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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AK294283 is the fusion of parental proteins TELO2, SMYD5 (from a repository: Fri Apr 7 07:56:22 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)33
The number (and %) of the onco-proteins9 (27.27 %)
The number (and %) of the tumor suppressors5 (15.15 %)
Total number of binary PPIs (saturation %)117 (22.16 %)
The number (and %) of affected PPIs32 (27.35 %)
The number of possible different fusions9
PPI diameter2
PPI radius1
The average degree of PPI6.303
Assortativity coefficient-0.3480
The network average Clustering coefficient0.649
The number (and %) of a zero Clustering coefficients2 (6.06 %)
The number (and %) of a zero Betweenness Centrality11 (33.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TELO2,SMYD5 All fusions
: AK294283;
Proteins found in more fusions ATR (see 1 fusions); VCP (see 4 fusions); COPG1 (see 1 fusions); DSP (see 4 fusions); EGFR (see 2 fusions); APC (see 1 fusions); PRKDC (see 3 fusions); MTOR (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AK294283chimera320.145572.969Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
2 AK2interactor31.0000ADK (PF00406, IPR000850): Adenylate kinase
AAA_33 (PF13671): AAA domain
3 APCsuppressor40.6671.000APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
4 ATMsuppressor60.7001.567FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
ANAPC5 (PF12862, IPR026000): Anaphase-promoting complex subunit 5
5 ATRsuppressor70.6672.467FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
Mad3_BUB1_I (PF08311, IPR013212, SM00777): Mad3/BUB1 homology region 1
THP2 (PF09432, IPR018557): Tho complex subunit THP2
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
UME (PF08064, IPR012993, SM00802): UME (NUC010) domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
SgrT (PF15894, IPR031767): Inhibitor of glucose uptake transporter SgrT
6 BSGinteractor60.5333.919Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
7 CACNA1Ainteractor100Ca_chan_IQ (PF08763, IPR014873, SM01062): Voltage gated calcium channel IQ domain
GRP (PF07172, IPR010800): Glycine rich protein family
Ion_trans (PF00520, IPR005821): Ion transport protein
Roughex (PF06020, IPR009259): Drosophila roughex protein
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
GPHH (PF16905, IPR031649): Voltage-dependent L-type calcium channel, IQ-associated
8 CLN3interactor30.6670.500CLN3 (PF02487, IPR003492): CLN3 protein
9 COPB2interactor70.8670.750Coatomer_WDAD (PF04053, IPR006692): Coatomer WD associated region
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
10 COPG1protein found in more fusions80.7143.250Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
COP-gamma_platf (PF08752, IPR013040): Coatomer gamma subunit appendage platform subdomain
Coatomer_g_Cpla (PF16381, IPR032154): Coatomer subunit gamma-1 C-terminal appendage platform
11 CORO1Binteractor100DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
Trimer_CC (PF08954, IPR015049, SM01167): Trimerisation motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_4 (PF16300): Type of WD40 repeat
12 CRKLoncoprotein31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
13 DNAJB1suppressor31.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
14 DSPsuppressor50.8330.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase
CLP_protease (PF00574, IPR023562): Clp protease
DUF1192 (PF06698, IPR009579): Protein of unknown function (DUF1192)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Fez1 (PF06818): Fez1
FIVAR (PF07554, IPR011490): Uncharacterised Sugar-binding Domain
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
Rho_Binding (PF08912, IPR015008): Rho Binding
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
Plectin (PF00681, IPR001101, SM00250): Plectin repeat
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
SOGA (PF11365, IPR027881): Protein SOGA
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
FAM184 (PF15665): Family with sequence similarity 184, A and B
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
15 EGFRoncoprotein110.48915.002Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
16 HSPA4interactor90.52811.419Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
17 KRT15interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 MTORoncoprotein80.5714.383DUF1104 (PF06518, IPR009488): Protein of unknown function (DUF1104)
EPSP_synthase (PF00275, IPR001986): EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
TPR_19 (PF14559): Tetratricopeptide repeat
19 NTRK1oncoprotein210.232125.050I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
20 PIDD1interactor40.5001.833Death (PF00531, IPR000488, SM00005): Death domain
ZU5 (PF00791, IPR000906, SM00218): ZU5 domain
Peptidase_S68 (PF10461, IPR019502): Peptidase S68
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
21 PIH1D1interactor40.8330.250PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
22 PPP4R3Ainteractor21.0000Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
SMK-1 (PF04802, IPR006887): Component of IIS longevity pathway SMK-1
WH1 (PF00568, IPR000697, SM00461): WH1 domain
DUF4611 (PF15387, IPR027893): Domain of unknown function (DUF4611)
23 PRKDCprotein found in more fusions80.4768.500FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
NUC194 (PF08163, IPR012582): NUC194 domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
24 PSMD6interactor21.0000RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
25 RPAP3interactor60.6003.917TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
RPAP3_C (PF13877, IPR025986): Potential Monad-binding region of RPAP3
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
26 RUFY1interactor61.0000DM (PF00751, IPR001275, SM00301): DM DNA binding domain
FAA_hydrolase_N (PF09298, IPR015377): Fumarylacetoacetase N-terminal
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
RUN (PF02759, IPR004012, SM00593): RUN domain
Tektin (PF03148, IPR000435): Tektin family
27 SENP3interactor60.4676.500Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis)
Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
28 SMG1interactor41.0000Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
FATC (PF02260, IPR003152): FATC domain
HEAT (PF02985, IPR000357): HEAT repeat
FRB_dom (PF08771, IPR009076): FKBP12-rapamycin binding domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
SMG1 (PF15785, IPR031559): Serine/threonine-protein kinase smg-1
29 TPM4oncoprotein31.0000Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
30 TRRAPinteractor30.6670.500BALF1 (PF06861, IPR010677): BALF1 protein
BP28CT (PF08146, IPR012954, SM01036): BP28CT (NUC211) domain
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
FAT (PF02259, IPR003151): FAT domain
FATC (PF02260, IPR003152): FATC domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
CLASP_N (PF12348, IPR024395): CLASP N terminal
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
TRC8_N (PF13705, IPR025754): TRC8 N-terminal domain
ACDC (PF14733, IPR028078): AP2-coincident C-terminal
31 TTI1interactor150.32455.252Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
VHS (PF00790, IPR002014, SM00288): VHS domain
CLASP_N (PF12348, IPR024395): CLASP N terminal
32 VCPprotein found in more fusions80.5716.019AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
33 XPO1interactor100.35622.286CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 HTR6interactor7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
2 MAGED1interactorMAGE (PF01454, IPR002190): MAGE family
3 MASTLinteractorPkinase (PF00069, IPR000719): Protein kinase domain
4 MOV10interactorAAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
5 NXF1interactorNTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
6 RUVBL1oncoproteinTIP49 (PF06068, IPR010339): TIP49 C-terminus
7 RUVBL2oncoproteinTIP49 (PF06068, IPR010339): TIP49 C-terminus
8 SMYD5parental proteinSET (PF00856, IPR001214, SM00317): SET domain
WCCH (PF03716, IPR005159): WCCH motif
9 TELO2parental proteinTelomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
HEAT_2 (PF13646): HEAT repeats
10 TMEM132AinteractorDUF4366 (PF14283, IPR025376): Domain of unknown function (DUF4366)
TMEM132D_N (PF15705, IPR031435): Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
TMEM132D_C (PF15706, IPR031436): Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
TMEM132 (PF16070, IPR031437): Transmembrane protein family 132
11 TTI2interactorTti2 (PF10521, IPR018870): Tti2 family
12 XRCC5suppressorKu (PF02735, IPR006164, SM00559): Ku70/Ku80 beta-barrel domain
Ku_C (PF03730, IPR005160): Ku70/Ku80 C-terminal arm
Ku_N (PF03731, IPR005161): Ku70/Ku80 N-terminal alpha/beta domain
Ku_PK_bind (PF08785, IPR014893): Ku C terminal domain like

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