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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW376261 is the fusion of parental proteins CHI3L1, XPNPEP1 (from a repository: Tue Feb 6 02:28:35 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)72
The number (and %) of the onco-proteins18 (25.00 %)
The number (and %) of the tumor suppressors4 (5.56 %)
Total number of binary PPIs (saturation %)290 (11.35 %)
The number (and %) of affected PPIs71 (24.48 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI7.361
Assortativity coefficient-0.1458
The network average Clustering coefficient0.530
The number (and %) of a zero Clustering coefficients8 (11.11 %)
The number (and %) of a zero Betweenness Centrality15 (20.83 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: XPNPEP1,CHI3L1 All fusions
: AW376261;
Proteins found in more fusions RNF40 (see 2 fusions); BAG3 (see 4 fusions); EZR (see 2 fusions); PUF60 (see 2 fusions); NAGK (see 1 fusions); GSK3B (see 1 fusions); PYGB (see 1 fusions); PCNA (see 1 fusions); UBC (see 1 fusions); MAPK9 (see 3 fusions); NOL3 (see 2 fusions); UBA1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW376261chimera710.0783579.706Creatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Glyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain
2 ADSLinteractor90.52810.400DUF1331 (PF07048, IPR009762): Protein of unknown function (DUF1331)
Lyase_1 (PF00206, IPR022761): Lyase
ADSL_C (PF10397, IPR019468, SM00998): Adenylosuccinate lyase C-terminus
HTH_Tnp_Tc5 (PF03221, IPR006600, SM00674): Tc5 transposase DNA-binding domain
DUF4089 (PF13318, IPR025148): Protein of unknown function (DUF4089)
3 ALDH1B1interactor50.5003.233Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
4 API5interactor90.52811.319API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
5 ASB6interactor40.6672.000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
6 ASNSoncoprotein50.8001.333Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
7 ATP6V1Ainteractor80.5369.848ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
8 ATP6V1Dinteractor40.8330.667ATP-synt_D (PF01813, IPR002699): ATP synthase subunit D
9 ATP6V1E1interactor50.5004.667vATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
10 BAG3oncoprotein70.4006.400BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
11 C12orf10interactor100UPF0160 (PF03690, IPR003226): Uncharacterised protein family (UPF0160)
12 CD55oncoprotein31.0000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
HYLS1_C (PF15311, IPR027918): Hydrolethalus syndrome protein 1 C-terminus
13 CIAPIN1interactor140.29539.419CIAPIN1 (PF05093, IPR007785): Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis
Methyltransf_11 (PF08241, IPR013216): Methyltransferase domain
Methyltransf_31 (PF13847, IPR025714): Methyltransferase domain
14 CSE1Loncoprotein80.5368.000CAS_CSE1 (PF03378, IPR005043): CAS/CSE protein, C-terminus
Cse1 (PF08506, IPR013713): Cse1
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
15 DARSinteractor120.42425.034tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
16 DCTPP1interactor80.4299.000MazG-like (PF12643, IPR025984): MazG-like family
17 DISC1interactor100HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Mnd1 (PF03962, IPR005647): Mnd1 family
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tropomyosin (PF00261, IPR000533): Tropomyosin
UVR (PF02151, IPR001943): UvrB/uvrC motif
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
18 DMGDHinteractor100DAO (PF01266, IPR006076): FAD dependent oxidoreductase
GCV_T (PF01571, IPR006222): Aminomethyltransferase folate-binding domain
GCV_T_C (PF08669, IPR013977): Glycine cleavage T-protein C-terminal barrel domain
FAO_M (PF16350, IPR032503): FAD dependent oxidoreductase central domain
19 EHD1interactor120.56412.786Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
Gtr1_RagA (PF04670, IPR006762): Gtr1/RagA G protein conserved region
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EHD_N (PF16880, IPR031692): N-terminal EH-domain containing protein
20 EZRprotein found in more fusions110.40018.986DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
21 FHsuppressor80.35713.500Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
22 FKBP9interactor120.50018.800FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 GARSinteractor80.6076.082HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
24 GNPDA1interactor110.27329.386Glucosamine_iso (PF01182, IPR006148): Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase
25 GSK3Bsuppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
26 GTF3C4interactor90.6116.486TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
27 H2AFVinteractor60.6003.233Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
28 HEXAinteractor70.6193.633Glyco_hydro_20 (PF00728, IPR015883): Glycosyl hydrolase family 20, catalytic domain
Glyco_hydro_20b (PF02838, IPR015882): Glycosyl hydrolase family 20, domain 2
Glycohydro_20b2 (PF14845, IPR029019): beta-acetyl hexosaminidase like
29 HMGCS1interactor60.4007.667HMG_CoA_synt_C (PF08540, IPR013746): Hydroxymethylglutaryl-coenzyme A synthase C terminal
HMG_CoA_synt_N (PF01154, IPR013528): Hydroxymethylglutaryl-coenzyme A synthase N terminal
30 IRGQinteractor21.0000AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
IIGP (PF05049, IPR007743): Interferon-inducible GTPase (IIGP)
IstB_IS21 (PF01695, IPR002611): IstB-like ATP binding protein
DUF4148 (PF13663, IPR025421): Domain of unknown function (DUF4148)
31 KARSinteractor80.5716.248tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N)
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
32 MAPK9suppressor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
