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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AL121228 is the fusion of parental proteins NEDD4L (from a repository: Mon Jan 30 21:27:27 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)174
The number (and %) of the onco-proteins47 (27.01 %)
The number (and %) of the tumor suppressors11 (6.32 %)
Total number of binary PPIs (saturation %)544 (3.61 %)
The number (and %) of affected PPIs173 (31.80 %)
The number of possible different fusions25
PPI diameter2
PPI radius1
The average degree of PPI5.598
Assortativity coefficient-0.3713
The network average Clustering coefficient0.525
The number (and %) of a zero Clustering coefficients45 (25.86 %)
The number (and %) of a zero Betweenness Centrality93 (53.45 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NEDD4L All fusions
: AL121228;
Proteins found in more fusions ABL2 (see 2 fusions); MERTK (see 1 fusions); RNF11 (see 1 fusions); YWHAG (see 1 fusions); MAP3K2 (see 2 fusions); NR3C1 (see 8 fusions); BMPR1A (see 1 fusions); HCN1 (see 1 fusions); MARK2 (see 2 fusions); SGK1 (see 2 fusions); YY1 (see 2 fusions); UBE2N (see 1 fusions); YWHAH (see 2 fusions); UBE2D2 (see 2 fusions); YWHAZ (see 1 fusions); BRAF (see 3 fusions); IKBKB (see 2 fusions); TSC22D3 (see 2 fusions); ZAK (see 2 fusions); DAZAP2 (see 2 fusions); MAP3K5 (see 1 fusions); UBC (see 1 fusions); KCNAB2 (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AL121228chimera1730.02126905.318C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
2 AATFoncoprotein50.4004.733DARPP-32 (PF05395, IPR008466): Protein phosphatase inhibitor 1/DARPP-32
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TRAUB (PF08164, IPR012617): Apoptosis-antagonizing transcription factor, C-terminal
Vif (PF00559, IPR000475): Retroviral Vif (Viral infectivity) protein
AATF-Che1 (PF13339, IPR025160): Apoptosis antagonizing transcription factor
3 ABL1oncoprotein130.62112.225Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
4 ABL2oncoprotein50.6671.500Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NHS (PF15273, IPR024845): NHS-like
5 ACVR1Boncoprotein70.6674.067Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase (PF00069, IPR000719): Protein kinase domain
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
6 ACY3interactor200AstE_AspA (PF04952, IPR007036): Succinylglutamate desuccinylase / Aspartoacylase family
7 ADAP2interactor21.0000ArfGap (PF01412, IPR001164, SM00105): Putative GTPase activating protein for Arf
PH (PF00169, IPR001849, SM00233): PH domain
8 AICDAinteractor50.5001.567APOBEC_N (PF08210, IPR013158): APOBEC-like N-terminal domain
9 AKT3oncoprotein100PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
10 AMOToncoprotein60.7002.667FAP (PF07174, IPR010801): Fibronectin-attachment protein (FAP)
Gastrin (PF00918, IPR001651, SM00029): Gastrin/cholecystokinin family
DUF2162 (PF09930, IPR017199): Predicted transporter (DUF2162)
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
11 AMOTL1interactor30.6670.667NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
Presenilin (PF01080, IPR001108): Presenilin
Angiomotin_C (PF12240, IPR024646): Angiomotin C terminal
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
12 APBB1interactor40.6671.000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
WW (PF00397, IPR001202, SM00456): WW domain
RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
PID_2 (PF14719, IPR006020): Phosphotyrosine interaction domain (PTB/PID)
13 APEX2interactor21.0000Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family
zf-GRF (PF06839, IPR010666): GRF zinc finger
14 ARHGDIAinteractor40.6670.200Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
15 ARRDC1interactor30.6671.000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
16 ARRDC3interactor21.0000Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
17 ARRDC4interactor100Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
18 ATP1B1interactor40.8330.200Na_K-ATPase (PF00287, IPR000402): Sodium / potassium ATPase beta chain
19 AURKCinteractor100Pkinase (PF00069, IPR000719): Protein kinase domain
20 BBXinteractor21.0000DUF2028 (PF09667, IPR019102): Domain of unknown function (DUF2028)
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
21 BMPR1Asuppressor41.0000Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
TGF_beta_GS (PF08515, IPR003605, SM00467): Transforming growth factor beta type I GS-motif
22 BRAFoncoprotein100.8062.848Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
