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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AL050182 is the fusion of parental proteins GABARAP (from a repository: Thu Nov 10 14:59:26 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)54
The number (and %) of the onco-proteins17 (31.48 %)
The number (and %) of the tumor suppressors1 (1.85 %)
Total number of binary PPIs (saturation %)216 (15.09 %)
The number (and %) of affected PPIs53 (24.54 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI7.407
Assortativity coefficient-0.3418
The network average Clustering coefficient0.666
The number (and %) of a zero Clustering coefficients6 (11.11 %)
The number (and %) of a zero Betweenness Centrality21 (38.89 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: GABARAP All fusions
: AL050182;
Proteins found in more fusions OPTN (see 1 fusions); FNBP1 (see 7 fusions); HDAC5 (see 1 fusions); CUL3 (see 1 fusions); SRPK2 (see 1 fusions); SQSTM1 (see 5 fusions); TFRC (see 1 fusions); ULK1 (see 2 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AL050182chimera530.1071790.192Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
2 AMBRA1interactor60.5334.952Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Spt20 (PF12090, IPR021950): Spt20 family
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
3 ANKFY1interactor40.8330.500Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
4 ATG13oncoprotein90.5567.497ATG13 (PF10033, IPR018731): Autophagy-related protein 13
5 ATG3interactor80.6433.778Autophagy_C (PF10381, IPR019461): Autophagocytosis associated protein C-terminal
Autophagy_N (PF03986, IPR007134): Autophagocytosis associated protein (Atg3), N-terminal domain
Autophagy_act_C (PF03987, IPR007135): Autophagocytosis associated protein, active-site domain
6 ATG4Binteractor80.7502.538Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
7 ATG7interactor80.6436.630ThiF (PF00899, IPR000594): ThiF family
ATG7_N (PF16420, IPR032197): Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
8 CALCOCO2interactor90.7142.249bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
zf-C2H2_4 (PF13894): C2H2-type zinc finger
9 CCPG1interactor100DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
YtxH (PF12732, IPR024623): YtxH-like protein
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
10 CUL3protein found in more fusions160.43841.444Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
11 DVL2interactor41.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
Dishevelled (PF02377, IPR003351): Dishevelled specific domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DIX (PF00778, IPR001158, SM00021): DIX domain
Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
12 DYX1C1interactor21.0000CS (PF04969, IPR007052): CS domain
Presenilin (PF01080, IPR001108): Presenilin
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
DUF3035 (PF11233, IPR021395): Protein of unknown function (DUF3035)
TPR_11 (PF13414, IPR011990): TPR repeat
G0-G1_switch_2 (PF15103, IPR016821): G0/G1 switch protein 2
CCDC66 (PF15236): Coiled-coil domain-containing protein 66
13 FKBP4interactor31.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
14 FLCNoncoprotein40.6672.000Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
Folliculin_C (PF16692, IPR032035): Folliculin C-terminal domain
15 FNBP1oncoprotein200FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
HR1 (PF02185, IPR011072, SM00742): Hr1 repeat
Laminin_II (PF06009, IPR010307): Laminin Domain II
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
16 FNIP1oncoprotein21.0000DUF1810 (PF08837, IPR014937): Protein of unknown function (DUF1810)
FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
FNIP_C (PF14638, IPR028086): Folliculin-interacting protein C-terminus
17 GABARAPL1interactor290.207202.748Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
VitD-bind_III (PF09164, IPR015247): Vitamin D binding protein, domain III
18 GABARAPL2interactor270.311126.540Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
19 GABRG2interactor100Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
20 GBASinteractor100.6449.933NIPSNAP (PF07978, IPR012577): NIPSNAP
21 HDAC5protein found in more fusions31.0000Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
22 IPO5interactor41.0000HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
23 KATNB1interactor200WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Katanin_con80 (PF13925, IPR028021): con80 domain of Katanin
24 KBTBD6interactor70.8570.344BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
25 KBTBD7interactor70.8570.344BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_2 (PF07646, IPR011498): Kelch motif
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_4 (PF13418): Galactose oxidase, central domain
Kelch_6 (PF13964): Kelch motif
26 KEAP1oncoprotein80.9520.100BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
27 MAP1LC3Binteractor210.30071.629Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
28 MAP1LC3Cinteractor180.34041.981Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
29 MAPK15interactor30.6670.100Pkinase (PF00069, IPR000719): Protein kinase domain
30 MEFVinteractor50.9000.1117TMR-HDED (PF07697, IPR011624): 7TM-HD extracellular
