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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW590921 is the fusion of parental proteins UBA3 (from a repository: Mon Nov 21 11:14:07 2016)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins6 (18.18 %)
The number (and %) of the tumor suppressors2 (6.06 %)
Total number of binary PPIs (saturation %)83 (15.72 %)
The number (and %) of affected PPIs32 (38.55 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.303
Assortativity coefficient-0.4212
The network average Clustering coefficient0.584
The number (and %) of a zero Clustering coefficients8 (24.24 %)
The number (and %) of a zero Betweenness Centrality19 (57.58 %)


List of the fusions

PPI for parental proteins: UBA3 All fusions
: AW590921;
Proteins found in more fusions KDM1A (see 2 fusions); VCL (see 2 fusions); NF2 (see 1 fusions); CHD3 (see 1 fusions); UBE2H (see 4 fusions); ACAT2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AW590921chimera320.079825.833E2_bind (PF08825, IPR014929): E2 binding domain
ThiF (PF00899, IPR000594): ThiF family
2 ACAT2protein found in more fusions41.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 AHCYinteractor60.6003.000AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
4 APIPinteractor200Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
5 ATG7interactor100ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
6 CAMK1Dinteractor51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
7 CAPN2interactor60.7332.667Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CHD3oncoprotein31.0000CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
9 CPNE2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
10 DCPSinteractor60.8002.000DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
11 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
12 IMPA2interactor200Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
13 KDM1Aprotein found in more fusions40.6671.000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
14 NAE1interactor130.30851.000ThiF (PF00899, IPR000594): ThiF family
15 NEDD8interactor60.5004.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
16 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
17 NSFL1Cinteractor50.8001.167SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
18 NT5DC1interactor1005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
19 NUDCD2interactor100CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
20 PAPSS1interactor60.6673.833APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
PUA_2 (PF14306, IPR025980): PUA-like domain
21 PCYT2interactor60.8671.000CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
DUF765 (PF05570, IPR008484): Circovirus protein of unknown function (DUF765)
22 PRDX2interactor21.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
23 TWF1interactor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
24 TXNDC17interactor21.0000DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
25 UBE2Finteractor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
26 UBE2Hprotein found in more fusions50.5003.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
27 UBE2Minteractor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 UFC1interactor40.5003.000UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
29 UIMC1suppressor21.0000Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
30 VCLoncoprotein50.6672.000Vinculin (PF01044, IPR006077): Vinculin family
31 WDR61interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
32 XPO1interactor80.57110.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
33 ZBTB44interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_assoc2 (PF16624): Unstructured region upstream of a zinc-finger
Glyco_tran_10_N (PF17039, IPR031481): Fucosyltransferase, N-terminal

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 UBA3parental proteinE2_bind (PF08825, IPR014929): E2 binding domain
ThiF (PF00899, IPR000594): ThiF family

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