23 C7orf50interactor21.0000DUF2373 (PF10180, IPR019327): Uncharacterised conserved protein (DUF2373)
24 CACNB1interactor100Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
VGCC_beta4Aa_N (PF12052, IPR000584): Voltage gated calcium channel subunit beta domain 4Aa N terminal
25 CAMK1Dinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
26 CAV3interactor21.0000Caveolin (PF01146, IPR001612): Caveolin
27 CCDC8interactor120.45516.529Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
28 CDC34oncoprotein40.6670.400UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
29 CDK3interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
30 CDK5oncoprotein50.5002.500Pkinase (PF00069, IPR000719): Protein kinase domain
31 CLIC2interactor100MKT1_C (PF12246, IPR022039): Temperature dependent protein affecting M2 dsRNA replication
GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
32 CUEDC1oncoprotein60.33310.000CUE (PF02845, IPR003892, SM00546): CUE domain
33 CYBRD1interactor100Cytochrom_B561 (PF03188, IPR004877): Eukaryotic cytochrome b561
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
34 CYP26B1interactor21.0000p450 (PF00067, IPR001128): Cytochrome P450
35 DAPK3suppressor40.6671.000OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pkinase (PF00069, IPR000719): Protein kinase domain
PspA_IM30 (PF04012, IPR007157): PspA/IM30 family
36 DAZAP2protein found in more fusions90.35713.333DAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
37 DDX54interactor21.0000DBP10CT (PF08147, IPR012541, SM01123): DBP10CT (NUC160) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Herpes_DNAp_acc (PF04929, IPR007013): Herpes DNA replication accessory factor
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
38 DECR2interactor21.0000adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
39 DMTNinteractor50.6001.952VHP (PF02209, IPR003128, SM00153): Villin headpiece domain
AbLIM_anchor (PF16182, IPR032402): Putative adherens-junction anchoring region of AbLIM
40 DYRK3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
41 EFEMP2interactor21.0000EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Adipogenin (PF15202, IPR027938): Adipogenin
42 ELAVL1oncoprotein400.090626.890RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
43 FAM189A2interactor60.5337.000CD20 (PF04103, IPR007237): CD20-like family
44 FAM189Binteractor21.0000CD20 (PF04103, IPR007237): CD20-like family
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
45 FBXL15interactor100LRV (PF01816, IPR004830): Leucine rich repeat variant
F-box (PF00646, IPR001810, SM00256): F-box domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
46 FGF12oncoprotein100FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
47 FKBP3interactor30.6670.667FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
48 GORABsuppressor100Transcrip_act (PF04949, IPR007033): Transcriptional activator
Histone_HNS (PF00816, IPR001801): H-NS histone family
MIT_C (PF16565, IPR032341): Phospholipase D-like domain at C-terminus of MIT
49 H1F0interactor40.6671.333OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Hid1 (PF12722): High-temperature-induced dauer-formation protein
Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family
50 HAX1interactor60.6003.983Mlf1IP (PF10248, IPR019376): Myelodysplasia-myeloid leukemia factor 1-interacting protein
51 HCN1protein found in more fusions200DUF1759 (PF03564, IPR005312): Protein of unknown function (DUF1759)
Hamartin (PF04388, IPR007483): Hamartin protein
Ion_trans (PF00520, IPR005821): Ion transport protein
Ion_trans_N (PF08412, IPR013621): Ion transport protein N-terminal
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
52 HGSinteractor150.22972.352FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VHS (PF00790, IPR002014, SM00288): VHS domain
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
Hrs_helical (PF12210, IPR024641): Hepatocyte growth factor-regulated tyrosine kinase substrate
PIEZO (PF15917, IPR031805): Piezo
53 IFRD2oncoprotein21.0000IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
IFRD_C (PF04836, IPR006921): Interferon-related protein conserved region
54 IKBKBprotein found in more fusions200FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
55 KCNAB1interactor30.6671.000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
56 KCNAB2protein found in more fusions40.6671.000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
57 KCNAB3interactor21.0000Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
