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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW390706 is the fusion of parental proteins PKP2, IDH3G (from a repository: Mon May 22 19:17:24 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)22
The number (and %) of the onco-proteins8 (36.36 %)
The number (and %) of the tumor suppressors1 (4.55 %)
Total number of binary PPIs (saturation %)48 (20.78 %)
The number (and %) of affected PPIs21 (43.75 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.818
Assortativity coefficient-0.3772
The network average Clustering coefficient0.595
The number (and %) of a zero Clustering coefficients3 (13.64 %)
The number (and %) of a zero Betweenness Centrality9 (40.91 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PKP2,IDH3G All fusions
: AW390706;
Proteins found in more fusions ILK (see 1 fusions); NDEL1 (see 1 fusions); MYC (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW390706chimera210.100342.333Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
2 ACO2interactor100Aconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
3 AGPSinteractor21.0000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
4 AHSA1interactor21.0000Aha1_N (PF09229, IPR015310, SM01000): Activator of Hsp90 ATPase, N-terminal
AHSA1 (PF08327, IPR013538): Activator of Hsp90 ATPase homolog 1-like protein
5 BCORoncoprotein31.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
6 CDV3interactor50.5005.000TraT (PF05818, IPR008874): Enterobacterial TraT complement resistance protein
CDV3 (PF15359, IPR026806): Carnitine deficiency-associated protein 3
7 EDF1interactor100MBF1 (PF08523, IPR013729): Multiprotein bridging factor 1
HTH_3 (PF01381, IPR001387, SM00530): Helix-turn-helix
8 HNRNPKoncoprotein50.5002.667ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
9 ILKsuppressor31.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
10 KPNA2interactor30.6670.667Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
IBB (PF01749, IPR002652): Importin beta binding domain
Arm_3 (PF16186, IPR032413): Atypical Arm repeat
11 MYConcoprotein40.6670.667HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
12 NDEL1protein found in more fusions200HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
13 POU5F1oncoprotein50.5002.667Pou (PF00157, IPR000327, SM00352): Pou domain - N-terminal to homeobox domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
14 PPP1R12Ainteractor30.6671.000DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
Mucin (PF01456, IPR000458): Mucin-like glycoprotein
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
AAA_23 (PF13476): AAA domain
Ank_5 (PF13857): Ankyrin repeats (many copies)
GEMIN8 (PF15348): Gemini of Cajal bodies-associated protein 8
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
15 PQBP1interactor30.6671.000WW (PF00397, IPR001202, SM00456): WW domain
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
16 RAB8Aoncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
17 RPGRIP1Linteractor21.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
C2 (PF00168, IPR000008, SM00239): C2 domain
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FtsL (PF04999, IPR011922): Cell division protein FtsL
T3SS_needle_F (PF09392, IPR021123): Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
C2-C2_1 (PF11618, IPR021656): First C2 domain of RPGR-interacting protein 1
BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4497 (PF14924): Protein of unknown function (DUF4497)
18 SBDSoncoprotein30.6670.667SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
19 SCP2interactor50.5005.000SCP2 (PF02036, IPR003033): SCP-2 sterol transfer family
Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
20 SPRinteractor30.6670.667adh_short (PF00106, IPR002198): short chain dehydrogenase
21 SUGP1interactor70.38112.333G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
22 TIMM44interactor50.6003.333Tim44 (PF04280, IPR007379, SM00978): Tim44-like domain
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3
RecG_N (PF17190): RecG N-terminal helical domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADRB2interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
2 APCsuppressorAPC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
3 BMI1oncoproteinzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
4 CEP250interactorACCA (PF03255, IPR001095): Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
DASH_Dam1 (PF08653, IPR013962): DASH complex subunit Dam1
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
EHN (PF06441, IPR010497): Epoxide hydrolase N terminus
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
IncA (PF04156, IPR007285): IncA protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Endonuc_Holl (PF10107, IPR019287): Endonuclease related to archaeal Holliday junction resolvase
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
DGF-1_C (PF11040, IPR021053): Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
DUF4472 (PF14739, IPR029329): Domain of unknown function (DUF4472)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
5 CLK2interactorDUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764)
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-met (PF12874): Zinc-finger of C2H2 type
6 CUL3interactorCullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
7 DROSHAinteractordsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
8 DSC1interactorCadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
UPF0114 (PF03350, IPR005134): Uncharacterized protein family, UPF0114
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
9 DSC2interactorCadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
10 DSG1interactorCadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
11 DSG2oncoproteinBAT2_N (PF07001, IPR009738): BAT2 N-terminus
Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
12 DSPsuppressorAPG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CLP_protease (PF00574, IPR023562): Clp protease
DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fez1 (PF06818): Fez1
FIVAR (PF07554, IPR011490): Uncharacterised Sugar-binding Domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Rho_Binding (PF08912, IPR015008): Rho Binding
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
SOGA (PF11365, IPR027881): Protein SOGA
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
13 EEDsuppressorWD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14 EFNB2interactorEphrin (PF00812, IPR001799): Ephrin
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
15 ESRRBsuppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
16 FAM188AsuppressorDUF4205 (PF13898, IPR025257): Domain of unknown function (DUF4205)
17 GRNoncoproteinGranulin (PF00396, IPR000118, SM00277): Granulin
Lustrin_cystein (PF14625, IPR028150): Lustrin, cysteine-rich repeated domain
18 GTF2BinteractorCyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
TFIIB (PF00382, IPR013150): Transcription factor TFIIB repeat
TF_Zn_Ribbon (PF08271, IPR013137): TFIIB zinc-binding
19 GTSE1interactorGTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
20 HSPB2interactorCrystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
21 IDH1suppressorIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
22 IDH2oncoproteinIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
23 IDH3AinteractorIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
24 IDH3BinteractorIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
25 IDH3Gparental proteinIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
26 JUPsuppressorArm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
27 KRT18interactorFilament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
28 KRT5interactorFilament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
29 LPAR6interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
MscS_TM (PF12794, IPR025692): Mechanosensitive ion channel inner membrane domain 1
30 MARK3interactorKA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
31 MAST3interactorDUF1908 (PF08926, IPR015022): Domain of unknown function (DUF1908)
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Pkinase (PF00069, IPR000719): Protein kinase domain
ACTL7A_N (PF16840, IPR031769): Actin-like protein 7A N-terminus
32 MATR3interactorDUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
33 MTUS2suppressorDUF496 (PF04363, IPR007458): Protein of unknown function (DUF496)
RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
FAM184 (PF15665): Family with sequence similarity 184, A and B
34 PKP2parental proteinArm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
35 POLR3AinteractorRNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1
RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2
RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3
RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4
RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5
36 PTGER3interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
FtsX (PF02687, IPR003838): FtsX-like permease family
37 RNF2interactorzf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
38 SCARNA22interactorNA
39 SEC16AinteractorAPC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
40 SFNsuppressor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
41 SMAD9interactorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
42 TMEM17interactorTransmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
43 UQCRFS1P1interactorNA
44 YWHABinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
45 YWHAEoncoprotein14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
46 YWHAQinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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