IPR025307): Function to find
20 NOD1oncoprotein51.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
Sigma54_AID (PF00309, IPR000394): Sigma-54 factor, Activator interacting domain (AID)
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
21 NOL3oncoprotein41.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
22 PIDD1interactor31.0000Death (PF00531, IPR000488, SM00005): Death domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Peptidase_S68 (PF10461, IPR019502): Peptidase S68
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
23 RAI1interactor100Lin-8 (PF03353, IPR005020): Ras-mediated vulval-induction antagonist
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
24 RXRAoncoprotein200zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nuc_recep-AF1 (PF11825, IPR021780): Nuclear/hormone receptor activator site AF-1
25 TNFRSF1Aoncoprotein90.50012.333Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
26 XIAPinteractor110.6898.167BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BIDoncoproteinBID (PF06393, IPR010479): BH3 interacting domain (BID)
2 CASP2parental proteinCARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
3 ELAVL1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
4 RPL30interactorNCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
5 SUMO1interactorRad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
6 UBE2IinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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