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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AI308067 is the fusion of parental proteins ALDOC, MARK2 (from a repository: Tue Dec 6 20:56:43 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)100
The number (and %) of the onco-proteins27 (27.00 %)
The number (and %) of the tumor suppressors14 (14.00 %)
Total number of binary PPIs (saturation %)529 (10.69 %)
The number (and %) of affected PPIs99 (18.71 %)
The number of possible different fusions23
PPI diameter2
PPI radius1
The average degree of PPI9.740
Assortativity coefficient-0.2199
The network average Clustering coefficient0.474
The number (and %) of a zero Clustering coefficients12 (12.00 %)
The number (and %) of a zero Betweenness Centrality24 (24.00 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MARK2,ALDOC All fusions
: AI308067;
Proteins found in more fusions AP2M1 (see 3 fusions); SMAD4 (see 2 fusions); YWHAG (see 1 fusions); VCP (see 4 fusions); GAB2 (see 3 fusions); PKD1 (see 1 fusions); HDAC7 (see 1 fusions); PINK1 (see 3 fusions); YWHAH (see 2 fusions); MAPT (see 1 fusions); UTRN (see 4 fusions); NEDD4L (see 3 fusions); BAG3 (see 4 fusions); YWHAZ (see 1 fusions); APC (see 1 fusions); MARK3 (see 1 fusions); COPS5 (see 1 fusions); RAB11FIP2 (see 1 fusions); PPP2R5E (see 1 fusions); UBC (see 1 fusions); PRKCE (see 3 fusions); NEDD4 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AI308067chimera990.0806797.857DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
2 AKT1oncoprotein180.25069.267PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
3 AP2M1protein found in more fusions70.4676.500Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family
Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
4 APCsuppressor90.5009.125APC_15aa (PF05972, IPR009240): APC 15 residue motif
APC_basic (PF05956, IPR009234): APC basic domain
APC_r (PF05923): APC repeat
Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EB1_binding (PF05937, IPR009232): EB-1 Binding Domain
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
SAMP (PF05924, IPR009224): SAMP Motif
Suppressor_APC (PF11414, IPR026831): Adenomatous polyposis coli tumour suppressor protein
AIF_C (PF14721, IPR029324): Apoptosis-inducing factor, mitochondrion-associated, C-term
SAS4 (PF15460, IPR029184): Something about silencing, SAS, complex subunit 4
Arm_APC_u3 (PF16629): Armadillo-associated region on APC
APC_u5 (PF16630): Unstructured region on APC between 1st and 2nd catenin-bdg motifs
APC_u9 (PF16633): Unstructured region on APC between 1st two creatine-rich regions
APC_u13 (PF16634): Unstructured region on APC between APC_crr and SAMP
APC_u14 (PF16635): Unstructured region on APC between SAMP and APC_crr
APC_u15 (PF16636): Unstructured region on APC between APC_crr regions 5 and 6
APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
5 ARHGEF2oncoprotein170.42635.697IncA (PF04156, IPR007285): IncA protein
PH (PF00169, IPR001849, SM00233): PH domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
6 AURKBinteractor120.30922.475Pkinase (PF00069, IPR000719): Protein kinase domain
7 BAG3oncoprotein140.42325.837BAG (PF02179, IPR003103, SM00264): BAG domain
WW (PF00397, IPR001202, SM00456): WW domain
8 BAIAP2interactor90.46410.967IMD (PF08397, IPR013606): IRSp53/MIM homology domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
9 C11orf58interactor100DUF3408 (PF11888, IPR021823): Protein of unknown function (DUF3408)
SMAP (PF15477, IPR028124): Small acidic protein family
10 CAMK1interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
Tyrosinase (PF00264, IPR002227): Common central domain of tyrosinase
11 CAMSAP2interactor31.0000Bundlin (PF05307, IPR007971): Bundlin
IncA (PF04156, IPR007285): IncA protein
Presenilin (PF01080, IPR001108): Presenilin
CAMSAP_CKK (PF08683, IPR014797, SM01051): Microtubule-binding calmodulin-regulated spectrin-associated
CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
FAM60A (PF15396, IPR026065): Protein Family FAM60A
CAMSAP_CC1 (PF17095, IPR031372): Spectrin-binding region of Ca2+-Calmodulin
12 CAPZA1interactor90.5007.718F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
13 CAPZA2interactor70.4298.367F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
14 CAPZBinteractor90.44411.799Cytochrom_B562 (PF07361, IPR009155): Cytochrome b562
F_actin_cap_B (PF01115, IPR001698): F-actin capping protein, beta subunit
15 CCDC8interactor200.32274.759Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
PNMA (PF14893, IPR026523): PNMA
16 CCDC82interactor100RNA_pol_3_Rpc31 (PF11705, IPR024661): DNA-directed RNA polymerase III subunit Rpc31
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
DUF4196 (PF13846, IPR025244): Domain of unknown function (DUF4196)
DUF4211 (PF13926, IPR025451): Domain of unknown function (DUF4211)
17 CDC5Linteractor180.40441.547OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
18 CDK15interactor100Pkinase (PF00069, IPR000719): Protein kinase domain
ACT_5 (PF13710): ACT domain
19 CDKN1Asuppressor80.4299.944CDI (PF02234, IPR003175): Cyclin-dependent kinase inhibitor
20 CEP57interactor40.8330.250Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family
21 CEP85Linteractor100ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
DUF16 (PF01519, IPR002862): Protein of unknown function DUF16
Phage_GP20 (PF06810, IPR009636): Phage minor structural protein GP20
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc42p (PF11544, IPR021611): Spindle pole body component Spc42p
22 CEP89interactor40.6671.167ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CorA (PF01544, IPR002523): CorA-like Mg2+ transporter protein
Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit
Lectin_N (PF03954, IPR005640): Hepatic lectin, N-terminal domain
Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
23 CLASP1interactor90.6118.467HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CTK3 (PF12243, IPR024638): CTD kinase subunit gamma CTK3
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
24 CLASP2interactor80.5713.572HEAT (PF02985, IPR000357): HEAT repeat
TAN (PF11640, IPR021668): Telomere-length maintenance and DNA damage repair
CLASP_N (PF12348, IPR024395): CLASP N terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Sec7_N (PF12783, IPR032691): Guanine nucleotide exchange factor in Golgi transport N-terminal
HEAT_EZ (PF13513): HEAT-like repeat
25 COL4A3BPinteractor31.0000Acyl_CoA_thio (PF02551, IPR025652): Acyl-CoA thioesterase
PH (PF00169, IPR001849, SM00233): PH domain
START (PF01852, IPR002913, SM00234): START domain
26 COPS5protein found in more fusions180.38255.735JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
27 DCTN1interactor140.32132.341Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
FlgN (PF05130, IPR007809): FlgN protein
HOOK (PF05622, IPR008636): HOOK protein
SlyX (PF04102, IPR007236): SlyX
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
DUF2443 (PF10398, IPR019469): Protein of unknown function (DUF2443)
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding
Dynactin (PF12455, IPR022157): Dynein associated protein
Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
KELK (PF15796, IPR031597): KELK-motif containing domain of MRCK Ser/Thr protein kinase
28 DLG5interactor40.5001.417Takusan (PF04822, IPR006907): Takusan
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EMP24_GP25L (PF01105, IPR009038): emp24/gp25L/p24 family/GOLD
Occludin_ELL (PF07303, IPR010844): Occludin homology domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding
Cep57_CLD_2 (PF14197, IPR025925): Centrosome localisation domain of PPC89
dbPDZ_assoc (PF16610): Unstructured region between two PDZ domains on Dlg5
29 DMDsuppressor40.5002.333CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
FliD_N (PF02465, IPR003481): Flagellar hook-associated protein 2 N-terminus
IncA (PF04156, IPR007285): IncA protein
Spectrin (PF00435, IPR002017): Spectrin repeat
WW (PF00397, IPR001202, SM00456): WW domain
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DinB_2 (PF12867, IPR024775): DinB superfamily
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
30 DTNAinteractor30.6670.667ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
CRISPR_Cse2 (PF09485, IPR013382): CRISPR-associated protein Cse2 (CRISPR_cse2)
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
PMC2NT (PF08066, IPR012588): PMC2NT (NUC016) domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
31 FBXL16interactor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
F-box-like (PF12937, IPR001810): F-box-like
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
32 FRYLoncoprotein41.0000MOR2-PAG1_N (PF14222, IPR025614): Cell morphogenesis N-terminal
MOR2-PAG1_C (PF14225, IPR025481): Cell morphogenesis C-terminal
MOR2-PAG1_mid (PF14228, IPR029473): Cell morphogenesis central region
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
33 FUCA1interactor21.0000Alpha_L_fucos (PF01120, IPR000933, SM00812): Alpha-L-fucosidase
Fucosidase_C (PF16757, IPR031919): Alpha-L-fucosidase C-terminal domain
34 GAB1oncoprotein70.3816.137PH (PF00169, IPR001849, SM00233): PH domain
35 GAB2oncoprotein60.7001.468PH (PF00169, IPR001849, SM00233): PH domain
Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
36 GPRASP1interactor100Arm_2 (PF04826, IPR006911): Armadillo-like
FXMRP1_C_core (PF12235, IPR022034): Fragile X-related 1 protein core C terminal
37 HDAC7protein found in more fusions130.6069.267Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
38 HECW2interactor70.4676.500C2 (PF00168, IPR000008, SM00239): C2 domain
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain
HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
39 HERC2interactor60.8001.067ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cyt-b5 (PF00173, IPR001199, SM01117): Cytochrome b5-like Heme/Steroid binding domain
MIB_HERC2 (PF06701, IPR010606): Mib_herc2
RCC1 (PF00415, IPR000408): Regulator of chromosome condensation (RCC1) repeat
zf-UBR (PF02207, IPR003126): Putative zinc finger in N-recognin (UBR box)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
RCC1_2 (PF13540): Regulator of chromosome condensation (RCC1) repeat
40 HNRNPA1interactor150.56012.122RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
41 HSPA1Ainteractor180.26171.299HSP70 (PF00012, IPR013126): Hsp70 protein
42 KIF13Binteractor31.0000CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
FHA (PF00498, IPR000253, SM00240): FHA domain
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
KIF1B (PF12423, IPR022140): Kinesin protein 1B
DUF3694 (PF12473, IPR022164): Kinesin protein
NCKAP5 (PF15246, IPR032769): Nck-associated protein 5, Peripheral clock protein
Kinesin_assoc (PF16183, IPR032405): Kinesin-associated
43 KIF5Binteractor130.64111.141ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Sec2p (PF06428, IPR009449): GDP/GTP exchange factor Sec2p
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584)
HAUS-augmin3 (PF14932, IPR032733): HAUS augmin-like complex subunit 3
DUF4226 (PF10774, IPR019710): Domain of unknown function (DUF4226)
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
44 LDHDinteractor21.0000FAD-oxidase_C (PF02913, IPR004113): FAD linked oxidases, C-terminal domain
FAD_binding_4 (PF01565, IPR006094): FAD binding domain
45 LNX1interactor40.6670.333PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
46 MAP2K3interactor40.6671.000Pkinase (PF00069, IPR000719): Protein kinase domain
47 MAP3K3oncoprotein90.35711.127PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
48 MAPTprotein found in more fusions130.36419.371Tubulin-binding (PF00418, IPR001084): Tau and MAP protein, tubulin-binding repeat
49 MARK1interactor90.44410.091KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
50 MARK3protein found in more fusions200.35768.815KA1 (PF02149, IPR001772): Kinase associated domain 1
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
51 MARK4oncoprotein140.27547.408KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
52 MOV10interactor140.36327.578AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
53 MTCL1interactor100.30613.895bZIP_1 (PF00170, IPR004827): bZIP transcription factor
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
SOGA (PF11365, IPR027881): Protein SOGA
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4201 (PF13870, IPR025254): Domain of unknown function (DUF4201)
DUF4407 (PF14362, IPR025519): Domain of unknown function (DUF4407)
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
54 NAP1L5interactor30.6671.000NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP)
SspB (PF04386, IPR007481): Stringent starvation protein B
