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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AI817698 is the fusion of parental proteins NFIX (from a repository: Tue Dec 6 04:16:48 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)19
The number (and %) of the onco-proteins6 (31.58 %)
The number (and %) of the tumor suppressors6 (31.58 %)
Total number of binary PPIs (saturation %)43 (25.15 %)
The number (and %) of affected PPIs18 (41.86 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI3.789
Assortativity coefficient-0.4963
The network average Clustering coefficient0.501
The number (and %) of a zero Clustering coefficients6 (31.58 %)
The number (and %) of a zero Betweenness Centrality11 (57.89 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NFIX All fusions
: AI817698;
Proteins found in more fusions FOS (see 4 fusions); CREB1 (see 2 fusions); SMAD4 (see 2 fusions); SKI (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AI817698chimera180.118243.333CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
2 CREB1oncoprotein60.5005.000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
pKID (PF02173, IPR003102): pKID domain
DUF4988 (PF16378, IPR032149): Domain of unknown function
3 FOSoncoprotein41.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
4 FOXA1suppressor21.0000Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
HNF_C (PF09354, IPR018533): HNF3 C-terminal domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
5 FOXC1suppressor21.0000TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PAF (PF15715, IPR031444): PCNA-associated factor
PRIMA1 (PF16101): Proline-rich membrane anchor 1
6 FOXN1interactor100Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
7 HDAC1suppressor70.6004.500FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
8 ISG15suppressor21.0000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
9 JMJD6interactor100AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
10 JUNoncoprotein80.5716.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Jun (PF03957, IPR005643): Jun-like transcription factor
11 NFIBoncoprotein21.0000CTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain
DUF3383 (PF11863, IPR021808): Protein of unknown function (DUF3383)
12 PIRinteractor100Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
13 QRICH1interactor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
14 RB1suppressor50.7001.833RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
15 RBPJinteractor100BTD (PF09270, IPR015350): Beta-trefoil DNA-binding domain
LAG1-DNAbind (PF09271, IPR015351): LAG1, DNA binding
TIG (PF01833, IPR002909): IPT/TIG domain
16 RFX1interactor40.6672.000Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
RFX1_trans_act (PF04589, IPR007668): RFX1 transcription activation region
RFX_DNA_binding (PF02257, IPR003150): RFX DNA-binding domain
17 SKIoncoprotein50.8330.500c-SKI_SMAD_bind (PF08782, IPR014890, SM01046): c-SKI Smad4 binding domain
Ski_Sno (PF02437, IPR003380): SKI/SNO/DAC family
SlyX (PF04102, IPR007236): SlyX
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
18 SMAD4suppressor70.5336.167MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
19 ZNF614interactor100KRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 NFIXparental proteinCTF_NFI (PF00859, IPR000647): CTF/NF-I family transcription modulation region
NfI_DNAbd_pre-N (PF10524, IPR019548): Nuclear factor I protein pre-N-terminus
MH1 (PF03165, IPR003619, SM00523): MH1 domain

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