1 |
AM491362 | chimera | 202 | 0.065 | 24983.831 | Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2 |
2 |
ABI1 | oncoprotein | 7 | 0.571 | 6.500 | Abi_HHR (PF07815, IPR012849): Abl-interactor HHR Cytochrom_B558a (PF05038, IPR007732): Cytochrome Cytochrome b558 alpha-subunit SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF4124 (PF13511, IPR025392): Domain of unknown function (DUF4124) PRIMA1 (PF16101): Proline-rich membrane anchor 1 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension |
3 |
ABI2 | suppressor | 4 | 0.667 | 0.333 | Abi_HHR (PF07815, IPR012849): Abl-interactor HHR NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region SH3_9 (PF14604, IPR001452): Variant SH3 domain TMEM171 (PF15471, IPR029173): Transmembrane protein family 171 ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension |
4 |
ABL2 | oncoprotein | 21 | 0.358 | 67.427 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain NHS (PF15273, IPR024845): NHS-like |
5 |
ACTA1 | interactor | 8 | 0.571 | 5.395 | Actin (PF00022, IPR004000, SM00268): Actin |
6 |
AFDN | oncoprotein | 12 | 0.500 | 15.356 | DIL (PF01843, IPR018444, SM01132): DIL domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FHA (PF00498, IPR000253, SM00240): FHA domain MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family MAS20 (PF02064, IPR002056): MAS20 protein import receptor Pap_E4 (PF02711, IPR003861): E4 protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain ARGLU (PF15346): Arginine and glutamate-rich 1 |
7 |
ANKRA2 | interactor | 2 | 1.000 | 0 | Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
8 |
AP2A1 | interactor | 13 | 0.590 | 12.071 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptin_C (PF02296, IPR003164): Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain HEAT_2 (PF13646): HEAT repeats |
9 |
AP2B1 | interactor | 12 | 0.758 | 4.234 | Adaptin_N (PF01602, IPR002553): Adaptin N terminal region Alpha_adaptinC2 (PF02883, IPR008152, SM00809): Adaptin C-terminal domain B2-adapt-app_C (PF09066, IPR015151, SM01020): Beta2-adaptin appendage, C-terminal sub-domain |
10 |
AP2M1 | protein found in more fusions | 17 | 0.500 | 30.249 | Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain |
11 |
ARHGAP17 | interactor | 10 | 0.533 | 8.603 | BAR (PF03114, IPR004148, SM00721): BAR domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain |
12 |
ATM | oncoprotein | 16 | 0.448 | 23.453 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5 |
13 |
ATR | oncoprotein | 12 | 0.527 | 13.503 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1 THP2 (PF09432, IPR018557): Tho complex subunit THP2 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat UME (PF08064, IPR012993, SM00802): UME (NUC010) domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT |
14 |
BAG1 | oncoprotein | 9 | 0.667 | 4.841 | BAG (PF02179, IPR003103, SM00264): BAG domain Presenilin (PF01080, IPR001108): Presenilin ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082) |
15 |
BCAR1 | oncoprotein | 20 | 0.426 | 42.159 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain |
16 |
BCL2L1 | oncoprotein | 7 | 0.467 | 5.458 | Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4 |
17 |
BMP2K | interactor | 5 | 0.800 | 1.000 | Pkinase (PF00069, IPR000719): Protein kinase domain TCP (PF03634, IPR005333): TCP family transcription factor Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal EOS1 (PF12326, IPR021100): N-glycosylation protein BMP2K_C (PF15282, IPR028182): BMP-2-inducible protein kinase C-terminus PNRC (PF15365, IPR028322): Proline-rich nuclear receptor coactivator FAM60A (PF15396, IPR026065): Protein Family FAM60A |
18 |
BRCA1 | oncoprotein | 40 | 0.217 | 311.105 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT |
19 |
CABLES2 | interactor | 2 | 1.000 | 0 | Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain |
20 |
CASP9 | oncoprotein | 5 | 0.700 | 2.167 | CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain Peptidase_C14 (PF00656, IPR011600): Caspase domain |
21 |
CAT | suppressor | 6 | 0.600 | 2.833 | Catalase (PF00199, IPR011614, SM01060): Catalase Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive |
22 |
CBL | oncoprotein | 52 | 0.262 | 462.604 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain |
23 |
CBLB | oncoprotein | 19 | 0.595 | 17.901 | Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 PRIMA1 (PF16101): Proline-rich membrane anchor 1 |
24 |
CCDC183 | interactor | 1 | 0 | 0 | MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63 |
25 |
CCND2 | oncoprotein | 3 | 0.667 | 0.400 | Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain |
26 |
CDC42 | oncoprotein | 17 | 0.233 | 55.847 | Ras (PF00071, IPR001806, SM00173): Ras family |
27 |
CDK1 | oncoprotein | 14 | 0.449 | 21.762 | Pkinase (PF00069, IPR000719): Protein kinase domain |
28 |
CDKN1B | oncoprotein | 15 | 0.390 | 28.535 | CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH |
29 |
CDON | oncoprotein | 2 | 1.000 | 0 | fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Glyco_hydro_76 (PF03663, IPR005198): Glycosyl hydrolase family 76 I-set (PF07679, IPR013098): Immunoglobulin I-set domain Fer4_2 (PF12797, IPR001450): 4Fe-4S binding domain Ig_3 (PF13927): Immunoglobulin domain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain |
30 |
CEP128 | interactor | 14 | 0.297 | 40.592 | DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1 |
31 |
CFTR | suppressor | 16 | 0.362 | 35.313 | ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain |
32 |
CKAP4 | protein found in more fusions | 10 | 0.444 | 5.608 | DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) FPP (PF05911, IPR008587): Filament-like plant protein, long coiled-coil Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) |
33 |
CREB1 | oncoprotein | 9 | 0.536 | 5.600 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF4988 (PF16378, IPR032149): Domain of unknown function |
34 |
CRK | oncoprotein | 49 | 0.240 | 448.316 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
35 |
CRKL | oncoprotein | 26 | 0.385 | 86.265 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
36 |
CSNK2A2 | interactor | 9 | 0.556 | 6.968 | Pkinase (PF00069, IPR000719): Protein kinase domain |
37 |
CTNNB1 | oncoprotein | 26 | 0.286 | 117.310 | Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat |
38 |
DDB1 | protein found in more fusions | 19 | 0.353 | 36.798 | CPSF_A (PF03178, IPR004871): CPSF A subunit region MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term |
39 |
DDX5 | oncoprotein | 16 | 0.457 | 19.599 | DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain |
40 |
DOK1 | suppressor | 19 | 0.582 | 16.417 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
41 |
DOK2 | suppressor | 9 | 0.722 | 1.780 | IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain |
42 |
DRG1 | interactor | 7 | 0.476 | 3.308 | MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase TGS (PF02824, IPR004095): TGS domain MMR_HSR1_Xtn (PF16897, IPR031662): C-terminal region of MMR_HSR1 domain |
43 |
EEF1G | protein found in more fusions | 13 | 0.485 | 11.327 | EF1G (PF00647, IPR001662): Elongation factor 1 gamma, conserved domain GST_C (PF00043, IPR004046): Glutathione S-transferase, C-terminal domain GST_N (PF02798, IPR004045): Glutathione S-transferase, N-terminal domain SAPS (PF04499, IPR007587): SIT4 phosphatase-associated protein |
44 |
EGFR | oncoprotein | 73 | 0.205 | 1078.220 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
45 |
EIF2A | interactor | 4 | 0.833 | 0.333 | Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A |
46 |
EPHA3 | oncoprotein | 4 | 1.000 | 0 | EGF_2 (PF07974, IPR013111): EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
47 |
EPHB2 | suppressor | 8 | 0.524 | 2.958 | EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain |
48 |
EPS15 | oncoprotein | 18 | 0.493 | 32.202 | Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
49 |
ERBB2 | oncoprotein | 31 | 0.386 | 97.843 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
50 |
ERBB3 | oncoprotein | 25 | 0.428 | 55.119 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
51 |
