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Visualization interactions

Cytoscape Web for: AK125156 is the fusion of parental proteins LIMK1 (from a repository: Tue Dec 6 05:27:22 2016)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	39
The number (and %) of the onco-proteins	16 (41.03 %)
The number (and %) of the tumor suppressors	4 (10.26 %)
Total number of binary PPIs (saturation %)	101 (13.63 %)
The number (and %) of affected PPIs	38 (37.62 %)
The number of possible different fusions	9
PPI diameter	2
PPI radius	1
The average degree of PPI	4.462
Assortativity coefficient	-0.3359
The network average Clustering coefficient	0.440
The number (and %) of a zero Clustering coefficients	12 (30.77 %)
The number (and %) of a zero Betweenness Centrality	20 (51.28 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: LIMK1	All fusions : AK125156;
Proteins found in more fusions	ERBIN (see 4 fusions); FYN (see 1 fusions); PAK4 (see 1 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); MAPK14 (see 1 fusions); APP (see 4 fusions); BRAF (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AK125156	chimera	38	0.070	1155.133	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2	APP	protein found in more fusions	14	0.256	52.900	APP_N (PF02177, IPR015849, SM00006): Amyloid A4 N-terminal heparin-binding Beta-APP (PF03494, IPR013803): Beta-amyloid peptide (beta-APP) BUD22 (PF09073, IPR015158): BUD22 IncA (PF04156, IPR007285): IncA protein Kunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain APP_amyloid (PF10515, IPR019543): beta-amyloid precursor protein C-terminus APP_Cu_bd (PF12924, IPR011178): Copper-binding of amyloid precursor, CuBD APP_E2 (PF12925, IPR024329): E2 domain of amyloid precursor protein
3	ARRB1	interactor	7	0.429	8.733	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
4	ARRB2	interactor	5	0.600	3.167	Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
5	BAD	oncoprotein	4	0.833	0.500	Bcl-2_BAD (PF10514, IPR018868): Pro-apoptotic Bcl-2 protein, BAD
6	BLMH	interactor	3	1.000	0	Peptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
7	BMPR2	suppressor	2	0	0	Activin_recp (PF01064, IPR000472): Activin types I and II receptor domain Pkinase (PF00069, IPR000719): Protein kinase domain Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
8	BRAF	oncoprotein	5	0.667	1.067	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RBD (PF02196, IPR003116, SM00455): Raf-like Ras-binding domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
9	CDKN1C	suppressor	1	0	0	CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor LCE6A (PF15858, IPR031716): Late cornified envelope protein 6A family TonB_N (PF16031): TonB N-terminal region
10	CFL1	interactor	5	0.500	3.067	Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
11	ELAVL1	oncoprotein	7	0.333	9.167	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
12	ERBIN	oncoprotein	2	0	0	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
13	FYN	oncoprotein	3	1.000	0	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14	HIST1H1A	interactor	4	0.500	2.667	Mucin (PF01456, IPR000458): Mucin-like glycoprotein Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
15	HSP90AA1	oncoprotein	11	0.333	24.733	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
16	HSPA4	interactor	4	1.000	0	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
17	ITGA1	interactor	1	0	0	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain VCBS (PF13517): Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP_2 (PF14312, IPR013517): FG-GAP repeat LYRIC (PF15686, IPR031402): Lysine-rich CEACAM1 co-isolated protein family
18	LAMTOR1	interactor	2	1.000	0	LAMTOR (PF15454, IPR028209): Late endosomal/lysosomal adaptor and MAPK and MTOR activator
19	LATS1	suppressor	2	1.000	0	Cas_Cas6 (PF01881, IPR010156): CRISPR associated protein Cas6 Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
20	LIMK2	interactor	5	0.400	5.167	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase (PF00069, IPR000719): Protein kinase domain PP1_inhibitor (PF05361, IPR008025): PKC-activated protein phosphatase-1 inhibitor
21	MAPK14	oncoprotein	6	0.400	5.000	Pkinase (PF00069, IPR000719): Protein kinase domain
22	MAPKAPK2	oncoprotein	5	0.500	2.333	Pkinase (PF00069, IPR000719): Protein kinase domain
23	MBP	interactor	3	0.667	1.000	Myelin_MBP (PF01669, IPR000548): Myelin basic protein
24	MIIP	interactor	1	0	0	Pheromone (PF08015, IPR012597): Fungal mating-type pheromone MIIP (PF15734, IPR031466): Migration and invasion-inhibitory
25	NRG1	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Neuregulin (PF02158, IPR002154): Neuregulin family
26	OSBPL5	interactor	2	1.000	0	Oxysterol_BP (PF01237, IPR000648): Oxysterol-binding protein PH (PF00169, IPR001849, SM00233): PH domain
27	PAK1	oncoprotein	6	0.700	1.733	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
28	PAK4	protein found in more fusions	6	0.600	3.667	PBD (PF00786, IPR000095, SM00285): P21-Rho-binding domain Pkinase (PF00069, IPR000719): Protein kinase domain
29	PARK2	suppressor	8	0.524	7.733	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
30	POLR2D	interactor	2	1.000	0	RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4 Tfb4 (PF03850, IPR004600): Transcription factor Tfb4
31	RAD54L	interactor	1	0	0	Rad54_N (PF08658, IPR013967): Rad54 N terminal SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
32	RRAS	oncoprotein	1	0	0	Ras (PF00071, IPR001806, SM00173): Ras family
33	RTEL1	oncoprotein	1	0	0	C1_2 (PF03107, IPR004146): C1 domain DEAD_2 (PF06733, IPR010614): DEAD_2 DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180) ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit DZR (PF12773, IPR025874): Double zinc ribbon Helicase_C_2 (PF13307, IPR006555): Helicase C-terminal domain CCM2_C (PF16545, IPR032375): Cerebral cavernous malformation protein, harmonin-homology
34	SARNP	oncoprotein	1	0	0	SAP (PF02037, IPR003034, SM00513): SAP domain HTH_Tnp_IS630 (PF01710, IPR002622): Transposase Prok-E2_A (PF14457, IPR032865): Prokaryotic E2 family A
35	SH3PXD2B	interactor	1	0	0	PX (PF00787, IPR001683, SM00312): PX domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
36	SRPK1	interactor	6	0.467	6.333	FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) Pkinase (PF00069, IPR000719): Protein kinase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
37	TADA3	interactor	1	0	0	GvpL_GvpF (PF06386, IPR009430): Gas vesicle synthesis protein GvpL/GvpF Ada3 (PF10198, IPR019340): Histone acetyltransferases subunit 3
38	UXT	interactor	2	1.000	0	Prefoldin (PF02996, IPR004127): Prefoldin subunit
39	YWHAZ	protein found in more fusions	9	0.393	13.900	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	LIMK1	parental protein	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase

B a c k t o T o p ⇑

Fusion ID: Protein names:	AK125156
Level of PPIs:	or Upload text file:	Update repository

Visible interactions:	all	affected	independent (normal)	missing	nothing (blank)
Chimeric state:	ordinary fusion	big fusion

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors