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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AK025789 is the fusion of parental proteins RFWD2, EVI5 (from a repository: Mon Apr 3 14:46:35 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)81
The number (and %) of the onco-proteins26 (32.10 %)
The number (and %) of the tumor suppressors14 (17.28 %)
Total number of binary PPIs (saturation %)517 (15.96 %)
The number (and %) of affected PPIs80 (15.47 %)
The number of possible different fusions13
PPI diameter2
PPI radius1
The average degree of PPI12.074
Assortativity coefficient-0.2666
The network average Clustering coefficient0.690
The number (and %) of a zero Clustering coefficients3 (3.70 %)
The number (and %) of a zero Betweenness Centrality20 (24.69 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: EVI5,RFWD2 All fusions
: AK025789;
Proteins found in more fusions PTPN11 (see 1 fusions); CUL4A (see 4 fusions); FOXO1 (see 1 fusions); DCAF1 (see 1 fusions); CUL1 (see 3 fusions); CUL3 (see 1 fusions); MDM4 (see 2 fusions); YWHAZ (see 1 fusions); FOS (see 4 fusions); COPS5 (see 1 fusions); DDB1 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AK025789chimera800.1293856.156DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
IncA (PF04156, IPR007285): IncA protein
Mit_proteolip (PF08039, IPR012574): Mitochondrial proteolipid
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
2 ATF6interactor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF2749 (PF10907, IPR024475): Protein of unknown function (DUF2749)
3 AURKBinteractor70.5335.420Pkinase (PF00069, IPR000719): Protein kinase domain
4 BIRC5interactor50.6671.500BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
5 BTBD2interactor90.8890.578BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
PHR (PF08005, IPR012983): PHR domain
6 CCT2interactor130.8213.383Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
7 CCT3interactor110.9450.300Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
8 CCT4interactor130.8213.383Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
9 CCT5interactor120.8482.690Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
10 CCT6Ainteractor110.9450.300Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
11 CCT7interactor110.9450.300Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
12 CCT8interactor130.8213.383Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
13 CDKN1Bsuppressor130.57714.453CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
Multi-haem_cyto (PF13447): Seven times multi-haem cytochrome CxxCH
14 CHMP4Binteractor50.6671.500Snf7 (PF03357, IPR005024): Snf7
15 COPS2suppressor220.68820.950YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
16 COPS3interactor250.66025.043RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
PCI (PF01399, IPR000717, SM00088): PCI domain
17 COPS4interactor270.59852.006DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_14 (PF13428): Tetratricopeptide repeat
18 COPS5protein found in more fusions410.383222.184JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
19 COPS6interactor310.501109.034DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
20 COPS7Ainteractor220.76610.483PCI (PF01399, IPR000717, SM00088): PCI domain
21 COPS7Binteractor200.75811.060PCI (PF01399, IPR000717, SM00088): PCI domain
22 COPS8interactor200.8424.485CSN8_PSD8_EIF3K (PF10075): CSN8/PSMD8/EIF3K family
23 CRTC2oncoprotein30.6670.400TORC_N (PF12884, IPR024783): Transducer of regulated CREB activity, N terminus
TORC_M (PF12885, IPR024784): Transducer of regulated CREB activity middle domain
TORC_C (PF12886, IPR024785): Transducer of regulated CREB activity, C terminus
24 CUL1suppressor270.44678.191Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
25 CUL2suppressor180.65418.448Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
26 CUL3protein found in more fusions350.378174.346Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
27 CUL4Aprotein found in more fusions270.61537.210Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
28 CUL4Boncoprotein240.66323.293Cullin (PF00888, IPR001373, SM00182): Cullin family
EBP50_C (PF09007, IPR015098): EBP50, C-terminal
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
PG_binding_4 (PF12229, IPR022029): Putative peptidoglycan binding domain
MDFI (PF15316, IPR026134): MyoD family inhibitor
29 DCAF1protein found in more fusions160.8951.696DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
LisH (PF08513, IPR013720, SM00667): LisH
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
30 DCAF11interactor111.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 DDA1interactor180.8375.141DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
32 DDB1protein found in more fusions240.68426.304CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
33 DDB2suppressor240.56152.403WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
34 DMC1interactor200Rad51 (PF08423, IPR013632): Rad51
HHH_5 (PF14520): Helix-hairpin-helix domain
35 ELAVL1oncoprotein210.300104.331RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
36 ERCC8oncoprotein160.8583.689WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
DUF4859 (PF16151, IPR032339): Domain of unknown function (DUF4859)
37 ETS1oncoprotein50.7001.452Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
38 ETS2suppressor50.7001.619Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
39 FBXO5oncoprotein40.5001.833IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
F-box (PF00646, IPR001810, SM00256): F-box domain
40 FOSoncoprotein90.35713.333bZIP_1 (PF00170, IPR004827): bZIP transcription factor
41 FOSL2oncoprotein60.4675.167bZIP_1 (PF00170, IPR004827): bZIP transcription factor
42 FOXO1suppressor40.6670.286K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
FOXO_KIX_bdg (PF16675, IPR032068): KIX-binding domain of forkhead box O, CR2
FOXO-TAD (PF16676, IPR032067): Transactivation domain of FOXO protein family
43 HSPA2interactor31.0000HSP70 (PF00012, IPR013126): Hsp70 protein
44 HSPA6interactor50.9000.111HSP70 (PF00012, IPR013126): Hsp70 protein
45 HSPA8oncoprotein150.56222.119HSP70 (PF00012, IPR013126): Hsp70 protein
46 INCENPinteractor31.0000ATP-synt_E (PF05680, IPR008386): ATP synthase E chain
Ctr (PF04145, IPR007274): Ctr copper transporter family
DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
DUF913 (PF06025, IPR010314): Domain of Unknown Function (DUF913)
