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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AI199579 is the fusion of parental proteins NRSN2, HNRNPUL2 (from a repository: Tue Apr 18 09:44:07 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)56
The number (and %) of the onco-proteins17 (30.36 %)
The number (and %) of the tumor suppressors5 (8.93 %)
Total number of binary PPIs (saturation %)275 (17.86 %)
The number (and %) of affected PPIs55 (20.00 %)
The number of possible different fusions7
PPI diameter2
PPI radius1
The average degree of PPI9.000
Assortativity coefficient-0.2701
The network average Clustering coefficient0.620
The number (and %) of a zero Clustering coefficients2 (3.57 %)
The number (and %) of a zero Betweenness Centrality15 (26.79 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: HNRNPUL2-BSCL2,NRSN2 All fusions
: AI199579;
Proteins found in more fusions HNRNPUL1 (see 1 fusions); ZDHHC17 (see 2 fusions); CUL7 (see 2 fusions); COPS5 (see 1 fusions); CUL3 (see 1 fusions); PDCD6 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AI199579chimera550.1331795.677CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
2 AK3interactor30.6671.000ADK (PF00406, IPR000850): Adenylate kinase
3 BARD1suppressor50.6671.333BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
zf-RING_6 (PF14835): zf-RING of BARD1-type protein
BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain
4 BTRConcoprotein40.6670.286WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
5 CAND1interactor230.40377.525Adaptin_N (PF01602, IPR002553): Adaptin N terminal region
DUF1981 (PF09324, IPR015403): Domain of unknown function (DUF1981)
HEAT (PF02985, IPR000357): HEAT repeat
TIP120 (PF08623, IPR013932): TATA-binding protein interacting (TIP20)
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
6 CEP57interactor30.6670.222Cep57_MT_bd (PF06657, IPR024957): Centrosome microtubule-binding domain of Cep57
Tup_N (PF08581, IPR013890): Tup N-terminal
CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit
Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
TRIQK (PF15168, IPR024842): Triple QxxK/R motif-containing protein family
7 COPS5protein found in more fusions180.47134.789JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
8 CRYABoncoprotein200Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
9 CUL3protein found in more fusions230.39879.187Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
10 CUL7protein found in more fusions180.36846.489ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
Cullin (PF00888, IPR001373, SM00182): Cullin family
DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918)
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
11 DROSHAinteractor30.6670.286dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Ribonuclease_3 (PF00636, IPR000999, SM00535): Ribonuclease III domain
Ribonucleas_3_3 (PF14622, IPR000999): Ribonuclease-III-like
DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614)
12 EEDsuppressor140.44918.272WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
13 ERGoncoprotein51.0000Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
14 ERLIN2interactor50.5003.067Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
15 FBXW11interactor110.46718.667WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Beta-TrCP_D (PF12125, IPR021977, SM01028): D domain of beta-TrCP
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
F-box-like (PF12937, IPR001810): F-box-like
16 FLOT2interactor50.5002.367YjbH (PF06082, IPR010344): Exopolysaccharide biosynthesis protein YbjH
Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
Flot (PF15975, IPR031905): Flotillin
17 FOXB1interactor30.6670.400Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
18 FOXE1oncoprotein21.0000Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
19 FOXG1oncoprotein21.0000SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SPX (PF03105, IPR004331): SPX domain
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
20 FOXL1oncoprotein30.6670.400Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
21 FOXL2suppressor21.0000K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
22 FOXQ1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
23 FOXS1interactor21.0000Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
24 HNRNPA1interactor240.45170.690RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
25 HNRNPCL1interactor50.7001.200FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
XhlA (PF10779, IPR019715): Haemolysin XhlA
26 HNRNPH2interactor170.57523.896RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-RNPHF (PF08080, IPR012996): RNPHF zinc finger
27 HNRNPUL1protein found in more fusions220.42968.907Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