33 MARSoncoprotein60.8670.468Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
34 MOV10interactor90.30617.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
35 MTHFD1interactor41.0000FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
36 MTHFD1Linteractor21.0000FTHFS (PF01268, IPR000559): Formate--tetrahydrofolate ligase
THF_DHG_CYH (PF00763, IPR020630): Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
THF_DHG_CYH_C (PF02882, IPR020631): Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
37 MTMR2interactor200GRAM (PF02893, IPR004182, SM00568): GRAM domain
Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain
3-PAP (PF12578, IPR022587): Myotubularin-associated protein
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
38 MTRF1Linteractor100PCRF (PF03462, IPR005139, SM00937): PCRF domain
RF-1 (PF00472, IPR000352): RF-1 domain
39 NAGKprotein found in more fusions200BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
40 NOL3oncoprotein80.7622.033CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
41 NTRK1oncoprotein370.152455.286I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
42 NUBP1interactor80.6077.900DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
ParA (PF10609, IPR019591): NUBPL iron-transfer P-loop NTPase
43 NUCB1interactor30.6670.500DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
44 NUDT3interactor30.6670.286NUDIX (PF00293, IPR000086): NUDIX domain
45 NUTF2interactor40.6670.286NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
46 NXF1interactor120.21833.500NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
47 PCNAoncoprotein120.29128.800PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain
PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain
48 PDE12interactor70.6195.067Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
49 PLAAinteractor50.7001.567PFU (PF09070, IPR015155): PFU (PLAA family ubiquitin binding)
PUL (PF08324, IPR013535): PUL domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
50 POLA2interactor100DNA_pol_E_B (PF04042, IPR007185): DNA polymerase alpha/epsilon subunit B
Pol_alpha_B_N (PF08418, IPR013627): DNA polymerase alpha subunit B N-terminal
51 PSMD9interactor30.6670.500Remorin_C (PF03763, IPR005516): Remorin, C-terminal region
DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
PDZ_2 (PF13180, IPR001478): PDZ domain
52 PUF60protein found in more fusions50.8330.500RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Titin_Z (PF09042, IPR015129): Titin Z
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
53 PYGBprotein found in more fusions50.6670.900Phosphorylase (PF00343, IPR000811): Carbohydrate phosphorylase
54 RAD23Bsuppressor110.41823.200K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123)
55 RNF20interactor80.6193.982Allexi_40kDa (PF05549, IPR008398): Allexivirus 40kDa protein
Atrophin-1 (PF03154, IPR002951): Atrophin-1 family
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Sox_N (PF12444, IPR022151): Sox developmental protein N terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
56 RNF40protein found in more fusions60.6001.915BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745)
ZapB (PF06005, IPR009252): Cell division protein ZapB
EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
FlgN (PF05130, IPR007809): FlgN protein
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
SpoIIE (PF07228, IPR001932): Stage II sporulation protein E (SpoIIE)
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
XhlA (PF10779, IPR019715): Haemolysin XhlA
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
57 SPIN2Binteractor100Spin-Ssty (PF02513, IPR003671): Spin/Ssty Family
58 STK39interactor80.7143.400BASP1 (PF05466, IPR008408): Brain acid soluble protein 1 (BASP1 protein)
FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
DUF4349 (PF14257, IPR025645): Domain of unknown function (DUF4349)
59 TARDBPinteractor50.6670.686RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
60 TBCBinteractor40.8330.667CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ubiquitin_2 (PF14560, IPR027933): Ubiquitin-like domain
61 TCEB1oncoprotein21.0000Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
62 TIPRLinteractor50.8001.167TIP41 (PF04176, IPR007303): TIP41-like family
63 TWF1interactor60.6004.015Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
64 UBA1protein found in more fusions140.34638.334ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
65 UBA6interactor120.34830.819ThiF (PF00899, IPR000594): ThiF family
E1_UFD (PF09358, IPR018965, SM00985): Ubiquitin fold domain
UBA_e1_thiolCys (PF10585, IPR019572): Ubiquitin-activating enzyme active site
66 UBCprotein found in more fusions170.31752.952ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
67 UBE2D3interactor60.6001.800UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
68 UCHL5oncoprotein80.6194.415Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
69 UQCRFS1interactor40.5001.452Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
70 VBP1interactor40.8330.286Prefoldin (PF02996, IPR004127): Prefoldin subunit
71 VTA1interactor40.6672.000Vta1 (PF04652): Vta1 like
72 WARSinteractor100.42217.819tRNA-synt_1b (PF00579, IPR002305): tRNA synthetases class I (W and Y)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BREoncoproteinBRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
2 CHI3L1parental proteinGlyco_hydro_18 (PF00704, IPR001223): Glycosyl hydrolases family 18
3 XPNPEP1parental proteinCreatinase_N (PF01321, IPR000587): Creatinase/Prolidase N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
Peptidase_M24_C (PF16188, IPR032416): C-terminal region of peptidase_M24
Creatinase_N_2 (PF16189): Creatinase/Prolidase N-terminal domain

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