Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	125
The number (and %) of the onco-proteins	49 (39.20 %)
The number (and %) of the tumor suppressors	16 (12.80 %)
Total number of binary PPIs (saturation %)	828 (10.68 %)
The number (and %) of affected PPIs	124 (14.98 %)
The number of possible different fusions	25
PPI diameter	2
PPI radius	1
The average degree of PPI	12.416
Assortativity coefficient	-0.2548
The network average Clustering coefficient	0.474
The number (and %) of a zero Clustering coefficients	8 (6.40 %)
The number (and %) of a zero Betweenness Centrality	15 (12.00 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: KMT2A,GMPS	All fusions : AF297748;
Proteins found in more fusions	AFF1 (see 2 fusions); CTBP1 (see 2 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); IMPDH2 (see 2 fusions); RUNX1 (see 1 fusions); CREBBP (see 6 fusions); CREBBP/KAT6A (see 10 fusions); PAX6 (see 2 fusions); EWSR1 (see 2 fusions); KIF11 (see 1 fusions); KAT8 (see 1 fusions); MCM2 (see 1 fusions); HSPB1 (see 4 fusions); POLR2A (see 2 fusions); CHD3 (see 1 fusions); SMARCC1 (see 2 fusions); HCFC1 (see 2 fusions); MAP3K5 (see 1 fusions); DDX5 (see 1 fusions); NCL (see 3 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of the fusions

PPI for parental proteins: KMT2A,GMPS

All fusions

: AF297748;

Proteins found in more fusions

AFF1 (see 2 fusions); CTBP1 (see 2 fusions); PPME1 (see 1 fusions); CUL3 (see 1 fusions); IMPDH2 (see 2 fusions); RUNX1 (see 1 fusions); CREBBP (see 6 fusions); CREBBP/KAT6A (see 10 fusions); PAX6 (see 2 fusions); EWSR1 (see 2 fusions); KIF11 (see 1 fusions); KAT8 (see 1 fusions); MCM2 (see 1 fusions); HSPB1 (see 4 fusions); POLR2A (see 2 fusions); CHD3 (see 1 fusions); SMARCC1 (see 2 fusions); HCFC1 (see 2 fusions); MAP3K5 (see 1 fusions); DDX5 (see 1 fusions); NCL (see 3 fusions); TP53 (see 3 fusions); SNW1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AF297748	chimera	124	0.085	9803.088	AT_hook (PF02178, IPR017956, SM00384): AT hook motif Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 GATase (PF00117, IPR017926): Glutamine amidotransferase class-I GMP_synt_C (PF00958, IPR001674): GMP synthase C terminal domain NAD_synthase (PF02540, IPR022310): NAD synthase Plasmodium_Vir (PF05795, IPR008780): Plasmodium vivax Vir protein Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Secretin_N_2 (PF07655, IPR011514): Secretin N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
2	AFDN	oncoprotein	7	0.429	5.771	DIL (PF01843, IPR018444, SM01132): DIL domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FHA (PF00498, IPR000253, SM00240): FHA domain MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family MAS20 (PF02064, IPR002056): MAS20 protein import receptor Pap_E4 (PF02711, IPR003861): E4 protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain ARGLU (PF15346): Arginine and glutamate-rich 1
3	AFF1	oncoprotein	11	0.600	9.533	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
4	AFF4	oncoprotein	9	0.694	5.486	AF-4 (PF05110, IPR007797): AF-4 proto-oncoprotein
5	AGO2	interactor	6	0.667	1.673	ArgoL1 (PF08699, IPR014811, SM01163): Argonaute linker 1 domain PAZ (PF02170, IPR003100, SM00949): PAZ domain Piwi (PF02171, IPR003165, SM00950): Piwi domain ArgoN (PF16486, IPR032474): N-terminal domain of argonaute ArgoMid (PF16487, IPR032473): Mid domain of argonaute ArgoL2 (PF16488, IPR032472): Argonaute linker 2 domain
6	AGPAT2	interactor	1	0	0	Acyltransferase (PF01553, IPR002123, SM00563): Acyltransferase DUF4131 (PF13567, IPR025405): Domain of unknown function (DUF4131)
7	AHCY	interactor	9	0.536	7.140	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
8	APRT	interactor	5	0.600	2.500	Pribosyltran (PF00156, IPR000836): Phosphoribosyl transferase domain
9	ASB2	interactor	7	0.467	6.833	Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) Ank_4 (PF13637): Ankyrin repeats (many copies) Ank_5 (PF13857): Ankyrin repeats (many copies) SOCS_box (PF07525, IPR001496): SOCS box
10	AVP	interactor	2	0	0	Protamine_P1 (PF00260, IPR000221): Protamine P1
11	BABAM1	interactor	3	0.667	0.250	VWA_2 (PF13519, IPR002035): von Willebrand factor type A domain
12	BMI1	oncoprotein	23	0.342	84.795	zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
13	CBX4	oncoprotein	11	0.444	13.521	Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region CBX7_C (PF17218): CBX family C-terminal motif
14	CBX8	interactor	11	0.600	9.186	Atrophin-1 (PF03154, IPR002951): Atrophin-1 family Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain RBR (PF17208): RNA binding Region CBX7_C (PF17218): CBX family C-terminal motif
15	CCNT1	oncoprotein	13	0.515	16.994	Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region RP-C_C (PF11800, IPR021760): Replication protein C C-terminal region CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit MDFI (PF15316, IPR026134): MyoD family inhibitor
16	CDC5L	interactor	21	0.321	66.113	OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat Cir_N (PF10197, IPR019339, SM01083): N-terminal domain of CBF1 interacting co-repressor CIR Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain Myb_Cef (PF11831, IPR021786): pre-mRNA splicing factor component Myb_DNA-bind_6 (PF13921): Myb-like DNA-binding domain
17	CDC73	suppressor	15	0.438	34.081	CDC73_C (PF05179, IPR007852): RNA pol II accessory factor, Cdc73 family, C-terminal CDC73_N (PF16050, IPR032041): Paf1 complex subunit CDC73 N-terminal
18	CDK9	protein found in more fusions	17	0.433	39.664	Pkinase (PF00069, IPR000719): Protein kinase domain
19	CHD3	oncoprotein	21	0.474	42.358	CHDCT2 (PF08074, IPR012957): CHDCT2 (NUC038) domain CHDNT (PF08073, IPR012958): CHDNT (NUC034) domain Chromo (PF00385, IPR023780, SM00298): Chromo (CHRromatin Organisation MOdifier) domain DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086) DUF1087 (PF06465, IPR009463, SM01147): Domain of Unknown Function (DUF1087) DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator FYDLN_acid (PF09538, IPR012644): Protein of unknown function (FYDLN_acid) PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein SMN (PF06003, IPR010304): Survival motor neuron protein (SMN) SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain DUF2956 (PF11169, IPR021339): Protein of unknown function (DUF2956) FAM176 (PF14851): FAM176 family
20	COASY	interactor	5	0.700	1.667	CoaE (PF01121, IPR001977): Dephospho-CoA kinase CTP_transf_like (PF01467, IPR004821): Cytidylyltransferase-like
21	CREBBP	suppressor	24	0.368	75.879	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
22	CRY1	interactor	4	0.667	0.400	DNA_photolyase (PF00875, IPR006050): DNA photolyase FAD_binding_7 (PF03441, IPR005101): FAD binding domain of DNA photolyase
23	CSNK2A2	interactor	12	0.409	15.323	Pkinase (PF00069, IPR000719): Protein kinase domain
24	CTBP1	protein found in more fusions	14	0.500	14.726	2-Hacid_dh_C (PF02826, IPR006140): D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Cellsynth_D (PF03500, IPR022798): Cellulose synthase subunit D
25	CTNNB1	oncoprotein	11	0.473	11.308	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
26	CTPS1	interactor	8	0.667	2.406	CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
27	CTR9	interactor	16	0.383	49.938	DUF702 (PF05142, IPR007818): Domain of unknown function (DUF702) Pap_E4 (PF02711, IPR003861): E4 protein SPT16 (PF08644, IPR013953): FACT complex subunit (SPT16/CDC68) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat DUF2175 (PF09943, IPR018686): Uncharacterized protein conserved in archaea (DUF2175) TPR_6 (PF13174, IPR019734): Tetratricopeptide repeat TPR_8 (PF13181, IPR019734): Tetratricopeptide repeat TPR_11 (PF13414, IPR011990): TPR repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_14 (PF13428): Tetratricopeptide repeat TPR_16 (PF13432): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
28	CUL3	protein found in more fusions	30	0.197	216.632	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
29	CXXC1	interactor	8	0.571	5.323	ATP-synt_E (PF05680, IPR008386): ATP synthase E chain PHD (PF00628, IPR019787, SM00249): PHD-finger PLATZ (PF04640, IPR006734): PLATZ transcription factor zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain DUF2116 (PF09889, IPR019216): Uncharacterized protein containing a Zn-ribbon (DUF2116) Med19 (PF10278, IPR019403): Mediator of RNA pol II transcription subunit 19 DUF3347 (PF11827, IPR021782): Protein of unknown function (DUF3347) zf-CpG_bind_C (PF12269, IPR022056): CpG binding protein zinc finger C terminal domain
30	DDA1	interactor	2	1.000	0	DDA1 (PF10172, IPR018276): Det1 complexing ubiquitin ligase
31	DDX5	oncoprotein	23	0.325	72.771	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase P68HR (PF08061, IPR012587): P68HR (NUC004) repeat ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
32	DOT1L	oncoprotein	7	0.524	5.300	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DivIC (PF04977, IPR007060): Septum formation initiator DOT1 (PF08123, IPR013110): Histone methylation protein DOT1 ZapB (PF06005, IPR009252): Cell division protein ZapB HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper TraV (PF09676, IPR014118): Type IV conjugative transfer system lipoprotein (TraV)
33	DYNLT1	interactor	4	0.667	1.667	Tctex-1 (PF03645, IPR005334): Tctex-1 family
34	E2F2	suppressor	1	0	0	E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
35	E2F4	suppressor	4	1.000	0	E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone SPX (PF03105, IPR004331): SPX domain DUF3584 (PF12128, IPR021979): Protein of unknown function (DUF3584) E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
36	E2F6	oncoprotein	6	0.800	1.033	BRCA-2_OB3 (PF09104, IPR015188): BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 E2F_TDP (PF02319, IPR003316): E2F/DP family winged-helix DNA-binding domain E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
37	EFHD2	interactor	6	0.600	5.000	SPARC_Ca_bdg (PF10591, IPR019577): Secreted protein acidic and rich in cysteine Ca binding region EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
38	ELL	oncoprotein	8	0.571	5.457	Occludin_ELL (PF07303, IPR010844): Occludin homology domain ELL (PF10390, IPR019464): RNA polymerase II elongation factor ELL
39	ENO2	interactor	8	0.429	13.500	Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
40	EWSR1	oncoprotein	22	0.314	77.304	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1 Keratin_2_head (PF16208, IPR032444): Keratin type II head
41	FBXO6	interactor	10	0.244	21.486	FBA (PF04300, IPR007397): F-box associated region F-box-like (PF12937, IPR001810): F-box-like
42	FN1	oncoprotein	20	0.253	77.230	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
43	GLO1	interactor	4	0.500	0.933	Glyoxalase (PF00903, IPR004360): Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily
44	H3F3A	oncoprotein	13	0.359	29.976	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
45	HCFC1	protein found in more fusions	17	0.375	43.733	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif zf-tcix (PF14952, IPR029269): Putative treble-clef, zinc-finger, Zn-binding
46	HCFC2	interactor	4	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Kelch_1 (PF01344, IPR006652, SM00612): Kelch motif Kelch_3 (PF13415): Galactose oxidase, central domain Kelch_5 (PF13854): Kelch motif
47	HDAC1	suppressor	32	0.340	161.409	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
48	HDAC2	suppressor	26	0.490	45.937	Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain NARP1 (PF12569, IPR021183): NMDA receptor-regulated protein 1
49	HECW2	interactor	12	0.327	27.633	C2 (PF00168, IPR000008, SM00239): C2 domain WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase) Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57 RFXA_RFXANK_bdg (PF15289, IPR029316): Regulatory factor X-associated C-terminal binding domain HECW_N (PF16562, IPR032348): N-terminal domain of E3 ubiquitin-protein ligase HECW1 and 2
50	HIST1H2BG	oncoprotein	7	0.381	6.037	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
51	HIST1H3A	interactor	25	0.286	115.023	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
52	HIST1H4A	interactor	18	0.359	44.536	CENP-T_C (PF15511): Centromere kinetochore component CENP-T histone fold
53	HIST2H3C	interactor	11	0.309	26.767	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
54	HIST3H3	interactor	28	0.270	151.595	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
55	HSPB1	oncoprotein	16	0.314	37.028	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
56	IMPDH1	interactor	5	0.800	0.619	IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
57	IMPDH2	protein found in more fusions	12	0.364	22.934	IMPDH (PF00478, IPR001093): IMP dehydrogenase / GMP reductase domain
58	ING4	suppressor	6	0.400	1.411	PHD (PF00628, IPR019787, SM00249): PHD-finger SOGA (PF11365, IPR027881): Protein SOGA ING (PF12998, IPR024610): Inhibitor of growth proteins N-terminal histone-binding zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
59	ITGA4	interactor	20	0.327	53.847	FG-GAP (PF01839, IPR013517): FG-GAP repeat Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
60	KAT6A	oncoprotein	11	0.364	19.399	BUD22 (PF09073, IPR015158): BUD22 MOZ_SAS (PF01853, IPR002717): MOZ/SAS family PHD (PF00628, IPR019787, SM00249): PHD-finger Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Linker_histone (PF00538, IPR005818, SM00526): linker histone H1 and H5 family DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306) zf-met (PF12874): Zinc-finger of C2H2 type
61	KAT8	protein found in more fusions	12	0.400	17.756	MOZ_SAS (PF01853, IPR002717): MOZ/SAS family Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) Tudor-knot (PF11717, IPR025995): RNA binding activity-knot of a chromodomain