ERBB4 | oncoprotein | 18 | 0.493 | 19.556 | Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain DUF3951 (PF13131, IPR025028): Protein of unknown function (DUF3951) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV |
52 |
ERBIN | oncoprotein | 8 | 0.714 | 1.777 | LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat |
53 |
ERCC3 | oncoprotein | 5 | 0.600 | 2.000 | ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit DUF2748 (PF10871, IPR020183): Protein of unknown function (DUF2748) Helicase_C_3 (PF13625, IPR032830): Helicase conserved C-terminal domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase |
54 |
EVL | oncoprotein | 6 | 0.600 | 1.162 | VASP_tetra (PF08776, IPR014885): VASP tetramerisation domain WH1 (PF00568, IPR000697, SM00461): WH1 domain |
55 |
EWSR1 | oncoprotein | 25 | 0.228 | 126.616 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
56 |
FES | oncoprotein | 9 | 0.571 | 4.874 | FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Remorin_C (PF03763, IPR005516): Remorin, C-terminal region SH2 (PF00017, IPR000980, SM00252): SH2 domain Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein |
57 |
FGFR1OP | oncoprotein | 8 | 0.476 | 6.560 | FOP_dimer (PF09398, IPR018993): FOP N terminal dimerisation domain |
58 |
FOS | oncoprotein | 7 | 0.467 | 3.105 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor |
59 |
FUS | oncoprotein | 24 | 0.279 | 98.361 | Herpes_PAP (PF03325, IPR004997): Herpesvirus polymerase accessory protein RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others Limkain-b1 (PF11608, IPR024582): Limkain b1 FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head |
60 |
GAB2 | oncoprotein | 18 | 0.456 | 21.549 | PH (PF00169, IPR001849, SM00233): PH domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone |
61 |
GAB3 | interactor | 3 | 1.000 | 0 | PH (PF00169, IPR001849, SM00233): PH domain |
62 |
GABRR1 | interactor | 2 | 0 | 0 | Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region |
63 |
GPX1 | oncoprotein | 3 | 0.667 | 0.667 | GSHPx (PF00255, IPR000889): Glutathione peroxidase |
64 |
GRAP2 | interactor | 7 | 0.619 | 1.625 | NADH_dhqG_C (PF09326, IPR015405): NADH-ubiquinone oxidoreductase subunit G, C-terminal SH2 (PF00017, IPR000980, SM00252): SH2 domain DUF2076 (PF09849, IPR018648): Uncharacterized protein conserved in bacteria (DUF2076) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
65 |
GRB10 | oncoprotein | 9 | 0.472 | 8.270 | BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos |
66 |
GRB2 | oncoprotein | 66 | 0.222 | 827.562 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093) |
67 |
GRK5 | protein found in more fusions | 13 | 0.348 | 14.758 | Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain |
68 |
GTF2F1 | interactor | 8 | 0.607 | 3.832 | TFIIF_alpha (PF05793, IPR008851): Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) |
69 |
HCK | oncoprotein | 17 | 0.382 | 42.261 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
70 |
HIF1A | suppressor | 18 | 0.464 | 27.783 | Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1 |
71 |
HIPK2 | oncoprotein | 6 | 0.700 | 2.500 | Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain |
72 |
HNRNPM | interactor | 14 | 0.440 | 24.567 | RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HnRNP_M (PF11532, IPR024666): Heterogeneous nuclear ribonucleoprotein M Collagen_mid (PF15984, IPR031929): Bacterial collagen, middle region |
73 |
HOXA9 | oncoprotein | 2 | 1.000 | 0 | Hox9_act (PF04617, IPR006711): Hox9 activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain |
74 |
HSP90AA1 | oncoprotein | 42 | 0.255 | 306.411 | HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein |
75 |
HSPA4 | interactor | 27 | 0.322 | 103.836 | Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5 |
76 |
HSPA8 | oncoprotein | 35 | 0.356 | 153.637 | HSP70 (PF00012, IPR013126): Hsp70 protein |
77 |
HSPD1 | oncoprotein | 14 | 0.516 | 13.973 | Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family |
78 |
HSPE1 | interactor | 7 | 0.381 | 8.521 | Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit |
79 |
