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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AK000234 is the fusion of parental proteins PRDM10, FABP1 (from a repository: Fri Nov 11 08:56:50 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)12
The number (and %) of the onco-proteins3 (25.00 %)
The number (and %) of the tumor suppressors6 (50.00 %)
Total number of binary PPIs (saturation %)20 (30.30 %)
The number (and %) of affected PPIs11 (55.00 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI2.833
Assortativity coefficient-0.3236
The network average Clustering coefficient0.551
The number (and %) of a zero Clustering coefficients4 (33.33 %)
The number (and %) of a zero Betweenness Centrality10 (83.33 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: FABP1,PRDM10 All fusions
: AK000234;
Proteins found in more fusions GRB2 (see 1 fusions); CUL1 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AK000234chimera110.10993.000Rep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Lipocalin_7 (PF14651): Lipocalin / cytosolic fatty-acid binding protein family
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers
2 BAP1suppressor21.0000Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
3 CASQ2interactor100Calsequestrin (PF01216, IPR001393): Calsequestrin
SDA1 (PF05285, IPR007949): SDA1
4 CUL1suppressor200Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
5 FLNAsuppressor31.0000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
6 FOXK2interactor21.0000FHA (PF00498, IPR000253, SM00240): FHA domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
7 GRB2oncoprotein60.5005.000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
8 PPARAsuppressor21.0000zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
9 PPARGsuppressor200zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
10 RELoncoprotein31.0000RHD_DNA_bind (PF00554, IPR011539): Rel homology DNA-binding domain
RHD_dimer (PF16179, IPR032397): Rel homology dimerisation domain
11 SNTA1interactor21.0000PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
12 TMEFF1suppressor100Kazal_2 (PF07648, IPR002350, SM00280): Kazal-type serine protease inhibitor domain
EGF_3 (PF12947, IPR024731): EGF domain
DUF3844 (PF12955, IPR024382): Domain of unknown function (DUF3844)
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 FABP1parental proteinLipocalin_7 (PF14651): Lipocalin / cytosolic fatty-acid binding protein family
2 PRDM10parental proteinRep_fac-A_C (PF08646, IPR013955): Replication factor-A C terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
Suf (PF05843, IPR008847): Suppressor of forked protein (Suf)
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-met (PF12874): Zinc-finger of C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
Tristanin_u2 (PF16638): Unstructured region on methyltransferase between zinc-fingers

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