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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AI114691 is the fusion of parental proteins FABP1, GOT1 (from a repository: Sat Aug 8 12:18:16 2020)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)43
The number (and %) of the onco-proteins7 (16.28 %)
The number (and %) of the tumor suppressors3 (6.98 %)
Total number of binary PPIs (saturation %)127 (14.06 %)
The number (and %) of affected PPIs42 (33.07 %)
The number of possible different fusions5
PPI diameter2
PPI radius1
The average degree of PPI5.302
Assortativity coefficient-0.3076
The network average Clustering coefficient0.579
The number (and %) of a zero Clustering coefficients4 (9.30 %)
The number (and %) of a zero Betweenness Centrality14 (32.56 %)


List of the fusions

PPI for parental proteins: FABP1,GOT1 All fusions
: AI114691;
Proteins found in more fusions NQO1 (see 2 fusions); UBE2H (see 4 fusions); EGFR (see 2 fusions); DCXR (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AI114691chimera420.0841353.567Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
GRAB (PF10375, IPR019459): GRIP-related Arf-binding domain
2 ABI3BPinteractor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Pur_ac_phosph_N (PF16656, IPR015914): Purple acid Phosphatase, N-terminal domain
3 ACP1interactor30.6671.000LMWPc (PF01451, IPR023485, SM00226): Low molecular weight phosphotyrosine protein phosphatase
4 C11orf54interactor80.35715.167DUF1907 (PF08925, IPR015021, SM01168): Domain of Unknown Function (DUF1907)
5 CBR1interactor40.5002.500adh_short (PF00106, IPR002198): short chain dehydrogenase
6 CCSinteractor41.0000Fer2_BFD (PF04324, IPR007419): BFD-like [2Fe-2S] binding domain
HMA (PF00403, IPR006121): Heavy-metal-associated domain
Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
7 CHRAC1interactor30.6670.500FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
CBFD_NFYB_HMF (PF00808, IPR003958): Histone-like transcription factor (CBF/NF-Y) and archaeal histone
8 DCXRprotein found in more fusions41.0000adh_short_C2 (PF13561): Enoyl-(Acyl carrier protein) reductase
9 EGFRoncoprotein80.33314.000Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
10 FAHD1interactor31.0000FAA_hydrolase (PF01557, IPR002529): Fumarylacetoacetate (FAA) hydrolase family
11 FHsuppressor60.4677.000Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
12 GAAinteractor100Glyco_hydro_31 (PF01055, IPR000322): Glycosyl hydrolases family 31
Trefoil (PF00088, IPR000519, SM00018): Trefoil (P-type) domain
Gal_mutarotas_2 (PF13802, IPR025887): Galactose mutarotase-like
NtCtMGAM_N (PF16863, IPR031727): N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
DUF5110 (PF17137): Domain of unknown function (DUF5110)
13 GPT2interactor100Aminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
14 HSPE1interactor80.35715.000Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
15 HTRA2suppressor41.0000Peptidase_S32 (PF05579, IPR008760): Equine arteritis virus serine endopeptidase S32
PDZ_2 (PF13180, IPR001478): PDZ domain
Trypsin_2 (PF13365): Trypsin-like peptidase domain
16 KIF2Cinteractor40.6670.400Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
17 MDH1interactor21.0000Ldh_1_C (PF02866, IPR022383): lactate/malate dehydrogenase, alpha/beta C-terminal domain
Ldh_1_N (PF00056, IPR001236): lactate/malate dehydrogenase, NAD binding domain
18 MOV10interactor50.4003.667AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
19 NANSinteractor60.5335.500NeuB (PF03102, IPR013132): NeuB family
SAF (PF08666, IPR013974, SM00858): SAF domain
20 NME1suppressor80.5248.167NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
21 NME1-NME2interactor60.7332.167NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
22 NME2interactor60.9000.333NDK (PF00334, IPR001564, SM00562): Nucleoside diphosphate kinase
23 NQO1oncoprotein50.5001.733Flavodoxin_2 (PF02525, IPR003680): Flavodoxin-like fold
24 NXF1interactor100.25022.833NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
25 PCinteractor21.0000Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
26 PDCD6IPinteractor70.5336.000BRO1 (PF03097, IPR004328, SM01041): BRO1-like domain
