Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	147
The number (and %) of the onco-proteins	52 (35.37 %)
The number (and %) of the tumor suppressors	17 (11.56 %)
Total number of binary PPIs (saturation %)	1031 (9.61 %)
The number (and %) of affected PPIs	146 (14.16 %)
The number of possible different fusions	39
PPI diameter	2
PPI radius	1
The average degree of PPI	13.156
Assortativity coefficient	-0.2501
The network average Clustering coefficient	0.516
The number (and %) of a zero Clustering coefficients	6 (4.08 %)
The number (and %) of a zero Betweenness Centrality	23 (15.65 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TPM3,ALK	All fusions : AF362886;
Proteins found in more fusions	MAPK1 (see 1 fusions); TPM2/MYH9 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); CENPF (see 1 fusions); TPM2 (see 1 fusions); AHCYL1 (see 3 fusions); ACTB (see 3 fusions); PRDX1 (see 1 fusions); PIK3R1 (see 1 fusions); ACTN2 (see 1 fusions); TLK1 (see 1 fusions); THOC1 (see 3 fusions); RACK1/FN1 (see 1 fusions); LRRK2 (see 1 fusions); DAPK1 (see 1 fusions); MYO6 (see 3 fusions); TP53 (see 3 fusions); HSPB1/OBSL1 (see 1 fusions); TPM1 (see 2 fusions); HSP90AA1 (see 2 fusions); JAK2 (see 3 fusions); TPM2/TPM1 (see 1 fusions); ACTN1 (see 3 fusions); HSP90AB1 (see 1 fusions); SP1 (see 1 fusions); STAT3 (see 2 fusions); MAD1L1 (see 3 fusions); EIF4A2 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); RACK1 (see 3 fusions); EPHB2 (see 1 fusions); HSPB1 (see 3 fusions); SHC1 (see 1 fusions); TNNT1 (see 1 fusions); ATP1A1/MAPK1 (see 1 fusions);

List of the fusions

PPI for parental proteins: TPM3,ALK

All fusions

: AF362886;

Proteins found in more fusions

MAPK1 (see 1 fusions); TPM2/MYH9 (see 1 fusions); CUL7 (see 2 fusions); CUL3 (see 1 fusions); GRB2 (see 1 fusions); CENPF (see 1 fusions); TPM2 (see 1 fusions); AHCYL1 (see 3 fusions); ACTB (see 3 fusions); PRDX1 (see 1 fusions); PIK3R1 (see 1 fusions); ACTN2 (see 1 fusions); TLK1 (see 1 fusions); THOC1 (see 3 fusions); RACK1/FN1 (see 1 fusions); LRRK2 (see 1 fusions); DAPK1 (see 1 fusions); MYO6 (see 3 fusions); TP53 (see 3 fusions); HSPB1/OBSL1 (see 1 fusions); TPM1 (see 2 fusions); HSP90AA1 (see 2 fusions); JAK2 (see 3 fusions); TPM2/TPM1 (see 1 fusions); ACTN1 (see 3 fusions); HSP90AB1 (see 1 fusions); SP1 (see 1 fusions); STAT3 (see 2 fusions); MAD1L1 (see 3 fusions); EIF4A2 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); RACK1 (see 3 fusions); EPHB2 (see 1 fusions); HSPB1 (see 3 fusions); SHC1 (see 1 fusions); TNNT1 (see 1 fusions); ATP1A1/MAPK1 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AF362886	chimera	146	0.078	13517.509	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SlyX (PF04102, IPR007236): SlyX Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
2	ACTB	oncoprotein	19	0.477	25.425	Actin (PF00022, IPR004000, SM00268): Actin
3	ACTN1	protein found in more fusions	26	0.460	71.446	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
4	ACTN2	protein found in more fusions	9	0.679	6.908	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5	ACTN4	interactor	28	0.429	85.969	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
6	ADD1	interactor	6	0.867	0.336	Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
7	AHCYL1	suppressor	9	0.393	9.494	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
8	ANLN	oncoprotein	16	0.700	13.626	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
9	ATP1A1	protein found in more fusions	11	0.382	15.171	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase Tetraspannin (PF00335, IPR018499): Tetraspanin family Cation_ATPase (PF13246): Cation transport ATPase (P-type)
10	ATP5F1	interactor	11	0.418	13.660	Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
11	BLOC1S6	interactor	5	0.500	3.000	BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
12	BRCA1	suppressor	21	0.258	80.816	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
13	C1orf216	interactor	3	0.667	1.000	DUF4653 (PF15546, IPR027812): Domain of unknown function (DUF4653)
14	CAP1	interactor	11	0.733	3.311	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
15	CAPZA2	interactor	26	0.489	58.218	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
16	CCDC102B	interactor	6	0.700	2.000	Filament (PF00038, IPR001664): Intermediate filament protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Myosin_tail_1 (PF01576, IPR002928): Myosin tail PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
17	CCDC114	interactor	2	1.000	0	FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Histone_HNS (PF00816, IPR001801): H-NS histone family Hydantoinase_B (PF02538, IPR003692): Hydantoinase B/oxoprolinase DUF2353 (PF09789, IPR019179): Uncharacterized coiled-coil protein (DUF2353) PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
