Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AW821160 is the fusion of parental proteins TMPO, ARPC1A (from a repository: Mon Oct 14 16:10:23 2019)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)112
The number (and %) of the onco-proteins33 (29.46 %)
The number (and %) of the tumor suppressors12 (10.71 %)
Total number of binary PPIs (saturation %)635 (10.22 %)
The number (and %) of affected PPIs111 (17.48 %)
The number of possible different fusions20
PPI diameter2
PPI radius1
The average degree of PPI10.571
Assortativity coefficient-0.2639
The network average Clustering coefficient0.501
The number (and %) of a zero Clustering coefficients7 (6.25 %)
The number (and %) of a zero Betweenness Centrality17 (15.18 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TMPO,ARPC1A All fusions
: AW821160;
Proteins found in more fusions TUBG1 (see 1 fusions); LMNA (see 3 fusions); CRY2 (see 3 fusions); U2AF2 (see 2 fusions); CUL7 (see 2 fusions); CSNK2A1/ELAVL1 (see 1 fusions); SRPK2 (see 1 fusions); CALR (see 6 fusions); MYC (see 1 fusions); NF2 (see 1 fusions); LGALS3 (see 2 fusions); FMNL1 (see 1 fusions); STOM (see 1 fusions); BAG3 (see 4 fusions); CSNK2A1 (see 1 fusions); SDC2 (see 2 fusions); RPA1 (see 1 fusions); PCGF2 (see 1 fusions); SNW1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW821160chimera1110.0798124.093LEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
2 ABCE1interactor110.42215.203ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ACTR2interactor160.53326.531Actin (PF00022, IPR004000, SM00268): Actin
4 ACTR3interactor120.6069.655Actin (PF00022, IPR004000, SM00268): Actin
5 ACTR3Binteractor31.0000Actin (PF00022, IPR004000, SM00268): Actin
6 AKAP8Linteractor50.5002.733AKAP95 (PF04988, IPR007071): A-kinase anchoring protein 95 (AKAP95)
DUF3464 (PF11947, IPR021855): Protein of unknown function (DUF3464)
7 AP4S1interactor100Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
8 ARPC2interactor160.42539.260P34-Arc (PF04045, IPR007188): Arp2/3 complex, 34 kD subunit p34-Arc
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
9 ARRB1interactor70.6193.383Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10 ARRB2interactor100.44411.741Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
11 ATP6V0D1interactor50.7001.667vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
12 ATRXoncoprotein60.7331.218DDHD (PF02862, IPR004177, SM01127): DDHD domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
Pap_E4 (PF02711, IPR003861): E4 protein
PHD (PF00628, IPR019787, SM00249): PHD-finger
Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2992 (PF11208, IPR016787): Protein of unknown function (DUF2992)
DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
FAM176 (PF14851): FAM176 family
DUF4746 (PF15928, IPR031827): Domain of unknown function (DUF4746)
13 BAG3oncoprotein70.4005.900BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
14 BANF1interactor41.0000BAF (PF02961, IPR004122, SM01023): Barrier to autointegration factor
15 BRD1interactor100PWWP (PF00855, IPR000313, SM00293): PWWP domain
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
AAA_23 (PF13476): AAA domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
16 BST2oncoprotein100DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
17 CALRoncoprotein150.46226.681Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
18 CALUinteractor190.30485.694EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
19 CCDC8interactor180.37535.447Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
20 CD81interactor50.6671.667Tetraspannin (PF00335, IPR018499): Tetraspanin family
21 CDC5Linteractor250.36690.058OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
22 CHD1suppressor60.6001.897CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Serglycin (PF04360, IPR007455): Serglycin
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Zip (PF02535, IPR003689): ZIP Zinc transporter
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF4208 (PF13907, IPR025260): Domain of unknown function (DUF4208)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
23 CIRBPoncoprotein50.7002.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24 CLK1interactor50.8330.667PDGF_N (PF04692, IPR006782): Platelet-derived growth factor, N terminal region
Pkinase (PF00069, IPR000719): Protein kinase domain
25 CLN3interactor40.5000.844CLN3 (PF02487, IPR003492): CLN3 protein
26 CRY2protein found in more fusions40.6670.667DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
27 CSNK2A1oncoprotein190.30771.248Pkinase (PF00069, IPR000719): Protein kinase domain
28 CUL7protein found in more fusions340.242202.072ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
29 EEDsuppressor250.210106.480WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
30 ELAVL1oncoprotein320.215263.254RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
31 EXOSC8interactor51.0000RNase_PH (PF01138, IPR001247): 3' exoribonuclease family, domain 1
RNase_PH_C (PF03725, IPR015847): 3' exoribonuclease family, domain 2
32 FBXO6interactor170.20672.611FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
