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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AI928208 is the fusion of parental proteins RDH11, CYCS (from a repository: Thu May 25 07:22:40 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)44
The number (and %) of the onco-proteins8 (18.18 %)
The number (and %) of the tumor suppressors3 (6.82 %)
Total number of binary PPIs (saturation %)94 (9.94 %)
The number (and %) of affected PPIs43 (45.74 %)
The number of possible different fusions6
PPI diameter2
PPI radius1
The average degree of PPI3.227
Assortativity coefficient-0.4510
The network average Clustering coefficient0.551
The number (and %) of a zero Clustering coefficients14 (31.82 %)
The number (and %) of a zero Betweenness Centrality33 (75.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: CYCS,RDH11 All fusions
: AI928208;
Proteins found in more fusions HSPB1 (see 4 fusions); BCL2L1 (see 1 fusions); ACP6 (see 1 fusions); TRAF6 (see 1 fusions); SPATA20 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AI928208chimera430.0311710.000Cytochrom_C (PF00034, IPR003088): Cytochrome c
2 ACAT1interactor40.6671.000Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
3 ACP6protein found in more fusions31.0000His_Phos_2 (PF00328, IPR000560): Histidine phosphatase superfamily (branch 2)
4 AGTPBP1interactor100Peptidase_M14 (PF00246, IPR000834, SM00631): Zinc carboxypeptidase
V-ATPase_H_N (PF03224, IPR004908): V-ATPase subunit H
5 APAF1suppressor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NB-ARC (PF00931, IPR002182): NB-ARC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cactin_mid (PF10312, IPR018816): Conserved mid region of cactin
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
6 ARL2interactor100Arf (PF00025, IPR006689, SM00177): ADP-ribosylation factor family
7 BCL2L1oncoprotein50.6672.000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
8 C19orf70interactor100QIL1 (PF15884, IPR026769): Protein QIL1
9 CASP9oncoprotein31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
10 CATsuppressor31.0000Catalase (PF00199, IPR011614, SM01060): Catalase
Catalase-rel (PF06628, IPR010582): Catalase-related immune-responsive
11 CCDC58interactor200Cid2 (PF09774, IPR019171): Caffeine-induced death protein 2
12 CDK2suppressor50.5003.000Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
13 COQ10Binteractor100Polyketide_cyc (PF03364, IPR005031): Polyketide cyclase / dehydrase and lipid transport
14 COQ6interactor31.0000FAD_binding_3 (PF01494, IPR002938): FAD binding domain
Lycopene_cycl (PF05834, IPR008671): Lycopene cyclase protein
15 COQ7interactor31.0000COQ7 (PF03232, IPR011566): Ubiquinone biosynthesis protein COQ7
16 COX4I2interactor100COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
17 CUL9interactor200ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Cullin (PF00888, IPR001373, SM00182): Cullin family
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SDA1 (PF05285, IPR007949): SDA1
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
18 CYB5Binteractor21.0000Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIP (PF00230, IPR000425): Major intrinsic protein
19 CYC1interactor30.6671.000Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
20 ETFRF1interactor200Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
21 FMC1interactor100Complex1_LYR_2 (PF13233): Complex1_LYR-like
22 GPD1Linteractor100NAD_Gly3P_dh_C (PF07479, IPR006109): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
23 GSTK1interactor31.0000DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
24 HECW2interactor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
25 HSPB1oncoprotein31.0000HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
26 IMPA1interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
27 IMPA2interactor31.0000Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
28 ITGA4interactor60.4006.000FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
29 KRT40interactor21.0000Filament (PF00038, IPR001664): Intermediate filament protein
UPF0184 (PF03670, IPR022788): Uncharacterised protein family (UPF0184)
30 MED20interactor40.6672.000Med20 (PF08612, IPR013921): TATA-binding related factor (TRF) of subunit 20 of Mediator complex
31 MED23interactor31.0000Med23 (PF11573, IPR021629): Mediator complex subunit 23