18	CCDC146	interactor	4	0.500	3.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
19	CCHCR1	interactor	8	0.333	12.000	HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
20	CDC123	interactor	2	1.000	0	D123 (PF07065, IPR009772): D123
21	CDK2	suppressor	37	0.295	192.781	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
22	CENPF	oncoprotein	4	1.000	0	APG6 (PF04111, IPR007243): Autophagy protein Apg6 ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like bZIP_1 (PF00170, IPR004827): bZIP transcription factor DivIC (PF04977, IPR007060): Septum formation initiator DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ZapB (PF06005, IPR009252): Cell division protein ZapB DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972) Fez1 (PF06818): Fez1 Filament (PF00038, IPR001664): Intermediate filament protein HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7) IncA (PF04156, IPR007285): IncA protein Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein Usp (PF00582, IPR006016): Universal stress protein family CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-F_N (PF10481, IPR018463): Cenp-F N-terminal domain CENP-F_C_Rb_bdg (PF10490, IPR018302): Rb-binding domain of kinetochore protein Cenp-F/LEK1 DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450) DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140) DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239) TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
23	CKB	interactor	13	0.487	13.495	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
24	CKMT1A	interactor	3	0.667	0.500	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
25	CKMT1B	interactor	4	0.667	0.682	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
26	CORO1C	oncoprotein	20	0.526	25.179	DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899) WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat WD40_4 (PF16300): Type of WD40 repeat
27	COX4I1	interactor	7	0.571	7.000	COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
28	COX5A	interactor	6	0.533	3.332	COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
29	CUL3	protein found in more fusions	32	0.183	230.893	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
30	CUL7	protein found in more fusions	28	0.234	122.763	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
31	CYC1	interactor	9	0.389	11.667	Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
32	DAPK1	suppressor	10	0.444	7.060	ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
33	DVL2	interactor	10	0.444	11.248	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
34	EGFR	oncoprotein	30	0.308	150.776	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
35	EIF4A2	oncoprotein	6	0.500	2.956	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
36	ELAVL1	oncoprotein	33	0.220	247.147	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
37	EPHA1	suppressor	3	0.667	0.200	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
38	EPHB2	suppressor	4	1.000	0	EGF_2 (PF07974, IPR013111): EGF-like domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
39	FAM9C	interactor	1	0	0	Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
40	FASN	interactor	16	0.476	19.853	Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain KR (PF08659, IPR013968, SM00130): KR domain L27 (PF02828, IPR014775, SM00569): L27 domain Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site Thioesterase (PF00975, IPR001031): Thioesterase domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
41	FBXO5	oncoprotein	6	0.333	4.046	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain F-box (PF00646, IPR001810, SM00256): F-box domain
42	FKBP4	interactor	11	0.655	5.596	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
43	FKBP5	interactor	11	0.491	15.991	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
44	FLII	oncoprotein	16	0.567	17.427	Gelsolin (PF00626, IPR007123): Gelsolin repeat SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
45	FN1	oncoprotein	28	0.257	126.191	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
46	GAK	oncoprotein	4	0.833	0.200	DnaJ (PF00226, IPR001623, SM00271): DnaJ domain DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain Pkinase (PF00069, IPR000719): Protein kinase domain PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
47	GRB2	oncoprotein	27	0.363	99.485	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
48	HDAC8	interactor	5	0.500	1.765	DNase-RNase (PF02577, IPR003729): Bifunctional nuclease Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
49	HDDC3	interactor	1	0	0	HD_4 (PF13328, IPR003607): HD domain
50	HOOK2	interactor	4	0.667	0.182	HOOK (PF05622, IPR008636): HOOK protein
51	HSF2	interactor	2	1.000	0	HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
52	HSP90AA1	oncoprotein	41	0.255	311.445	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
