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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins10 (23.26 %)
The number (and %) of the tumor suppressors5 (11.63 %)
Total number of binary PPIs (saturation %)70 (7.75 %)
The number (and %) of affected PPIs42 (60.00 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI2.651
Assortativity coefficient-0.6709
The network average Clustering coefficient0.272
The number (and %) of a zero Clustering coefficients28 (65.12 %)
The number (and %) of a zero Betweenness Centrality36 (83.72 %)


List of the fusions

PPI for parental proteins: EPS8 All fusions
: AW673298;
Proteins found in more fusions AIMP2 (see 1 fusions); RUNX1T1 (see 1 fusions); HNRNPC (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AW673298chimera420.0171673.500PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
2 ABI1oncoprotein40.6671.333Abi_HHR (PF07815, IPR012849): Abl-interactor HHR
Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
3 ADAM22interactor100EGF_2 (PF07974, IPR013111): EGF-like domain
Pep_M12B_propep (PF01562, IPR002870): Reprolysin family propeptide
Reprolysin (PF01421, IPR001590): Reprolysin (M12B) family zinc metalloprotease
ADAM_CR (PF08516, IPR006586, SM00608): ADAM cysteine-rich
Disintegrin (PF00200, IPR001762, SM00050): Disintegrin
4 AIMP2suppressor31.0000GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
AIMP2_LysRS_bd (PF16780, IPR031889): AIMP2 lysyl-tRNA synthetase binding domain
5 ALDH7A1interactor100Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
6 ARMC1interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HMA (PF00403, IPR006121): Heavy-metal-associated domain
7 BAIAP2interactor60.4005.500IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
8 BAIAP2L1interactor21.0000IMD (PF08397, IPR013606): IRSp53/MIM homology domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
SH3_9 (PF14604, IPR001452): Variant SH3 domain
9 BCKDKinteractor100HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
10 BLOC1S6interactor200BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
11 BORCS6interactor100DUF2365 (PF10157, IPR019314): Uncharacterized conserved protein (DUF2365)
12 BYSLinteractor21.0000Bystin (PF05291, IPR007955): Bystin
MEA1 (PF06910, IPR009685): Male enhanced antigen 1 (MEA1)
13 C8orf33interactor100DUF4615 (PF15393, IPR029274): Domain of unknown function (DUF4615)
14 CBLsuppressor70.5336.167Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1
Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain
Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
15 CFTRsuppressor31.0000ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain
CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
16 CTNNA3suppressor100Vinculin (PF01044, IPR006077): Vinculin family
17 DNALI1interactor200Ax_dynein_light (PF10211, IPR019347): Axonemal dynein light chain
18 DVL1interactor200DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
19 EGFRoncoprotein60.6003.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
20 GULP1interactor100PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
21 HNRNPCprotein found in more fusions31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
22 INPP5Jinteractor100CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
MRI (PF15325, IPR028278): Modulator of retrovirus infection
23 MDC1suppressor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
24 MRPL20interactor100Herpes_UL49_5 (PF05702, IPR008647): Herpesvirus UL49.5 envelope/tegument protein
Ribosomal_L20 (PF00453, IPR005813): Ribosomal protein L20
25 MYO15Ainteractor100FERM_M (PF00373, IPR019748): FERM central domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
MyTH4 (PF00784, IPR000857, SM00139): MyTH4 domain
RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
26 NFKB2oncoprotein200Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Death (PF00531, IPR000488, SM00005): Death domain
RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
27 PCM1oncoprotein21.0000FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
RseA_C (PF03873, IPR005573): Anti sigma-E protein RseA, C-terminal domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
V_ATPase_I (PF01496, IPR002490): V-type ATPase 116kDa subunit family
AAA_23 (PF13476): AAA domain
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
PCM1_C (PF15717, IPR031446): Pericentriolar material 1 C terminus
DUF4829 (PF16111, IPR032256): Domain of unknown function (DUF4829)
28 PROSER2interactor100SARG (PF15385): Specifically androgen-regulated gene protein
29 RCAN3interactor100Calcipressin (PF04847, IPR006931): Calcipressin
30 RFXAPinteractor100RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
31 RSPH14interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
32 RUNX1T1oncoprotein200NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
33 SCRN3interactor100AAT (PF03417, IPR005079): Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase
Peptidase_C69 (PF03577, IPR005322): Peptidase family C69
34 SF3B3interactor100CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
35 SHBinteractor21.0000Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
SH2 (PF00017, IPR000980, SM00252): SH2 domain
Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
36 SLC27A4interactor100AMP-binding (PF00501, IPR000873): AMP-binding enzyme
AMP-binding_C (PF13193, IPR025110): AMP-binding enzyme C-terminal domain
37 SMARCE1interactor100DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
GCN5L1 (PF06320, IPR009395): GCN5-like protein 1 (GCN5L1)
Ndc1_Nup (PF09531, IPR019049): Nucleoporin protein Ndc1-Nup
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
Ferlin_C (PF16165, IPR032362): Ferlin C-terminus
38 SOS1oncoprotein40.8330.500Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
PH (PF00169, IPR001849, SM00233): PH domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
39 SOX2oncoprotein200HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
40 SRConcoprotein50.6672.000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
41 TDP2interactor100Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
DUF4150 (PF13665, IPR025425): Domain of unknown function (DUF4150)
UBA_4 (PF14555): UBA-like domain
42 TPRNinteractor100DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052)
Phostensin (PF13914, IPR025907): Phostensin PP1-binding and SH3-binding region
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
43 ZZZ3interactor100Cript (PF10235, IPR019367): Microtubule-associated protein CRIPT
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANKRD28interactorAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
2 C19orf25interactorUPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
3 C6orf141interactorNA
4 CCDC85BinteractorCCDC85 (PF10226, IPR019359): CCDC85 family
5 CSNK2BinteractorCK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
6 CXCL2oncoproteinIL8 (PF00048, IPR001811, SM00199): Small cytokines (intecrine/chemokine), interleukin-8 like
7 EPS8parental proteinDEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
PTB (PF08416, IPR013625): Phosphotyrosine-binding domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
8 GOLGA8EPinteractorNA
9 GRB2oncoproteinSH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
10 HOOK2interactorHOOK (PF05622, IPR008636): HOOK protein
11 MAP1LC3BinteractorAtg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
12 MAP3K11interactorAPG6 (PF04111, IPR007243): Autophagy protein Apg6
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH3_9 (PF14604, IPR001452): Variant SH3 domain
13 NACC2interactorBTB (PF00651, IPR013069, SM00225): BTB/POZ domain
BEN (PF10523, IPR018379, SM01025): BEN domain
14 SERPINA5interactorSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
15 SHC1oncoproteinPID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
16 TEX28interactorTmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
17 XAGE2interactorGAGE (PF05831, IPR008625): GAGE protein
18 XRCC6oncoproteinKu (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
SAP (PF02037, IPR003034, SM00513): SAP domain

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