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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AI803594 is the fusion of parental proteins ADGRA2, PACS2 (from a repository: Fri Feb 2 02:00:40 2018)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)10
The number (and %) of the onco-proteins5 (50.00 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)17 (37.78 %)
The number (and %) of affected PPIs9 (52.94 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI2.600
Assortativity coefficient-0.4356
The network average Clustering coefficient0.511
The number (and %) of a zero Clustering coefficients4 (40.00 %)
The number (and %) of a zero Betweenness Centrality9 (90.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PACS2,ADGRA2 All fusions
: AI803594;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AI803594chimera90.11164.000Pacs-1 (PF10254, IPR019381): PACS-1 cytosolic sorting protein
2 ANAPC15interactor100Na_trans_assoc (PF06512, IPR010526): Sodium ion transport-associated
ANAPC15 (PF15243, IPR026182): Anaphase-promoting complex subunit 15
3 ASPMoncoprotein100CcmD (PF04995, IPR007078): Heme exporter protein D (CcmD)
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RST (PF12174, IPR022003): RCD1-SRO-TAF4 (RST) plant domain
ASH (PF15780, IPR031549): Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin
4 BIRC2oncoprotein41.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
5 BIRC3oncoprotein41.0000BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
6 LRRC46interactor21.0000LRR_9 (PF14580): Leucine-rich repeat
7 RSRP1oncoprotein100RSRP (PF17069): Arginine/Serine-Rich protein 1
8 TINF2interactor200TINF2_N (PF14973, IPR029400): TERF1-interacting nuclear factor 2 N-terminus
9 TRAF2interactor41.0000MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
10 WDR37interactor21.0000DUF1640 (PF07798, IPR024461): Protein of unknown function (DUF1640)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ADGRA2parental protein7tm_2 (PF00002, IPR000832): 7 transmembrane receptor (Secretin family)
Phage_holin_3_6 (PF07332, IPR009937): Putative Actinobacterial Holin-X, holin superfamily III
GPS (PF01825, IPR000203, SM00303): GPCR proteolysis site, GPS, motif
HRM (PF02793, IPR001879, SM00008): Hormone receptor domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
Ig_3 (PF13927): Immunoglobulin domain
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
2 DLG1suppressorL27_1 (PF09058, IPR015143): L27_1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
SH3_2 (PF07653, IPR011511): Variant SH3 domain
KOG2701 (PF09762, IPR019159): Coiled-coil domain-containing protein (DUF2037)
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
PDZ_assoc (PF10600, IPR019583): PDZ-associated domain of NMDA receptors
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
3 PACS2parental proteinPacs-1 (PF10254, IPR019381): PACS-1 cytosolic sorting protein
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
4 RYKoncoproteinPkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
WIF (PF02019, IPR003306, SM00469): WIF domain

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