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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AK091498 is the fusion of parental proteins SHMT1, MLLT11 (from a repository: Thu Dec 5 16:20:49 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)41
The number (and %) of the onco-proteins10 (24.39 %)
The number (and %) of the tumor suppressors6 (14.63 %)
Total number of binary PPIs (saturation %)124 (15.12 %)
The number (and %) of affected PPIs40 (32.26 %)
The number of possible different fusions10
PPI diameter2
PPI radius1
The average degree of PPI5.463
Assortativity coefficient-0.4021
The network average Clustering coefficient0.530
The number (and %) of a zero Clustering coefficients10 (24.39 %)
The number (and %) of a zero Betweenness Centrality17 (41.46 %)


List of the fusions

PPI for parental proteins: SHMT1,MLLT11 All fusions
: AK091498;
Proteins found in more fusions MAPK9 (see 3 fusions); ITPA (see 1 fusions); APEH (see 1 fusions); STAT1 (see 1 fusions); CUL3 (see 1 fusions); SMAD4 (see 2 fusions); TSN (see 1 fusions); ATP6V1C1 (see 3 fusions); CTTN (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AK091498chimera400.0921272.467SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
2 APEHoncoprotein80.6194.733Peptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
3 ARFIP1interactor40.6671.667Arfaptin (PF06456, IPR010504, SM01015): Arfaptin-like domain
4 ATIConcoprotein21.0000AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
5 ATP6V1C1protein found in more fusions120.60013.700V-ATPase_C (PF03223, IPR004907): V-ATPase subunit C
6 C18orf25interactor100RNF111_N (PF15303, IPR029306): E3 ubiquitin-protein ligase Arkadia N-terminus
7 CARSoncoprotein80.46412.400tRNA-synt_1e (PF01406, IPR024909): tRNA synthetases class I (C) catalytic domain
8 CTTNoncoprotein100.52813.200FadA (PF09403, IPR018543): Adhesion protein FadA
HS1_rep (PF02218, IPR003134): Repeat in HS1/Cortactin
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
9 CUL3protein found in more fusions70.3339.333Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 DEDDinteractor200DED (PF01335, IPR001875, SM00031): Death effector domain
11 DLEU1suppressor100DD_K (PF12121, IPR022731): Dermaseptin
12 DNAJA4interactor100DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DnaJ_C (PF01556, IPR002939): DnaJ C terminal domain
13 FAM129Binteractor60.9330.333PH (PF00169, IPR001849, SM00233): PH domain
14 GARSinteractor70.5716.833HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
15 GSPT2interactor60.9330.333GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
PAM2 (PF07145, IPR009818): Ataxin-2 C-terminal region
16 GTF2F2interactor100TFIIF_beta (PF02270, IPR003196): Transcription initiation factor IIF, beta subunit
17 HARSinteractor50.6003.667HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
WHEP-TRS (PF00458, IPR000738, SM00991): WHEP-TRS domain
Sugarporin_N (PF11471, IPR021570): Maltoporin periplasmic N-terminal extension
tRNA-synt_His (PF13393): Histidyl-tRNA synthetase
18 HIST1H4Ainteractor60.5336.000CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
19 HSPA1Linteractor21.0000HSP70 (PF00012, IPR013126): Hsp70 protein
20 HSPE1interactor30.6671.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
21 IDEinteractor80.6076.733Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
Peptidase_M16_M (PF16187, IPR032632): Middle or third domain of peptidase_M16
22 ITPAprotein found in more fusions200Ham1p_like (PF01725, IPR002637): Ham1 family
23 MAPK9suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
24 PAICSinteractor60.4005.667AIRC (PF00731, IPR000031, SM01001): AIR carboxylase
SAICAR_synt (PF01259, IPR028923): SAICAR synthetase
25 PAWRsuppressor100.6229.933ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
26 PBDC1interactor21.0000Polysacc_synt_4 (PF04669, IPR021148): Polysaccharide biosynthesis
27 PGK2interactor21.0000PGK (PF00162, IPR001576): Phosphoglycerate kinase
28 PIM1oncoprotein31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
29 PPATinteractor30.6670.667Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
GATase_6 (PF13522): Glutamine amidotransferase domain
30 PRRC1interactor21.0000NTPase_I-T (PF01931, IPR026533): Protein of unknown function DUF84
31 SMAD4suppressor31.0000MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
32 SNX2interactor110.58216.100PX (PF00787, IPR001683, SM00312): PX domain
Sorting_nexin (PF03700, IPR005329): Sorting nexin, N-terminal domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
33 SNX6interactor100.62212.433PX (PF00787, IPR001683, SM00312): PX domain
Vps5 (PF09325, IPR015404): Vps5 C terminal like
34 STAT1suppressor110.6896.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
STAT1_TAZ2bind (PF12162, IPR022752): STAT1 TAZ2 binding domain
35 STXBP1interactor100Sec1 (PF00995, IPR001619): Sec1 family
36 SULT1A3interactor100Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
37 TSNprotein found in more fusions70.9330.333Translin (PF01997, IPR002848): Translin family
38 TTC1interactor70.5248.667TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
39 VPS29interactor80.8571.467Metallophos_2 (PF12850, IPR024654): Calcineurin-like phosphoesterase superfamily domain
40 XPO5suppressor40.6672.000IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
41 ZC3H4interactor100API5 (PF05918, IPR008383): Apoptosis inhibitory protein 5 (API5)
Baculo_PP31 (PF05311, IPR007975): Baculovirus 33KDa late protein (PP31)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
DUF3381 (PF11861, IPR024576): Domain of unknown function (DUF3381)
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
Metal_resist (PF13801, IPR025961): Heavy-metal resistance
Torus (PF16131, IPR032297): Torus domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AGO2interactorArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain
PAZ (PF02170, IPR003100, SM00949): PAZ domain
Piwi (PF02171, IPR003165, SM00950): Piwi domain
ArgoN (PF16486, IPR032474): N-terminal domain of argonaute
ArgoMid (PF16487, IPR032473): Mid domain of argonaute
ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
2 MCATinteractorAcyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
3 MLLT11parental proteinWRNPLPNID (PF15017): Putative WW-binding domain and destruction box
4 PRSS23interactorTrypsin (PF00089, IPR001254, SM00020): Trypsin
5 SHMT1parental proteinSHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
6 SHMT2interactorSHMT (PF00464, IPR001085): Serine hydroxymethyltransferase

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