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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AI033698 is the fusion of parental proteins SEPHS1, BEX1 (from a repository: Mon Sep 16 05:23:19 2019)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)53
The number (and %) of the onco-proteins13 (24.53 %)
The number (and %) of the tumor suppressors4 (7.55 %)
Total number of binary PPIs (saturation %)135 (9.80 %)
The number (and %) of affected PPIs52 (38.52 %)
The number of possible different fusions8
PPI diameter2
PPI radius1
The average degree of PPI4.491
Assortativity coefficient-0.3571
The network average Clustering coefficient0.534
The number (and %) of a zero Clustering coefficients13 (24.53 %)
The number (and %) of a zero Betweenness Centrality28 (52.83 %)


List of the fusions

PPI for parental proteins: BEX1,SEPHS1 All fusions
: AI033698;
Proteins found in more fusions HSPB1 (see 4 fusions); SAT1 (see 5 fusions); AHCYL1 (see 3 fusions); CUL3 (see 1 fusions); PDCD6 (see 1 fusions); FGFR2 (see 3 fusions); G6PD (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AI033698chimera520.0512254.000AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
2 ACADSinteractor21.0000Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
3 AHCYL1suppressor70.6004.667AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515)
Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
4 BCAR3oncoprotein100RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
5 C14orf1interactor21.0000Erg28 (PF03694, IPR005352): Erg28 like protein
6 CCDC130interactor100DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
7 CDCA4interactor31.0000SERTA (PF06031, IPR009263): SERTA motif
8 CLIC1interactor100GST_N_2 (PF13409, IPR004045): Glutathione S-transferase, N-terminal domain
GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
9 CLIC4oncoprotein70.33313.667GST_C_2 (PF13410): Glutathione S-transferase, C-terminal domain
GST_N_3 (PF13417, IPR004045): Glutathione S-transferase, N-terminal domain
10 COPS2suppressor21.0000YozE_SAM_like (PF06855, IPR023089): YozE SAM-like fold
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2087 (PF09860, IPR018656): Uncharacterized protein conserved in bacteria (DUF2087)
PCI (PF01399, IPR000717, SM00088): PCI domain
TPR_7 (PF13176, IPR019734): Tetratricopeptide repeat
11 CRKLoncoprotein40.6671.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
12 CRMP1interactor31.0000Amidohydro_1 (PF01979, IPR006680): Amidohydrolase family
Amidohydro_3 (PF07969, IPR013108): Amidohydrolase family
13 CUL3protein found in more fusions110.24430.667Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
14 DDX19Ainteractor31.0000DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
15 DEPDC7interactor21.0000DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)
16 DIS3interactor21.0000RNB (PF00773, SM00955): RNB domain
rve (PF00665, IPR001584): Integrase core domain
PIN_4 (PF13638, IPR002716): PIN domain
Rrp44_CSD1 (PF17216): Rrp44-like cold shock domain
Rrp44_S1 (PF17215): S1 domain
17 ECH1interactor100ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
18 ELAVL1oncoprotein120.29134.667RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
19 FBXW7suppressor200Mem_trans (PF03547, IPR004776): Membrane transport protein
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
F-box-like (PF12937, IPR001810): F-box-like
20 FDPSinteractor40.6671.667polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
21 FGFR2oncoprotein200Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
22 FZR1suppressor21.0000WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
23 G6PDprotein found in more fusions70.5335.667G6PD_C (PF02781, IPR022675): Glucose-6-phosphate dehydrogenase, C-terminal domain
G6PD_N (PF00479, IPR022674): Glucose-6-phosphate dehydrogenase, NAD binding domain
24 GARTinteractor50.5004.333AIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
Formyl_trans_N (PF00551, IPR002376): Formyl transferase
GARS_A (PF01071, IPR020561): Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain
GARS_C (PF02843, IPR020560): Phosphoribosylglycinamide synthetase, C domain
GARS_N (PF02844, IPR020562): Phosphoribosylglycinamide synthetase, N domain
25 GBP2interactor30.6670.667GBP (PF02263, IPR015894): Guanylate-binding protein, N-terminal domain
GBP_C (PF02841, IPR003191): Guanylate-binding protein, C-terminal domain
26 HSPB1oncoprotein100.36119.667HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
27 HYPKinteractor100Utp11 (PF03998, IPR007144): Utp11 protein
28 IGSF21interactor21.0000C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
29 MAT2Binteractor50.6003.333RmlD_sub_bind (PF04321, IPR005913): RmlD substrate binding domain
30 MCFD2interactor100EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
31 PDCD6oncoprotein50.6671.333EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
32 PFASinteractor30.6670.667AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
33 PPIL3interactor40.8330.667Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
34 PTPRFinteractor100Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST)
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
35 PUM1interactor40.8330.500K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PUF (PF00806, IPR001313, SM00025): Pumilio-family RNA binding repeat
YppG (PF14179, IPR025555): YppG-like protein
36 QRICH1interactor31.0000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
PAT1 (PF09770, IPR019167): Topoisomerase II-associated protein PAT1
DUF3504 (PF12012, IPR021893): Domain of unknown function (DUF3504)
RBM39linker (PF15519, IPR029123): linker between RRM2 and RRM3 domains in RBM39 protein
37 REXO2interactor100RNase_T (PF00929, IPR013520): Exonuclease
38 RTCBinteractor40.6671.000RtcB (PF01139, IPR001233): tRNA-splicing ligase RtcB
39 SAT1protein found in more fusions70.3339.667Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
40 SEC13interactor60.6003.333WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
41 SLC35F6interactor21.0000EamA (PF00892, IPR000620): EamA-like transporter family
SLC35F (PF06027, IPR009262): Solute carrier family 35
42 SOX2oncoprotein60.6003.667HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
43 SPACA9interactor100DUF4561 (PF15120, IPR027818): Domain of unknown function (DUF4561)
44 SUGT1interactor50.5004.667CheC (PF04509, IPR007597): CheC-like family
CS (PF04969, IPR007052): CS domain
SGS (PF05002, IPR007699): SGS domain
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_16 (PF13432): Tetratricopeptide repeat
TPR_19 (PF14559): Tetratricopeptide repeat
45 TAS2R41interactor100TAS2R (PF05296, IPR007960): Taste receptor protein (TAS2R)
46 TPD52oncoprotein31.0000TPD52 (PF04201, IPR007327): Tumour protein D52 family
47 TUFMinteractor40.6671.000GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
48 UMPSinteractor21.0000OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
49 UNC119interactor21.0000GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
50 WDR12interactor70.5335.500NLE (PF08154, IPR012972): NLE (NUC135) domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
51 XPO1interactor180.203110.667CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
52 XPO7interactor30.6670.667IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Rep_fac_C (PF08542, IPR013748): Replication factor C C-terminal domain
53 ZBTB25interactor200BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BAG4interactorBAG (PF02179, IPR003103, SM00264): BAG domain
DMP12 (PF16779, IPR031891): DNA-mimic protein
2 BEX1parental proteinBEX (PF04538, IPR021156): Brain expressed X-linked like family
3 CASP8suppressorDED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
4 CHEK2suppressorFHA (PF00498, IPR000253, SM00240): FHA domain
Pkinase (PF00069, IPR000719): Protein kinase domain
5 GSK3BsuppressorPkinase (PF00069, IPR000719): Protein kinase domain
6 MDFIinteractorMDFI (PF15316, IPR026134): MyoD family inhibitor
7 OMPinteractorOlfactory_mark (PF06554, IPR009103): Olfactory marker protein
8 PAX2oncoproteinPAX (PF00292, IPR001523, SM00351): 'Paired box' domain
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
Pax2_C (PF12403, IPR022130): Paired-box protein 2 C terminal
9 PIK3CAoncoproteinPI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
DUF2321 (PF10083, IPR016891): Uncharacterized protein conserved in bacteria (DUF2321)
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
10 PIPSLinteractorNA
11 PTENsuppressorDSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
12 SEPHS1parental proteinAIRS (PF00586, IPR000728): AIR synthase related protein, N-terminal domain
AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
13 SMAD4suppressorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
14 TEX11interactorSPO22 (PF08631, IPR013940): Meiosis protein SPO22/ZIP4 like
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2547 (PF10818, IPR020508): Protein of unknown function (DUF2547)
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
AAA_28 (PF13521): AAA domain
TPR_19 (PF14559): Tetratricopeptide repeat

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