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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AW119175 is the fusion of parental proteins HIP1, ANGPT1 (from a repository: Fri Jun 2 21:01:38 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)24
The number (and %) of the onco-proteins10 (41.67 %)
The number (and %) of the tumor suppressors4 (16.67 %)
Total number of binary PPIs (saturation %)56 (20.29 %)
The number (and %) of affected PPIs23 (41.07 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI3.917
Assortativity coefficient-0.4177
The network average Clustering coefficient0.572
The number (and %) of a zero Clustering coefficients7 (29.17 %)
The number (and %) of a zero Betweenness Centrality15 (62.50 %)


List of the fusions

PPI for parental proteins: ANGPT1,HIP1 All fusions
: AW119175;
Proteins found in more fusions DAZAP2 (see 2 fusions); MAP3K1 (see 1 fusions); HTT (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AW119175chimera230.095430.800DUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
2 BFARinteractor31.0000SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2231 (PF09990, IPR019251): Predicted membrane protein (DUF2231)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
3 CASP8suppressor41.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
4 CLTConcoprotein80.5719.800Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
5 DAZAP2protein found in more fusions200DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
6 DEUP1suppressor200APG6 (PF04111, IPR007243): Autophagy protein Apg6
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
7 EIF6interactor31.0000eIF-6 (PF01912, IPR002769, SM00654): eIF-6 family
8 FBXO25suppressor30.6671.000Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
9 GAKoncoprotein50.9000.400DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
10 GTSE1interactor50.9000.400GTSE1_N (PF15259, IPR032768): G-2 and S-phase expressed 1
11 HIP1Rinteractor60.8670.800ANTH (PF07651, IPR011417): ANTH domain
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
12 HTTprotein found in more fusions200HEAT (PF02985, IPR000357): HEAT repeat
SPX (PF03105, IPR004331): SPX domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3652 (PF12372, IPR024613): Huntingtin protein region
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
13 IFT57interactor31.0000IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
14 ITSN1interactor50.5003.000C2 (PF00168, IPR000008, SM00239): C2 domain
VIT1 (PF01988, IPR008217): VIT family
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
FmdE (PF02663, IPR003814): FmdE, Molybdenum formylmethanofuran dehydrogenase operon
GSH_synthase (PF03199, IPR004887): Eukaryotic glutathione synthase
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
INTAP (PF16617): Intersectin and clathrin adaptor AP2 binding region
PH_13 (PF16652, IPR001849): Pleckstrin homology domain
15 MAP3K1oncoprotein31.0000zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
16 MAPK6oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
17 MAPK8IP2interactor31.0000BUD22 (PF09073, IPR015158): BUD22
CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SH3_9 (PF14604, IPR001452): Variant SH3 domain
18 MYH9suppressor60.6674.400IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
19 NTRK1oncoprotein80.5717.400I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 PFDN1interactor100Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit
21 RELoncoprotein100RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
22 RPS10interactor21.0000S10_plectin (PF03501, IPR005326): Plectin/S10 domain
23 TEKoncoprotein100EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_Tie2_1 (PF10430, IPR018941): Tie-2 Ig-like domain 1
Ig_3 (PF13927): Immunoglobulin domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
24 TMEM17interactor100Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANGPT1parental proteinDUF1690 (PF07956, IPR012471): Protein of Unknown function (DUF1690)
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
SHE3 (PF17078, IPR031398): SWI5-dependent HO expression protein 3
2 HIP1parental proteinANTH (PF07651, IPR011417): ANTH domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1

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