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
ALIX_LYPXL_bnd (PF13949, IPR025304): ALIX V-shaped domain binding to HIV
27 PEPDinteractor40.5001.567AMP_N (PF05195, IPR007865, SM01011): Aminopeptidase P, N-terminal domain
Peptidase_M24 (PF00557, IPR001714): Metallopeptidase family M24
DUF3793 (PF12672, IPR024523): Protein of unknown function (DUF3793)
28 PIRinteractor120.30340.333Pirin (PF02678, IPR003829): Pirin
Pirin_C (PF05726, IPR008778): Pirin C-terminal cupin domain
29 PTGR1interactor21.0000ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ADH_N_2 (PF16884): N-terminal domain of oxidoreductase
30 RAE1interactor50.5004.667Exonuc_X-T_C (PF08411, IPR013620): Exonuclease C-terminal
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
31 RFKinteractor30.6671.000Flavokinase (PF01687, IPR015865, SM00904): Riboflavin kinase
32 SBDSoncoprotein21.0000SBDS (PF01172, IPR019783): Shwachman-Bodian-Diamond syndrome (SBDS) protein
SBDS_C (PF09377, IPR018978): SBDS protein C-terminal domain
33 SHMT2interactor30.6670.667SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
34 SOD1interactor120.32732.833Sod_Cu (PF00080, IPR001424): Copper/zinc superoxide dismutase (SODC)
35 SRXN1interactor21.0000ParBc (PF02195, IPR003115): ParB-like nuclease domain
36 TALDO1interactor60.4676.833TAL_FSA (PF00923, IPR001585): Transaldolase/Fructose-6-phosphate aldolase
37 TPI1interactor50.6671.500TIM (PF00121, IPR000652): Triosephosphate isomerase
38 TYMSinteractor30.6671.000Thymidylat_synt (PF00303, IPR000398): Thymidylate synthase
39 UBE2Hprotein found in more fusions200UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
40 UFM1interactor40.6672.000Ufm1 (PF03671, IPR005375): Ubiquitin fold modifier 1 protein
41 WDR1interactor100.31125.067eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
42 WDR82oncoprotein21.0000MinC_C (PF03775, IPR005526): Septum formation inhibitor MinC, C-terminal domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Frtz (PF11768, IPR024511): WD repeat-containing and planar cell polarity effector protein Fritz
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
43 YKT6interactor30.6671.000Synaptobrevin (PF00957, IPR001388): Synaptobrevin
Longin (PF13774, IPR010908): Regulated-SNARE-like domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALDH4A1interactorAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
2 ALDH7A1interactorAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
3 ANXA11interactorAnnexin (PF00191, IPR018502, SM00335): Annexin
4 ANXA6interactorAnnexin (PF00191, IPR018502, SM00335): Annexin
5 CRIP1interactorLIM (PF00412, IPR001781, SM00132): LIM domain
6 FABP1parental proteinLipocalin_7 (PF14651): Lipocalin / cytosolic fatty-acid binding protein family
7 FLNAsuppressorCH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
8 GLOD4interactorGlyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
9 GOT1parental proteinAminotran_1_2 (PF00155, IPR004839): Aminotransferase class I and II
10 GRB2oncoproteinSH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
11 HPRT1interactorPribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
12 IDH1suppressorIso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
13 MTAPsuppressorPNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
14 OATinteractorAminotran_3 (PF00202, IPR005814): Aminotransferase class-III
15 PHGDHinteractor2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
16 PITPNAoncoproteinIP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
17 PITPNBinteractorIP_trans (PF02121, IPR001666): Phosphatidylinositol transfer protein
18 PPARAsuppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
19 PPARGsuppressorzf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
PPARgamma_N (PF12577, IPR022590): PPAR gamma N-terminal region
20 PPIL3interactorPro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
21 SNTA1interactorPDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
PH (PF00169, IPR001849, SM00233): PH domain
22 SNX3interactorPX (PF00787, IPR001683, SM00312): PX domain

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