HUWE1 | oncoprotein | 33 | 0.290 | 173.134 | BUD22 (PF09073, IPR015158): BUD22 DUF908 (PF06012, IPR010309): Domain of Unknown Function (DUF908) DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913) FdhE (PF04216, IPR006452): Protein involved in formate dehydrogenase formation HABP4_PAI-RBP1 (PF04774, IPR006861): Hyaluronan / mRNA binding family Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Mucin (PF01456, IPR000458): Mucin-like glycoprotein Nop14 (PF04147, IPR007276): Nop14-like family PBP_sp32 (PF07222, IPR009865): Proacrosin binding protein sp32 RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain WWE (PF02825, IPR004170, SM00678): WWE domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54 U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF4414 (PF14377, IPR025527): Domain of unknown function (DUF4414) |
80 |
IGSF21 | interactor | 1 | 0 | 0 | C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain |
81 |
IL3 | oncoprotein | 1 | 0 | 0 | IL3 (PF02059, IPR002183): Interleukin-3 |
82 |
ILF3 | oncoprotein | 12 | 0.409 | 19.420 | dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif DZF (PF07528, IPR006561, SM00572): DZF domain |
83 |
INPP5D | interactor | 14 | 0.626 | 10.450 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain |
84 |
INPPL1 | oncoprotein | 20 | 0.526 | 30.367 | Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
85 |
JAK1 | oncoprotein | 15 | 0.451 | 20.666 | FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
86 |
JUN | oncoprotein | 22 | 0.300 | 72.133 | bZIP_1 (PF00170, IPR004827): bZIP transcription factor Jun (PF03957, IPR005643): Jun-like transcription factor |
87 |
KIT | oncoprotein | 17 | 0.515 | 29.393 | ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain |
88 |
LARS | interactor | 8 | 0.429 | 11.350 | Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V) |
89 |
LATS2 | oncoprotein | 14 | 0.308 | 30.379 | Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain |
90 |
LNX1 | interactor | 6 | 0.800 | 0.800 | PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) |
91 |
LRRC59 | interactor | 7 | 0.571 | 3.436 | Hid1 (PF12722): High-temperature-induced dauer-formation protein LRR_8 (PF13855, IPR001611): Leucine rich repeat DUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366) |
92 |
LRRK1 | interactor | 11 | 0.444 | 13.113 | Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain |
93 |
MAPT | protein found in more fusions | 15 | 0.527 | 12.605 | Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat |
94 |
MAVS | interactor | 5 | 0.667 | 1.000 | Ice_nucleation (PF00818, IPR000258): Ice nucleation protein repeat CARD_2 (PF16739, IPR031964): Caspase recruitment domain |
95 |
MBP | interactor | 5 | 0.400 | 3.519 | Myelin_MBP (PF01669, IPR000548): Myelin basic protein |
96 |
MDM2 | oncoprotein | 40 | 0.193 | 325.547 | Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region Presenilin (PF01080, IPR001108): Presenilin SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
97 |
MDM4 | oncoprotein | 17 | 0.467 | 25.602 | zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2 SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger) |
98 |
MICAL1 | interactor | 6 | 0.733 | 1.327 | CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DAO (PF01266, IPR006076): FAD dependent oxidoreductase FAD_binding_3 (PF01494, IPR002938): FAD binding domain LIM (PF00412, IPR001781, SM00132): LIM domain DUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585) NAD_binding_7 (PF13241, IPR006367): Putative NAD(P)-binding |
99 |
MSH5 | interactor | 2 | 1.000 | 0 | MutS_V (PF00488, IPR000432, SM00534): MutS domain V MutS_III (PF05192, IPR007696, SM00533): MutS domain III |
100 |
MTOR | oncoprotein | 15 | 0.396 | 25.399 | DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104) EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain HEAT (PF02985, IPR000357): HEAT repeat FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385) HEAT_EZ (PF13513): HEAT-like repeat HEAT_2 (PF13646): HEAT repeats TPR_19 (PF14559): Tetratricopeptide repeat |
101 |
MUC1 | oncoprotein | 11 | 0.545 | 7.201 | SEA (PF01390, IPR000082, SM00200): SEA domain Shisa (PF13908, IPR026910): Wnt and FGF inhibitory regulator Collectrin (PF16959, IPR031588): Renal amino acid transporter |