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
55 NEDD4suppressor90.28612.270Rota_NS26 (PF01525, IPR002512): Rotavirus NS26
WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
56 NEDD4Lsuppressor130.6368.418WW (PF00397, IPR001202, SM00456): WW domain
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
57 NSFL1Cinteractor50.6001.238SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
58 NTRK1oncoprotein350.276250.043I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
59 NUPL2interactor31.0000zf-CCCH (PF00642, IPR000571): Zinc finger C-x8-C-x5-C-x3-H type (and similar)
60 NXF1interactor140.29524.560NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
61 PARD3interactor130.46224.449PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF3534 (PF12053, IPR021922): Domain of unknown function (DUF3534)
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
62 PARD6Ainteractor70.6675.452PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
63 PARD6Ginteractor51.0000PB1 (PF00564, IPR000270, SM00666): PB1 domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
64 PDCD7interactor100PDCD7 (PF16021, IPR031974): Programmed cell death protein 7
65 PHLPP1suppressor21.0000LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
PH (PF00169, IPR001849, SM00233): PH domain
PP2C (PF00481, IPR001932): Protein phosphatase 2C
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
PRIMA1 (PF16101): Proline-rich membrane anchor 1
66 PINK1protein found in more fusions50.5000.667Pkinase (PF00069, IPR000719): Protein kinase domain
67 PKD1suppressor200Stress-antifung (PF01657, IPR002902): Salt stress response/antifungal
LRRCT (PF01463, IPR000483, SM00082): Leucine rich repeat C-terminal domain
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
PKD (PF00801, IPR000601, SM00089): PKD domain
PKD_channel (PF08016, IPR013122): Polycystin cation channel
PLAT (PF01477, IPR001024, SM00308): PLAT/LH2 domain
REJ (PF02010, IPR002859): REJ domain
WSC (PF01822, IPR002889, SM00321): WSC domain
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
68 PMPCAinteractor100Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
69 PPIBinteractor60.5334.067Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
70 PPP2R1Aoncoprotein160.33351.952TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
71 PPP2R5Eprotein found in more fusions31.0000B56 (PF01603, IPR002554): Protein phosphatase 2A regulatory B subunit (B56 family)
72 PRDX3interactor40.6670.667AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
73 PRKAA1suppressor100.48911.421Pkinase (PF00069, IPR000719): Protein kinase domain
AdenylateSensor (PF16579, IPR032270): Adenylate sensor of SNF1-like protein kinase
74 PRKCEsuppressor31.0000C2 (PF00168, IPR000008, SM00239): C2 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
75 PRKCIinteractor110.50915.305PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
76 PTPAsuppressor80.32110.887PTPA (PF03095, IPR004327): Phosphotyrosyl phosphate activator (PTPA) protein
77 RAB11FIP2protein found in more fusions70.9330.400C2 (PF00168, IPR000008, SM00239): C2 domain
RBD-FIP (PF09457, IPR019018): FIP domain
78 RHOAsuppressor60.3334.233Ras (PF00071, IPR001806, SM00173): Ras family
79 RNF41interactor70.4676.000Sina (PF03145, IPR018121): Seven in absentia protein family
USP8_interact (PF08941, IPR015036): USP8 interacting
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
80 RSF1oncoprotein100DDT (PF02791, IPR004022, SM00571): DDT domain
DTHCT (PF08070, IPR012542): DTHCT (NUC029) region
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
PHD (PF00628, IPR019787, SM00249): PHD-finger
UPF0239 (PF06783, IPR009621): Uncharacterised protein family (UPF0239)
TFIIE-A_C (PF11521, IPR021600): C-terminal general transcription factor TFIIE alpha
Spt5_N (PF11942, IPR022581): Spt5 transcription elongation factor, acidic N-terminal
WHIM1 (PF15612, IPR028942): WSTF, HB1, Itc1p, MBD9 motif 1
81 SFNsuppressor160.41932.37614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
82 SHMT2interactor60.6672.582SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
83 SMAD4suppressor60.5002.633MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
84 SNTB2interactor50.4004.500PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
