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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AK074577 is the fusion of parental proteins MAP3K2 (from a repository: Tue Dec 6 11:13:51 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)34
The number (and %) of the onco-proteins13 (38.24 %)
The number (and %) of the tumor suppressors8 (23.53 %)
Total number of binary PPIs (saturation %)138 (24.60 %)
The number (and %) of affected PPIs33 (23.91 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI6.882
Assortativity coefficient-0.2998
The network average Clustering coefficient0.613
The number (and %) of a zero Clustering coefficients2 (5.88 %)
The number (and %) of a zero Betweenness Centrality8 (23.53 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MAP3K2 All fusions
: AK074577;
Proteins found in more fusions NEDD4L (see 3 fusions); YWHAG (see 1 fusions); HSP90AA1 (see 2 fusions); YWHAZ (see 1 fusions); NEDD4 (see 1 fusions); STUB1 (see 1 fusions); GSK3B (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AK074577chimera330.159638.600PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
2 AXIN1suppressor70.8001.667Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
3 AXIN2suppressor41.0000Axin_b-cat_bind (PF08833, IPR014936): Axin beta-catenin binding domain
RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
THP2 (PF09432, IPR018557): Tho complex subunit THP2
DIX (PF00778, IPR001158, SM00021): DIX domain
AXIN1_TNKS_BD (PF16646, IPR032101): Axin-1 tankyrase binding domain
4 BIRC2oncoprotein60.7001.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
5 BTRConcoprotein130.39430.300WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
6 CTNNB1oncoprotein90.50013.567Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
7 GSK3Bsuppressor110.44419.833Pkinase (PF00069, IPR000719): Protein kinase domain
8 HSP90AA1oncoprotein110.35622.367HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
9 IKBKGinteractor70.6005.167CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
10 MAP2K3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
11 MAP2K4suppressor50.8330.667Pkinase (PF00069, IPR000719): Protein kinase domain
12 MAP2K5oncoprotein70.5335.200PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
13 MAP2K7interactor60.6004.400Pkinase (PF00069, IPR000719): Protein kinase domain
14 MAP3K3oncoprotein150.20963.500PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
15 MAPK7oncoprotein90.5369.567Pkinase (PF00069, IPR000719): Protein kinase domain
Rrn6 (PF10214, IPR019350): RNA polymerase I-specific transcription-initiation factor
16 MAPK8oncoprotein60.6003.667DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
17 NEDD4suppressor40.6670.333Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
18 NEDD4Lsuppressor80.7622.367WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
19 PIBF1interactor100bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
Mnd1 (PF03962, IPR005647): Mnd1 family
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
Raptor_N (PF14538, IPR029347): Raptor N-terminal CASPase like domain
20 SFNsuppressor70.8001.66714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
21 SH2D2Ainteractor21.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
22 SMURF1interactor80.4297.800C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
23 STAMBPinteractor21.0000USP8_dimer (PF08969, IPR015063): USP8 dimerisation domain
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
DUF3526 (PF12040, IPR021913): Domain of unknown function (DUF3526)
24 STK38interactor60.5002.300MEKHLA (PF08670, IPR013978): MEKHLA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
25 STUB1suppressor40.6670.500U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_20 (PF14561): Tetratricopeptide repeat
26 STX3interactor100XhlA (PF10779, IPR019715): Haemolysin XhlA
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
27 TRAF7oncoprotein21.0000Sina (PF03145, IPR018121): Seven in absentia protein family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
DUF4164 (PF13747, IPR025310): Domain of unknown function (DUF4164)
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
PKcGMP_CC (PF16808, IPR031831): Coiled-coil N-terminus of cGMP-dependent protein kinase
WD40_like (PF17005, IPR031544): WD40-like domain
28 USP2interactor21.0000UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
29 XIAPinteractor60.6002.733BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
30 YWHABinteractor90.6675.80014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
31 YWHAEoncoprotein80.7143.10014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
32 YWHAGprotein found in more fusions110.6447.16714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
33 YWHAQinteractor80.6794.46714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
34 YWHAZprotein found in more fusions140.44929.53314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 MAP3K2parental proteinPB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain

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