53	HSP90AB1	oncoprotein	35	0.312	165.888	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
54	HSPB1	oncoprotein	22	0.324	91.081	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
55	HSPD1	suppressor	20	0.358	49.037	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
56	IFIT3	interactor	3	1.000	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
57	IKBIP	interactor	2	1.000	0	Fez1 (PF06818): Fez1 Occludin_ELL (PF07303, IPR010844): Occludin homology domain GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
58	IKBKG	interactor	19	0.268	70.202	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
59	IQGAP1	interactor	36	0.368	157.945	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
60	IRS1	interactor	8	0.643	6.400	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
61	JAK2	oncoprotein	17	0.483	27.262	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
62	JAK3	oncoprotein	7	0.429	8.300	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
63	KCNE1	interactor	1	0	0	ISK_Channel (PF02060, IPR000369): Slow voltage-gated potassium channel
64	KIFC3	oncoprotein	5	0.833	0.667	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
65	KRT18	interactor	13	0.303	26.610	Filament (PF00038, IPR001664): Intermediate filament protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
66	KXD1	interactor	2	1.000	0	KxDL (PF10241, IPR019371): Uncharacterized conserved protein
67	KYNU	interactor	3	0.667	1.000	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
68	LCA5L	interactor	1	0	0	DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515) Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
69	LRRK2	oncoprotein	14	0.397	20.078	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
70	LURAP1	interactor	2	1.000	0	LURAP (PF14854): Leucine rich adaptor protein DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
71	MAD1L1	suppressor	5	0.500	1.487	MAD (PF05557, IPR008672): Mitotic checkpoint protein Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
72	MAGEA11	interactor	6	0.400	5.333	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
73	MAGED2	interactor	13	0.500	18.915	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 MAGE (PF01454, IPR002190): MAGE family SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
74	MAP2K7	interactor	7	0.429	5.166	Pkinase (PF00069, IPR000719): Protein kinase domain
75	MAP3K1	oncoprotein	14	0.359	26.039	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Pkinase (PF00069, IPR000719): Protein kinase domain zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
76	MAPK1	oncoprotein	18	0.301	45.251	Pkinase (PF00069, IPR000719): Protein kinase domain
77	MAPK8IP3	interactor	5	0.700	1.400	Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1 Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449 JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
78	MCC	suppressor	4	0.500	2.500	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair FAM76 (PF16046, IPR032017): FAM76 protein
79	MCM2	oncoprotein	31	0.361	111.911	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
80	MCM3	interactor	13	0.526	10.521	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
81	MDC1	suppressor	10	0.556	10.597	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
82	MGEA5	oncoprotein	11	0.509	14.794	NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
83	MOV10	interactor	16	0.233	55.895	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
84	MTCH1	interactor	4	0.500	0.952	YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
85	MYBPC2	interactor	1	0	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain
86	MYH10	interactor	12	0.470	14.667	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
87	MYH7B	interactor	7	0.714	2.650	Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
88	MYH9	suppressor	31	0.501	62.397	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
89	MYO18A	interactor	22	0.532	38.323	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
90	MYO19	interactor	19	0.649	13.714	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
91	MYO5C	interactor	16	0.650	12.283	DIL (PF01843, IPR018444, SM01132): DIL domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD) Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) YtxH (PF12732, IPR024623): YtxH-like protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
92	MYO6	protein found in more fusions	18	0.449	29.760	BUD22 (PF09073, IPR015158): BUD22 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Rad9 (PF04139, IPR007268): Rad9 Sec62 (PF03839, IPR004728): Translocation protein Sec62 XhlA (PF10779, IPR019715): Haemolysin XhlA Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887) Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
93	NDUFB10	interactor	5	0.700	1.083	NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
94	NEK2	interactor	7	0.467	6.786	Pkinase (PF00069, IPR000719): Protein kinase domain
95	NTRK1	oncoprotein	60	0.167	934.454	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
96	NXF1	interactor	19	0.268	61.826	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
97	OBSL1	protein found in more fusions	30	0.268	140.180	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
98	OIP5	interactor	3	0.667	0.500	Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
99	OSTF1	interactor	5	0.500	1.305	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
100	PAN2	interactor	22	0.377	53.439	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
101	PARK2	suppressor	20	0.263	56.028	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
102	PAXIP1	interactor	7	0.524	4.971	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
103	PBX3	interactor	1	0	0	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain PBC (PF03792, IPR005542): PBC domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
104	PDLIM3	interactor	2	1.000	0	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
105	PDLIM7	interactor	15	0.581	17.756	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
106	PIK3R1	oncoprotein	13	0.576	10.218	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
107	PLCG1	oncoprotein	11	0.509	12.797	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
108	PPP1CB	interactor	24	0.580	31.521	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
109	PPP1CC	oncoprotein	20	0.384	61.531	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
110	PRDX1	oncoprotein	12	0.400	5.750	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
111	PRKCQ	interactor	4	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
112	PSMA2	interactor	7	0.733	0.697	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
113	PSMA6	interactor	12	0.379	17.899	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
114	RAB35	oncoprotein	2	1.000	0	Ras (PF00071, IPR001806, SM00173): Ras family
115	RACK1	suppressor	17	0.333	37.549	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
116	RAD21	oncoprotein	11	0.527	9.637	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
117	RNF2	interactor	14	0.269	29.511	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
118	SEC23IP	interactor	3	0.667	1.000	DDHD (PF02862, IPR004177, SM01127): DDHD domain SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) WWE (PF02825, IPR004170, SM00678): WWE domain
119	SEPT9	oncoprotein	7	0.429	4.255	Septin (PF00735, IPR000038): Septin DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
120	SF3A2	interactor	8	0.679	2.645	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
121	SHC1	oncoprotein	22	0.376	46.491	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
122	SHC3	interactor	3	1.000	0	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
123	SHMT2	interactor	10	0.311	13.660	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
124	SMC6	interactor	3	1.000	0	SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
125	SOCS1	suppressor	7	0.810	1.293	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS_box (PF07525, IPR001496): SOCS box
126	SP1	protein found in more fusions	17	0.425	33.517	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
127	SRC	oncoprotein	19	0.333	63.491	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
128	STAT3	suppressor	16	0.352	34.235	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
129	STMN1	interactor	7	0.429	4.624	Stathmin (PF00836, IPR000956): Stathmin family
130	SYCE1	interactor	5	0.500	3.952	CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
131	TBCD	interactor	5	0.700	0.908	HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal HEAT_EZ (PF13513): HEAT-like repeat
132	TFPT	oncoprotein	3	1.000	0	GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
133	THAP1	interactor	4	1.000	0	THAP (PF05485, IPR006612, SM00980): THAP domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
134	THOC1	protein found in more fusions	5	0.500	0.801	Death (PF00531, IPR000488, SM00005): Death domain efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
135	TLK1	protein found in more fusions	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
136	TNNT1	protein found in more fusions	4	0.667	0.154	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
137	TP53	suppressor	36	0.255	236.343	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
138	TP73	suppressor	6	0.900	0.200	P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
139	TPM1	protein found in more fusions	41	0.221	412.050	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
140	TPM2	protein found in more fusions	28	0.362	134.157	DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
141	TPM4	oncoprotein	39	0.273	304.125	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
142	TRAP1	oncoprotein	12	0.424	13.790	HSP90 (PF00183, IPR001404): Hsp90 protein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
143	TRIM27	oncoprotein	9	0.357	15.876	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
144	TRIP6	interactor	8	0.357	11.438	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region LIM (PF00412, IPR001781, SM00132): LIM domain
145	TUBB4B	interactor	19	0.427	24.773	Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
146	UQCRC2	oncoprotein	8	0.571	6.003	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
147	VPS52	interactor	4	0.667	1.000	Vps52 (PF04129, IPR007258): Vps52 / Sac2 family COG5 (PF10392, IPR019465): Golgi transport complex subunit 5 Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ALK	parental protein	MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A Gly_rich (PF12810): Glycine rich protein FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
2	BCAR1	oncoprotein	Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513) Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
3	BICD2	interactor	BicD (PF09730, IPR018477): Microtubule-associated protein Bicaudal-D
4	CDK13	interactor	K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Pkinase (PF00069, IPR000719): Protein kinase domain Macoilin (PF09726, IPR019130): Transmembrane protein THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
5	EIF4B	interactor	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3774 (PF12609, IPR022251): Wound-induced protein PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
6	ERRFI1	suppressor	GTPase_binding (PF09027, IPR015116): GTPase binding Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
7	IRF7	interactor	IRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
8	IRS4	interactor	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence PH_11 (PF15413): Pleckstrin homology domain
9	KRT74	interactor	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region Keratin_2_head (PF16208, IPR032444): Keratin type II head
10	MAP3K4	suppressor	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Pkinase (PF00069, IPR000719): Protein kinase domain PLU-1 (PF08429, IPR013637): PLU-1-like protein Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3 DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
11	MAP3K5	oncoprotein	Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
12	MEP1B	interactor	Astacin (PF01400, IPR001506): Astacin (Peptidase family M12A) EGF (PF00008, IPR000742, SM00181): EGF-like domain MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
13	MTIF2	interactor	GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family IF-2 (PF11987, IPR023115): Translation-initiation factor 2
14	MYLK	interactor	Amelogenin (PF02948, IPR004116, SM00818): Amelogenin fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase (PF00069, IPR000719): Protein kinase domain 23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
15	PDX1	suppressor	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Homeobox (PF00046, IPR001356, SM00389): Homeobox domain TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
16	PIK3CB	oncoprotein	PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) RWD (PF05773, IPR006575, SM00591): RWD domain PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
17	PLCB2	oncoprotein	C2 (PF00168, IPR000008, SM00239): C2 domain DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154) EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682) FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
18	PTN	oncoprotein	PTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
19	PXN	oncoprotein	LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family
20	RAD17	interactor	Mvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12 Rad17 (PF03215): Rad17 cell cycle checkpoint protein
21	SOCS5	interactor	SH2 (PF00017, IPR000980, SM00252): SH2 domain SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling SOCS_box (PF07525, IPR001496): SOCS box
22	TNK2	interactor	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal GTPase_binding (PF09027, IPR015116): GTPase binding Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6 UBA_4 (PF14555): UBA-like domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
23	TPM3	parental protein	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
24	TUBGCP2	interactor	Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
25	UBASH3A	interactor	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Ste5 (PF11610, IPR021651): Scaffold protein Ste5-Fus5 binding region SH3_9 (PF14604, IPR001452): Variant SH3 domain
26	VIM	suppressor	Filament (PF00038, IPR001664): Intermediate filament protein Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
27	WASH3P	interactor	NA
28	ZC3HC1	interactor	Rsm1 (PF08600, IPR013909): Rsm1-like zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like

B a c k t o T o p ⇑

Fusion ID: Protein names:	AF362886
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