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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW376106 is the fusion of parental proteins SPTLC2 (from a repository: Mon Dec 9 12:29:14 2019)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins3 (30.00 %)
The number (and %) of the tumor suppressors1 (10.00 %)
Total number of binary PPIs (saturation %)13 (28.89 %)
The number (and %) of affected PPIs9 (69.23 %)
The number of possible different fusions2
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.5092
The network average Clustering coefficient0.203
The number (and %) of a zero Clustering coefficients7 (70.00 %)
The number (and %) of a zero Betweenness Centrality9 (90.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: SPTLC2 All fusions
: AW376106;
Proteins found in more fusions BCL6 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW376106chimera90.02870.000Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
2 BCL6oncoprotein200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
DZR (PF12773, IPR025874): Double zinc ribbon
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2HE (PF16278, IPR032566): C2HE / C2H2 / C2HC zinc-binding finger
3 EVA1Cinteractor100Gal_Lectin (PF02140, IPR000922): Galactose binding lectin domain
FAM176 (PF14851): FAM176 family
4 FAM189A2interactor100CD20 (PF04103, IPR007237): CD20-like family
5 HERC2interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
6 NOTCH3suppressor21.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
7 NRG1interactor100EGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
8 NTRK1oncoprotein31.0000I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
9 P2RX4interactor100P2X_receptor (PF00864, IPR001429): ATP P2X receptor
10 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 SPINT2suppressorKunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
2 SPTLC2parental proteinAminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II

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