102 |
MYC | oncoprotein | 33 | 0.248 | 191.094 | HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region |
103 |
NAA25 | interactor | 3 | 1.000 | 0 | BTAD (PF03704, IPR005158, SM01043): Bacterial transcriptional activator domain NatB_MDM20 (PF09797, IPR019183): N-acetyltransferase B complex (NatB) non catalytic subunit ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 Alkyl_sulf_dimr (PF14863, IPR029228): Alkyl sulfatase dimerisation |
104 |
NARS | interactor | 7 | 0.429 | 7.383 | tRNA-synt_2 (PF00152, IPR004364): tRNA synthetases class II (D, K and N) tRNA_anti-codon (PF01336, IPR004365): OB-fold nucleic acid binding domain |
105 |
NCK1 | oncoprotein | 20 | 0.416 | 40.164 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
106 |
NCOA3 | oncoprotein | 11 | 0.255 | 25.558 | DUF1518 (PF07469, IPR010011, SM01151): Domain of unknown function (DUF1518) HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Nuc_rec_co-act (PF08815, IPR014920): Nuclear receptor coactivator PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region SRC-1 (PF08832, IPR014935): Steroid receptor coactivator PAS_11 (PF14598): PAS domain DUF4927 (PF16279, IPR032565): Domain of unknown function (DUF4927) NCOA_u2 (PF16665): Unstructured region on nuclear receptor coactivator protein AIM3 (PF17096, IPR031370): Altered inheritance of mitochondria protein 3 |
107 |
NEDD4 | suppressor | 23 | 0.264 | 93.840 | Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
108 |
NEDD4L | oncoprotein | 13 | 0.621 | 6.866 | WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) |
109 |
NEDD9 | protein found in more fusions | 10 | 0.528 | 7.428 | Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) SH3_9 (PF14604, IPR001452): Variant SH3 domain |
110 |
NFKBIA | oncoprotein | 12 | 0.273 | 30.481 | Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) |
111 |
NINL | interactor | 8 | 0.464 | 8.967 | PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat TBCA (PF02970, IPR004226): Tubulin binding cofactor A DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain |
112 |
NTRK1 | oncoprotein | 84 | 0.141 | 1853.486 | I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain |
113 |
PAG1 | protein found in more fusions | 7 | 0.867 | 0.389 | PAG (PF15347, IPR032748): Phosphoprotein associated with glycosphingolipid-enriched |
114 |
PAK2 | protein found in more fusions | 15 | 0.440 | 19.217 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
115 |
PAK4 | protein found in more fusions | 20 | 0.310 | 70.444 | PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain |
116 |
PARK2 | suppressor | 30 | 0.232 | 146.149 | IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
117 |
PARP1 | suppressor | 15 | 0.560 | 12.221 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain WGR (PF05406, IPR008893, SM00773): WGR domain zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region |
118 |
PCNA | oncoprotein | 19 | 0.399 | 41.499 | PCNA_C (PF02747, IPR022649): Proliferating cell nuclear antigen, C-terminal domain PCNA_N (PF00705, IPR022648): Proliferating cell nuclear antigen, N-terminal domain |
119 |
PDE4D | oncoprotein | 7 | 0.600 | 2.237 | Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated PDEase_I (PF00233, IPR002073): 3'5'-cyclic nucleotide phosphodiesterase |
120 |
PFDN4 | interactor | 2 | 1.000 | 0 | Prefoldin_2 (PF01920, IPR002777): Prefoldin subunit |
121 |
PIK3CG | oncoprotein | 2 | 1.000 | 0 | Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244) DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135) |
122 |
PIK3R1 | oncoprotein | 38 | 0.342 | 190.903 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
123 |
PIK3R2 | oncoprotein | 20 | 0.605 | 19.900 | RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain |
124 |
PLCG1 | oncoprotein | 22 | 0.416 | 66.368 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain |
125 |
PPM1B | interactor | 6 | 0.600 | 2.852 | PP2C (PF00481, IPR001932): Protein phosphatase 2C PP2C_C (PF07830, IPR012911, SM00332): Protein serine/threonine phosphatase 2C, C-terminal domain |
126 |
PRDX1 | oncoprotein | 15 | 0.396 | 23.471 | AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin |
127 |
PRKCZ | interactor | 14 | 0.410 | 22.205 | PB1 (PF00564, IPR000270, SM00666): PB1 domain Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) |
128 |
PRKDC | protein found in more fusions | 24 | 0.364 | 75.473 | FAT (PF02259, IPR003151): FAT domain FATC (PF02260, IPR003152): FATC domain NUC194 (PF08163, IPR012582): NUC194 domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase |
129 |
PSMA4 | interactor | 10 | 0.489 | 10.493 | Proteasome (PF00227, IPR001353): Proteasome subunit U79_P34 (PF03064, IPR004138): HSV U79 / HCMV P34 Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
130 |
PSMA7 | protein found in more fusions | 17 | 0.433 | 31.043 | Proteasome (PF00227, IPR001353): Proteasome subunit Peptidase_C65 (PF10275, IPR019400): Peptidase C65 Otubain Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature |
131 |
PSMD4 | interactor | 14 | 0.582 | 11.893 | UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain |
132 |
PSTPIP1 | interactor | 1 | 0 | 0 | ABATE (PF07336, IPR010852): Putative stress-induced transcription regulator FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain WXG100 (PF06013, IPR010310): Proteins of 100 residues with WXG Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 |
133 |
PTGES3 | interactor | 9 | 0.607 | 4.615 | CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain |
134 |
PTPN6 | oncoprotein | 12 | 0.621 | 7.789 | SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus |
135 |
PXN | oncoprotein | 13 | 0.577 | 10.677 | LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family |
136 |
RAC1 | oncoprotein | 10 | 0.278 | 13.827 | Ras (PF00071, IPR001806, SM00173): Ras family |
137 |
RAD51 | interactor | 8 | 0.667 | 2.947 | Rad51 (PF08423, IPR013632): Rad51 HHH_5 (PF14520): Helix-hairpin-helix domain |
138 |
RAD9A | oncoprotein | 5 | 0.500 | 3.067 | Rad9 (PF04139, IPR007268): Rad9 |
139 |
RAN | oncoprotein | 9 | 0.389 | 14.127 | Ras (PF00071, IPR001806, SM00173): Ras family |
140 |
RAPGEF1 | oncoprotein | 10 | 0.733 | 3.469 | RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif |
141 |
RASA1 | oncoprotein | 21 | 0.367 | 63.474 | C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
142 |
RB1 | oncoprotein | 18 | 0.359 | 53.158 | RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592) |
143 |
REPS1 | protein found in more fusions | 5 | 0.500 | 0.736 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator MCLC (PF05934, IPR009231): Mid-1-related chloride channel (MCLC) DUF3123 (PF11321, IPR021470): Protein of unknown function (DUF3123) EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand |
144 |
RFX1 | interactor | 2 | 1.000 | 0 | Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region RFX1_trans_act (PF04589, IPR007668): RFX1 transcription activation region RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain |
145 |
RHOA | oncoprotein | 6 | 0.467 | 3.502 | Ras (PF00071, IPR001806, SM00173): Ras family |
146 |
RPL37 | interactor | 4 | 0.667 | 1.067 | Ribosomal_L37e (PF01907, IPR001569): Ribosomal protein L37e |
147 |
RPLP1 | interactor | 5 | 0.500 | 2.286 | Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein |
148 |
RPS21 | interactor | 4 | 0.667 | 2.000 | Ribosomal_S21e (PF01249, IPR001931): Ribosomal protein S21e |
149 |
RSPH9 | interactor | 1 | 0 | 0 | Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein |
150 |
RTFDC1 | interactor | 2 | 1.000 | 0 | Rtf2 (PF04641, IPR027799): Rtf2 RING-finger |
151 |
RYBP | interactor | 6 | 0.600 | 2.087 | DUF11 (PF01345, IPR001434): Domain of unknown function DUF11 fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain PPAK (PF02818, IPR004168): PPAK motif Titin_Z (PF09042, IPR015129): Titin Z V-set (PF07686, IPR013106): Immunoglobulin V-set domain Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369) Ig_3 (PF13927): Immunoglobulin domain |
152 |
SEC13 | interactor | 6 | 0.700 | 0.633 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein |
153 |
SFN | suppressor | 27 | 0.286 | 134.722 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
154 |
SH3BP1 | interactor | 4 | 0.667 | 0.900 | BAR (PF03114, IPR004148, SM00721): BAR domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein PRCC (PF10253, IPR018800): Mitotic checkpoint regulator, MAD2B-interacting |
155 |
SH3KBP1 | protein found in more fusions | 21 | 0.458 | 42.442 | Tmemb_cc2 (PF10267, IPR019394): Predicted transmembrane and coiled-coil 2 protein SH3_9 (PF14604, IPR001452): Variant SH3 domain |
156 |
SHB | interactor | 9 | 0.722 | 2.120 | Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein SH2 (PF00017, IPR000980, SM00252): SH2 domain Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region |
157 |
SHC1 | oncoprotein | 40 | 0.320 | 227.128 | PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain |
158 |
SHD | interactor | 1 | 0 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain |
159 |
SHE | interactor | 1 | 0 | 0 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein |
160 |
SLC9A2 | oncoprotein | 4 | 0.667 | 1.667 | Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family Sigma_reg_N (PF13800, IPR029101): Sigma factor regulator N-terminal NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin |
161 |
SOCS1 | oncoprotein | 15 | 0.495 | 22.254 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
162 |
SOCS3 | suppressor | 6 | 0.600 | 2.900 | SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box |
163 |
SORBS1 | interactor | 10 | 0.511 | 9.231 | SH3_2 (PF07653, IPR011511): Variant SH3 domain Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain SCAB-ABD (PF16711, IPR032012): Actin-binding domain of plant-specific actin-binding protein |
164 |
SORBS2 | oncoprotein | 12 | 0.491 | 11.545 | Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain |
165 |
SOS1 | oncoprotein | 18 | 0.477 | 30.892 | Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif |
166 |
SPAG9 | interactor | 3 | 1.000 | 0 | DUF501 (PF04417, IPR007511): Protein of unknown function (DUF501) DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IncA (PF04156, IPR007285): IncA protein Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Alanine_zipper (PF11839, IPR021793): Alanine-zipper, major outer membrane lipoprotein UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II |
167 |
SPRR2A | interactor | 4 | 0.833 | 0.182 | SPRR2 (PF14820, IPR029142): Small proline-rich 2 |
168 |
SPTA1 | interactor | 7 | 0.524 | 6.665 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair |
169 |
SPTAN1 | oncoprotein | 13 | 0.397 | 27.221 | EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Tetrabrachion (PF11401, IPR021535): Tetrabrachion EF-hand_7 (PF13499, IPR011992): EF-hand domain pair E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain |
170 |
SRC | oncoprotein | 48 | 0.189 | 572.509 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain |
171 |
SRPK2 | oncoprotein | 12 | 0.327 | 25.973 | DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator Pkinase (PF00069, IPR000719): Protein kinase domain S-antigen (PF05756, IPR008825): S-antigen protein DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) |
172 |
ST5 | oncoprotein | 2 | 1.000 | 0 | dDENN (PF03455, IPR005112, SM00801): dDENN domain DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) uDENN (PF03456, IPR005113, SM00800): uDENN domain SEEEED (PF14797, IPR029394): Serine-rich region of AP3B1, clathrin-adaptor complex |
173 |
STK4 | oncoprotein | 7 | 0.467 | 3.068 | Pkinase (PF00069, IPR000719): Protein kinase domain Mst1_SARAH (PF11629, IPR024205): C terminal SARAH domain of Mst1 DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611) |
174 |
STON2 | interactor | 3 | 1.000 | 0 | Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Stonin2_N (PF12016, IPR022699): Stonin 2 |
175 |
STUB1 | suppressor | 22 | 0.424 | 45.219 | U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat |
176 |
SUB1 | interactor | 4 | 0.667 | 0.200 | Dehydrin (PF00257, IPR000167): Dehydrin PC4 (PF02229, IPR003173): Transcriptional Coactivator p15 (PC4) |
177 |