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
31 MLH1oncoprotein21.0000DNA_mis_repair (PF01119, IPR013507): DNA mismatch repair protein, C-terminal domain
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Mlh1_C (PF16413, IPR032189): DNA mismatch repair protein Mlh1 C-terminus
32 MUL1interactor41.0000DUF1049 (PF06305, IPR010445): Protein of unknown function (DUF1049)
DUF3040 (PF11239, IPR021401): Protein of unknown function (DUF3040)
GIDE (PF12483, IPR022170): E3 Ubiquitin ligase
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
33 NBR1oncoprotein70.8000.344CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF2681 (PF10883, IPR020274): Protein of unknown function (DUF2681)
N_BRCA1_IG (PF16158, IPR032350): Ig-like domain from next to BRCA1 gene
34 NCOA7interactor100GRAM (PF02893, IPR004182, SM00568): GRAM domain
LysM (PF01476, IPR018392, SM00257): LysM domain
TLD (PF07534, IPR006571, SM00584): TLD
Bclt (PF15318, IPR029296): Putative Bcl-2 like protein of testis
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
35 NEDD4suppressor41.0000Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
36 NIPSNAP1interactor60.9330.100NIPSNAP (PF07978, IPR012577): NIPSNAP
37 OPTNprotein found in more fusions100.52813.630ARD (PF03079, IPR004313): ARD/ARD' family
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
38 PI4K2Ainteractor21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Ribosomal_S15 (PF00312, IPR000589): Ribosomal protein S15
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
39 RB1CC1oncoprotein70.6193.397Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
40 RWDD2Ainteractor21.0000DUF1115 (PF06544, IPR010541): Protein of unknown function (DUF1115)
RWD (PF05773, IPR006575, SM00591): RWD domain
41 SQSTM1oncoprotein230.33394.449PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
42 SRPK1interactor41.0000FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
Pkinase (PF00069, IPR000719): Protein kinase domain
NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
43 SRPK2oncoprotein60.8001.167DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
44 TAX1BP1interactor70.8100.630CALCOCO1 (PF07888, IPR012852): Calcium binding and coiled-coil domain (CALCOCO1) like
zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
PolyA_pol (PF01743, IPR002646): Poly A polymerase head domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
zf-C2H2_4 (PF13894): C2H2-type zinc finger
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
45 TBC1D15interactor21.0000Cortex-I_coil (PF09304, IPR015383): Cortexillin I, coiled coil
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3548 (PF12068, IPR021935): Domain of unknown function (DUF3548)
46 TECPR2interactor100Hyd_WA (PF06462, IPR006624, SM00706): Propeller
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
47 TFRConcoprotein40.6671.000PA (PF02225, IPR003137): PA domain
Peptidase_M28 (PF04389, IPR007484): Peptidase family M28
TFR_dimer (PF04253, IPR007365): Transferrin receptor-like dimerisation domain
DUF3855 (PF12967, IPR024482): Domain of Unknown Function with PDB structure (DUF3855)
48 TP53INP1oncoprotein31.0000DOR (PF14839, IPR029431): DOR family
49 TRIM21interactor80.8570.344DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313)
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
Prok-RING_1 (PF14446): Prokaryotic RING finger family 1
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
50 TSPAN3interactor21.0000Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein
Tetraspannin (PF00335, IPR018499): Tetraspanin family
51 TUBB3interactor30.6671.000Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
52 ULK1protein found in more fusions150.47329.597Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
53 ULK2interactor40.6670.619Pkinase (PF00069, IPR000719): Protein kinase domain
DUF3543 (PF12063, IPR022708): Domain of unknown function (DUF3543)
54 WDFY3interactor50.9000.111Beach (PF02138, IPR000409, SM01026): Beige/BEACH domain
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Laminin_G_3 (PF13385): Concanavalin A-like lectin/glucanases superfamily
E3_UbLigase_R4 (PF13764, IPR025704): E3 ubiquitin-protein ligase UBR4
PH_BEACH (PF14844, IPR023362): PH domain associated with Beige/BEACH
DUF4704 (PF15787, IPR031570): Domain of unknown function (DUF4704)
DUF4800 (PF16057): Domain of unknown function (DUF4800)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATG101interactorATG101 (PF07855, IPR012445): Autophagy-related protein 101
2 ATG12interactorAPG12 (PF04110, IPR007242): Ubiquitin-like autophagy protein Apg12
3 BNIP3LsuppressorBNIP3 (PF06553, IPR010548): BNIP3
4 FNIP2interactorDUF1645 (PF07816, IPR012442): Protein of unknown function (DUF1645)
DUF508 (PF04370, IPR007465): Domain of unknown function (DUF508)
FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
FNIP_M (PF14637, IPR028085): Folliculin-interacting protein middle domain
FNIP_C (PF14638, IPR028086): Folliculin-interacting protein C-terminus
5 GABARAPparental proteinAtg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
6 STBD1interactorCBM_20 (PF00686, IPR002044): Starch binding domain
7 TBC1D25interactorRabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain

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