58 KCNB1interactor200Ion_trans (PF00520, IPR005821): Ion transport protein
BTB_2 (PF02214, IPR003131): BTB/POZ domain
Kv2channel (PF03521, IPR003973): Kv2 voltage-gated K+ channel
DUF4790 (PF16037, IPR032004): Domain of unknown function (DUF4790)
59 KCNH2interactor30.6671.000Ion_trans (PF00520, IPR005821): Ion transport protein
cNMP_binding (PF00027, IPR000595, SM00100): Cyclic nucleotide-binding domain
PAS_9 (PF13426, IPR000014): PAS domain
60 KCNQ1interactor100Ion_trans (PF00520, IPR005821): Ion transport protein
KCNQ_channel (PF03520, IPR013821): KCNQ voltage-gated potassium channel
Sensor (PF13796, IPR025828): Putative sensor
61 KIF3Binteractor31.0000DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
62 KIFC3oncoprotein40.6671.000Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
63 LAPTM5oncoprotein21.0000Mtp (PF03821, IPR004687): Golgi 4-transmembrane spanning transporter
64 LDLRAD4interactor40.6672.000Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
65 LITAFsuppressor30.6670.333zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
DUF3824 (PF12868, IPR024436): Domain of unknwon function (DUF3824)
66 MAGEB1interactor100MAGE (PF01454, IPR002190): MAGE family
MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
67 MAP2oncoprotein41.0000MAP2_projctn (PF08377, IPR013588): MAP2/Tau projection domain
Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
RII_binding_1 (PF10522, IPR018459): RII binding domain
CCSAP (PF15748, IPR029774): Centriole, cilia and spindle-associated
68 MAP3K2protein found in more fusions80.7622.082PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
69 MAP3K3oncoprotein70.5335.071PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
70 MAP3K5oncoprotein51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
71 MAPKAPK3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
72 MARK2protein found in more fusions110.7115.053DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
73 MED28interactor50.5002.000cwf21 (PF08312, IPR013170, SM01115): cwf21 domain
Med28 (PF11594, IPR021640): Mediator complex subunit 28
74 MERTKoncoprotein31.0000fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ig_3 (PF13927): Immunoglobulin domain
75 MINK1interactor100CNH (PF00780, IPR001180, SM00036): CNH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
SOBP (PF15279, IPR026092): Sine oculis-binding protein
76 MOB3Ainteractor21.0000Mob1_phocein (PF03637, IPR005301): Mob1/phocein family
77 MOV10interactor130.25648.906AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
78 MRPL19interactor21.0000Ribosomal_L19 (PF01245, IPR001857): Ribosomal protein L19
EABR (PF12180, IPR022008): TSG101 and ALIX binding domain of CEP55
79 MT2Asuppressor100Metallothio (PF00131, IPR003019): Metallothionein
80 NDFIP1interactor50.4005.500DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
Comm (PF15957, IPR031878): Commissureless
81 NDFIP2interactor21.0000DUF2370 (PF10176, IPR019325): Protein of unknown function (DUF2370)
82 NHP2interactor21.0000Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
83 NOTCH1suppressor70.4677.500Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
84 NPC2interactor100E1_DerP2_DerF2 (PF02221, IPR003172, SM00737): ML domain
85 NR3C1protein found in more fusions110.33323.889GCR (PF02155, IPR001409): Glucocorticoid receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
86 NSRP1interactor100Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
DUF2040 (PF09745, IPR018612): Coiled-coil domain-containing protein 55 (DUF2040)
Macoilin (PF09726, IPR019130): Transmembrane protein
PepSY_2 (PF13670, IPR025711): Peptidase propeptide and YPEB domain
87 NTRK1oncoprotein300.197279.816I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
88 NUDT16L1interactor100HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
89 OCLNinteractor30.6671.000MARVEL (PF01284, IPR008253): Membrane-associating domain
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
90 PBX1oncoprotein31.0000PBC (PF03792, IPR005542): PBC domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
91 PRKXinteractor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
92 PRR16interactor100EzrA (PF06160, IPR010379): Septation ring formation regulator, EzrA
DUF4589 (PF15252, IPR027997): Domain of unknown function (DUF4589)
93 PRRG1interactor21.0000Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
RCR (PF12273, IPR020999): Chitin synthesis regulation, resistance to Congo red
TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
