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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AK291194 is the fusion of parental proteins PLS3, COL4A5 (from a repository: Tue Mar 14 09:10:20 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins15 (34.09 %)
The number (and %) of the tumor suppressors4 (9.09 %)
Total number of binary PPIs (saturation %)185 (19.56 %)
The number (and %) of affected PPIs43 (23.24 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI7.591
Assortativity coefficient-0.2866
The network average Clustering coefficient0.617
The number (and %) of a zero Clustering coefficients4 (9.09 %)
The number (and %) of a zero Betweenness Centrality12 (27.27 %)


List of the fusions

PPI for parental proteins: COL4A5,PLS3 All fusions
: AK291194;
Proteins found in more fusions SHC1 (see 1 fusions); APP (see 4 fusions); EWSR1 (see 2 fusions); HLA-B (see 2 fusions); SOD1/TAGLN2 (see 1 fusions); STAU1 (see 2 fusions); EZR (see 2 fusions); TKT (see 5 fusions); EGFR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AK291194chimera430.1371091.451CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
2 ANXA6interactor50.8001.000Annexin (PF00191, IPR018502, SM00335): Annexin
3 APPprotein found in more fusions80.4767.500APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding
Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP)
BUD22 (PF09073, IPR015158): BUD22
IncA (PF04156, IPR007285): IncA protein
Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain
APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus
APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD
APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
4 ARHGDIAinteractor80.7141.619Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
5 CLNS1Ainteractor21.0000Voldacs (PF03517): Regulator of volume decrease after cellular swelling
6 CUL5suppressor50.9000.500Cullin (PF00888, IPR001373, SM00182): Cullin family
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7 EGFRoncoprotein110.46714.217Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
8 ELAVL1oncoprotein150.36342.217RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
9 ENO2interactor110.6737.544Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
10 EWSR1oncoprotein150.39633.210RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
11 EZRprotein found in more fusions150.54920.610DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
12 FDPSinteractor50.8000.900polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
13 FKBP14interactor21.0000FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
14 HARSinteractor30.6671.000HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
15 HDGFinteractor50.7001.333PWWP (PF00855, IPR000313, SM00293): PWWP domain
16 HLA-Boncoprotein41.0000MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
17 HSPE1interactor140.48429.807Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
18 IKBKEinteractor200IncA (PF04156, IPR007285): IncA protein
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
zf-RING_9 (PF13901, IPR025258): Putative zinc-RING and/or ribbon
19 ISG15suppressor70.5714.819ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
20 LUZP4interactor200Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
DUF2570 (PF10828, IPR022538): Protein of unknown function (DUF2570)
21 MSNoncoprotein130.57613.560DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
22 MYO5Ainteractor21.0000DIL (PF01843, IPR018444, SM01132): DIL domain
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
SOGA (PF11365, IPR027881): Protein SOGA
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
CYTL1 (PF15153, IPR029253): Cytokine-like protein 1
23 NR1H2oncoprotein100zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
24 NTRK1oncoprotein260.227190.143I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
25 PSMD6interactor21.0000RPN7 (PF10602, IPR019585): 26S proteasome subunit RPN7
PCI (PF01399, IPR000717, SM00088): PCI domain
26 RANBP1interactor50.9000.333PKI (PF02827, IPR004171): cAMP-dependent protein kinase inhibitor
Ran_BP1 (PF00638, IPR000156, SM00160): RanBP1 domain
27 RDXinteractor100.6228.194ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
28 SHC1oncoprotein50.8330.333PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
29 SNX3interactor40.5001.233PX (PF00787, IPR001683, SM00312): PX domain
30 SOD1protein found in more fusions90.6794.805Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
31 SORDinteractor70.6672.800ADH_N (PF08240, IPR013154): Alcohol dehydrogenase GroES-like domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
32 STAU1protein found in more fusions60.7001.500dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
33 STIP1interactor160.49233.732TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
34 TAGLNsuppressor60.5333.633Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
35 TAGLN2protein found in more fusions110.61812.852Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
36 TALDO1interactor80.6075.408TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
37 THG1Linteractor31.0000Thg1 (PF04446, IPR024956): tRNAHis guanylyltransferase
Thg1C (PF14413, IPR025845): Thg1 C terminal domain
38 THOP1interactor80.5008.022Peptidase_M3 (PF01432, IPR001567): Peptidase family M3
39 TKTprotein found in more fusions130.63610.658Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
40 TP63suppressor200Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
41 TXNRD1interactor50.7002.067Glutaredoxin (PF00462, IPR002109): Glutaredoxin
Pyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
42 TYMSinteractor21.0000Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
43 UFD1Linteractor31.0000UFD1 (PF03152, IPR004854): Ubiquitin fusion degradation protein UFD1
44 UNKinteractor30.6671.000MbeD_MobD (PF04899, IPR006983): MbeD/MobD like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
zf-CCCH_2 (PF14608): RNA-binding, Nab2-type zinc finger
Torus (PF16131, IPR032297): Torus domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ANTXR2interactorAnt_C (PF05586, IPR008399): Anthrax receptor C-terminus region
Anth_Ig (PF05587, IPR008400): Anthrax receptor extracellular domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
zf-LITAF-like (PF10601, IPR006629, SM00714): LITAF-like zinc ribbon domain
2 ANXA7suppressorAnnexin (PF00191, IPR018502, SM00335): Annexin
3 CDKN1AsuppressorCDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
4 CEP170P1interactorNA
5 COL4A5parental proteinC4 (PF01413, IPR001442, SM00111): C-terminal tandem repeated domain in type 4 procollagen
Collagen (PF01391, IPR008160): Collagen triple helix repeat (20 copies)
DUF1860 (PF08949, IPR015044): Domain of unknown function (DUF1860)
6 DAP3interactorDAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
7 DAZAP2interactorDAZAP2 (PF11029, IPR022730): DAZ associated protein 2 (DAZAP2)
8 KIF21BinteractorCENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF812 (PF05667, IPR008530): Protein of unknown function (DUF812)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
Thioredoxin_4 (PF13462, IPR012336): Thioredoxin
BORG_CEP (PF14957, IPR029273): Cdc42 effector
TSNAXIP1_N (PF15739, IPR032755): Translin-associated factor X-interacting N-terminus
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
9 KNL1oncoproteinDASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
10 PDK1interactorHATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
BCDHK_Adom3 (PF10436, IPR018955): Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
11 PLS3parental proteinCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
12 SMN1interactorSMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
13 STRN3interactorStriatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
14 TK1oncoproteinTK (PF00265, IPR001267, SM00203): Thymidine kinase
15 VHLsuppressorTrypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
VHL (PF01847, IPR022772): von Hippel-Lindau disease tumour suppressor protein
VHL_C (PF17211): VHL box domain
16 VPS26BinteractorVps26 (PF03643, IPR005377): Vacuolar protein sorting-associated protein 26

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