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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AF310158 is the fusion of parental proteins RPN1, MECOM (from a repository: Sun Nov 20 09:47:11 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)164
The number (and %) of the onco-proteins50 (30.49 %)
The number (and %) of the tumor suppressors12 (7.32 %)
Total number of binary PPIs (saturation %)1677 (12.55 %)
The number (and %) of affected PPIs163 (9.72 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI19.793
Assortativity coefficient-0.1342
The network average Clustering coefficient0.439
The number (and %) of a zero Clustering coefficients4 (2.44 %)
The number (and %) of a zero Betweenness Centrality10 (6.10 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: MECOM,RPN1 All fusions
: AF310158;
Proteins found in more fusions TUBG1 (see 1 fusions); PSMC2 (see 1 fusions); CTBP1 (see 2 fusions); SMAD4 (see 2 fusions); STAU1 (see 2 fusions); PRPF19 (see 2 fusions); U2AF2 (see 2 fusions); CUL3 (see 1 fusions); MYC (see 1 fusions); UBQLN1 (see 2 fusions); KAT2B (see 1 fusions); NELFB (see 1 fusions); COPS5 (see 1 fusions); HDAC5 (see 1 fusions); OS9 (see 2 fusions); ILK (see 1 fusions); ATP1A1/VDAC3 (see 2 fusions); CRY2 (see 3 fusions); VCP (see 4 fusions); HDAC4 (see 1 fusions); ERBB3 (see 2 fusions); CREBBP (see 5 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); ATP5A1 (see 1 fusions); SUV39H1 (see 1 fusions); PSMC5 (see 2 fusions); SMAD3 (see 3 fusions); CDK9 (see 2 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AF310158chimera1630.11112698.685Ribophorin_I (PF04597, IPR007676): Ribophorin I
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
2 ABCB7interactor40.5000.687ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region
ABC_tran (PF00005, IPR003439): ABC transporter
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
AAA_23 (PF13476): AAA domain
3 ACADMoncoprotein220.46341.834Acyl-CoA_dh_1 (PF00441, IPR009075): Acyl-CoA dehydrogenase, C-terminal domain
Acyl-CoA_dh_M (PF02770, IPR006091): Acyl-CoA dehydrogenase, middle domain
Acyl-CoA_dh_N (PF02771, IPR013786): Acyl-CoA dehydrogenase, N-terminal domain
4 ADRB2interactor240.37540.0327tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
5 AFG3L2interactor140.6157.634AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
FtsH_ext (PF06480, IPR011546): FtsH Extracellular
Peptidase_M41 (PF01434, IPR000642): Peptidase family M41
TniB (PF05621, IPR008868): Bacterial TniB protein
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
6 ASB11interactor30.6670.500Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
7 ASB5interactor30.6670.200Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
SOCS_box (PF07525, IPR001496): SOCS box
8 ATAD3Ainteractor200.34733.235AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
9 ATAD3Binteractor120.4559.754AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
TsaE (PF02367, IPR003442): Threonylcarbamoyl adenosine biosynthesis protein TsaE
DUF3523 (PF12037, IPR021911): Domain of unknown function (DUF3523)
10 ATF2oncoprotein220.32963.695bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
11 ATP1A1protein found in more fusions510.268408.738Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
12 ATP5A1protein found in more fusions360.311147.810ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_C (PF00306, IPR000793): ATP synthase alpha/beta chain, C terminal domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
13 ATP5C1interactor340.396115.738ATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
14 ATP5Linteractor160.38329.730ATP-synt_G (PF04718, IPR006808): Mitochondrial ATP synthase g subunit
15 ATP6V0D1interactor180.51024.003vATP-synt_AC39 (PF01992, IPR002843): ATP synthase (C/AC39) subunit
16 ATP6V1Ainteractor190.53824.153ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain
ATP-synt_ab_N (PF02874, IPR004100): ATP synthase alpha/beta family, beta-barrel domain
ATP-synt_ab_Xtn (PF16886, IPR031686): ATPsynthase alpha/beta subunit N-term extension
17 BAG6interactor140.34631.995DUF1179 (PF06678, IPR009564): Protein of unknown function (DUF1179)
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
DUF2939 (PF11159, IPR021330): Protein of unknown function (DUF2939)
DUF3538 (PF12057, IPR021925): Domain of unknown function (DUF3538)
PRIMA1 (PF16101): Proline-rich membrane anchor 1
18 BCAP29interactor40.6670.571Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