85 SOGA1interactor80.42912.095ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68)
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
SOGA (PF11365, IPR027881): Protein SOGA
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
DUF4482 (PF14818, IPR027882): Domain of unknown function (DUF4482)
86 STK11suppressor50.6002.900Pkinase (PF00069, IPR000719): Protein kinase domain
87 TADA2Ainteractor40.5001.389SWIRM (PF04433, IPR007526): SWIRM domain
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
88 TMEM17interactor60.6003.583Transmemb_17 (PF09799, IPR019184): Predicted membrane protein
DUF3043 (PF11241, IPR021403): Protein of unknown function (DUF3043)
89 UBCprotein found in more fusions250.225145.000ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
90 USP21interactor120.25528.917UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
91 UTP18interactor100Cytochrom_D1 (PF02239): Cytochrome D1 heme domain
SAMP (PF05924, IPR009224): SAMP Motif
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
92 UTRNprotein found in more fusions70.3337.667bZIP_1 (PF00170, IPR004827): bZIP transcription factor
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
EF-hand_2 (PF09068, IPR015153): EF hand
EF-hand_3 (PF09069, IPR015154): EF-hand
Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Spectrin (PF00435, IPR002017): Spectrin repeat
TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein
WW (PF00397, IPR001202, SM00456): WW domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
CCDC-167 (PF15188, IPR028194): Coiled-coil domain-containing protein 167
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
93 VCPprotein found in more fusions220.45256.321AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
94 WDR46interactor100BING4CT (PF08149, IPR012952, SM01033): BING4CT (NUC141) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
95 YWHABinteractor250.37790.80714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
Virulence_fact (PF13769, IPR025989): Virulence factor
96 YWHAEoncoprotein290.325151.16614-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
97 YWHAGprotein found in more fusions290.381107.52014-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
98 YWHAHprotein found in more fusions250.39190.92314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
99 YWHAQinteractor210.51041.52314-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein
100 YWHAZprotein found in more fusions320.351154.64714-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ACO2interactorAconitase (PF00330, IPR001030): Aconitase family (aconitate hydratase)
Aconitase_C (PF00694, IPR000573): Aconitase C-terminal domain
2 ACTN4interactorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
3 ADI1interactorARD (PF03079, IPR004313): ARD/ARD' family
4 ALDOAinteractorGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
5 ALDOCparental proteinGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
6 ARHGAP17interactorBAR (PF03114, IPR004148, SM00721): BAR domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
7 ARHGDIAinteractorRho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
8 ATP6V1E1interactorvATP-synt_E (PF01991, IPR002842): ATP synthase (E/31 kDa) subunit
9 BLMHinteractorPeptidase_C1_2 (PF03051, IPR004134): Peptidase C1-like family
10 CDK2suppressorKdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
11 CKBinteractorATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
12 CKMT1AinteractorATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
13 CKMT1BinteractorATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
14 CKMT2interactorATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
15 DLDinteractorPyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_dim (PF02852, IPR004099): Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
16 DUTinteractordUTPase (PF00692, IPR008180): dUTPase
17 EWSR1oncoproteinRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
18 FABP5interactorLipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
19 FAHD1interactorFAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
20 FHsuppressorLyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