INCENP_ARK-bind (PF03941, IPR005635): Inner centromere protein, ARK binding region
INCENP_N (PF12178, IPR022006): Chromosome passenger complex (CPC) protein INCENP N terminal
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
PRKCSH-like (PF12999, IPR028146): Glucosidase II beta subunit-like
47 JUNoncoprotein110.42217.256bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
48 JUNBoncoprotein30.6670.333bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
49 JUNDoncoprotein70.5715.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
50 KLHL42interactor61.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
51 LRR1interactor130.9101.325LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
52 MDM2oncoprotein170.40844.340Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region
Presenilin (PF01080, IPR001108): Presenilin
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-FPG_IleRS (PF06827, IPR010663): Zinc finger found in FPG and IleRS
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
53 MDM4oncoprotein80.6674.019zf-FLZ (PF04570, IPR007650): zinc-finger of the FCS-type, C2-C2
SWIB (PF02201, IPR003121, SM00151): SWIB/MDM2 domain
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
54 MVPoncoprotein60.5005.000Vault (PF01505, IPR002499): Major Vault Protein repeat
DUF2543 (PF10820, IPR020251): Protein of unknown function (DUF2543)
MVP_shoulder (PF11978, IPR021870): Shoulder domain
55 MYO5Binteractor41.00005_3_exonuc (PF01367, IPR020045, SM00475): 5'-3' exonuclease, C-terminal SAM fold
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DIL (PF01843, IPR018444, SM01132): DIL domain
Fez1 (PF06818): Fez1
HalX (PF08663, IPR013971): HalX domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
DUF3251 (PF11622, IPR021658): Protein of unknown function (DUF3251)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
56 PARP4interactor21.0000BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
VIT (PF08487, IPR013694, SM00609): Vault protein inter-alpha-trypsin domain
VWA (PF00092, IPR002035, SM00327): von Willebrand factor type A domain
57 PLK1suppressor60.6003.767Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
58 PTPN1suppressor21.0000Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
59 PTPN11suppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
60 RAB11Aoncoprotein60.5336.500Ras (PF00071, IPR001806, SM00173): Ras family
61 RB1CC1suppressor21.0000Arc_PepC_II (PF06847, IPR009655): Archaeal Peptidase A24 C-terminus Type II
DHC (PF09626, IPR018588): Dihaem cytochrome c
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
ATG11 (PF10377, IPR019460): Autophagy-related protein 11
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
Jag_N (PF14804, IPR032782): Jag N-terminus
NPBW (PF15180, IPR013297): Neuropeptides B and W
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
Goodbye (PF17109, IPR031350): fungal STAND N-terminal Goodbye domain
62 RBX1oncoprotein240.64421.222zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
63 RCHY1suppressor70.5334.319C1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
64 REG1Ainteractor100Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
65 RNF41interactor31.0000Sina (PF03145, IPR018121): Seven in absentia protein family
USP8_interact (PF08941, IPR015036): USP8 interacting
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
66 SFNsuppressor70.6671.90114-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
67 SIPA1oncoprotein100IncA (PF04156, IPR007285): IncA protein
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Rap_GAP (PF02145, IPR000331): Rap/ran-GAP
68 SKP1oncoprotein130.70512.286Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain
Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
69 STK40interactor80.35717.000Pkinase (PF00069, IPR000719): Protein kinase domain
Kinase-like (PF14531, IPR027916): Kinase-like
70 STX3interactor41.0000XhlA (PF10779, IPR019715): Haemolysin XhlA
Syntaxin (PF00804, IPR006011, SM00503): Syntaxin
SNARE (PF05739, IPR000727, SM00397): SNARE domain
71 SYTL4interactor41.0000AreA_N (PF07573, IPR011420): Nitrogen regulatory protein AreA N terminus
C2 (PF00168, IPR000008, SM00239): C2 domain
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
72 TCEB2interactor91.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
73 TCP1interactor120.8941.272Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
74 TP53suppressor390.205406.551DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
75 TRIB1interactor50.6002.667Pkinase (PF00069, IPR000719): Protein kinase domain
76 TRIB2interactor21.0000Pkinase (PF00069, IPR000719): Protein kinase domain
77 TRIB3interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
78 WDR5interactor70.8570.309WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
79 YWHABinteractor70.5246.22214-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
80 YWHAZprotein found in more fusions130.43920.74314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
81 ZNF397interactor21.0000SCAN (PF02023, IPR003309, SM00431): SCAN domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 DET1interactorDet1 (PF09737, IPR019138): De-etiolated protein 1 Det1
2 ETV1oncoproteinEts (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
3 ETV4oncoproteinEts (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
4 ETV5oncoproteinEts (PF00178, IPR000418, SM00413): Ets-domain
ETS_PEA3_N (PF04621, IPR006715): PEA3 subfamily ETS-domain transcription factor N terminal domain
5 EVI5parental proteinbZIP_1 (PF00170, IPR004827): bZIP transcription factor
DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129)
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
LMBR1 (PF04791, IPR006876): LMBR1-like membrane protein
PAP_central (PF04928, IPR007012): Poly(A) polymerase central domain
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
DUF2730 (PF10805, IPR020269): Protein of unknown function (DUF2730)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
6 RFWD2parental proteinHerpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
IncA (PF04156, IPR007285): IncA protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
WD40_like (PF17005, IPR031544): WD40-like domain
7 UBE2D1interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
8 UBE2D2oncoproteinUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme

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