TERF1 | interactor | 21 | 0.242 | 84.879 | TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain |
178 |
TOPBP1 | protein found in more fusions | 8 | 0.619 | 4.069 | BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain PTCB-BRCT (PF12738, IPR001357): twin BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain |
179 |
TP53 | oncoprotein | 57 | 0.168 | 808.697 | DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif |
180 |
TP73 | oncoprotein | 14 | 0.423 | 18.439 | P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif) |
181 |
TSG101 | oncoprotein | 13 | 0.485 | 11.167 | APG6 (PF04111, IPR007243): Autophagy protein Apg6 Laminin_II (PF06009, IPR010307): Laminin Domain II UEV (PF05743, IPR008883): UEV domain Vps23_core (PF09454, IPR017916): Vps23 core domain |
182 |
TUB | interactor | 2 | 1.000 | 0 | Tub (PF01167, IPR000007): Tub family Tub_N (PF16322, IPR005398): Tubby N-terminal |
183 |
UBASH3B | interactor | 19 | 0.510 | 30.234 | His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain |
184 |
UBC | protein found in more fusions | 45 | 0.240 | 369.788 | ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family |
185 |
UNC119 | interactor | 4 | 0.500 | 2.067 | GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit |
186 |
USP7 | oncoprotein | 13 | 0.530 | 11.620 | MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal |
187 |
VAV1 | oncoprotein | 19 | 0.415 | 50.147 | PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain |
188 |
VPS28 | interactor | 4 | 0.833 | 0.105 | VPS28 (PF03997, IPR007143): VPS28 protein |
189 |
WASF1 | interactor | 5 | 0.400 | 3.486 | Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator WH2 (PF02205, IPR003124, SM00246): WH2 motif |
190 |
WDR48 | suppressor | 7 | 0.714 | 1.491 | WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337) |
191 |
WRNIP1 | interactor | 7 | 0.600 | 2.605 | AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RuvB_N (PF05496, IPR008824): Holliday junction DNA helicase ruvB N-terminus Sgf11 (PF08209, IPR013246): Sgf11 (transcriptional regulation protein) MgsA_C (PF12002, IPR021886): MgsA AAA+ ATPase C terminal AAA_assoc_2 (PF16193, IPR032423): AAA C-terminal domain |
192 |
XPO1 | interactor | 51 | 0.159 | 688.698 | CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region |
193 |
XRCC6 | oncoprotein | 17 | 0.358 | 38.669 | Ku (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain SAP (PF02037, IPR003034, SM00513): SAP domain |
194 |
YAP1 | oncoprotein | 16 | 0.392 | 31.678 | Bindin (PF02084, IPR000775): Bindin WW (PF00397, IPR001202, SM00456): WW domain GspL_C (PF12693, IPR025691): GspL periplasmic domain FAM181 (PF15238, IPR029359): FAM181 |
195 |
YTHDC1 | interactor | 3 | 1.000 | 0 | DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Merozoite_SPAM (PF07133, IPR010784): Merozoite surface protein (SPAM) Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family YTH (PF04146, IPR007275): YT521-B-like domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term TFB6 (PF17110, IPR031349): Subunit 11 of the general transcription factor TFIIH |
196 |
YWHAB | interactor | 26 | 0.409 | 71.956 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor |
197 |
YWHAE | oncoprotein | 28 | 0.357 | 103.831 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
198 |
YWHAG | protein found in more fusions | 26 | 0.420 | 64.870 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
199 |
YWHAH | protein found in more fusions | 20 | 0.503 | 28.581 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
200 |
YWHAQ | interactor | 32 | 0.325 | 145.780 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
201 |
YWHAZ | protein found in more fusions | 33 | 0.369 | 112.824 | 14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein |
202 |
ZAP70 | interactor | 18 | 0.588 | 17.949 | Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain |
203 |
ZDHHC16 | interactor | 1 | 0 | 0 | DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049) NS3_envE (PF02723, IPR003873): Non-structural protein NS3/Small envelope protein E zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase |