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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AI973221 is the fusion of parental proteins CPEB4, SSR3 (from a repository: Sat Mar 25 16:49:31 2017)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)51
The number (and %) of the onco-proteins15 (29.41 %)
The number (and %) of the tumor suppressors4 (7.84 %)
Total number of binary PPIs (saturation %)167 (13.10 %)
The number (and %) of affected PPIs50 (29.94 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI6.118
Assortativity coefficient-0.3680
The network average Clustering coefficient0.583
The number (and %) of a zero Clustering coefficients8 (15.69 %)
The number (and %) of a zero Betweenness Centrality18 (35.29 %)


List of the fusions

PPI for parental proteins: CPEB4,SSR3 All fusions
: AI973221;
Proteins found in more fusions HNRNPC (see 1 fusions); UBE3C (see 1 fusions); HSP90AA1 (see 2 fusions); RPLP2 (see 1 fusions); RTN4 (see 11 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AI973221chimera500.0871939.548TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
2 ASPMoncoprotein100CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
3 BREoncoprotein21.0000BRE (PF06113, IPR010358): Brain and reproductive organ-expressed protein (BRE)
4 CEP164interactor21.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
WW (PF00397, IPR001202, SM00456): WW domain
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
XhlA (PF10779, IPR019715): Haemolysin XhlA
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
5 CHORDC1interactor31.0000CHORD (PF04968, IPR007051): CHORD
CS (PF04969, IPR007052): CS domain
6 CLTConcoprotein120.51524.202Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
7 CNTRLoncoprotein21.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
BcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Laminin_II (PF06009, IPR010307): Laminin Domain II
Ly49 (PF08391, IPR013600): Ly49-like protein, N-terminal region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Syntaxin-6_N (PF09177, IPR015260): Syntaxin 6, N-terminal
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
TMPIT (PF07851, IPR012926): TMPIT-like protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
Uso1_p115_C (PF04871, IPR006955): Uso1 / p115 like vesicle tethering protein, C terminal region
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
LRR_9 (PF14580): Leucine-rich repeat
8 COX4I1interactor80.8930.771COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
9 DDOSTinteractor180.40560.295DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
10 DDX21interactor40.6671.667CRT10 (PF08728, IPR014839): CRT10
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
GUCT (PF08152, IPR012562): GUCT (NUC152) domain
Sulfatase (PF00884, IPR000917): Sulfatase
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal
11 DDX39Ainteractor60.8000.786DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
12 DDX39Binteractor50.9000.400DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
13 EPHA2suppressor40.6670.500fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Laminin_EGF (PF00053, IPR002049, SM00180): Laminin EGF domain
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
14 ERLIN1interactor21.0000Ribosomal_L33 (PF00471, IPR001705): Ribosomal protein L33
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
15 FAM162Ainteractor30.6670.500DUF1075 (PF06388, IPR009432): Protein of unknown function (DUF1075)
16 HNRNPCprotein found in more fusions50.8330.667APG6 (PF04111, IPR007243): Autophagy protein Apg6
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SURF2 (PF05477, IPR008833): Surfeit locus protein 2 (SURF2)
17 HSP90AA1oncoprotein100.25025.000HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
18 KLHL29interactor21.0000BACK (PF07707, IPR011705, SM00875): BTB And C-terminal Kelch
BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_5 (PF13854): Kelch motif
Kelch_6 (PF13964): Kelch motif
19 MAGT1interactor100.55610.038OST3_OST6 (PF04756, IPR021149): OST3 / OST6 family, transporter family
20 MYH14interactor100IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
21 PCDHB15oncoprotein21.0000Cadherin_2 (PF08266, IPR013164): Cadherin-like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cadherin_3 (PF16184): Cadherin-like
Cadherin_C_2 (PF16492, IPR032455): Cadherin cytoplasmic C-terminal
22 PHBsuppressor110.58218.057Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4290 (PF14123, IPR025632): Domain of unknown function (DUF4290)
23 PRMT7interactor100Cons_hypoth95 (PF03602, IPR004398): Conserved hypothetical protein 95
PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
24 PRRC2Ainteractor100BAT2_N (PF07001, IPR009738): BAT2 N-terminus
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
25 RPL14interactor40.8330.667KOW (PF00467, IPR005824, SM00739): KOW motif
Ribosomal_L14e (PF01929, IPR002784): Ribosomal protein L14
UPF0688 (PF15772, IPR031530): UPF0688 family
26 RPL5suppressor80.38111.833Ribosomal_L18_c (PF14204, IPR025607): Ribosomal L18 C-terminal region
Ribosomal_L5e (PF17144): Ribosomal large subunit proteins 60S L5, and 50S L18
27 RPLP2protein found in more fusions41.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
28 RPN1oncoprotein140.47327.157Ribophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
29 RTN4suppressor31.0000CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Reticulon (PF02453, IPR003388): Reticulon
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
30 SAP18interactor60.4677.333SAP18 (PF06487, IPR010516): Sin3 associated polypeptide p18 (SAP18)
31 SCLT1oncoprotein100DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF641 (PF04859, IPR006943): Plant protein of unknown function (DUF641)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
SlyX (PF04102, IPR007236): SlyX
XhlA (PF10779, IPR019715): Haemolysin XhlA
TMF_TATA_bd (PF12325, IPR022091): TATA element modulatory factor 1 TATA binding
Imm7 (PF15585, IPR028965): Immunity protein 7
CCCAP (PF15964, IPR031887): Centrosomal colon cancer autoantigen protein family
DUF5082 (PF16888, IPR031681): Domain of unknown function (DUF5082)
32 SEC61A1interactor50.6002.619DUF1430 (PF07242, IPR006541): Protein of unknown function (DUF1430)
SecY (PF00344, IPR002208): SecY translocase
Plug_translocon (PF10559, IPR019561): Plug domain of Sec61p
33 SEPT7interactor31.0000Fez1 (PF06818): Fez1
Septin (PF00735, IPR000038): Septin
34 SF3B1oncoprotein30.6671.000Dopey_N (PF04118, IPR007249): Dopey, N-terminal
HEAT (PF02985, IPR000357): HEAT repeat
SF3b1 (PF08920, IPR015016): Splicing factor 3B subunit 1
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
35 SF3B3interactor30.6671.000CPSF_A (PF03178, IPR004871): CPSF A subunit region
MMS1_N (PF10433): Mono-functional DNA-alkylating methyl methanesulfonate N-term
36 SND1interactor40.6670.800TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
37 SNU13interactor60.5004.667Ribosomal_L7Ae (PF01248, IPR004038): Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
38 SSR1interactor80.7142.738TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
39 TCEAL1interactor100BEX (PF04538, IPR021156): Brain expressed X-linked like family
40 TCTN2interactor50.7001.202DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
41 TCTN3interactor60.7331.702DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
42 TMCO1interactor80.4649.533DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
43 TOMM22interactor70.38110.700Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Tom22 (PF04281, IPR005683): Mitochondrial import receptor subunit Tom22
44 UBE3Cprotein found in more fusions200IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
45 UQCRC2oncoprotein150.40041.693Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
46 VDAC1interactor100.8222.290Porin_3 (PF01459, IPR027246): Eukaryotic porin
47 VDAC2interactor120.60617.457Porin_3 (PF01459, IPR027246): Eukaryotic porin
48 VDAC3interactor110.6737.676Porin_3 (PF01459, IPR027246): Eukaryotic porin
49 XRCC3oncoprotein40.5003.000Rad51 (PF08423, IPR013632): Rad51
RNA_pol_A_CTD (PF03118, IPR011260): Bacterial RNA polymerase, alpha chain C terminal domain
50 YIPF5interactor30.6670.500Yip1 (PF04893, IPR006977): Yip1 domain
51 ZWINTinteractor200Zwint (PF15556, IPR029092): ZW10 interactor

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ATP5LinteractorATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
2 BMI1oncoproteinzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
3 C20orf24interactorRab5ip (PF07019, IPR029008): Rab5-interacting protein (Rab5ip)
4 CPEB4parental proteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
CEBP_ZZ (PF16366, IPR032296): Cytoplasmic polyadenylation element-binding protein ZZ domain
RRM_7 (PF16367, IPR000504): RNA recognition motif
5 HSD17B12interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
6 NDST1interactorSulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
HSNSD (PF12062, IPR021930): heparan sulfate-N-deacetylase
7 RPL10AinteractorRibosomal_L1 (PF00687, IPR028364): Ribosomal protein L1p/L10e family
8 SAV1oncoproteinWW (PF00397, IPR001202, SM00456): WW domain
9 SSR3parental proteinTRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
10 USP43interactorUCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase

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