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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AF422925 is the fusion of parental proteins CASP8, PCGF5 (from a repository: Thu Mar 30 09:29:18 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)139
The number (and %) of the onco-proteins50 (35.97 %)
The number (and %) of the tumor suppressors28 (20.14 %)
Total number of binary PPIs (saturation %)723 (7.54 %)
The number (and %) of affected PPIs138 (19.09 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI9.439
Assortativity coefficient-0.3906
The network average Clustering coefficient0.517
The number (and %) of a zero Clustering coefficients24 (17.27 %)
The number (and %) of a zero Betweenness Centrality47 (33.81 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: PCGF5,CASP8 All fusions
: AF422925;
Proteins found in more fusions TRAF6 (see 1 fusions); BIRC6 (see 1 fusions); TNF (see 1 fusions); TNFSF10 (see 1 fusions); CASP2 (see 3 fusions); MAPK1 (see 1 fusions); TICAM1 (see 1 fusions); HDAC7 (see 1 fusions); CUL3 (see 1 fusions); SQSTM1 (see 5 fusions); BCAP31 (see 3 fusions); FAF1 (see 2 fusions); TNFRSF1A (see 2 fusions); NOD1 (see 1 fusions); KHDRBS1 (see 1 fusions); EZR (see 2 fusions); RIPK1 (see 1 fusions); BCL2L1 (see 1 fusions); CSNK2A1 (see 1 fusions); CHD3 (see 1 fusions); IKBKB (see 2 fusions); PARP1 (see 1 fusions); TSC22D3 (see 2 fusions); UBC (see 1 fusions); LRRK2 (see 1 fusions); PRDX6 (see 1 fusions); ERRFI1 (see 1 fusions); NOL3 (see 2 fusions); TP53 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AF422925chimera1380.05514678.213DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
2 AGR3interactor21.0000Thioredoxin_7 (PF13899): Thioredoxin-like
3 ANGPTL4suppressor100SlyX (PF04102, IPR007236): SlyX
Fibrinogen_C (PF00147, IPR002181, SM00186): Fibrinogen beta and gamma chains, C-terminal globular domain
4 APAF1suppressor50.7001.733CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NB-ARC (PF00931, IPR002182): NB-ARC domain
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Cactin_mid (PF10312, IPR018816): Conserved mid region of cactin
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
Nbas_N (PF15492, IPR029145): Neuroblastoma-amplified sequence, N terminal
5 ARHGDIAinteractor170.68315.460Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
6 ATAD2interactor100AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC45 (PF02724, IPR003874): CDC45-like protein
Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
SDA1 (PF05285, IPR007949): SDA1
YL1 (PF05764, IPR008895): YL1 nuclear protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
7 ATG4Dinteractor21.0000Peptidase_C54 (PF03416, IPR005078): Peptidase family C54
8 ATP1A3interactor21.0000Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9 BAP1suppressor40.8330.667Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
10 BAXsuppressor140.46225.164Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
11 BCAP31protein found in more fusions70.6005.000Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
DUF948 (PF06103, IPR009293): Bacterial protein of unknown function (DUF948)
12 BCL2oncoprotein180.35354.912Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
13 BCL2L1oncoprotein170.33350.849Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
BH4 (PF02180, IPR003093, SM00265): Bcl-2 homology region 4
14 BCL2L10interactor41.0000Bcl-2 (PF00452, IPR026298): Apoptosis regulator proteins, Bcl-2 family
15 BEX1interactor21.0000BEX (PF04538, IPR021156): Brain expressed X-linked like family
16 BFARinteractor80.39313.611SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
DUF2231 (PF09990, IPR019251): Predicted membrane protein (DUF2231)
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
17 BIDoncoprotein200.53244.552BID (PF06393, IPR010479): BH3 interacting domain (BID)
18 BIRC2oncoprotein200.55029.011BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
19 BIRC3oncoprotein180.58121.736BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
20 BIRC6oncoprotein80.5713.892BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
SlyX (PF04102, IPR007236): SlyX
UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
BIRC6 (PF12356, IPR022103): Baculoviral IAP repeat-containing protein 6
ABC_tran_CTD (PF16326, IPR032524): ABC transporter C-terminal domain
21 BLMsuppressor60.7001.015BDHCT (PF08072, IPR012532): BDHCT (NUC031) domain
DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
HRDC (PF00570, IPR002121, SM00341): HRDC domain
RQC (PF09382, IPR018982, SM00956): RQC domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
ALMT (PF11744, IPR020966): Aluminium activated malate transporter
RecQ_Zn_bind (PF16124, IPR032284): RecQ zinc-binding
BLM_N (PF16202, IPR032437): N-terminal region of Bloom syndrome protein
BDHCT_assoc (PF16204, IPR032439): BDHCT-box associated domain on Bloom syndrome protein
22 CARD11oncoprotein50.8330.286CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Cnn_1N (PF07989, IPR012943): Centrosomin N-terminal motif 1
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-C4H2 (PF10146, IPR018482): Zinc finger-containing protein
Guanylate_kin (PF00625, IPR008145, SM00072): Guanylate kinase
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
23 CASC3oncoprotein100Btz (PF09405, IPR018545, SM01044): CASC3/Barentsz eIF4AIII binding
UPF0560 (PF10577, IPR018890): Uncharacterised protein family UPF0560
PRIMA1 (PF16101): Proline-rich membrane anchor 1
24 CASP1oncoprotein130.24239.706CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
25 CASP10interactor370.271309.655DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
26 CASP14interactor50.7001.300Peptidase_C14 (PF00656, IPR011600): Caspase domain
27 CASP2suppressor160.47630.119CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
28 CASP3interactor300.251200.629Peptidase_C14 (PF00656, IPR011600): Caspase domain
29 CASP4interactor70.5245.667CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
30 CASP6interactor100.5009.605Peptidase_C14 (PF00656, IPR011600): Caspase domain
31 CASP7interactor200.37456.616Peptidase_C14 (PF00656, IPR011600): Caspase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
32 CASP8AP2interactor70.6001.689CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC)
IncA (PF04156, IPR007285): IncA protein
RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4
DUF3304 (PF11745, IPR021733): Protein of unknown function (DUF3304)
PNISR (PF15996, IPR031937): Arginine/serine-rich protein PNISR
33 CASP9oncoprotein180.39249.271CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
34 CDH13suppressor100Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
Cu-binding_MopE (PF11617, IPR021655): Putative metal-binding motif
35 CEBPBoncoprotein50.5002.167RhlB (PF12300, IPR022077): ATP-dependent RNA helicase RhlB
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
36 CFLARoncoprotein210.34771.733DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
37 CHD3oncoprotein80.4768.067CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain
CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087)
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid)
PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956)
FAM176 (PF14851): FAM176 family
38 CHUKsuppressor170.48334.454Pkinase (PF00069, IPR000719): Protein kinase domain
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
39 CLIP3interactor41.0000Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
CAP_GLY (PF01302, IPR000938, SM01052): CAP-Gly domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
40 CNBPoncoprotein100zf-CCHC (PF00098, IPR001878): Zinc knuckle
zf-ribbon_3 (PF13248): zinc-ribbon domain
41 COPS6interactor100.36112.836DUF320 (PF03777, IPR005528): Small secreted domain (DUF320)
JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
MitMem_reg (PF13012, IPR024969): Maintenance of mitochondrial structure and function
42 CRYABoncoprotein120.6557.370Crystallin (PF00525, IPR003090): Alpha crystallin A chain, N terminal
HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
43 CSNK2A1oncoprotein140.35935.769Pkinase (PF00069, IPR000719): Protein kinase domain
44 CSNK2A2interactor80.4649.700Pkinase (PF00069, IPR000719): Protein kinase domain
45 CUL3protein found in more fusions200.205105.717Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
46 DEDDinteractor60.9000.500DED (PF01335, IPR001875, SM00031): Death effector domain
47 DEDD2interactor51.0000DED (PF01335, IPR001875, SM00031): Death effector domain
48 EPSTI1interactor100TAF8_C (PF10406, IPR019473): Transcription factor TFIID complex subunit 8 C-term
DUF4355 (PF14265, IPR025580): Domain of unknown function (DUF4355)
DUF4666 (PF15697, IPR031421): Domain of unknown function (DUF4666)
49 ERLIN2interactor21.0000Band_7 (PF01145, IPR001107, SM00244): SPFH domain / Band 7 family
DUF4346 (PF14251, IPR025595): Domain of unknown function (DUF4346)
50 ERRFI1suppressor200GTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
51 EZRprotein found in more fusions131.0000DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
52 FADDsuppressor330.294240.432Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
53 FAF1protein found in more fusions80.4766.686UBX (PF00789, IPR001012, SM00166): UBX domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
AAA_11 (PF13086): AAA domain
UBA_4 (PF14555): UBA-like domain
54 FASsuppressor220.49050.328Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
55 FASLGinteractor130.9101.936PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
56 FIS1interactor31.0000Fis1_TPR_N (PF14852, IPR028058): Fis1 N-terminal tetratricopeptide repeat
Fis1_TPR_C (PF14853, IPR028061): Fis1 C-terminal tetratricopeptide repeat
57 GLCEinteractor100C5-epim_C (PF06662, IPR010598): D-glucuronyl C5-epimerase C-terminus
EspG (PF06872, IPR009669): EspG protein
58 GMNNinteractor30.6670.667Geminin (PF07412, IPR022786): Geminin
59 GREB1interactor100GREB1 (PF15782, IPR028422): Gene regulated by oestrogen in breast cancer
60 GZMBinteractor40.8330.250Trypsin (PF00089, IPR001254, SM00020): Trypsin
61 HBP1suppressor21.0000AXH (PF08517, IPR013723, SM00536): Ataxin-1 and HBP1 module (AXH)
HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
62 HDAC7protein found in more fusions200Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
CBP_BcsO (PF17037, IPR031484): Cellulose biosynthesis protein BcsO
63 HECTD3interactor21.0000ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10)
HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
64 HIP1oncoprotein41.0000ANTH (PF07651, IPR011417): ANTH domain
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
I_LWEQ (PF01608, IPR002558, SM00307): I/LWEQ domain
HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
65 IFT57interactor31.0000IFT57 (PF10498, IPR019530): Intra-flagellar transport protein 57
66 IKBKBprotein found in more fusions170.47531.031FliT (PF05400, IPR008622): Flagellar protein FliT
Glyco_hydro_65m (PF03632, IPR005195): Glycosyl hydrolase family 65 central catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
SlyX (PF04102, IPR007236): SlyX
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
IKKbetaNEMObind (PF12179, IPR022007): I-kappa-kinase-beta NEMO binding domain
67 IL13RA2interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
IL6Ra-bind (PF09240, IPR015321): Interleukin-6 receptor alpha chain, binding
Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III
68 IL24suppressor30.6670.667IL22 (PF14565, IPR020453): Interleukin 22 IL-10-related T-cell-derived-inducible factor
69 KHDRBS1protein found in more fusions70.6004.571KH_1 (PF00013, IPR004088, SM00322): KH domain
Qua1 (PF16274, IPR032571): Qua1 domain
Sam68-YY (PF16568, IPR032335): Tyrosine-rich domain of Sam68
70 KLK5oncoprotein100Trypsin (PF00089, IPR001254, SM00020): Trypsin
71 KLK9interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
72 LRRK2oncoprotein90.5009.039Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043)
T2SSE (PF00437, IPR001482): Type II/IV secretion system protein
Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase
Pkinase (PF00069, IPR000719): Protein kinase domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
PQQ_2 (PF13360, IPR002372): PQQ-like domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
73 LYPD3oncoprotein21.0000DUF753 (PF05444, IPR008472): Protein of unknown function (DUF753)
UPAR_LY6 (PF00021, IPR001526): u-PAR/Ly-6 domain
74 MAP1LC3Ainteractor50.8001.067Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
75 MAP1LC3Binteractor60.6672.122Atg8 (PF02991, IPR004241): Autophagy protein Atg8 ubiquitin like
76 MAP3K14interactor130.6825.819Pkinase (PF00069, IPR000719): Protein kinase domain
77 MAPK1oncoprotein120.27329.729Pkinase (PF00069, IPR000719): Protein kinase domain
78 MAPK8oncoprotein210.47461.179DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
