Find Fusion Network

Enter
Fusion ID:
Protein names:


Level of PPIs:
or Upload text file:
Update repository
Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW590921 is the fusion of parental proteins UBA3 (from a repository: Mon Nov 21 11:14:07 2016)
Examples

Cytoscape Web will replace the contents your graph
PPI Properties:

Click on nodes
or edges

Layout Tree
Circle
Radial
Force Directed
Preset
Export graph
PDF file
SVG file
SIF file
XML file
GraphML file

Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins6 (18.18 %)
The number (and %) of the tumor suppressors2 (6.06 %)
Total number of binary PPIs (saturation %)83 (15.72 %)
The number (and %) of affected PPIs32 (38.55 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI4.303
Assortativity coefficient-0.4212
The network average Clustering coefficient0.584
The number (and %) of a zero Clustering coefficients8 (24.24 %)
The number (and %) of a zero Betweenness Centrality19 (57.58 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: UBA3 All fusions
: AW590921;
Proteins found in more fusions KDM1A (see 2 fusions); VCL (see 2 fusions); NF2 (see 1 fusions); CHD3 (see 1 fusions); UBE2H (see 4 fusions); ACAT2 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW590921chimera320.079825.833E2_bind (PF08825, IPR014929): E2 binding domain
ThiF (PF00899, IPR000594): ThiF family
2 ACAT2protein found in more fusions41.0000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 AHCYinteractor60.6003.000AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
4 APIPinteractor200Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
5 ATG7interactor100ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
6 CAMK1Dinteractor51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
7 CAPN2interactor60.7332.667Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
8 CHD3oncoprotein31.0000CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
9 CPNE2interactor100C2 (PF00168, IPR000008, SM00239): C2 domain
Copine (PF07002, IPR010734): Copine
10 DCPSinteractor60.8002.000DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
11 DSTNinteractor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
12 IMPA2interactor200Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
13 KDM1Aprotein found in more fusions40.6671.000Amino_oxidase (PF01593, IPR002937): Flavin containing amine oxidoreductase
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
SWIRM (PF04433, IPR007526): SWIRM domain
DUF4298 (PF14131, IPR025384): Domain of unknown function (DUF4298)
14 NAE1interactor130.30851.000ThiF (PF00899, IPR000594): ThiF family
15 NEDD8interactor60.5004.500ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
16 NF2suppressor31.0000ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
17 NSFL1Cinteractor50.8001.167SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
18 NT5DC1interactor1005_nucleotid (PF05761, IPR008380): 5' nucleotidase family
19 NUDCD2interactor100CS (PF04969, IPR007052): CS domain
DUF3110 (PF11360, IPR021503): Protein of unknown function (DUF3110)
20 PAPSS1interactor60.6673.833APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
PUA_2 (PF14306, IPR025980): PUA-like domain
21 PCYT2interactor60.8671.000CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
DUF765 (PF05570, IPR008484): Circovirus protein of unknown function (DUF765)
22 PRDX2interactor21.0000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
23 TWF1interactor100Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
24 TXNDC17interactor21.0000DUF953 (PF06110, IPR010357): Eukaryotic protein of unknown function (DUF953)
Glutaredoxin (PF00462, IPR002109): Glutaredoxin
25 UBE2Finteractor21.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
26 UBE2Hprotein found in more fusions50.5003.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
27 UBE2Minteractor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
28 UFC1interactor40.5003.000UFC1 (PF08694, IPR014806): Ubiquitin-fold modifier-conjugating enzyme 1
29 UIMC1suppressor21.0000Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
30 VCLoncoprotein50.6672.000Vinculin (PF01044, IPR006077): Vinculin family
31 WDR61interactor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
32 XPO1interactor80.57110.000CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
33 ZBTB44interactor31.0000BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
zf-C2H2_assoc2 (PF16624): Unstructured region upstream of a zinc-finger
Glyco_tran_10_N (PF17039, IPR031481): Fucosyltransferase, N-terminal

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 UBA3parental proteinE2_bind (PF08825, IPR014929): E2 binding domain
ThiF (PF00899, IPR000594): ThiF family

B a c k    t o    T o p ⇑