21 FKBP2interactorFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
22 FKBP7interactorFKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
23 GLO1interactorGlyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
24 GLOD4interactorGlyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
25 GNL1interactorHbrB (PF08539, IPR013745): HbrB-like
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
26 GPD1LinteractorNAD_Gly3P_dh_C (PF07479, IPR006109): NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
NAD_Gly3P_dh_N (PF01210, IPR011128): NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
27 GPX4interactorGSHPx (PF00255, IPR000889): Glutathione peroxidase
28 HCFC1interactorfn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif
Kelch_3 (PF13415): Galactose oxidase, central domain
Kelch_5 (PF13854): Kelch motif
zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
29 HSD17B10interactoradh_short (PF00106, IPR002198): short chain dehydrogenase
30 IMPA2interactorInositol_P (PF00459, IPR000760): Inositol monophosphatase family
31 ISYNA1interactorNAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase
32 LMAN1interactorLectin_leg-like (PF03388, IPR005052): Legume-like lectin family
Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5
KxDL (PF10241, IPR019371): Uncharacterized conserved protein
DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404)
33 MARK2parental proteinDUF702 (PF05142, IPR007818): Domain of unknown function (DUF702)
KA1 (PF02149, IPR001772): Kinase associated domain 1
Pkinase (PF00069, IPR000719): Protein kinase domain
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
34 MARS2interactorAnticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1g (PF09334, IPR015413): tRNA synthetases class I (M)
35 MCM2oncoproteinAAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
36 MYH7BinteractorMyosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
37 NDUFS4interactorETC_C1_NDUFA4 (PF04800, IPR006885): ETC complex I subunit conserved region
38 OLA1interactorRoc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
MMR_HSR1 (PF01926, IPR006073): 50S ribosome-binding GTPase
YchF-GTPase_C (PF06071, IPR013029): Protein of unknown function (DUF933)
39 PGAM1interactorHis_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
40 PGAM2interactorHis_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
41 PGK1interactorPGK (PF00162, IPR001576): Phosphoglycerate kinase
42 PGK2interactorPGK (PF00162, IPR001576): Phosphoglycerate kinase
43 PRDX5interactorRedoxin (PF08534, IPR013740): Redoxin
NAD_binding_10 (PF13460, IPR016040): NAD(P)H-binding
44 PREPinteractorPeptidase_S9 (PF00326, IPR001375): Prolyl oligopeptidase family
Peptidase_S9_N (PF02897, IPR023302): Prolyl oligopeptidase, N-terminal beta-propeller domain
45 RAE1interactorExonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
46 SF1interactorUPF0181 (PF03701, IPR005371): Uncharacterised protein family (UPF0181)
zf-CCHC (PF00098, IPR001878): Zinc knuckle
KH_1 (PF00013, IPR004088, SM00322): KH domain
RCDG1 (PF15725, IPR031457): Renal cancer differentiation gene 1 protein
PRIMA1 (PF16101): Proline-rich membrane anchor 1
SF1-HH (PF16275, IPR032570): Splicing factor 1 helix-hairpin domain
47 SOD2suppressorSod_Fe_C (PF02777, IPR019832): Iron/manganese superoxide dismutases, C-terminal domain
Sod_Fe_N (PF00081, IPR019831): Iron/manganese superoxide dismutases, alpha-hairpin domain
48 SQLEinteractorFAD_binding_3 (PF01494, IPR002938): FAD binding domain
SE (PF08491, IPR013698): Squalene epoxidase
CBP_BcsF (PF11120, IPR019995): Cellulose biosynthesis protein BcsF
49 STXBP1interactorSec1 (PF00995, IPR001619): Sec1 family
50 TAGLNsuppressorCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
51 TAGLN2interactorCalponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
52 TRAP1oncoproteinHSP90 (PF00183, IPR001404): Hsp90 protein
HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
53 TXNDC5interactorThioredoxin (PF00085, IPR013766): Thioredoxin
54 UMPSinteractorOMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
55 WDFY1interactorFYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
ELYS-bb (PF16687, IPR032040): beta-propeller of ELYS nucleoporin

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