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Fusion ID: Protein names:	AK091498
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Visualization interactions

Cytoscape Web for: AK091498 is the fusion of parental proteins SHMT1, MLLT11 (from a repository: Thu Dec 5 16:20:49 2019)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	41
The number (and %) of the onco-proteins	10 (24.39 %)
The number (and %) of the tumor suppressors	6 (14.63 %)
Total number of binary PPIs (saturation %)	124 (15.12 %)
The number (and %) of affected PPIs	40 (32.26 %)
The number of possible different fusions	10
PPI diameter	2
PPI radius	1
The average degree of PPI	5.463
Assortativity coefficient	-0.4021
The network average Clustering coefficient	0.530
The number (and %) of a zero Clustering coefficients	10 (24.39 %)
The number (and %) of a zero Betweenness Centrality	17 (41.46 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: SHMT1,MLLT11	All fusions : AK091498;
Proteins found in more fusions	MAPK9 (see 3 fusions); ITPA (see 1 fusions); APEH (see 1 fusions); STAT1 (see 1 fusions); CUL3 (see 1 fusions); SMAD4 (see 2 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); CTTN (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AK091498	chimera	40	0.092	1272.467	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2	APEH	oncoprotein	8	0.619	4.733	Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3	ARFIP1	interactor	4	0.667	1.667	Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
4	ATIC	oncoprotein	2	1.000	0	AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme MGS (PF02142, IPR011607, SM00851): MGS-like domain
5	ATP6V1C1	protein found in more fusions	12	0.600	13.700	V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
6	C18orf25	interactor	1	0	0	RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
7	CARS	oncoprotein	8	0.464	12.400	tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
8	CTTN	oncoprotein	10	0.528	13.200	FadA (PF09403, IPR018543): Adhesion protein FadA HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9	CUL3	protein found in more fusions	7	0.333	9.333	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10	DEDD	interactor	2	0	0	DED (PF01335, IPR001875, SM00031): Death effector domain
11	DLEU1	suppressor	1	0	0	DD_K (PF12121, IPR022731): Dermaseptin
12	DNAJA4	interactor	1	0	0	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13	FAM129B	interactor	6	0.933	0.333	PH (PF00169, IPR001849, SM00233): PH domain
14	GARS	interactor	7	0.571	6.833	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T) WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
15	GSPT2	interactor	6	0.933	0.333	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2 GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
16	GTF2F2	interactor	1	0	0	TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
17	HARS	interactor	5	0.600	3.667	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
18	HIST1H4A	interactor	6	0.533	6.000	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
19	HSPA1L	interactor	2	1.000	0	HSP70 (PF00012, IPR013126): Hsp70 protein
20	HSPE1	interactor	3	0.667	1.000	Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
21	IDE	interactor	8	0.607	6.733	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
22	ITPA	protein found in more fusions	2	0	0	Ham1p_like (PF01725, IPR002637): Ham1 family
23	MAPK9	suppressor	2	0	0	Pkinase (PF00069, IPR000719): Protein kinase domain Kinase-like (PF14531, IPR027916): Kinase-like
24	PAICS	interactor	6	0.400	5.667	AIRC (PF00731, IPR000031, SM01001): AIR carboxylase SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
25	PAWR	suppressor	10	0.622	9.933	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
26	PBDC1	interactor	2	1.000	0	Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
27	PGK2	interactor	2	1.000	0	PGK (PF00162, IPR001576): Phosphoglycerate kinase
28	PIM1	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain
29	PPAT	interactor	3	0.667	0.667	Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain GATase_6 (PF13522): Glutamine amidotransferase domain
30	PRRC1	interactor	2	1.000	0	NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
31	SMAD4	suppressor	3	1.000	0	MH1 (PF03165, IPR003619, SM00523): MH1 domain MH2 (PF03166, IPR001132, SM00524): MH2 domain
32	SNX2	interactor	11	0.582	16.100	PX (PF00787, IPR001683, SM00312): PX domain Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
33	SNX6	interactor	10	0.622	12.433	PX (PF00787, IPR001683, SM00312): PX domain Vps5 (PF09325, IPR015404): Vps5 C terminal like
34	STAT1	suppressor	11	0.689	6.333	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
35	STXBP1	interactor	1	0	0	Sec1 (PF00995, IPR001619): Sec1 family
36	SULT1A3	interactor	1	0	0	Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
37	TSN	protein found in more fusions	7	0.933	0.333	Translin (PF01997, IPR002848): Translin family
38	TTC1	interactor	7	0.524	8.667	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
39	VPS29	interactor	8	0.857	1.467	Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
40	XPO5	suppressor	4	0.667	2.000	IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein
41	ZC3H4	interactor	1	0	0	API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5) Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381) CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal Metal_resist (PF13801, IPR025961): Heavy-metal resistance Torus (PF16131, IPR032297): Torus domain

B a c k t o T o p ⇑

List of missing interactors