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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AK074141 is the fusion of parental proteins CCDC88B, ADGRE5 (from a repository: Wed Feb 21 20:01:32 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)8
The number (and %) of the onco-proteins6 (75.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)11 (39.29 %)
The number (and %) of affected PPIs7 (63.64 %)
The number of possible different fusions4
PPI diameter2
PPI radius1
The average degree of PPI2.000
Assortativity coefficient-0.4880
The network average Clustering coefficient0.256
The number (and %) of a zero Clustering coefficients5 (62.50 %)
The number (and %) of a zero Betweenness Centrality7 (87.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ADGRE5,CCDC88B All fusions
: AK074141;
Proteins found in more fusions PLEKHA5 (see 1 fusions); SRPK2 (see 1 fusions); HNRNPD (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AK074141chimera70.04840.0007tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
APG6 (PF04111, IPR007243): Autophagy protein Apg6
Gp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HOOK (PF05622, IPR008636): HOOK protein
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
2 GOLT1Binteractor100Got1 (PF04178, IPR007305): Got1/Sft2-like family
3 HNRNPDoncoprotein200CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain
NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Keratin_2_head (PF16208, IPR032444): Keratin type II head
4 KNL1oncoprotein100DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
5 LPAR1oncoprotein1007tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
6 PLEKHA5protein found in more fusions31.0000PH (PF00169, IPR001849, SM00233): PH domain
WW (PF00397, IPR001202, SM00456): WW domain
MKLP1_Arf_bdg (PF16540, IPR032384): Arf6-interacting domain of mitotic kinesin-like protein 1
7 SRPK2oncoprotein31.0000DUF1387 (PF07139, IPR009816): Protein of unknown function (DUF1387)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Pkinase (PF00069, IPR000719): Protein kinase domain
S-antigen (PF05756, IPR008825): S-antigen protein
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
8 TMEM63Binteractor100RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADGRE5parental protein7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EGF_MSP1_1 (PF12946, IPR024730): MSP1 EGF domain 1
2 CCDC88Bparental proteinGp-FAR-1 (PF05823, IPR008632): Nematode fatty acid retinoid binding protein (Gp-FAR-1)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HOOK (PF05622, IPR008636): HOOK protein
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
KASH_CCD (PF14662, IPR028168): Coiled-coil region of CCDC155 or KASH
NYD-SP28_assoc (PF14775, IPR029440): Sperm tail C-terminal domain
3 TMEM171interactorTMEM171 (PF15471, IPR029173): Transmembrane protein family 171
4 XRN1interactorXRN_N (PF03159, IPR004859): XRN 5'-3' exonuclease N-terminus

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