ZapB (PF06005, IPR009252): Cell division protein ZapB
19 BMI1oncoprotein170.36729.212zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
20 CANXinteractor440.293272.541Calreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
21 CCDC47interactor150.24838.843DUF1682 (PF07946, IPR012879): Protein of unknown function (DUF1682)
STAC2_u1 (PF16664): Unstructured on SH3 and cysteine-rich domain-containing protein 2
22 CCT3interactor320.42178.706Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
23 CCT6Ainteractor360.403105.627Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
24 CCT7interactor240.55822.061Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
25 CCT8interactor300.43265.790Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
26 CDC5Linteractor350.340130.964OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component
Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
27 CDK9protein found in more fusions160.38125.921Pkinase (PF00069, IPR000719): Protein kinase domain
28 CLGNinteractor110.5278.590Calreticulin (PF00262, IPR001580): Calreticulin family
CDC45 (PF02724, IPR003874): CDC45-like protein
S-antigen (PF05756, IPR008825): S-antigen protein
DUF3742 (PF12553, IPR022213): Protein of unknown function (DUF3742)
SieB (PF14163, IPR025982): Super-infection exclusion protein B
29 CLN3interactor160.45016.935CLN3 (PF02487, IPR003492): CLN3 protein
30 CLN5interactor70.5243.634CLN5 (PF15014, IPR026138): Ceroid-lipofuscinosis neuronal protein 5
31 CLTConcoprotein420.345187.605Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
Clathrin_propel (PF01394, IPR022365): Clathrin propeller repeat
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
Clathrin_H_link (PF13838): Clathrin-H-link
32 COPS5protein found in more fusions330.365102.414JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
33 CREBBPsuppressor180.43435.665Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
34 CRY2protein found in more fusions120.38212.409DNA_photolyase (PF00875, IPR006050): DNA photolyase
FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
35 CTBP1protein found in more fusions180.30954.3342-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
36 CUL3protein found in more fusions530.272312.129Cullin (PF00888, IPR001373, SM00182): Cullin family
Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain
WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
37 CYC1interactor260.37871.528Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
38 DDOSTinteractor380.340199.760DDOST_48kD (PF03345, IPR005013): Oligosaccharyltransferase 48 kDa subunit beta
39 DDX39Ainteractor120.43613.403DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
40 DDX39Binteractor210.35743.589DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
41 ECT2suppressor90.27813.871BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
PTCB-BRCT (PF12738, IPR001357): twin BRCT domain
PGBA_C (PF15437, IPR032737): Plasminogen-binding protein pgbA C-terminal
42 EEDsuppressor260.29391.408WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
43 EGFRoncoprotein360.249225.837Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
44 EHMT2interactor100.5287.592CDC45 (PF02724, IPR003874): CDC45-like protein
Pre-SET (PF05033, IPR007728): Pre-SET motif
Ribosomal_L32p (PF01783, IPR002677): Ribosomal L32p protein family
SET (PF00856, IPR001214, SM00317): SET domain
SMN (PF06003, IPR010304): Survival motor neuron protein (SMN)
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
CSRNP_N (PF16019, IPR031972): Cysteine/serine-rich nuclear protein N-terminus
45 EIF2S1interactor80.5362.609EIF_2_alpha (PF07541, IPR011488): Eukaryotic translation initiation factor 2 alpha subunit
S1 (PF00575, IPR003029, SM00316): S1 RNA binding domain
46 EIF3Minteractor41.0000Death (PF00531, IPR000488, SM00005): Death domain
PCI (PF01399, IPR000717, SM00088): PCI domain
47 ELAVL1oncoprotein410.201364.644RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
48 ERBB3oncoprotein100.4177.390Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
49 ESR1suppressor380.237218.068Oest_recep (PF02159, IPR001292): Oestrogen receptor
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
ESR1_C (PF12743, IPR024736): Oestrogen-type nuclear receptor final C-terminal
50 EVC2interactor30.6670.333HBS1_N (PF08938, IPR015033): HBS1 N-terminus
DUF342 (PF03961, IPR005646): Protein of unknown function (DUF342)
Histone_HNS (PF00816, IPR001801): H-NS histone family
EVC2_like (PF12297, IPR022076): Ellis van Creveld protein 2 like protein
51 FBXO25suppressor190.33932.826Elongin_A (PF06881, IPR010684): RNA polymerase II transcription factor SIII (Elongin) subunit A
52 FBXO6interactor560.212533.412FBA (PF04300, IPR007397): F-box associated region
F-box-like (PF12937, IPR001810): F-box-like
53 FN1oncoprotein400.213220.142fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
54 FOXJ2interactor31.0000SARAF (PF06682, IPR009567): SOCE-associated regulatory factor of calcium homoeostasis
DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360)
Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
Spt20 (PF12090, IPR021950): Spt20 family
Pro-rich (PF15240, IPR026086): Proline-rich
55 FOXRED2interactor70.5713.755Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
56 GSTK1interactor80.5713.066DSBA (PF01323, IPR001853): DSBA-like thioredoxin domain
57 HDAC1suppressor290.291147.629FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
58 HDAC4oncoprotein120.52711.091Borrelia_P83 (PF05262, IPR007926): Borrelia P83/100 protein
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
59 HDAC5protein found in more fusions380.305153.984Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
NOA36 (PF06524, IPR010531): NOA36 protein
Activator_LAG-3 (PF11498, IPR021587): Transcriptional activator LAG-3
HDAC4_Gln (PF12203, IPR024643): Glutamine rich N terminal domain of histone deacetylase 4
60 HIC1suppressor80.4765.500BTB (PF00651, IPR013069, SM00225): BTB/POZ domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_4 (PF13894): C2H2-type zinc finger
61 HNRNPUinteractor350.308169.742CDC45 (PF02724, IPR003874): CDC45-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
SAP (PF02037, IPR003034, SM00513): SAP domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
AAA_33 (PF13671): AAA domain
WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
62 HSD17B12interactor250.39759.383adh_short (PF00106, IPR002198): short chain dehydrogenase
63 HSP90B1suppressor350.360140.310CobT (PF06213, IPR006538): Cobalamin biosynthesis protein CobT
HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
Sigma70_ner (PF04546, IPR007631): Sigma-70, non-essential region
64 HSPA5oncoprotein390.283227.223HSP70 (PF00012, IPR013126): Hsp70 protein
65 IDH3Ainteractor160.38326.369Iso_dh (PF00180, IPR024084): Isocitrate/isopropylmalate dehydrogenase
66 ILF3oncoprotein290.33593.145dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
67 ILKsuppressor210.45330.184Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_4 (PF13637): Ankyrin repeats (many copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
68 INSIG2interactor80.6073.659INSIG (PF07281, IPR025929): Insulin-induced protein (INSIG)
69 IPO5interactor180.37926.244HEAT (PF02985, IPR000357): HEAT repeat
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RTP1_C1 (PF10363, IPR019451): Required for nuclear transport of RNA pol II C-terminus 1
DUF3385 (PF11865, IPR024585): Domain of unknown function (DUF3385)
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_EZ (PF13513): HEAT-like repeat
AAA_30 (PF13604): AAA domain
HEAT_2 (PF13646): HEAT repeats
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
70 IPO9interactor150.40028.100IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
RIX1 (PF08167, IPR012583): rRNA processing/ribosome biogenesis
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
71 KAT2Bprotein found in more fusions110.48911.255Acetyltransf_1 (PF00583, IPR000182): Acetyltransferase (GNAT) family
PCAF_N (PF06466, IPR009464): PCAF (P300/CBP-associated factor) N-terminal domain
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
72 KDSRoncoprotein100.6006.2467kD_coat (PF02495, IPR003411): 7kD viral coat protein
adh_short (PF00106, IPR002198): short chain dehydrogenase
73 LGR4interactor110.3785.5737tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family)
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
74 MBD3interactor70.4673.634DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
75 MCM2oncoprotein390.354112.282AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
76 MED23interactor110.47314.239Med23 (PF11573, IPR021629): Mediator complex subunit 23
77 MMS19interactor160.35035.361DUF3437 (PF11919, IPR021843): Domain of unknown function (DUF3437)
MMS19_C (PF12460, IPR024687): RNAPII transcription regulator C-terminal
HEAT_2 (PF13646): HEAT repeats
MMS19_N (PF14500): Dos2-interacting transcription regulator of RNA-Pol-II
78 MTCH1interactor150.35230.537YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase
Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
79 MTCH2interactor220.48133.380Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
80 MYConcoprotein320.288139.571HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
81 NDUFA12interactor90.6672.325NDUFA12 (PF05071, IPR007763): NADH ubiquinone oxidoreductase subunit NDUFA12
82 NDUFB8interactor130.55110.726NDUF_B8 (PF05821, IPR008699): NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)
83 NDUFB9interactor90.6114.346Complex1_LYR (PF05347, IPR008011): Complex 1 protein (LYR family)
84 NELFBprotein found in more fusions80.6191.312COBRA1 (PF06209, IPR010405): Cofactor of BRCA1 (COBRA1)
85 NHSinteractor30.6670.333Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
NHS (PF15273, IPR024845): NHS-like
86 NLRP14interactor100Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
LRR_1 (PF00560, IPR001611): Leucine Rich Repeat
NACHT (PF05729): NACHT domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
AAA_16 (PF13191): AAA ATPase domain
LRR_6 (PF13516, IPR001611): Leucine Rich repeat
87 NOMO1interactor70.4765.746DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
DUF2141 (PF09912, IPR018673): Uncharacterized protein conserved in bacteria (DUF2141)
NikM (PF10670, IPR019613): Domain of unknown function (DUF4198)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
SdrD_B (PF17210): SdrD B-like domain
88 NOMO2interactor21.0000DUF2012 (PF09430, IPR019008): Protein of unknown function (DUF2012)
NikM (PF10670, IPR019613): Domain of unknown function (DUF4198)
CarboxypepD_reg (PF13620): Carboxypeptidase regulatory-like domain
fn3_3 (PF14686, IPR029413): Polysaccharide lyase family 4, domain II
SdrD_B (PF17210): SdrD B-like domain
89 NTRK1oncoprotein790.1911145.764I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
90 OS9protein found in more fusions130.50015.102DNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
91 OST4interactor21.0000Ost4 (PF10215, IPR018943): Oligosaccaryltransferase
92 PCinteractor140.6265.513Biotin_carb_C (PF02785, IPR005482, SM00878): Biotin carboxylase C-terminal domain
Biotin_lipoyl (PF00364, IPR000089): Biotin-requiring enzyme
Biotin_carb_N (PF00289, IPR005481): Biotin carboxylase, N-terminal domain
CPSase_L_D2 (PF02786, IPR005479): Carbamoyl-phosphate synthase L chain, ATP binding domain
HMGL-like (PF00682, IPR000891): HMGL-like
PYC_OADA (PF02436, IPR003379): Conserved carboxylase domain
93 PDIA6interactor150.45711.103FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
94 PIAS4interactor90.6116.261CENP-B_dimeris (PF09026, IPR015115): Centromere protein B dimerisation domain
SAP (PF02037, IPR003034, SM00513): SAP domain
zf-MIZ (PF02891, IPR004181): MIZ/SP-RING zinc finger
PINIT (PF14324, IPR023321): PINIT domain
95 PIK3R3interactor40.6670.667SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
96 PKMoncoprotein130.4499.905PK (PF00224, IPR015793): Pyruvate kinase, barrel domain
PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
97 PPIBinteractor160.31737.921Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD
98 PPP2R1Aoncoprotein320.345111.776TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain
HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
99 PPP2R1Bsuppressor90.5363.910HEAT (PF02985, IPR000357): HEAT repeat
Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region
HEAT_2 (PF13646): HEAT repeats
100 PRPF19protein found in more fusions150.46216.082Prp19 (PF08606, IPR013915): Prp19/Pso4-like
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
U-box (PF04564, IPR003613, SM00504): U-box domain
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
101 PSMC1interactor140.48416.103AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
DivIC (PF04977, IPR007060): Septum formation initiator
DUF815 (PF05673, IPR008533): Protein of unknown function (DUF815)
Prot_ATP_ID_OB (PF16450, IPR032501): Proteasomal ATPase OB/ID domain
102 PSMC2protein found in more fusions230.39056.390AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
103 PSMC3interactor190.33352.373AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
DUF3713 (PF12506, IPR022186): Protein of unknown function (DUF3713)
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
104 PSMC5protein found in more fusions250.31986.461AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
