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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)129
The number (and %) of the onco-proteins31 (24.03 %)
The number (and %) of the tumor suppressors14 (10.85 %)
Total number of binary PPIs (saturation %)576 (6.98 %)
The number (and %) of affected PPIs128 (22.22 %)
The number of possible different fusions17
PPI diameter2
PPI radius1
The average degree of PPI8.233
Assortativity coefficient-0.3023
The network average Clustering coefficient0.524
The number (and %) of a zero Clustering coefficients14 (10.85 %)
The number (and %) of a zero Betweenness Centrality33 (25.58 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: USP11 All fusions
: AW955052;
Proteins found in more fusions CRY2 (see 3 fusions); CTNNA1 (see 3 fusions); CUL1 (see 3 fusions); IVNS1ABP (see 2 fusions); FAF1 (see 2 fusions); MAPK14 (see 1 fusions); UBA1 (see 2 fusions); NUP153 (see 2 fusions); HNRNPD (see 1 fusions); POLR2E (see 2 fusions); RANBP9 (see 2 fusions); UBC (see 1 fusions); MYO6 (see 3 fusions); RING1 (see 1 fusions); PCGF2 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW955052chimera1280.05012334.998DUF1610 (PF07754, IPR011668): Domain of unknown function (DUF1610)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
2 AMOToncoprotein40.6670.333FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
3 ATAD3Binteractor40.6671.333AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
TsaE (PF02367, IPR003442): Threonylcarbamoyl adenosine biosynthesis protein TsaE
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
4 ATG10interactor21.0000Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
5 ATG4Cinteractor100Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
6 BMI1oncoprotein140.38530.655zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
7 BRCA2suppressor50.5004.000BRCA-2_helical (PF09169, IPR015252): BRCA2, helical
BRCA-2_OB1 (PF09103, IPR015187): BRCA2, oligonucleotide/oligosaccharide-binding, domain 1
BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3
BRCA2 (PF00634, IPR002093): BRCA2 repeat
Tower (PF09121, IPR015205): Tower
8 BUB3interactor50.7001.500WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
9 CAND1interactor180.36854.605Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
10 CBX8interactor90.6435.883Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
11 CDC27oncoprotein80.33311.583TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
12 CDKN1Asuppressor110.25529.367CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
13 CIAO1interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14 CLK3interactor50.8330.250Pkinase (PF00069, IPR000719): Protein kinase domain
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
15 CNOT8interactor100CAF1 (PF04857, IPR006941): CAF1 family ribonuclease
16 CRY1interactor80.5244.571DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
17 CRY2protein found in more fusions100.44412.007DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
18 CSinteractor50.6001.121Citrate_synt (PF00285, IPR002020): Citrate synthase, C-terminal domain
19 CTNNA1oncoprotein110.7563.787Vinculin (PF01044, IPR006077): Vinculin family
20 CUL1suppressor170.34252.017Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
21 CUL4Boncoprotein170.36848.484Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
22 DDX19Binteractor30.6670.400DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
23 DYRK1Boncoprotein70.4007.667Pkinase (PF00069, IPR000719): Protein kinase domain
24 DYRK4interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
25 ECT2suppressor40.5001.233BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
26 EIF4Binteractor120.54513.000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
27 ELMSAN1interactor30.6670.500ELM2 (PF01448, IPR000949): ELM2 domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
28 ESPL1interactor40.8330.133Peptidase_C50 (PF03568, IPR005314): Peptidase family C50
29 FAF1protein found in more fusions130.45522.002UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
30 FARSAinteractor41.0000tRNA-synt_2d (PF01409, IPR002319): tRNA synthetases class II core domain (F)
MarR_2 (PF12802): MarR family
31 FBXO45interactor21.0000SPRY (PF00622, IPR003877, SM00449): SPRY domain
F-box-like (PF12937, IPR001810): F-box-like
32 FOXI2interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
33 FOXJ3interactor21.0000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
34 FOXP3suppressor30.6670.667Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain
35 GARSinteractor100.57811.652HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
36 GIGYF2interactor80.39312.051DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