33 FMNL1protein found in more fusions60.5003.567CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Drf_FH3 (PF06367, IPR010472, SM01139): Diaphanous FH3 Domain
Drf_GBD (PF06371, IPR010473, SM01140): Diaphanous GTPase-binding Domain
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FH2 (PF02181, IPR015425, SM00498): Formin Homology 2 Domain
SlyX (PF04102, IPR007236): SlyX
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
34 FYCO1interactor50.8000.619Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region
RUN (PF02759, IPR004012, SM00593): RUN domain
Sec8_exocyst (PF04048, IPR007191): Sec8 exocyst complex component specific domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
GOLD_2 (PF13897, IPR009038): Golgi-dynamics membrane-trafficking
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4578 (PF15147, IPR028106): Domain of unknown function (DUF4578)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
35 GON7interactor100DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
36 HDAC11interactor80.32112.867Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
37 HDAC3suppressor70.4675.733Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
38 HDAC9interactor40.6670.667Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
SAE2 (PF08573, IPR013882): DNA repair protein endonuclease SAE2/CtIP C-terminus
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
CEP19 (PF14933, IPR029412): CEP19-like protein
39 HDGFinteractor110.38220.198PWWP (PF00855, IPR000313, SM00293): PWWP domain
40 HIRIP3interactor30.6670.333CHZ (PF09649, IPR019098, SM01082): Histone chaperone domain CHZ
41 HIST1H2BCinteractor21.0000Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
42 HIST1H3Einteractor100.28917.217Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
43 HP1BP3interactor100.4448.613RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
44 HSPG2oncoprotein21.0000C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Laminin_B (PF00052, IPR000034): Laminin B (Domain IV)
Laminin_G_1 (PF00054, IPR001791): Laminin G domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
hEGF (PF12661, IPR013032): Human growth factor-like EGF
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
45 ILF3oncoprotein210.30086.677dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
46 JADE1interactor30.6671.000C1_2 (PF03107, IPR004146): C1 domain
Glyco_hydro_57 (PF03065, IPR004300): Glycosyl hydrolase family 57
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
eIF-5_eIF-2B (PF01873, IPR002735, SM00653): Domain found in IF2B/IF5
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
47 KAT7interactor21.0000MOZ_SAS (PF01853, IPR002717): MOZ/SAS family
zf-C2HC (PF01530, IPR002515, SM00343): Zinc finger, C2HC type
zf-met (PF12874): Zinc-finger of C2H2 type
EFTUD2 (PF16004, IPR031950): 116 kDa U5 small nuclear ribonucleoprotein component N-terminus
48 LARSinteractor40.8330.133Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
49 LGALS3oncoprotein50.6671.500Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
50 LIG3interactor90.6113.586DNA_ligase_A_C (PF04679, IPR012309): ATP dependent DNA ligase C terminal region
DNA_ligase_A_M (PF01068, IPR012310): ATP dependent DNA ligase domain
DNA_ligase_A_N (PF04675, IPR012308): DNA ligase N terminus
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
HD_2 (PF12917, IPR027366): HD containing hydrolase-like enzyme
Synaptonemal_3 (PF15191, IPR028145): Synaptonemal complex central element protein 3
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
51 LMNAprotein found in more fusions270.314128.082Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
52 LMNB1interactor200.35365.496Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
53 LMNB2interactor110.50910.997Filament (PF00038, IPR001664): Intermediate filament protein
LTD (PF00932, IPR001322): Lamin Tail Domain
54 MESDC2interactor100Mesd (PF10185, IPR019330): Chaperone for wingless signalling and trafficking of LDL receptor
55 MLLT10oncoprotein31.0000SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
Tnp_zf-ribbon_2 (PF13842, IPR032718): DDE_Tnp_1-like zinc-ribbon
CCDC106 (PF15794, IPR031591): Coiled-coil domain-containing protein 106
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
AP3D1 (PF06375): AP-3 complex subunit delta-1
56 MRE11Aoncoprotein160.42921.444APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
57 MTRinteractor60.6672.639B12-binding (PF02310, IPR006158): B12 binding domain
B12-binding_2 (PF02607, IPR003759, SM01018): B12 binding domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
Met_synt_B12 (PF02965, IPR004223): Vitamin B12 dependent methionine synthase, activation domain
Pterin_bind (PF00809, IPR000489): Pterin binding enzyme
S-methyl_trans (PF02574, IPR003726): Homocysteine S-methyltransferase
DUF2760 (PF10816, IPR021212): Domain of unknown function (DUF2760)
58 MYConcoprotein160.34338.956HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
59 NF2suppressor90.5009.055ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
60 NOLC1interactor100.5567.108DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
SRP40_C (PF05022, IPR007718): SRP40, C-terminal domain
Stm1_N (PF09598, IPR019084): Stm1
stn_TNFRSF12A (PF12191, IPR022316): Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain
NST1 (PF13945, IPR025279): Salt tolerance down-regulator
SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
PAF (PF15715, IPR031444): PCNA-associated factor
IMUP (PF15761, IPR026621): Immortalisation up-regulated protein
NuDC (PF16273, IPR032572): Nuclear distribution C domain
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
61 NTRK1oncoprotein440.182432.365I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
62 NUP133oncoprotein90.4728.285Nucleoporin_C (PF03177, IPR007187): Non-repetitive/WGA-negative nucleoporin C-terminal
63 NUP160interactor60.6001.022Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
64 NUP35interactor50.7002.333Nup35_RRM (PF05172, IPR007846): Nup53/35/40-type RNA recognition motif
65 NUSAP1interactor31.0000GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
NUSAP (PF16006, IPR026756): Nucleolar and spindle-associated protein
66 OBSL1interactor300.264134.573BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
67 OIP5interactor100Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
68 OLA1interactor90.4729.863Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
69 PAXIP1interactor110.36420.438BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase
SURF6 (PF04935, IPR007019): Surfeit locus protein 6
DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
70 PCGF2suppressor70.8000.626zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
71 PFKPinteractor80.4647.522PFK (PF00365, IPR000023): Phosphofructokinase
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
72 PHBsuppressor170.31654.659Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
73 PHB2interactor130.26944.844DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
74 PHIPoncoprotein40.6671.067DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
E7 (PF00527, IPR000148): E7 protein, Early protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
75 PRKACAinteractor90.5569.694Pkinase (PF00069, IPR000719): Protein kinase domain
76 PRKCDBPsuppressor50.4003.667A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
77 RAD21oncoprotein120.37919.664Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein
Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein
FAM176 (PF14851): FAM176 family
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
78 RB1suppressor100.48913.550RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
79 RNF185interactor31.0000zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
80 RPA1suppressor340.271227.458Rep-A_N (PF04057, IPR007199): Replication factor-A protein 1, N-terminal domain
Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
REPA_OB_2 (PF16900, IPR031657): Replication protein A OB domain
81 RPA2oncoprotein200.31170.429RPA_C (PF08784, IPR014892): Replication protein A C terminal
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
RMI2 (PF16100, IPR032245): RecQ-mediated genome instability protein 2
82 RPA3interactor180.36039.343Rep_fac-A_3 (PF08661, IPR013970): Replication factor A protein 3
83 RPL35interactor70.3818.452Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
84 RRBP1interactor50.6002.077Fez1 (PF06818): Fez1
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Pentapeptide_2 (PF01469, IPR002989): Pentapeptide repeats (8 copies)
Rib_recp_KP_reg (PF05104, IPR007794): Ribosome receptor lysine/proline rich region
RTBV_P46 (PF06216, IPR009347): Rice tungro bacilliform virus P46 protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
UPF0767 (PF15990, IPR031933): UPF0767 family
85 SDC2protein found in more fusions31.0000Glycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
86 SGMS2interactor100PDR_CDR (PF06422, IPR010929): CDR ABC transporter
PAP2_C (PF14360, IPR025749): PAP2 superfamily C-terminal
87 SH3GL1oncoprotein110.6896.578BAR (PF03114, IPR004148, SM00721): BAR domain
PhnG (PF06754, IPR009609): Phosphonate metabolism protein PhnG
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
88 SH3GLB1suppressor110.6675.863BAR (PF03114, IPR004148, SM00721): BAR domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
89 SMARCAD1interactor100.5335.968CUE (PF02845, IPR003892, SM00546): CUE domain
Pox_D5 (PF03288, IPR004968): Poxvirus D5 protein-like
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
90 SMN1interactor60.6003.667SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
91 SMURF1interactor40.6670.667C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
92 SNW1protein found in more fusions230.35979.519SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
SIR4_SID (PF16991, IPR031556): Sir4 SID domain
93 SPRTNinteractor40.6670.450GreA_GreB (PF01272, IPR001437): Transcription elongation factor, GreA/GreB, C-term
SprT-like (PF10263, IPR006640, SM00731): SprT-like family
PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
94 SRPK2oncoprotein140.34634.246DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
95 STOMprotein found in more fusions50.6671.667Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
96 SUMO2interactor90.3576.656Rad60-SLD (PF11976, IPR022617): Ubiquitin-2 like Rad60 SUMO-like
97 SUPT6Hinteractor70.4294.849Afi1 (PF07792, IPR012860): Docking domain of Afi1 for Arf3 in vesicle trafficking
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
Tex_N (PF09371, IPR018974): Tex-like protein N-terminal domain
zf-Sec23_Sec24 (PF04810, IPR006895): Sec23/Sec24 zinc finger
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SPT6_acidic (PF14632, IPR028083): Acidic N-terminal SPT6
SH2_2 (PF14633, IPR000980): SH2 domain
HHH_7 (PF14635, IPR032706): Helix-hairpin-helix motif
YqgF (PF14639, IPR028231): Holliday-junction resolvase-like of SPT6
HTH_44 (PF14641, IPR028088): Helix-turn-helix DNA-binding domain of SPT6
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
DLD (PF14878, IPR027999): Death-like domain of SPT6
98 TCTN2interactor30.6670.500DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
99 TCTN3interactor40.8330.400DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
100 TMEM216interactor40.5001.900Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
101 TMEM63Binteractor70.3818.056RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
102 TP53BP1suppressor70.5712.79053-BP1_Tudor (PF09038, IPR015125): Tumour suppressor p53-binding protein-1 Tudor
BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
DUF4772 (PF15997, IPR031940): Domain of unknown function (DUF4772)
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
103 TUBG1protein found in more fusions120.34518.350Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
104 U2AF2protein found in more fusions180.45633.545RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
105 UBTFinteractor60.6671.364Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein
HMG_box_2 (PF09011, IPR009071): HMG-box domain
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
DUF4473 (PF14747, IPR027913): Domain of unknown function (DUF4473)
HMG_box_5 (PF14887, IPR029215): HMG (high mobility group) box 5
106 UNKinteractor80.4297.586MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain
107 USP7oncoprotein150.30837.448MATH (PF00917, IPR002083, SM00061): MATH domain
UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7
USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
108 VARSinteractor70.4294.545Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
Val_tRNA-synt_C (PF10458, IPR019499): Valyl tRNA synthetase tRNA binding arm
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
109 XRCC3oncoprotein40.6671.333Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
110 XRCC5suppressor260.223144.687Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like
111 YWHAEoncoprotein180.28173.20914-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
112 ZWINTinteractor40.6670.400Zwint (PF15556, IPR029092): ZW10 interactor

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AARSD1interactortRNA-synt_2c (PF01411, IPR018164): tRNA synthetases class II (A)
tRNA_SAD (PF07973, IPR012947, SM00863): Threonyl and Alanyl tRNA synthetase second additional domain
2 AGFG1interactorArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
3 ARPC1Aparental proteinWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
4 ARPC3interactorP21-Arc (PF04062, IPR007204): ARP2/3 complex ARPC3 (21 kDa) subunit
5 ARPC4interactorARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4)
6 ARPC4-TTLL3interactorARPC4 (PF05856, IPR008384): ARP2/3 complex 20 kDa subunit (ARPC4)
TTL (PF03133, IPR004344): Tubulin-tyrosine ligase family
7 ARPC5interactorP16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
8 ARPC5LinteractorP16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
9 CNDP2suppressorPeptidase_M20 (PF01546, IPR002933): Peptidase family M20/M25/M40
10 DBN1oncoproteinPinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
11 NCAPD2oncoproteinAdaptin_N (PF01602, IPR002553): Adaptin N terminal region
RMI1_N (PF08585, IPR013894, SM01161): RecQ mediated genome instability protein
HEAT (PF02985, IPR000357): HEAT repeat
LrgA (PF03788, IPR005538): LrgA family
Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
Cnd1_N (PF12922, IPR024324): non-SMC mitotic condensation complex subunit 1, N-term
12 NCAPGinteractorP16-Arc (PF04699, IPR006789): ARP2/3 complex 16 kDa subunit (p16-Arc)
Terminase_2 (PF03592, IPR005335): Terminase small subunit
UVR (PF02151, IPR001943): UvrB/uvrC motif
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Cnd3 (PF12719, IPR025977): Nuclear condensing complex subunits, C-term domain
HEAT_2 (PF13646): HEAT repeats
13 NCAPHinteractorCnd2 (PF05786, IPR022816): Condensin complex subunit 2
14 PPP2R1BsuppressorHEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
15 SCARNA22interactorNA
16 THG1LinteractorThg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
17 TMPOparental proteinLEM (PF03020, IPR003887, SM00540): LEM domain
Thymopoietin (PF08198, IPR013146): Thymopoietin protein
LAP2alpha (PF11560, IPR021623): Lamina-associated polypeptide 2 alpha
18 TPD52L2interactorTPD52 (PF04201, IPR007327): Tumour protein D52 family
19 TPRKBinteractorCGI-121 (PF08617, IPR013926): Kinase binding protein CGI-121
20 TRMT10AoncoproteinASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
tRNA_m1G_MT (PF01746, IPR016009): tRNA (Guanine-1)-methyltransferase
21 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k    t o    T o p ⇑