94 PRRG3interactor21.0000Gla (PF00594, IPR000294, SM00069): Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain
RCR (PF12273, IPR020999): Chitin synthesis regulation, resistance to Congo red
95 PSMD4interactor60.6004.567UIM (PF02809, IPR003903, SM00726): Ubiquitin interaction motif
VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
96 PTCH1suppressor100Patched (PF02460, IPR003392): Patched family
97 PYM1interactor30.6670.400CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
Mago-bind (PF09282, IPR015362): Mago binding
AAA_23 (PF13476): AAA domain
98 RAF1oncoprotein180.35358.380Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
99 RANBP10interactor21.0000LisH (PF08513, IPR013720, SM00667): LisH
SPRY (PF00622, IPR003877, SM00449): SPRY domain
CLTH (PF10607, IPR024964): CTLH/CRA C-terminal to LisH motif domain
100 RASL10Bsuppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
101 RASL11Boncoprotein100Ras (PF00071, IPR001806, SM00173): Ras family
Transferase (PF02458, IPR003480): Transferase family
102 RHOBsuppressor21.0000Ras (PF00071, IPR001806, SM00173): Ras family
103 RNF11protein found in more fusions110.37818.367zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
zf-ANAPC11 (PF12861, IPR024991): Anaphase-promoting complex subunit 11 RING-H2 finger
104 RNF7oncoprotein60.5003.000zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
105 ROBO3interactor100Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
106 RPL30interactor100NCBP3 (PF10309, IPR019416): Nuclear cap-binding protein subunit 3
107 RPS6KB2interactor50.7001.300Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
108 SCDinteractor21.0000MerC (PF03203, IPR004891): MerC mercury resistance protein
109 SCNN1Ainteractor31.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
110 SCNN1Boncoprotein70.4769.833ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
111 SCNN1Ginteractor21.0000ASC (PF00858, IPR001873): Amiloride-sensitive sodium channel
112 SENP2interactor21.0000Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
113 SERPINF1oncoprotein100Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
114 SFNsuppressor150.46225.68414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
115 SGK1oncoprotein110.46714.127Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
116 SGK2interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
117 SGK3interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
118 SIVA1interactor21.0000Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
119 SLC22A11interactor100Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
120 SLC22A8interactor100Sugar_tr (PF00083, IPR005828): Sugar (and other) transporter
121 SLC7A7interactor100AA_permease_2 (PF13520, IPR002293): Amino acid permease
122 SLC9A3interactor100Na_H_Exchanger (PF00999, IPR006153): Sodium/hydrogen exchanger family
NEXCaM_BD (PF16644, IPR032103): Regulatory region of Na+/H+ exchanger NHE binds to calmodulin
123 SMAD2suppressor100.52810.733MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
124 SMAD3oncoprotein120.36428.000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
125 SMAD6interactor60.7332.667MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
126 SMAD7interactor90.41715.667MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
127 SNCAinteractor90.28615.933Synuclein (PF01387, IPR001058): Synuclein
128 SPAG8interactor100Zip (PF02535, IPR003689): ZIP Zinc transporter
129 SRMSinteractor100Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
130 STACinteractor21.0000SH3_2 (PF07653, IPR011511): Variant SH3 domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
131 STK40interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
132 SUSD6interactor21.0000Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
133 TAF1Binteractor100Cytochrom_NNT (PF03264, IPR005126): NapC/NirT cytochrome c family, N-terminal region
zf-RRN7 (PF11781, IPR021752): Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
134 TARBP2interactor200dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
135 TBC1D7interactor100RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
136 TCEAL2interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
137 TGFB1I1interactor50.6002.233LIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
138 TMA16interactor21.0000Tma16 (PF11176, IPR021346): Translation machinery-associated protein 16
139 TMEM171interactor21.0000TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
140 TMEM51interactor30.6671.000WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
TMEM51 (PF15345, IPR029265): Transmembrane protein 51
141 TMEM52Binteractor21.0000LSR (PF05624, IPR008664): Lipolysis stimulated receptor (LSR)
TMEM52 (PF14979): Transmembrane 52
142 TMEM55Ainteractor100Tmemb_55A (PF09788, IPR019178): Transmembrane protein 55A
143 TMEM92interactor30.6671.000WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
144 TNK2interactor40.6671.000CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
145 TOLLIPinteractor70.5333.483C2 (PF00168, IPR000008, SM00239): C2 domain
CUE (PF02845, IPR003892, SM00546): CUE domain
146 TRIM41interactor40.6671.000BUD22 (PF09073, IPR015158): BUD22
Fer2 (PF00111, IPR001041): 2Fe-2S iron-sulfur cluster binding domain
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
RecR (PF02132, IPR023628): RecR protein
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
DUF3631 (PF12307, IPR022081): Protein of unknown function (DUF3631)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
147 TSC22D3protein found in more fusions70.6671.806TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
148 UBAC1interactor30.6670.667CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
HEAT_2 (PF13646): HEAT repeats
Rad60-SLD_2 (PF13881): Ubiquitin-2 like Rad60 SUMO-like
149 UBCprotein found in more fusions300.160285.295ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
150 UBE2D1interactor70.6004.900UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
151 UBE2D2oncoprotein100.38917.650UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
152 UBE2D3interactor70.4006.733UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
153 UBE2E3interactor41.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
154 UBE2J2interactor31.0000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
155 UBE2Kinteractor40.8330.500UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
156 UBE2L3interactor100.30620.000UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
157 UBE2Nprotein found in more fusions60.6002.333UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
158 VDAC2interactor50.6002.400Porin_3 (PF01459, IPR027246): Eukaryotic porin
159 WBP1interactor100WBP-1 (PF11669, IPR021684): WW domain-binding protein 1
160 WBP2interactor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
Vps36_ESCRT-II (PF11605, IPR021648): Vacuolar protein sorting protein 36 Vps36
161 WNK1interactor80.7621.394SynMuv_product (PF06047, IPR009269): Ras-induced vulval development antagonist
Pkinase (PF00069, IPR000719): Protein kinase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
162 WNK3interactor100DP (PF08781, IPR014889, SM01138): Transcription factor DP
Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
PHtD_u1 (PF16645): Unstructured region on Pneumococcal histidine triad protein
163 WNK4interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
OSR1_C (PF12202, IPR024678): Oxidative-stress-responsive kinase 1 C terminal
164 XPO1interactor230.190177.116CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
165 YWHABinteractor170.46333.99714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
166 YWHAGprotein found in more fusions220.42969.39414-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
167 YWHAHprotein found in more fusions160.58119.50214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
168 YWHAQinteractor210.35789.56114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
169 YWHAZprotein found in more fusions230.39082.52214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
170 YY1protein found in more fusions80.4299.456zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Keratin_2_tail (PF16210, IPR032449): Keratin type II cytoskeletal 1 tail
171 ZADH2interactor21.0000ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
172 ZAKprotein found in more fusions70.6671.318Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
DUF3552 (PF12072, IPR022711): Domain of unknown function (DUF3552)
173 ZC3HAV1Linteractor21.0000FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
174 ZDHHC3oncoprotein21.0000DUF898 (PF05987, IPR010295): Bacterial protein of unknown function (DUF898)
EI24 (PF07264): Etoposide-induced protein 2.4 (EI24)
zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
IGFBP (PF00219, IPR000867, SM00121): Insulin-like growth factor binding protein
DUF3615 (PF12274, IPR022059): Protein of unknown function (DUF3615)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 NEDD4Lparental proteinWW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)

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