GYF (PF02213, IPR003169, SM00444): GYF domain
Macoilin (PF09726, IPR019130): Transmembrane protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
DUF3801 (PF12687, IPR024234): Protein of unknown function (DUF3801)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
AAA_23 (PF13476): AAA domain
ARGLU (PF15346): Arginine and glutamate-rich 1
PRTase_3 (PF15610, IPR028944): PRTase ComF-like
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
37 GTSE1interactor40.5001.352GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
38 H2AFXsuppressor130.35934.729Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
39 HNRNPDoncoprotein150.30845.292CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
40 HSPH1oncoprotein90.6675.200HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
41 IVNS1ABPprotein found in more fusions31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
42 KCTD6interactor200BTB_2 (PF02214, IPR003131): BTB/POZ domain
43 KEAP1oncoprotein60.5003.500BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
44 KIAA0930interactor100DUF2045 (PF09741, IPR019141): Uncharacterized conserved protein (DUF2045)
45 KLHL13interactor31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
46 LRP8interactor30.6670.133EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Ldl_recept_b (PF00058, IPR000033, SM00135): Low-density lipoprotein receptor repeat class B
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
TMEM154 (PF15102, IPR028064): TMEM154 protein family
47 MAP1LC3Cinteractor21.0000Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
48 MAPK14oncoprotein90.42912.500Pkinase (PF00069, IPR000719): Protein kinase domain
49 MIER2interactor30.6670.500ELM2 (PF01448, IPR000949): ELM2 domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
50 MOGSinteractor40.6670.417Glyco_hydro_63 (PF03200, IPR004888): Glycosyl hydrolase family 63 C-terminal domain
Glyco_hydro_63N (PF16923, IPR031631): Glycosyl hydrolase family 63 N-terminal domain
51 MOV10interactor220.203129.656AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
52 MPHOSPH9interactor100CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
IL15 (PF02372, IPR003443): Interleukin 15
Tup_N (PF08581, IPR013890): Tup N-terminal
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
53 MRE11Aoncoprotein100.52810.734APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
54 MYCBP2interactor90.38914.067ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal
PHR (PF08005, IPR012983): PHR domain
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
SH3_3 (PF08239, IPR003646): Bacterial SH3 domain
XPA_N (PF01286, IPR022652): XPA protein N-terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
55 MYO6protein found in more fusions80.5714.573BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
56 MZT1interactor100Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
MOZART1 (PF12554, IPR022214): Mitotic-spindle organizing gamma-tubulin ring associated
57 NEDD8interactor80.5246.413ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
58 NET1oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
59 NOTCH1suppressor110.35620.252Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
60 NTRK1oncoprotein450.140652.796I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
61 NUP153protein found in more fusions80.5244.586Nup153 (PF08604, IPR013913): Nucleoporin Nup153-like
Nup_retrotrp_bd (PF10599, IPR018892): Retro-transposon transporting motif
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
Nucleoporin_FG (PF13634, IPR025574): Nucleoporin FG repeat region
62 NXF1interactor250.188153.198NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
63 OSBPinteractor100.7334.440Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
HlyD_D23 (PF16576, IPR032317): Barrel-sandwich domain of CusB or HlyD membrane-fusion
64 OSBPL10interactor60.4006.167Flagellar_rod (PF05149, IPR007824): Paraflagellar rod protein
Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH_8 (PF15409): Pleckstrin homology domain
65 OSBPL9interactor30.6670.400Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein
PH (PF00169, IPR001849, SM00233): PH domain
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
66 OTUD1interactor21.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
67 OTUD5interactor41.0000OTU (PF02338, IPR003323): OTU-like cysteine protease
Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain
68 PALB2suppressor50.5002.333IncA (PF04156, IPR007285): IncA protein
PALB2_WD40 (PF16756, IPR031920): Partner and localizer of BRCA2 WD40 domain
69 PCGF2suppressor61.0000zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
70 PCK1interactor30.6670.500PEPCK (PF00821, IPR008209): Phosphoenolpyruvate carboxykinase
71 PCNPinteractor50.7001.200PCNP (PF15473, IPR029169): PEST, proteolytic signal-containing nuclear protein family
72 PGAM5interactor110.25528.868His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
73 PIK3C3interactor40.5002.250PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
74 PKN2interactor200C2 (PF00168, IPR000008, SM00239): C2 domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
75 POLR1Ainteractor90.44412.950RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
76 POLR1Binteractor60.6673.067RNA_pol_Rpa2_4 (PF06883, IPR009674): RNA polymerase I, Rpa2 specific domain
RNA_pol_Rpb2_1 (PF04563, IPR007644): RNA polymerase beta subunit
RNA_pol_Rpb2_3 (PF04565, IPR007645): RNA polymerase Rpb2, domain 3
RNA_pol_Rpb2_6 (PF00562, IPR007120): RNA polymerase Rpb2, domain 6
RNA_pol_Rpb2_7 (PF04560, IPR007641): RNA polymerase Rpb2, domain 7
77 POLR1Cinteractor90.47211.933RNA_pol_A_bac (PF01000, IPR011262): RNA polymerase Rpb3/RpoA insert domain
78 POLR2Eprotein found in more fusions60.8001.067RNA_pol_Rpb5_C (PF01191, IPR000783): RNA polymerase Rpb5, C-terminal domain
RNA_pol_Rpb5_N (PF03871, IPR005571): RNA polymerase Rpb5, N-terminal domain
79 PRMT3interactor110.61810.071PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
zf-C2H2_2 (PF12756, IPR015880): C2H2 type zinc-finger (2 copies)
80 PRRC2Binteractor21.0000BAT2_N (PF07001, IPR009738): BAT2 N-terminus
DUF2346 (PF09803, IPR018625): Uncharacterized conserved protein (DUF2346)
Kri1 (PF05178, IPR018034): KRI1-like family
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
MEIOC (PF15189, IPR027963): Meiosis-specific coiled-coil domain-containing protein MEIOC
81 RAD50interactor80.5365.415DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
YscO (PF07321, IPR009929): Type III secretion protein YscO
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2703 (PF10865, IPR021219): Domain of unknown function (DUF2703)
DUF3015 (PF11220, IPR021383): Protein of unknown function (DUF3015)
AAA_13 (PF13166, IPR026866): AAA domain
AAA_23 (PF13476): AAA domain
SbcCD_C (PF13558): Putative exonuclease SbcCD, C subunit
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
DUF4795 (PF16043, IPR032013): Domain of unknown function (DUF4795)
82 RAE1interactor110.40019.774Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
83 RANBP9suppressor80.4296.186Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
84 RAPGEF2interactor40.6672.000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
85 RBM15Binteractor30.6670.154CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
RRM_3 (PF08777, IPR014886): RNA binding motif
SPOC (PF07744, IPR012921): SPOC domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
DUF5094 (PF17015, IPR031519): Domain of unknown function (DUF5094)
86 RELBoncoprotein100RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
RelB_leu_zip (PF16180, IPR032399): RelB leucine zipper
RelB_transactiv (PF16181, IPR032400): RelB transactivation domain
87 RING1protein found in more fusions90.7503.133zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
88 RNF2interactor200.29286.945zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
89 RNF4interactor50.6670.952Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-UDP (PF14569, IPR027934): Zinc-binding RING-finger
90 SEC23Ainteractor160.42542.406Gelsolin (PF00626, IPR007123): Gelsolin repeat
Sec23_BS (PF08033, IPR012990): Sec23/Sec24 beta-sandwich domain
Sec23_helical (PF04815, IPR006900): Sec23/Sec24 helical domain
Sec23_trunk (PF04811, IPR006896): Sec23/Sec24 trunk domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
91 SEC61A1interactor50.8000.287DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430)
SecY (PF00344, IPR002208): SecY translocase
Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
92 SEMA3Bsuppressor100ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
PSI (PF01437, IPR002165, SM00423): Plexin repeat
Sema (PF01403, IPR001627, SM00630): Sema domain
93 SETDB1interactor80.28614.600MBD (PF01429, IPR001739, SM00391): Methyl-CpG binding domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
DUF4537 (PF15057, IPR032770): Domain of unknown function (DUF4537)
PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator
94 SIPA1L1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
SPAR_C (PF11881, IPR021818): C-terminal domain of SPAR protein
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
IQCJ-SCHIP1 (PF15157, IPR029362): Fusion protein IQCJ-SCHIP1 with IQ-like motif
95 SIRT7interactor190.23487.176DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
