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Fusion ID: Protein names:	AI133452
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Visualization interactions

Cytoscape Web for: AI133452 is the fusion of parental proteins FGG, OSMR (from a repository: Wed Jan 20 18:10:55 2021)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	11
The number (and %) of the onco-proteins	6 (54.55 %)
The number (and %) of the tumor suppressors	1 (9.09 %)
Total number of binary PPIs (saturation %)	21 (38.18 %)
The number (and %) of affected PPIs	10 (47.62 %)
The number of possible different fusions	4
PPI diameter	2
PPI radius	1
The average degree of PPI	3.091
Assortativity coefficient	-0.5865
The network average Clustering coefficient	0.611
The number (and %) of a zero Clustering coefficients	2 (18.18 %)
The number (and %) of a zero Betweenness Centrality	7 (63.64 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: OSMR,FGG	All fusions : AI133452;
Proteins found in more fusions	EGFR (see 2 fusions); GAPDH (see 2 fusions); BAG3 (see 4 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AI133452	chimera	10	0.156	66.000	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
2	ASB12	interactor	2	1.000	0	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_3 (PF13606, IPR002110): Ankyrin repeat SOCS_box (PF07525, IPR001496): SOCS box
3	ASB6	interactor	2	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
4	ASB7	interactor	2	1.000	0	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
5	BAG3	oncoprotein	2	0	0	BAG (PF02179, IPR003103, SM00264): BAG domain WW (PF00397, IPR001202, SM00456): WW domain
6	CUL5	suppressor	5	0.400	6.000	Cullin (PF00888, IPR001373, SM00182): Cullin family GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
7	DDX19B	interactor	1	0	0	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8	EGFR	oncoprotein	4	0.667	1.000	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
9	ERBB2	oncoprotein	5	0.500	3.000	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10	GAPDH	oncoprotein	3	1.000	0	Gp_dh_C (PF02800, IPR020829): Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N (PF00044, IPR020828, SM00846): Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain OstA (PF03968, IPR005653): OstA-like protein
11	IL6ST	oncoprotein	2	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding Lep_receptor_Ig (PF06328, IPR010457): Ig-like C2-type domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain

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List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ALDH2	oncoprotein	Aldedh (PF00171, IPR015590): Aldehyde dehydrogenase family DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
2	ASCC1	interactor	AKAP7_NLS (PF10469, IPR019510): AKAP7 2'5' RNA ligase-like domain KH_1 (PF00013, IPR004088, SM00322): KH domain
3	CA8	interactor	Carb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
4	CHD9	oncoprotein	BUD22 (PF09073, IPR015158): BUD22 CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain Chorion_2 (PF03964, IPR005649): Chorion family 2 Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain cIII (PF08134, IPR012995): cIII protein family Peptidase_M10 (PF00413, IPR001818): Matrixin SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Vpu (PF00558, IPR008187): Vpu protein Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain BRK (PF07533, IPR006576, SM00592): BRK domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain Sox_N (PF12444, IPR022151): Sox developmental protein N terminal FNIP_N (PF14636, IPR028084): Folliculin-interacting protein N-terminus
5	F13B	interactor	Sushi_2 (PF09014, IPR015104): Beta-2-glycoprotein-1 fifth domain V-set_CD47 (PF08204, IPR013270): CD47 immunoglobulin-like domain Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
6	FGA	interactor	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Pentapeptide_2 (PF01469, IPR002989): Pentapeptide repeats (8 copies) Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain Fibrinogen_aC (PF12160, IPR021996): Fibrinogen alpha C domain
7	FGB	interactor	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
8	FGG	parental protein	Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
9	FN1	oncoprotein	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
10	ICAM1	oncoprotein	Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
11	KHDRBS2	interactor	KH_1 (PF00013, IPR004088, SM00322): KH domain Qua1 (PF16274, IPR032571): Qua1 domain Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
12	NUP93	oncoprotein	Nic96 (PF04097, IPR007231): Nup93/Nic96
13	OSMR	parental protein	EpoR_lig-bind (PF09067, IPR015152): Erythropoietin receptor, ligand binding fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
14	VKORC1	interactor	VKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family

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