Laminin_II (PF06009, IPR010307): Laminin Domain II
RILP (PF11461, IPR021563): Rab interacting lysosomal protein
AAA_16 (PF13191): AAA ATPase domain
105 RAB1Aoncoprotein300.303150.287Ras (PF00071, IPR001806, SM00173): Ras family
106 RAB1Boncoprotein190.40940.609Ras (PF00071, IPR001806, SM00173): Ras family
107 RAB2Aoncoprotein200.27978.548Ras (PF00071, IPR001806, SM00173): Ras family
108 RAB5Aoncoprotein70.7621.091Ras (PF00071, IPR001806, SM00173): Ras family
109 RAB5Boncoprotein90.5564.437Ras (PF00071, IPR001806, SM00173): Ras family
110 RAB5Concoprotein150.43821.406Ras (PF00071, IPR001806, SM00173): Ras family
111 RABGAP1Loncoprotein100PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
RabGAP-TBC (PF00566, IPR000195, SM00164): Rab-GTPase-TBC domain
DUF3694 (PF12473, IPR022164): Kinesin protein
112 RDH13interactor70.6192.852adh_short (PF00106, IPR002198): short chain dehydrogenase
113 RNF185interactor130.31824.909zf-C3HC4_3 (PF13920): Zinc finger, C3HC4 type (RING finger)
114 RNF2interactor310.225141.313zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
115 RPL35interactor80.7141.151Ribosomal_L29 (PF00831, IPR001854): Ribosomal L29 protein
XFP_N (PF09364, IPR018970): XFP N-terminal domain
116 RPN2interactor380.279211.900Ribophorin_II (PF05817, IPR008814): Oligosaccharyltransferase subunit Ribophorin II
117 RPS6KB2interactor210.31442.930Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
118 RPSAinteractor220.46827.037Ribosomal_S2 (PF00318, IPR001865): Ribosomal protein S2
40S_SA_C (PF16122, IPR032281): 40S ribosomal protein SA C-terminus
119 SCAMP2interactor30.6670.333SCAMP (PF04144, IPR007273): SCAMP family
KfrA_N (PF11740, IPR021104): Plasmid replication region DNA-binding N-term
120 SCCPDHinteractor21.0000Sacchrp_dh_NADP (PF03435, IPR005097): Saccharopine dehydrogenase NADP binding domain
121 SEL1Loncoprotein90.6114.778fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
Sel1 (PF08238, IPR006597, SM00671): Sel1 repeat
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
122 SGTAinteractor50.7001.233TOM20_plant (PF06552, IPR010547): Plant specific mitochondrial import receptor subunit TOM20
TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
XPC-binding (PF09280, IPR015360): XPC-binding domain
TPR_17 (PF13431): Tetratricopeptide repeat
SGTA_dimer (PF16546, IPR032374): Homodimerisation domain of SGTA
123 SLC25A3interactor420.317207.046Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
124 SLC25A5interactor250.30772.816Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
125 SLX4IPinteractor100UPF0492 (PF15744, IPR031479): Uncharacterized protein family UPF0492
126 SMAD1interactor90.8211.769MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
127 SMAD2suppressor210.38454.685MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
128 SMAD3oncoprotein200.39851.111MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
129 SMAD4suppressor130.53012.740MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
130 SND1interactor140.46218.265TUDOR (PF00567, IPR002999, SM00333): Tudor domain
SNase (PF00565, IPR016071, SM00318): Staphylococcal nuclease homologue
131 SOX2oncoprotein130.30324.102HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
132 SPDEFinteractor100Ets (PF00178, IPR000418, SM00413): Ets-domain
SAM_PNT (PF02198, IPR003118, SM00251): Sterile alpha motif (SAM)/Pointed domain
133 SSR1interactor270.33094.027TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
134 SSR2interactor31.0000TRAP_beta (PF05753, IPR008856): Translocon-associated protein beta (TRAPB)
135 SSR3interactor160.42524.693TRAP-gamma (PF07074, IPR009779): Translocon-associated protein, gamma subunit (TRAP-gamma)
136 SSR4interactor270.35969.371TRAP-delta (PF05404, IPR008855): Translocon-associated protein, delta subunit precursor (TRAP-delta)
OppC_N (PF12911, IPR025966): N-terminal TM domain of oligopeptide transport permease C
137 STAU1protein found in more fusions270.36359.482dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
Staufen_C (PF16482, IPR032478): Staufen C-terminal domain
138 STT3Binteractor120.39427.178STT3 (PF02516, IPR003674): Oligosaccharyl transferase STT3 subunit
139 SUCLG2interactor100.48910.164ATP-grasp_2 (PF08442, IPR013650): ATP-grasp domain
Ligase_CoA (PF00549, IPR005811): CoA-ligase
140 SUV39H1protein found in more fusions90.6794.804Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain
Pre-SET (PF05033, IPR007728): Pre-SET motif
SET (PF00856, IPR001214, SM00317): SET domain
141 SYNCRIPinteractor210.39047.695RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Limkain-b1 (PF11608, IPR024582): Limkain b1
142 TCP1interactor280.45549.782Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
143 TCTN1interactor110.4918.675DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
144 TCTN2interactor170.40423.938DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
145 TCTN3interactor200.33755.821DUF1619 (PF07773, IPR011677): Protein of unknown function (DUF1619)
146 TECRinteractor280.43954.312Steroid_dh (PF02544, IPR001104): 3-oxo-5-alpha-steroid 4-dehydrogenase
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
147 TMCO1interactor190.46829.845DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
148 TMEM63Binteractor90.6114.826RSN1_7TM (PF02714, IPR003864): Calcium-dependent channel, 7TM region, putative phosphate
Wzy_C (PF04932, IPR007016): O-Antigen ligase
DUF4006 (PF13179, IPR025065): Family of unknown function (DUF4006)
RSN1_TM (PF13967, IPR032880): Late exocytosis, associated with Golgi transport
PHM7_cyt (PF14703, IPR027815): Cytosolic domain of 10TM putative phosphate transporter
149 TMEM67interactor70.3817.258Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
NCD3G (PF07562, IPR011500): Nine Cysteines Domain of family 3 GPCR
Tme5_EGF_like (PF09064, IPR015149): Thrombomodulin like fifth domain, EGF-like
Meckelin (PF09773, IPR019170): Meckelin (Transmembrane protein 67)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
150 TUBA1Cinteractor260.46247.304Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
151 TUBG1protein found in more fusions180.51518.762Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
152 TUFMinteractor250.31761.488GTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
GTP_EFTU_D2 (PF03144, IPR004161): Elongation factor Tu domain 2
GTP_EFTU_D3 (PF03143, IPR004160): Elongation factor Tu C-terminal domain
153 U2AF2protein found in more fusions330.38982.803RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
154 UBE2Iinteractor180.34647.593UQ_con (PF00179, IPR000608): Ubiquitin-conjugating enzyme
155 UBL4Ainteractor270.276104.251ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
156 UBQLN1protein found in more fusions130.37916.495Clathrin-link (PF09268, IPR015348): Clathrin, heavy-chain linker
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
FAM199X (PF15814, IPR029672): Protein family FAM199X
157 UBQLN4interactor90.4299.541CRF (PF00473, IPR000187, SM00039): Corticotropin-releasing factor family
DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
Arm_2 (PF04826, IPR006911): Armadillo-like
NUDE_C (PF04880, IPR006964): NUDE protein, C-terminal conserved region
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
XPC-binding (PF09280, IPR015360): XPC-binding domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
Fur_reg_FbpB (PF13040, IPR025004): Fur-regulated basic protein B
partial_CstF (PF15861, IPR031721): Partial cleavage stimulation factor domain
158 UQCRC2oncoprotein500.280349.756Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16)
Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
159 USP49interactor30.6670.333UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase
zf-UBP (PF02148, IPR001607, SM00290): Zn-finger in ubiquitin-hydrolases and other protein
160 VCAM1interactor290.25683.136C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
161 VCPprotein found in more fusions420.317241.479AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
162 VDAC1interactor270.43371.299Porin_3 (PF01459, IPR027246): Eukaryotic porin
163 VDAC2interactor390.324207.403Porin_3 (PF01459, IPR027246): Eukaryotic porin
164 VDAC3protein found in more fusions220.55824.773Porin_3 (PF01459, IPR027246): Eukaryotic porin

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 MECOMparental proteinSET (PF00856, IPR001214, SM00317): SET domain
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
zf-C2H2_6 (PF13912, IPR007087): C2H2-type zinc finger
2 MT-CO2interactorNA
3 PRMT1interactorMethyltransf_25 (PF13649): Methyltransferase domain
4 RPN1parental proteinRibophorin_I (PF04597, IPR007676): Ribophorin I
CtIP_N (PF10482, IPR019518): Tumour-suppressor protein CtIP N-terminal domain
5 SCARNA22interactorNA
6 SIRT1suppressorDUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain

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