96 SMAD6interactor41.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
97 SMAD7interactor60.6673.167MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
98 SORT1interactor40.6671.000Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal
Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
99 SPRYD3interactor100Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
100 SSX2IPinteractor40.6670.667ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
101 STK11suppressor40.6671.667Pkinase (PF00069, IPR000719): Protein kinase domain
102 SUMO2interactor100.33315.338Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
103 TCEAL1interactor110.34526.467BEX (PF04538, IPR021156): Brain expressed X-linked like family
104 TCEAL2interactor40.6670.733BEX (PF04538, IPR021156): Brain expressed X-linked like family
105 TCEAL4interactor70.6194.067BEX (PF04538, IPR021156): Brain expressed X-linked like family
MAP17 (PF15807, IPR031627): Membrane-associated protein 117 kDa, PDZK1-interacting protein 1
106 TCEAL9interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
107 TCEB2interactor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
108 TCF4suppressor60.5333.717CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
109 TEAD2interactor50.4003.800TEA (PF01285, IPR000818, SM00426): TEA/ATTS domain family
110 TGFBR1oncoprotein80.5009.400Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
111 TP53suppressor350.155385.962DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
112 TRIM27oncoprotein110.53313.719IncA (PF04156, IPR007285): IncA protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
113 TRIP12interactor50.6002.200Alpha_GJ (PF03229, IPR004913): Alphavirus glycoprotein J
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
WWE (PF02825, IPR004170, SM00678): WWE domain
SOG2 (PF10428, IPR019487): RAM signalling pathway protein
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_2 (PF13646): HEAT repeats
114 UBA1protein found in more fusions80.5245.033ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
115 UBCprotein found in more fusions400.151498.304ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
116 UBE2Q1interactor31.0000Josephin (PF02099, IPR006155): Josephin
RWD (PF05773, IPR006575, SM00591): RWD domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
117 UHRF1interactor100.41713.836PHD (PF00628, IPR019787, SM00249): PHD-finger
SAD_SRA (PF02182, IPR003105, SM00466): SAD/SRA domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
TTD (PF12148, IPR021991): Tandem tudor domain within UHRF1
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
118 UHRF1BP1interactor40.5002.500Chorein_N (PF12624, IPR026854): N-terminal region of Chorein or VPS13
VPS13 (PF16908, IPR031646): Vacuolar sorting-associated protein 13, N-terminal
119 USP15oncoprotein150.40738.275UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
120 USP4oncoprotein110.44416.136UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain
121 USP7oncoprotein290.212220.629MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
122 VGLL4interactor100Vg_Tdu (PF07545, IPR011520): Vestigial/Tondu family
VGLL4 (PF15245, IPR028184): Transcription cofactor vestigial-like protein 4
123 WRAP53oncoprotein31.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
124 WRNIP1interactor60.5003.567AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus
Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein)
MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal
AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain
125 XIAPinteractor80.33310.786BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
126 XPConcoprotein60.7332.619Rad4 (PF03835, IPR018325): Rad4 transglutaminase-like domain
BHD_1 (PF10403, IPR018326, SM01030): Rad4 beta-hairpin domain 1
BHD_2 (PF10404, IPR018327, SM01031): Rad4 beta-hairpin domain 2
BHD_3 (PF10405, IPR018328, SM01032): Rad4 beta-hairpin domain 3
Macoilin (PF09726, IPR019130): Transmembrane protein
SOG2 (PF10428, IPR019487): RAM signalling pathway protein
Abdominal-A (PF12407, IPR022132): Homeobox protein
DUF4820 (PF16091, IPR032150): Domain of unknown function (DUF4820)
127 XPO7interactor160.42545.940IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
128 ZNF24interactor30.6670.500SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
129 ZNF598interactor31.0000Arc_trans_TRASH (PF08394, IPR013603): Archaeal TRASH domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 USP11parental proteinRibosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
DUSP (PF06337, IPR006615, SM00695): DUSP domain
Ubiquitin_3 (PF14836, IPR028135): Ubiquitin-like domain

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