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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AK094488 is the fusion of parental proteins TNFRSF25, CCDC175 (from a repository: Fri Feb 2 05:00:58 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)4
The number (and %) of the onco-proteins3 (75.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)6 (100.00 %)
The number (and %) of affected PPIs3 (50.00 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI1.500
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients4 (100.00 %)
The number (and %) of a zero Betweenness Centrality3 (75.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: TNFRSF25,CCDC175 All fusions
: AK094488;
Proteins found in more fusions NOL3 (see 2 fusions); MAPK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AK094488chimera306.000CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF1542 (PF07564, IPR011439): Domain of Unknown Function (DUF1542)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SlyX (PF04102, IPR007236): SlyX
TMA7 (PF09072, IPR015157): Translation machinery associated TMA7
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
2 MAPK1oncoprotein200Pkinase (PF00069, IPR000719): Protein kinase domain
3 NOL3oncoprotein200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
4 TRAF2interactor200MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BAG4interactorBAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
2 CCDC175interactorCENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
ZapB (PF06005, IPR009252): Cell division protein ZapB
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TMA7 (PF09072, IPR015157): Translation machinery associated TMA7
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Tup_N (PF08581, IPR013890): Tup N-terminal
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
3 DAP3interactorDAP3 (PF10236, IPR019368): Mitochondrial ribosomal death-associated protein 3
4 RIPK1interactorDeath (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
5 TNFRSF25parental proteinDeath (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
6 TNFSF15oncoproteinTNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
7 TRADDinteractorDeath (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat

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