79 MLKLinteractor21.0000Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Kinase-like (PF14531, IPR027916): Kinase-like
80 MSNoncoprotein131.0000DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
81 NLRC4oncoprotein50.6672.000CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
82 NLRP3oncoprotein30.6671.000NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
LRR_8 (PF13855, IPR001611): Leucine rich repeat
FISNA (PF14484, IPR029495): Fish-specific NACHT associated domain
83 NOD1oncoprotein120.32723.057CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
NACHT (PF05729): NACHT domain
Sigma54_AID (PF00309, IPR000394): Sigma-54 factor, Activator interacting domain (AID)
SpoU_sub_bind (PF08032, IPR013123, SM00967): RNA 2'-O ribose methyltransferase substrate binding
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
84 NOL3oncoprotein80.7142.222CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
85 NR1H4interactor100LRV_FeS (PF05484, IPR008665): LRV protein FeS4 cluster
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
86 PARK7suppressor80.4766.083DJ-1_PfpI (PF01965, IPR002818): DJ-1/PfpI family
87 PARP1suppressor100.38915.768BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
PADR1 (PF08063, IPR012982): PADR1 (NUC008) domain
PARP (PF00644, IPR012317): Poly(ADP-ribose) polymerase catalytic domain
PARP_reg (PF02877, IPR004102): Poly(ADP-ribose) polymerase, regulatory domain
WGR (PF05406, IPR008893, SM00773): WGR domain
zf-PARP (PF00645, IPR001510): Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
88 PDIA6interactor30.6670.400FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
89 PEA15suppressor30.6670.667DED (PF01335, IPR001875, SM00031): Death effector domain
90 PLA2G4Binteractor40.6670.800C2 (PF00168, IPR000008, SM00239): C2 domain
PLA2_B (PF01735, IPR002642): Lysophospholipase catalytic domain
91 PLIN4interactor100ACP_syn_III (PF08545, IPR013751): 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III
DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
Perilipin (PF03036, IPR004279): Perilipin family
92 PLK2suppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
93 PRDM14interactor100Desulfoferrod_N (PF06397, IPR004462): Desulfoferrodoxin, N-terminal domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-C2H2_jaz (PF12171, IPR022755): Zinc-finger double-stranded RNA-binding
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
94 PRDX6protein found in more fusions50.8330.667AhpC-TSA (PF00578, IPR000866): AhpC/TSA family
1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
95 PRKCIinteractor60.6003.667PB1 (PF00564, IPR000270, SM00666): PB1 domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
96 PRMT6interactor30.6671.000Methyltransf_25 (PF13649): Methyltransferase domain
97 PRSS50interactor100Trypsin (PF00089, IPR001254, SM00020): Trypsin
98 PSMC3IPinteractor100Spc24 (PF08286, IPR013252): Spc24 subunit of Ndc80
TBPIP (PF07106, IPR010776): Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
99 PTENsuppressor110.34528.738DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
100 QDPRinteractor31.0000adh_short (PF00106, IPR002198): short chain dehydrogenase
101 RALBP1interactor31.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SlyX (PF04102, IPR007236): SlyX
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968)
DUF3505 (PF12013, IPR022698): Protein of unknown function (DUF3505)
Nod1 (PF17114, IPR032634): Gef2-related medial cortical node protein Nod1
102 RALGDSoncoprotein21.0000RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain
RasGEF (PF00617, IPR001895, SM00147): RasGEF domain
Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
103 RB1suppressor110.41821.628RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain
RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain
Rb_C (PF08934, IPR015030): Rb C-terminal domain
DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452)
DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
104 RHOAsuppressor180.53644.419Ras (PF00071, IPR001806, SM00173): Ras family
105 RIPK1protein found in more fusions280.39692.333Death (PF00531, IPR000488, SM00005): Death domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
106 RIPK3interactor90.7502.614Pkinase (PF00069, IPR000719): Protein kinase domain
TrbM (PF07424, IPR009989): TrbM
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
107 RNF34interactor50.6001.306Cwf_Cwc_15 (PF04889, IPR006973): Cwf15/Cwc15 cell cycle control protein
FYVE (PF01363, IPR000306, SM00064): FYVE zinc finger
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
108 RYBPinteractor60.5334.286DUF11 (PF01345, IPR001434): Domain of unknown function DUF11
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PPAK (PF02818, IPR004168): PPAK motif
Titin_Z (PF09042, IPR015129): Titin Z
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Y_Y_Y (PF07495, IPR011123): Y_Y_Y domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
Ig_3 (PF13927): Immunoglobulin domain
109 S100A14oncoprotein100S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
110 SCGB2A2interactor100Uteroglobin (PF01099, IPR016126, SM00096): Uteroglobin family
111 SERPINB5suppressor31.0000Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
112 SNRPD3interactor30.6670.222LSM (PF01423, IPR001163): LSM domain
113 SORBS1interactor21.0000SH3_2 (PF07653, IPR011511): Variant SH3 domain
Sorb (PF02208, IPR003127, SM00459): Sorbin homologous domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
SCAB-ABD (PF16711, IPR032012): Actin-binding domain of plant-specific actin-binding protein
114 SOX2oncoprotein40.6670.500HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
115 SQSTM1oncoprotein190.27568.149PB1 (PF00564, IPR000270, SM00666): PB1 domain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
UBA_5 (PF16577, IPR015940): UBA domain
116 ST14interactor100CUB (PF00431, IPR000859, SM00042): CUB domain
SEA (PF01390, IPR000082, SM00200): SEA domain
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Trypsin (PF00089, IPR001254, SM00020): Trypsin
117 TFCP2interactor40.5002.400CP2 (PF04516, IPR007604): CP2 transcription factor
DUF2967 (PF11179, IPR021349): Protein of unknown function (DUF2967)
118 TICAM1protein found in more fusions90.7501.969Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
RHIM (PF12721, IPR025735): RIP homotypic interaction motif
TIR_2 (PF13676, IPR000157): TIR domain
119 TNFoncoprotein140.62812.000TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
120 TNFAIP3suppressor180.58819.112OTU (PF02338, IPR003323): OTU-like cysteine protease
zf-A20 (PF01754, IPR002653, SM00259): A20-like zinc finger
Thioredoxin_3 (PF13192, IPR012336): Thioredoxin domain
121 TNFRSF10Asuppressor100.6226.010Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
TMIE (PF16038, IPR032006): TMIE protein
122 TNFRSF10Bsuppressor200.58928.579Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
123 TNFRSF1Aoncoprotein320.370158.771Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
124 TNFSF10oncoprotein100.7502.760NERD (PF08378, IPR011528): Nuclease-related domain
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
125 TOPORSsuppressor40.8330.667Rad50_zn_hook (PF04423, IPR007517): Rad50 zinc hook motif
Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19
PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
126 TP53suppressor320.155307.408DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
127 TRADDinteractor160.55219.015Death (PF00531, IPR000488, SM00005): Death domain
TRADD_N (PF09034, IPR009095): TRADD, N-terminal domain
TPR_14 (PF13428): Tetratricopeptide repeat
128 TRAF1oncoprotein200.53830.489HypA (PF01155, IPR000688): Hydrogenase/urease nickel incorporation, metallochaperone, hypA
SlyX (PF04102, IPR007236): SlyX
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
129 TRAF2interactor300.350145.790MATH (PF00917, IPR002083, SM00061): MATH domain
Sina (PF03145, IPR018121): Seven in absentia protein family
SlyX (PF04102, IPR007236): SlyX
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
zf-C3HC4_5 (PF17121, IPR001841): Zinc finger, C3HC4 type (RING finger)
130 TRAF6protein found in more fusions210.39566.618SlyX (PF04102, IPR007236): SlyX
zf-TRAF (PF02176, IPR001293): TRAF-type zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
131 TSC22D3protein found in more fusions41.0000TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
132 UBCprotein found in more fusions310.221255.919ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
133 UMPSinteractor30.6670.222OMPdecase (PF00215, IPR001754, SM00934): Orotidine 5'-phosphate decarboxylase / HUMPS family
Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
134 USP2interactor90.6118.426UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
135 VIMsuppressor80.3817.523Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
136 VPS45interactor100Sec1 (PF00995, IPR001619): Sec1 family
137 WHSC1L1suppressor100PHD (PF00628, IPR019787, SM00249): PHD-finger
Presenilin (PF01080, IPR001108): Presenilin
PWWP (PF00855, IPR000313, SM00293): PWWP domain
SET (PF00856, IPR001214, SM00317): SET domain
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2
138 XIAPinteractor230.35987.433BIR (PF00653, IPR001370, SM00238): Inhibitor of Apoptosis domain
zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
139 YBX1oncoprotein60.4673.172CSD (PF00313, IPR002059): 'Cold-shock' DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
FXR_C1 (PF16096, IPR032172): Fragile X-related 1 protein C-terminal region 2

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AUTS2interactorSelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SPX (PF03105, IPR004331): SPX domain
Auts2 (PF15336): Autism susceptibility gene 2 protein
2 BCORoncoproteinAnk_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
BCOR (PF15808, IPR031628): BCL-6 co-repressor, non-ankyrin-repeat region
PUFD (PF16553, IPR032365): BCORL-PCGF1-binding domain
3 BLIDsuppressorNA
4 CASP8parental proteinDED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
5 CBX6interactorChromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
6 CBX7interactorChromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
CBX7_C (PF17218): CBX family C-terminal motif
7 CBX8interactorAtrophin-1 (PF03154, IPR002951): Atrophin-1 family
Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
RBR (PF17208): RNA binding Region
CBX7_C (PF17218): CBX family C-terminal motif
8 CSNK2BinteractorCK_II_beta (PF01214, IPR000704, SM01085): Casein kinase II regulatory subunit
9 FBRSinteractorCENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pox_Ag35 (PF03286, IPR004966): Pox virus Ag35 surface protein
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein
Auts2 (PF15336): Autism susceptibility gene 2 protein
10 FBRSL1interactorDUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
Auts2 (PF15336): Autism susceptibility gene 2 protein
11 KIF2CinteractorFib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
12 PCGF1interactorzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
13 PCGF5parental proteinDZR (PF12773, IPR025874): Double zinc ribbon
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
zf-RING_10 (PF16685, IPR032043): zinc RING finger of MSL2
14 PHC2interactorSAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-CGNR (PF11706, IPR021005): CGNR zinc finger
DUF4692 (PF15763, IPR031517): Domain of unknown function (DUF4692)
PHC2_SAM_assoc (PF16616): Unstructured region on Polyhomeotic-like protein 1 and 2
15 POLKinteractorATP-cone (PF03477, IPR005144): ATP cone domain
IMS (PF00817, IPR001126): impB/mucB/samB family
IMS_HHH (PF11798, IPR024728): IMS family HHH motif
IMS_C (PF11799, IPR017961): impB/mucB/samB family C-terminal domain
16 RING1interactorzf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
17 RNF2interactorzf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
18 TRIM8interactordCache_2 (PF08269, IPR004010, SM01049): Cache domain
CASP_C (PF08172, IPR012955): CASP C terminal
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Zn_ribbon_recom (PF13408, IPR025827): Recombinase zinc beta ribbon domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
19 UBE2D3interactorUQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
20 XPO1interactorCRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
21 YAF2interactorDUF460 (PF04312, IPR007408): Protein of unknown function (DUF460)
OAD_gamma (PF04277, IPR005899): Oxaloacetate decarboxylase, gamma chain
Exo5 (PF09810, IPR019190): Exonuclease V - a 5' deoxyribonuclease
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
MPDZ_u10 (PF16667, IPR032078): Unstructured region 10 on multiple PDZ protein
YAF2_RYBP (PF17219): Yaf2/RYBP C-terminal binding motif
22 YWHAZinteractor14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein

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