Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	78
The number (and %) of the onco-proteins	38 (48.72 %)
The number (and %) of the tumor suppressors	6 (7.69 %)
Total number of binary PPIs (saturation %)	406 (13.52 %)
The number (and %) of affected PPIs	77 (18.97 %)
The number of possible different fusions	18
PPI diameter	2
PPI radius	1
The average degree of PPI	9.564
Assortativity coefficient	-0.2250
The network average Clustering coefficient	0.549
The number (and %) of a zero Clustering coefficients	6 (7.69 %)
The number (and %) of a zero Betweenness Centrality	17 (21.79 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: CCDC6,RET	All fusions : AF395885;
Proteins found in more fusions	EGFR/PTPRF (see 1 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); CD2AP (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); TRIM28 (see 1 fusions); NR3C1 (see 8 fusions); GSK3B (see 1 fusions); CSNK2A1 (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); CUL1 (see 3 fusions); GRB2 (see 1 fusions); CREB1 (see 2 fusions);

List of the fusions

PPI for parental proteins: CCDC6,RET

All fusions

: AF395885;

Proteins found in more fusions

EGFR/PTPRF (see 1 fusions); STAT3 (see 2 fusions); HNRNPD (see 1 fusions); CD2AP (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); EGFR (see 2 fusions); CBL (see 1 fusions); TRIM28 (see 1 fusions); NR3C1 (see 8 fusions); GSK3B (see 1 fusions); CSNK2A1 (see 1 fusions); SHC1 (see 1 fusions); PTK2 (see 2 fusions); CUL1 (see 3 fusions); GRB2 (see 1 fusions); CREB1 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AF395885	chimera	77	0.101	3636.570	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046)
2	AIP	suppressor	5	0.900	0.400	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
3	ATF2	oncoprotein	9	0.393	11.733	bZIP_1 (PF00170, IPR004827): bZIP transcription factor zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
4	BAG6	interactor	8	0.333	10.539	DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939) DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538) PRIMA1 (PF16101): Proline-rich membrane anchor 1
5	BRCC3	interactor	10	0.556	9.586	JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
6	CBL	oncoprotein	17	0.517	26.979	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
7	CBLC	oncoprotein	7	0.571	5.315	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
8	CCNB1	oncoprotein	5	0.800	0.786	Adeno_E1A (PF02703, IPR003853): Early E1A protein Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
9	CD2AP	protein found in more fusions	9	0.571	6.286	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
10	CDK1	oncoprotein	10	0.556	8.927	Pkinase (PF00069, IPR000719): Protein kinase domain
11	CEP170	interactor	9	0.694	5.227	FHA (PF00498, IPR000253, SM00240): FHA domain DUF4254 (PF14063, IPR025350): Protein of unknown function (DUF4254) CEP170_C (PF15308, IPR029300): CEP170 C-terminus
12	CREB1	oncoprotein	8	0.476	7.067	bZIP_1 (PF00170, IPR004827): bZIP transcription factor pKID (PF02173, IPR003102): pKID domain DUF4988 (PF16378, IPR032149): Domain of unknown function
13	CRK	oncoprotein	12	0.621	10.294	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
14	CSNK2A1	oncoprotein	15	0.418	29.097	Pkinase (PF00069, IPR000719): Protein kinase domain
15	CUL1	oncoprotein	14	0.423	26.691	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
16	DDI2	interactor	1	0	0	Asp_protease (PF09668, IPR019103): Aspartyl protease ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
17	DOK1	suppressor	9	0.821	1.732	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
18	DOK2	suppressor	6	0.800	1.083	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
19	DOK4	interactor	4	0.833	0.167	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
20	DOK5	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
21	DOK6	interactor	2	1.000	0	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
22	EGFR	oncoprotein	30	0.276	199.141	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
23	ELAVL1	oncoprotein	19	0.281	62.575	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
24	FBXW7	oncoprotein	7	0.600	3.567	Mem_trans (PF03547, IPR004776): Membrane transport protein WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160 F-box-like (PF12937, IPR001810): F-box-like