32 MED4interactor31.0000Med4 (PF10018, IPR019258): Vitamin-D-receptor interacting Mediator subunit 4
33 NDOR1interactor200FAD_binding_1 (PF00667, IPR003097): FAD binding domain
Flavodoxin_1 (PF00258, IPR008254): Flavodoxin
NAD_binding_1 (PF00175, IPR001433): Oxidoreductase NAD-binding domain
34 NLE1oncoprotein100NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
35 NME4interactor31.0000NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
36 PRDX2interactor50.4006.000AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
37 PTPMT1interactor50.5003.000DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
38 SPATA20protein found in more fusions31.0000Thioredox_DsbH (PF03190, IPR004879): Protein of unknown function, DUF255
GlcNAc_2-epim (PF07221, IPR010819): N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
39 SUGCTinteractor200CoA_transf_3 (PF02515, IPR003673): CoA-transferase family III
40 TRAF6protein found in more fusions31.0000SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
41 TRUB2interactor31.0000TruB_N (PF01509, IPR002501): TruB family pseudouridylate synthase (N terminal domain)
TruB_C_2 (PF16198, IPR032819): tRNA pseudouridylate synthase B C-terminal domain
42 UQCRC1interactor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
43 UQCRFS1interactor50.4006.000Rieske (PF00355, IPR017941): Rieske [2Fe-2S] domain
Ubiq-Cytc-red_N (PF09165, IPR015248): Ubiquinol-cytochrome c reductase 8 kDa, N-terminal
UCR_TM (PF02921, IPR004192): Ubiquinol cytochrome reductase transmembrane region
44 VDAC1interactor60.33310.000Porin_3 (PF01459, IPR027246): Eukaryotic porin

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BAXsuppressorBcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
2 BLOC1S2interactorBLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
XhlA (PF10779, IPR019715): Haemolysin XhlA
3 C15orf48interactorB12D (PF06522, IPR010530): NADH-ubiquinone reductase complex 1 MLRQ subunit
4 CA12interactorCarb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
Lamp (PF01299, IPR002000): Lysosome-associated membrane glycoprotein (Lamp)
5 COQ9interactorCOQ9 (PF08511, IPR013718): COQ9
6 CYB5AsuppressorCyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
7 CYCSparental proteinCytochrom_C (PF00034, IPR003088): Cytochrome c
8 GINM1interactorNA
9 GLRX2interactorGlutaredoxin (PF00462, IPR002109): Glutaredoxin
10 HEPACAM2interactorV-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
PgaD (PF13994, IPR023829): PgaD-like protein
11 HSPA8oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
12 HTR3CinteractorNeur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
13 ISG15suppressorubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
14 MCOLN3interactorPKD_channel (PF08016, IPR013122): Polycystin cation channel
15 NRG1interactorEGF (PF00008, IPR000742, SM00181): EGF-like domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Neuregulin (PF02158, IPR002154): Neuregulin family
16 NTRK1oncoproteinI-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
17 PLTPinteractorLBP_BPI_CETP (PF01273, IPR017942, SM00328): LBP / BPI / CETP family, N-terminal domain
LBP_BPI_CETP_C (PF02886, IPR001124, SM00329): LBP / BPI / CETP family, C-terminal domain
18 POMKinteractorPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
19 PON2interactorArylesterase (PF01731, IPR002640): Arylesterase
20 RDH11parental proteinadh_short (PF00106, IPR002198): short chain dehydrogenase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Acetyltransf_13 (PF13880, IPR028009): ESCO1/2 acetyl-transferase
21 ROBO2interactorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Ig_3 (PF13927): Immunoglobulin domain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
22 SRPRBinteractorMHYT (PF03707, IPR005330): Bacterial signalling protein N terminal repeat
SRPRB (PF09439, IPR019009): Signal recognition particle receptor beta subunit
23 TSPAN5interactorTetraspannin (PF00335, IPR018499): Tetraspanin family
24 UBAC1interactorCENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
HEAT_2 (PF13646): HEAT repeats
Rad60-SLD_2 (PF13881): Ubiquitin-2 like Rad60 SUMO-like
25 ZACNinteractorNeur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain
Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region

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