Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	92
The number (and %) of the onco-proteins	32 (34.78 %)
The number (and %) of the tumor suppressors	17 (18.48 %)
Total number of binary PPIs (saturation %)	498 (11.90 %)
The number (and %) of affected PPIs	91 (18.27 %)
The number of possible different fusions	22
PPI diameter	2
PPI radius	1
The average degree of PPI	10.000
Assortativity coefficient	-0.3071
The network average Clustering coefficient	0.567
The number (and %) of a zero Clustering coefficients	6 (6.52 %)
The number (and %) of a zero Betweenness Centrality	23 (25.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: HCFC1	All fusions : AW836706;
Proteins found in more fusions	MPHOSPH8 (see 5 fusions); LMNA (see 3 fusions); NFE2L1 (see 1 fusions); POU2F1 (see 1 fusions); KMT2A (see 16 fusions); KAT8 (see 1 fusions); HSP90AA1 (see 2 fusions); CREBZF (see 1 fusions); EGFR (see 2 fusions); TRIM28 (see 1 fusions); ASH2L/DPY30 (see 1 fusions); MAP3K7 (see 7 fusions); HDAC5 (see 1 fusions); CUL3 (see 1 fusions); NCOA6 (see 1 fusions); RPA1 (see 1 fusions); USF1 (see 3 fusions); YY1 (see 2 fusions); EEF1D (see 3 fusions); SP1 (see 1 fusions); THAP7 (see 1 fusions);

List of the fusions

PPI for parental proteins: HCFC1

All fusions

: AW836706;

Proteins found in more fusions

MPHOSPH8 (see 5 fusions); LMNA (see 3 fusions); NFE2L1 (see 1 fusions); POU2F1 (see 1 fusions); KMT2A (see 16 fusions); KAT8 (see 1 fusions); HSP90AA1 (see 2 fusions); CREBZF (see 1 fusions); EGFR (see 2 fusions); TRIM28 (see 1 fusions); ASH2L/DPY30 (see 1 fusions); MAP3K7 (see 7 fusions); HDAC5 (see 1 fusions); CUL3 (see 1 fusions); NCOA6 (see 1 fusions); RPA1 (see 1 fusions); USF1 (see 3 fusions); YY1 (see 2 fusions); EEF1D (see 3 fusions); SP1 (see 1 fusions); THAP7 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AW836706	chimera	91	0.090	5540.258	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Guanylin (PF02058, IPR000879): Guanylin precursor Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
2	ALDOC	interactor	3	1.000	0	Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
3	ASCL2	interactor	3	1.000	0	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
4	ASF1B	interactor	3	1.000	0	ASF1_hist_chap (PF04729, IPR006818): ASF1 like histone chaperone
5	ASH2L	protein found in more fusions	17	0.442	40.450	SPRY (PF00622, IPR003877, SM00449): SPRY domain PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
6	ASXL1	suppressor	6	0.600	2.252	HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain ASXH (PF13919, IPR028020): Asx homology domain PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx
7	ASXL2	interactor	5	0.800	0.733	DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain HARE-HTH (PF05066, IPR007759): HB1, ASXL, restriction endonuclease HTH domain ASXH (PF13919, IPR028020): Asx homology domain PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx DUF4551 (PF15087, IPR027878): Protein of unknown function (DUF4551)
8	BAP1	suppressor	9	0.500	9.219	Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1 TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
9	BTRC	oncoprotein	10	0.444	13.205	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
10	CDK2	suppressor	20	0.316	71.696	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
11	CLP1	oncoprotein	2	1.000	0	Clp1 (PF06807, IPR010655): Pre-mRNA cleavage complex II protein Clp1 CLP1_N (PF16573, IPR032324): N-terminal beta-sandwich domain of polyadenylation factor CLP1_P (PF16575, IPR032319): mRNA cleavage and polyadenylation factor CLP1 P-loop
12	CREB3	interactor	5	0.500	3.000	bZIP_1 (PF00170, IPR004827): bZIP transcription factor GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
13	CREBZF	protein found in more fusions	4	0.667	0.500	bZIP_1 (PF00170, IPR004827): bZIP transcription factor TSC22 (PF01166, IPR000580): TSC-22/dip/bun family Fungus-induced (PF10917, IPR024415): Fungus-induced protein
14	CUL3	protein found in more fusions	17	0.392	45.252	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
15	CXXC1	interactor	11	0.600	11.983	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain PHD (PF00628, IPR019787, SM00249): PHD-finger PLATZ (PF04640, IPR006734): PLATZ transcription factor zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347) zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
16	DDAH2	interactor	2	1.000	0	Amidinotransf (PF02274, IPR003198): Amidinotransferase
17	DPY30	protein found in more fusions	11	0.644	9.200	Dpy-30 (PF05186, IPR007858): Dpy-30 motif
18	DYNLT1	interactor	5	0.400	3.067	Tctex-1 (PF03645, IPR005334): Tctex-1 family
19	E2F1	suppressor	9	0.444	13.556	Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
20	E2F3	suppressor	5	0.600	1.872	E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
21	E2F4	suppressor	7	0.619	4.111	E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone SPX (PF03105, IPR004331): SPX domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
22	EED	suppressor	17	0.375	37.910	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23	EEF1D	protein found in more fusions	7	0.667	2.087	EF1_GNE (PF00736, IPR014038, SM00888): EF-1 guanine nucleotide exchange domain EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
24	EEF2	interactor	6	0.933	0.222	EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
25	EGFR	oncoprotein	10	0.583	9.967	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
26	EGR2	suppressor	1	0	0	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
27	ELAVL1	oncoprotein	23	0.216	141.354	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
28	FBXW11	interactor	8	0.571	4.805	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain F-box-like (PF12937, IPR001810): F-box-like
29	FOXK1	interactor	13	0.474	24.889	Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
30	FOXK2	interactor	14	0.462	32.786	FHA (PF00498, IPR000253, SM00240): FHA domain Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
31	FOXN2	interactor	4	1.000	0	Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
32	GABPA	interactor	4	1.000	0	Ets (PF00178, IPR000418, SM00413): Ets-domain SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain GABP-alpha (PF11620, IPR024668): GA-binding protein alpha chain Wap1 (PF16997, IPR031550): Wap1 domain
33	HCFC1R1	interactor	1	0	0	HPIP (PF15226, IPR029195): HCF-1 beta-propeller-interacting protein family
34	HCFC2	interactor	9	0.500	17.667	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
35	HDAC1	suppressor	30	0.273	182.248	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
36	HDAC2	suppressor	22	0.405	62.683	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37	HDAC5	protein found in more fusions	13	0.455	12.708	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NOA36 (PF06524, IPR010531): NOA36 protein Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3 HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
38	HSP90AA1	oncoprotein	20	0.251	103.690	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
39	HSPA4	interactor	16	0.450	30.140	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
40	HSPA8	oncoprotein	16	0.458	34.602	HSP70 (PF00012, IPR013126): Hsp70 protein
41	IRF1	suppressor	4	0.667	1.286	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
42	IRF2	interactor	6	0.467	6.833	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
43	KAT8	protein found in more fusions	7	0.667	2.800	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
44	KLF5	suppressor	7	0.429	7.655	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
45	KMT2A	oncoprotein	17	0.425	45.286	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
46	KMT2E	interactor	8	0.536	4.240	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal PHD (PF00628, IPR019787, SM00249): PHD-finger SET (PF00856, IPR001214, SM00317): SET domain MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124) PHD_3 (PF13922, IPR026905): PHD domain of transcriptional enhancer, Asx DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666) PRIMA1 (PF16101): Proline-rich membrane anchor 1
47	LMNA	protein found in more fusions	11	0.489	12.534	Filament (PF00038, IPR001664): Intermediate filament protein LTD (PF00932, IPR001322): Lamin Tail Domain Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
48	MAP3K7	oncoprotein	3	1.000	0	Mnd1 (PF03962, IPR005647): Mnd1 family Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
49	MEN1	suppressor	14	0.462	27.171	Menin (PF05053, IPR007747): Menin
50	MPHOSPH8	protein found in more fusions	2	0	0	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat Ank_5 (PF13857): Ankyrin repeats (many copies) YqzE (PF14038, IPR025622): YqzE-like protein
51	NCOA6	oncoprotein	10	0.528	12.567	DUF719 (PF05334, IPR007998): Protein of unknown function (DUF719) Fes1 (PF08609, IPR013918): Nucleotide exchange factor Fes1 Presenilin (PF01080, IPR001108): Presenilin DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) Nucleic_acid_bd (PF13820, IPR032715): Putative nucleic acid-binding region NST1 (PF13945, IPR025279): Salt tolerance down-regulator
52	NFE2L1	protein found in more fusions	5	0.667	1.333	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor
53	NOTCH1	suppressor	7	0.533	4.322	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
54	NR2C1	interactor	7	0.857	0.867	zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) DUF2318 (PF10080, IPR018758): Predicted membrane protein (DUF2318) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
55	NTRK1	oncoprotein	26	0.297	136.392	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
56	NUDCD3	interactor	3	1.000	0	CS (PF04969, IPR007052): CS domain DUF1737 (PF08410, IPR013619): Domain of unknown function (DUF1737) Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc.
57	OGT	interactor	21	0.181	145.297	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat Glyco_transf_41 (PF13844, IPR029489): Glycosyl transferase family 41 TPR_19 (PF14559): Tetratricopeptide repeat
58	PDCD2	interactor	1	0	0	PDCD2_C (PF04194, IPR007320): Programmed cell death protein 2, C-terminal putative domain zf-MYND (PF01753, IPR002893): MYND finger
59	PHF8	interactor	5	0.500	4.000	JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase PHD (PF00628, IPR019787, SM00249): PHD-finger TSGP1 (PF07771, IPR011694): Tick salivary peptide group 1 AC_N (PF16214, IPR032628): Adenylyl cyclase N-terminal extracellular and transmembrane region
60	POLR2J	interactor	2	1.000	0	RNA_pol_L_2 (PF13656): RNA polymerase Rpb3/Rpb11 dimerisation domain
61	POU2F1	protein found in more fusions	5	0.667	0.833	Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain DUF3597 (PF12200, IPR022016): Domain of unknown function (DUF3597)
62	PPARGC1A	interactor	4	0.500	2.400	Pap_E4 (PF02711, IPR003861): E4 protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSRP (PF17069): Arginine/Serine-Rich protein 1
63	PPP1CA	suppressor	15	0.486	21.896	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
64	PPP1CB	interactor	14	0.495	20.248	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
65	PSMD7	interactor	2	1.000	0	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function Auts2 (PF15336): Autism susceptibility gene 2 protein Coilin_N (PF15862, IPR031722): Coilin N-terminus
66	RBBP4	oncoprotein	19	0.374	56.207	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
67	RBBP5	oncoprotein	18	0.412	48.636	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
68	RBBP7	suppressor	18	0.431	47.286	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
69	RPA1	suppressor	13	0.561	13.173	Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
70	RPA2	oncoprotein	11	0.564	9.629	RPA_C (PF08784, IPR014892): Replication protein A C terminal tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
71	RPA3	interactor	11	0.644	5.345	Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
72	SETD1A	interactor	8	0.893	1.200	E7 (PF00527, IPR000148): E7 protein, Early protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET (PF00856, IPR001214, SM00317): SET domain TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit N-SET (PF11764, IPR024657): COMPASS (Complex proteins associated with Set1p) component N DUF4632 (PF15451, IPR027952): Domain of unknown function (DUF4632) DUF4667 (PF15700, IPR031426): Domain of unknown function (DUF4667) PRIMA1 (PF16101): Proline-rich membrane anchor 1
73	SIN3A	oncoprotein	22	0.381	69.852	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
74	SIN3B	interactor	7	1.000	0	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
75	SIRT7	interactor	10	0.511	8.852	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
76	SNRPB	interactor	5	0.900	0.250	LSM (PF01423, IPR001163): LSM domain
77	SNRPN	interactor	2	1.000	0	LSM (PF01423, IPR001163): LSM domain
78	SP1	protein found in more fusions	14	0.436	25.905	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
79	SUDS3	interactor	9	0.964	0.286	Sds3 (PF08598, IPR013907): Sds3-like
80	THAP1	interactor	3	1.000	0	THAP (PF05485, IPR006612, SM00980): THAP domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
81	THAP11	interactor	7	0.533	4.230	THAP (PF05485, IPR006612, SM00980): THAP domain DUF2722 (PF10846, IPR021216): Protein of unknown function (DUF2722) MRP-S31 (PF15433, IPR026299): Mitochondrial 28S ribosomal protein S31 FAM76 (PF16046, IPR032017): FAM76 protein
82	THAP2	interactor	2	1.000	0	THAP (PF05485, IPR006612, SM00980): THAP domain
83	THAP3	interactor	2	1.000	0	Pfg27 (PF09216, IPR015299): Pfg27 THAP (PF05485, IPR006612, SM00980): THAP domain
84	THAP7	protein found in more fusions	2	0	0	THAP (PF05485, IPR006612, SM00980): THAP domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
85	TRIM28	protein found in more fusions	21	0.305	84.917	ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PHD (PF00628, IPR019787, SM00249): PHD-finger FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
86	USF1	oncoprotein	11	0.422	18.400	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
87	USP53	interactor	1	0	0	UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
88	WDR5	interactor	20	0.347	75.083	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
89	WDR82	oncoprotein	15	0.457	35.417	MinC_C (PF03775, IPR005526): Septum formation inhibitor MinC, C-terminal domain WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
90	YY1	protein found in more fusions	13	0.409	20.260	zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
91	ZBTB17	interactor	4	0.667	1.000	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain C1_4 (PF07975, IPR004595, SM01047): TFIIH C1-like domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6 zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger
92	ZNF335	interactor	5	1.000	0	Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-H2C2_5 (PF13909): C2H2-type zinc-finger domain zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	HCFC1	parental protein	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding

B a c k t o T o p ⇑

Fusion ID: Protein names:	AW836706
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

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List of the fusions

List of active interactors

List of missing interactors