25	GAPVD1	interactor	9	0.611	6.039	RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase VPS9 (PF02204, IPR003123, SM00167): Vacuolar sorting protein 9 (VPS9) domain
26	GRB10	oncoprotein	5	0.700	0.667	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain Argos (PF11581, IPR021633): Antagonist of EGFR signalling, Argos
27	GRB2	oncoprotein	21	0.405	63.301	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
28	GRB7	interactor	2	1.000	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
29	GSK3B	oncoprotein	13	0.303	28.039	Pkinase (PF00069, IPR000719): Protein kinase domain
30	HDAC1	suppressor	15	0.341	38.924	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
31	HIST1H3A	interactor	7	0.533	3.867	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
32	HNRNPD	oncoprotein	11	0.444	17.375	CBFNT (PF08143, IPR012956): CBFNT (NUC161) domain NID (PF07292, IPR009909): Nmi/IFP 35 domain (NID) RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Keratin_2_head (PF16208, IPR032444): Keratin type II head
33	HNRNPR	interactor	14	0.429	31.589	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
34	HSP90AA1	oncoprotein	23	0.320	93.090	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
35	IKBKG	interactor	11	0.422	16.500	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
36	KYNU	interactor	1	0	0	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
37	MAFF	interactor	3	1.000	0	bZIP_Maf (PF03131, IPR004826): bZIP Maf transcription factor APC_N_CC (PF16689, IPR032038): Coiled-coil N-terminus of APC, dimerisation domain
38	MAPK1	oncoprotein	10	0.361	15.106	Pkinase (PF00069, IPR000719): Protein kinase domain
39	MAPK3	oncoprotein	7	0.400	6.333	Pkinase (PF00069, IPR000719): Protein kinase domain
40	MCRS1	interactor	2	1.000	0	FHA (PF00498, IPR000253, SM00240): FHA domain MCRS_N (PF13325, IPR025999): N-terminal region of micro-spherule protein
41	NOTCH2NL	interactor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
42	NOTCH3	oncoprotein	4	0.667	0.722	Ank (PF00023, IPR002110, SM00248): Ankyrin repeat EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain NOD (PF06816, IPR010660): NOTCH protein NODP (PF07684, IPR011656): NOTCH protein Notch (PF00066, IPR000800, SM00004): LNR domain DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454) hEGF (PF12661, IPR013032): Human growth factor-like EGF cEGF (PF12662, IPR026823): Complement Clr-like EGF-like Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_5 (PF13857): Ankyrin repeats (many copies)
43	NR3C1	protein found in more fusions	16	0.371	40.617	GCR (PF02155, IPR001409): Glucocorticoid receptor zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains) Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
44	NTRK1	oncoprotein	39	0.220	384.289	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
45	NUDC	interactor	3	1.000	0	CS (PF04969, IPR007052): CS domain D5_N (PF08706, IPR014818, SM00885): D5 N terminal like Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 Nudc_N (PF14050, IPR025934): N-terminal conserved domain of Nudc. NuDC (PF16273, IPR032572): Nuclear distribution C domain
46	P4HB	interactor	7	0.667	2.633	Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain Thioredoxin (PF00085, IPR013766): Thioredoxin Thioredoxin_6 (PF13848): Thioredoxin-like domain
47	PAAF1	interactor	3	0.667	0.667	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
48	PDLIM7	interactor	4	0.500	2.067	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
49	PLCG1	oncoprotein	10	0.778	4.153	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
50	POLG2	interactor	1	0	0	HGTP_anticodon (PF03129, IPR004154): Anticodon binding domain
51	PPP1CA	oncoprotein	17	0.316	62.905	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
52	PPP2CA	suppressor	10	0.489	15.236	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
53	PPP2CB	suppressor	6	0.733	4.000	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
54	PPP2R1A	oncoprotein	12	0.424	22.072	TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat HEAT_2 (PF13646): HEAT repeats
55	PPP4C	interactor	11	0.364	23.683	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
56	PPP4R1	interactor	8	0.643	5.333	HEAT (PF02985, IPR000357): HEAT repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
57	PPP4R2	interactor	4	0.500	2.667	BT1 (PF03092, IPR004324): BT1 family PPP4R2 (PF09184, IPR015267): PPP4R2
58	PTK2	protein found in more fusions	17	0.508	32.866	FERM_M (PF00373, IPR019748): FERM central domain Focal_AT (PF03623, IPR005189): Focal adhesion targeting region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase UCMA (PF17085, IPR031386): Unique cartilage matrix associated protein
59	PTPRF	protein found in more fusions	4	0.833	0.400	Arylsulfotrans (PF05935, IPR010262): Arylsulfotransferase (ASST) C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase DUF3377 (PF11857, IPR021805): Domain of unknown function (DUF3377)
60	RASSF7	interactor	3	1.000	0	RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SlyX (PF04102, IPR007236): SlyX Tryp_alpha_amyl (PF00234, IPR016140, SM00499): Protease inhibitor/seed storage/LTP family ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
61	SARS	interactor	3	1.000	0	NOD (PF06816, IPR010660): NOTCH protein Seryl_tRNA_N (PF02403, IPR015866): Seryl-tRNA synthetase N-terminal domain tRNA-synt_2b (PF00587, IPR002314): tRNA synthetase class II core domain (G, H, P, S and T)
62	SEPT2	oncoprotein	4	1.000	0	FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger Septin (PF00735, IPR000038): Septin
63	SF3A1	interactor	9	0.556	10.208	TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit Surp (PF01805, IPR000061, SM00648): Surp module ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family PRP21_like_P (PF12230, IPR022030): Pre-mRNA splicing factor PRP21 like protein
64	SGTB	interactor	2	1.000	0	TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20 TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat XPC-binding (PF09280, IPR015360): XPC-binding domain TPR_11 (PF13414, IPR011990): TPR repeat SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
65	SHC1	oncoprotein	16	0.533	23.156	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
66	SKP1	oncoprotein	6	0.667	1.639	Skp1 (PF01466, IPR016072, SM00512): Skp1 family, dimerisation domain Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
67	SORT1	interactor	5	0.700	1.300	Sortilin_C (PF15901, IPR031777): Sortilin, neurotensin receptor 3, C-terminal Sortilin-Vps10 (PF15902, IPR031778): Sortilin, neurotensin receptor 3
68	SRC	oncoprotein	17	0.483	28.016	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
69	STAT3	oncoprotein	14	0.487	19.578	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
70	SYNCRIP	interactor	9	0.611	7.019	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 (PF11608, IPR024582): Limkain b1
71	TCL1B	oncoprotein	1	0	0	TCL1_MTCP1 (PF01840, IPR004832): TCL1/MTCP1 family
72	TRIM28	protein found in more fusions	12	0.473	15.406	ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain PHD (PF00628, IPR019787, SM00249): PHD-finger FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
73	USP7	oncoprotein	7	0.533	5.119	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
74	XPO1	interactor	23	0.249	137.234	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
75	YWHAB	interactor	12	0.470	19.721	14-3-3 (PF00244, IPR023410, SM00101): 14-3-3 protein Virulence_fact (PF13769, IPR025989): Virulence factor
76	ZBTB48	oncoprotein	2	0	0	BTB (PF00651, IPR013069, SM00225): BTB/POZ domain zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
77	ZCCHC8	interactor	6	0.600	2.706	Herpes_BLRF2 (PF05812, IPR008642): Herpesvirus BLRF2 protein PSP (PF04046, IPR006568, SM00581): PSP zf-CCHC (PF00098, IPR001878): Zinc knuckle DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
78	ZNF444	interactor	2	1.000	0	FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	CCDC6	parental protein	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal DUF2046 (PF09755, IPR019152): Uncharacterized conserved protein H4 (DUF2046) FAM199X (PF15814, IPR029672): Protein family FAM199X
2	FRS2	interactor	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
3	GFRA1	interactor	GDNF (PF02351, IPR016017, SM00907): GDNF/GAS1 domain
4	ICE2	interactor	NARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
5	NRTN	interactor	TGF_beta (PF00019, IPR001839, SM00204): Transforming growth factor beta like domain
6	RET	parental protein	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
7	TXNL4A	interactor	DIM1 (PF02966, IPR004123): Mitosis protein DIM1

B a c k t o T o p ⇑

Fusion ID: Protein names:	AF395885
Level of PPIs:	or Upload text file:	Update repository

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors