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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AI365359 is the fusion of parental proteins HOOK3 (from a repository: Wed Dec 7 14:02:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)16
The number (and %) of the onco-proteins6 (37.50 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)37 (30.83 %)
The number (and %) of affected PPIs15 (40.54 %)
The number of possible different fusions3
PPI diameter2
PPI radius1
The average degree of PPI3.625
Assortativity coefficient-0.2885
The network average Clustering coefficient0.580
The number (and %) of a zero Clustering coefficients4 (25.00 %)
The number (and %) of a zero Betweenness Centrality10 (62.50 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: HOOK3 All fusions
: AI365359;
Proteins found in more fusions CUL3 (see 1 fusions); HOOK1 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AI365359chimera150.133164.667HOOK (PF05622, IPR008636): HOOK protein
DUF4710 (PF15828, IPR031667): Domain of unknown function (DUF4710)
2 CCDC8interactor200Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
3 CEP63interactor21.0000DASH_Hsk3 (PF08227, IPR013183): DASH complex subunit Hsk3 like
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
CEP63 (PF17045, IPR031470): Centrosomal protein of 63 kDa
4 COMTD1interactor100FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
5 CUL3protein found in more fusions40.6670.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
6 FNTBinteractor21.0000Prenyltrans (PF00432, IPR001330): Prenyltransferase and squalene oxidase repeat
7 HOOK1protein found in more fusions60.8001.333HOOK (PF05622, IPR008636): HOOK protein
8 HOOK2interactor80.47610.000HOOK (PF05622, IPR008636): HOOK protein
9 IFT57interactor100IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
10 MRE11Aoncoprotein31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
Mre11_DNA_bind (PF04152, IPR007281): Mre11 DNA-binding presumed domain
11 NTRK1oncoprotein50.5002.667I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
12 SSX2IPinteractor31.0000ZapB (PF06005, IPR009252): Cell division protein ZapB
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
Surfac_D-trimer (PF09006, IPR015097): Lung surfactant protein D coiled-coil trimerisation
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
YqzH (PF14164, IPR025546): YqzH-like protein
13 TNFSF13Boncoprotein41.0000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
14 VPS16interactor50.7002.667Vps16_C (PF04840, IPR006925): Vps16, C-terminal region
Vps16_N (PF04841, IPR006926): Vps16, N-terminal region
15 VPS41interactor41.0000Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
16 ZC4H2interactor100zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AKTIPinteractorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
2 FAM160A2interactorRAI16-like (PF10257, IPR019384): Retinoic acid induced 16-like protein
3 HOOK3parental proteinHOOK (PF05622, IPR008636): HOOK protein
4 SCFD1interactorSec1 (PF00995, IPR001619): Sec1 family

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