Rox3 (PF08633, IPR013942): Rox3 mediator complex subunit
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
28 HSPA5oncoprotein180.45648.610HSP70 (PF00012, IPR013126): Hsp70 protein
29 IARSinteractor110.38229.147Anticodon_1 (PF08264, IPR013155): Anticodon-binding domain of tRNA
tRNA-synt_1 (PF00133, IPR002300): tRNA synthetases class I (I, L, M and V)
30 IGF2BP3interactor130.46220.699RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
KH_1 (PF00013, IPR004088, SM00322): KH domain
KH_4 (PF13083): KH domain
31 IL7Rinteractor30.6670.222fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
32 KHDRBS2interactor60.7001.083KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
33 LIN28Ainteractor50.5003.619CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-CCHC_6 (PF15288): Zinc knuckle
34 MATR3interactor180.56620.579DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
zf-U1 (PF06220, IPR013085, SM00451): U1 zinc finger
Tim54 (PF11711, IPR021056): Inner membrane protein import complex subunit Tim54
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
RRM_5 (PF13893): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
FAM60A (PF15396, IPR026065): Protein Family FAM60A
35 MCM5oncoprotein70.5714.394MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
36 MDC1suppressor60.4003.660FHA (PF00498, IPR000253, SM00240): FHA domain
DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274)
Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain
RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
37 MEPCEinteractor130.59017.562Bin3 (PF06859, IPR010675): Bicoid-interacting protein 3 (Bin3)
Methyltransf_23 (PF13489): Methyltransferase domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
DLEU7 (PF15760, IPR031510): Leukemia-associated protein 7
38 MEX3Cinteractor21.0000KH_1 (PF00013, IPR004088, SM00322): KH domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
39 NANOGinteractor40.6670.333Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
40 NTRK1oncoprotein180.51529.940I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
41 OBSL1interactor140.46217.081BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain
Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
42 PDCD6oncoprotein90.5007.839EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
43 PRMT8interactor41.0000PrmA (PF06325, IPR010456): Ribosomal protein L11 methyltransferase (PrmA)
44 RAB11Boncoprotein31.0000Ras (PF00071, IPR001806, SM00173): Ras family
45 RALYinteractor150.34354.431RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
46 RNF2interactor100.5289.667zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
47 RPL18interactor120.45517.676Ribosomal_L18 (PF17135): Ribosomal protein 60S L18 and 50S L18e
48 RPL35Ainteractor51.0000Ribosomal_L35Ae (PF01247, IPR001780): Ribosomal protein L35Ae
49 RPS14interactor120.42422.560Ribosomal_S11 (PF00411, IPR001971): Ribosomal protein S11
50 SDHBsuppressor41.0000Fer2_3 (PF13085, IPR025192): 2Fe-2S iron-sulfur cluster binding domain
Fer4_8 (PF13183, IPR017896): 4Fe-4S dicluster domain
Fer4_17 (PF13534): 4Fe-4S dicluster domain
51 SEC16Ainteractor60.8001.019APC_r (PF05923): APC repeat
Sec16_C (PF12931, IPR024298): Sec23-binding domain of Sec16
Sec16 (PF12932, IPR024340): Vesicle coat trafficking protein Sec16 mid-region
52 SLC25A17interactor100Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
53 TARDBPinteractor170.57520.221RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
54 TMOD3interactor31.0000Tropomodulin (PF03250, IPR004934): Tropomodulin
Usher (PF00577, IPR000015): Outer membrane usher protein
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
55 TNRC6Cinteractor31.0000RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Ago_hook (PF10427, IPR019486): Argonaute hook
DUF3439 (PF11921, IPR024592): Domain of unknown function (DUF3439)
M_domain (PF12938, IPR026805): M domain of GW182
DUF4718 (PF15842, IPR031695): Domain of unknown function (DUF4718)
TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain
56 ZDHHC17protein found in more fusions40.6671.000zf-DHHC (PF01529, IPR001594): DHHC palmitoyltransferase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_3 (PF13606, IPR002110): Ankyrin repeat
Ank_4 (PF13637): Ankyrin repeats (many copies)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 CD1BinteractorC1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
MLANA (PF14991, IPR029242): Protein melan-A
MHC_I_3 (PF16497, IPR011161): MHC-I family domain
2 HNRNPUL2parental proteinCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
3 NRSN2parental proteinNeurensin (PF14927): Neurensin
4 SCARNA22interactorNA

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