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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW352228 is the fusion of parental proteins PHLDB1, TAGLN (from a repository: Tue Feb 28 05:47:26 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)55
The number (and %) of the onco-proteins13 (23.64 %)
The number (and %) of the tumor suppressors3 (5.45 %)
Total number of binary PPIs (saturation %)252 (16.97 %)
The number (and %) of affected PPIs54 (21.43 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI8.509
Assortativity coefficient-0.2246
The network average Clustering coefficient0.565
The number (and %) of a zero Clustering coefficients5 (9.09 %)
The number (and %) of a zero Betweenness Centrality15 (27.27 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TAGLN,PHLDB1 All fusions
: AW352228;
Proteins found in more fusions JAK1 (see 1 fusions); SRPK2 (see 1 fusions); SF1 (see 1 fusions); BAG3 (see 4 fusions); SH3KBP1 (see 1 fusions); GAN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AW352228chimera540.1261823.951Calponin (PF00402, IPR000557): Calponin family repeat
DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
FHA (PF00498, IPR000253, SM00240): FHA domain
PH (PF00169, IPR001849, SM00233): PH domain
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
2 ACAA2interactor90.6396.188Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 ACDinteractor70.6195.500TPP1 (PF10341, IPR019437): Shelterin complex subunit, TPP1/ACD
4 ACTA1interactor40.8330.286Actin (PF00022, IPR004000, SM00268): Actin
5 ALDOAinteractor140.51319.121Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
6 ALDOCinteractor100.51111.840Glycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
7 BAG3oncoprotein120.25533.305BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 CCDC8interactor70.4005.015Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
9 CFL1interactor110.43618.125Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
10 DUSP6suppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Rhodanese (PF00581, IPR001763, SM00450): Rhodanese-like domain
11 EEF2interactor80.46411.352EFG_C (PF00679, IPR000640, SM00838): Elongation factor G C-terminus
EFG_IV (PF03764, IPR005517, SM00889): Elongation factor G, domain IV
GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
EFG_II (PF14492, IPR009022): Elongation Factor G, domain II
12 ENO1oncoprotein210.41072.921Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
13 ENO2interactor200.45857.418Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
14 ENO3interactor140.7037.603Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
15 FABP3suppressor30.6670.333Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
16 FABP5interactor120.56113.627Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
17 FABP7interactor100Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
18 FKBP1Ainteractor160.50534.606FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
Hemopexin (PF00045, IPR018487, SM00120): Hemopexin
19 FKBP1Binteractor90.6946.238FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
20 FKBP2interactor140.58219.267FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
21 GANprotein found in more fusions31.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
22 GIPC1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
23 GPX4interactor130.59014.253GSHPx (PF00255, IPR000889): Glutathione peroxidase
24 GSTO1interactor50.4003.217GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_3 (PF14497, IPR004046): Glutathione S-transferase, C-terminal domain
25 HSD17B10interactor170.55123.756adh_short (PF00106, IPR002198): short chain dehydrogenase
26 HSPE1interactor120.48516.017Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
27 ISG15suppressor90.38914.233ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
28 JAK1oncoprotein31.0000FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
29 NCF1interactor200p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
30 NDUFA7interactor40.6672.000CI-B14_5a (PF07347, IPR009947): NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a)
31 NME1-NME2interactor120.53022.097NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
32 NME2interactor110.7333.764NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
33 NTRK1oncoprotein230.212149.991I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
34 NUTF2interactor41.0000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
35 PGDoncoprotein60.4673.5336PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
36 PIK3CDoncoprotein100PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
37 PLS3interactor70.5246.702CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
38 POT1interactor80.6194.619POT1 (PF02765, IPR011564, SM00976): Telomeric single stranded DNA binding POT1/CDC13
tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain
POT1PC (PF16686, IPR032042): ssDNA-binding domain of telomere protection protein
39 PPIBinteractor120.57614.894Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
40 RBM27interactor21.0000DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
PWI (PF01480, IPR002483, SM00311): PWI domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF2203 (PF09969, IPR018699): Uncharacterized conserved protein (DUF2203)
DUF2408 (PF10303, IPR018810): Protein of unknown function (DUF2408)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
Nup35_RRM_2 (PF14605): Nup53/35/40-type RNA recognition motif
41 RNF14interactor200IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
RWD (PF05773, IPR006575, SM00591): RWD domain
T5orf172 (PF10544, IPR018306, SM00974): T5orf172 domain
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-RING_11 (PF17123, IPR001841): RING-like zinc finger
42 S100A9oncoprotein31.0000S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
43 SARNPoncoprotein21.0000SAP (PF02037, IPR003034, SM00513): SAP domain
HTH_Tnp_IS630 (PF01710, IPR002622): Transposase
Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
44 SF1protein found in more fusions60.7002.000UPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
45 SH3KBP1protein found in more fusions31.0000Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein
SH3_9 (PF14604, IPR001452): Variant SH3 domain
46 SNX12interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
47 SNX3interactor60.4676.833PX (PF00787, IPR001683, SM00312): PX domain
48 SRPK2oncoprotein50.6671.000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
49 SRPRBinteractor70.42910.167MHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
50 STIP1interactor150.41032.325TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
51 SUGP1interactor60.4676.500G-patch (PF01585, IPR000467, SM00443): G-patch domain
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
OrfB_IS605 (PF01385, IPR001959): Probable transposase
RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
Surp (PF01805, IPR000061, SM00648): Surp module
G-patch_2 (PF12656, IPR026822): DExH-box splicing factor binding site
52 TINF2interactor60.9000.333TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
53 UCHL3interactor110.53310.734Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
54 XPO1interactor60.4006.333CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
55 YKT6interactor31.0000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 HINT1suppressorHIT (PF01230, IPR001310): HIT domain
2 MRPL53interactorMRP_L53 (PF10780, IPR019716): 39S ribosomal protein L53/MRP-L53
3 PHLDB1parental proteinDUF501 (PF04417, IPR007511): Protein of unknown function (DUF501)
FHA (PF00498, IPR000253, SM00240): FHA domain
PH (PF00169, IPR001849, SM00233): PH domain
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
WD40_alt (PF14077, IPR026987): Alternative WD40 repeat motif
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
4 TAGLNparental proteinCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain

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