62	KIF11	protein found in more fusions	8	0.429	4.637	Baculo_PEP_C (PF04513, IPR007601): Baculovirus polyhedron envelope protein, PEP, C terminus COG2 (PF06148, IPR024602): COG (conserved oligomeric Golgi) complex component, COG2 DUF106 (PF01956, IPR002809): Integral membrane protein DUF106 DUF16 (PF01519, IPR002862): Protein of unknown function DUF16 Gag_p17 (PF00540, IPR000071): gag gene protein p17 (matrix protein) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF3510 (PF12022, IPR024603): Domain of unknown function (DUF3510) Microtub_bind (PF13931, IPR025901): Kinesin-associated microtubule-binding
63	KIF7	suppressor	1	0	0	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) MMR_HSR1_C (PF08438, IPR013646): GTPase of unknown function C-terminal Nbs1_C (PF08599, IPR013908): DNA damage repair protein Nbs1 XhlA (PF10779, IPR019715): Haemolysin XhlA Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain YlqD (PF11068, IPR021297): YlqD protein DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200)
64	KRAS	oncoprotein	7	0.400	6.122	Ras (PF00071, IPR001806, SM00173): Ras family
65	LEO1	interactor	10	0.689	5.792	Leo1 (PF04004, IPR007149): Leo1-like protein PPP4R2 (PF09184, IPR015267): PPP4R2 EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region
66	LGR4	interactor	5	0.500	1.900	7tm_1 (PF00001, IPR000276): 7 transmembrane receptor (rhodopsin family) LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRRNT (PF01462, IPR000372, SM00013): Leucine rich repeat N-terminal domain LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
67	MAP3K5	oncoprotein	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
68	MBD3	interactor	13	0.742	3.851	DUF2201_N (PF13203, IPR025154): Putative metallopeptidase domain
69	MCM2	oncoprotein	29	0.217	191.043	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
70	MLLT1	oncoprotein	15	0.448	33.721	DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DDRGK (PF09756, IPR019153, SM01128): DDRGK domain
71	MLLT3	oncoprotein	11	0.527	14.736	Peptidase_S64 (PF08192, IPR012985): Peptidase family S64 YEATS (PF03366, IPR005033): YEATS family DUF3446 (PF11928, IPR021849): Domain of unknown function (DUF3446) Sox_N (PF12444, IPR022151): Sox developmental protein N terminal PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal NKAP (PF15692): NF-kappa-B-activating protein BET (PF17035, IPR027353): Bromodomain extra-terminal - transcription regulation
72	MTAP	suppressor	4	0.833	0.667	PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
73	MTM1	interactor	1	0	0	GRAM (PF02893, IPR004182, SM00568): GRAM domain Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain 3-PAP (PF12578, IPR022587): Myotubularin-associated protein
74	MYB	oncoprotein	8	0.464	4.833	Cmyb_C (PF09316, IPR015395): C-myb, C-terminal LMSTEN (PF07988, IPR012642): LMSTEN motif Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
75	NCL	protein found in more fusions	21	0.337	66.348	DUF1754 (PF08555, IPR013865): Eukaryotic family of unknown function (DUF1754) Myc_N (PF01056, IPR012682): Myc amino-terminal region RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YL1 (PF05764, IPR008895): YL1 nuclear protein Limkain-b1 (PF11608, IPR024582): Limkain b1
76	NTRK1	oncoprotein	43	0.174	472.797	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77	OXT	interactor	1	0	0	Hormone_4 (PF00220, IPR022423): Neurohypophysial hormones, N-terminal Domain Hormone_5 (PF00184, IPR000981, SM00003): Neurohypophysial hormones, C-terminal Domain
78	PAF1	oncoprotein	14	0.440	28.445	Paf1 (PF03985, IPR007133): Paf1 MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
79	PAX6	suppressor	5	0.667	0.800	PAX (PF00292, IPR001523, SM00351): 'Paired box' domain Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
80	PKN1	interactor	6	0.700	1.267	C2 (PF00168, IPR000008, SM00239): C2 domain HR1 (PF02185, IPR011072, SM00742): Hr1 repeat Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
81	PNP	interactor	13	0.273	38.430	PNP_UDP_1 (PF01048, IPR000845): Phosphorylase superfamily
82	POLR2A	protein found in more fusions	19	0.359	56.891	RNA_pol_Rpb1_1 (PF04997, IPR007080): RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 (PF00623, IPR000722): RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 (PF04983, IPR007066): RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 (PF05000, IPR007083): RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_5 (PF04998, IPR007081): RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_R (PF05001, IPR000684): RNA polymerase Rpb1 C-terminal repeat
83	PPIE	interactor	4	0.833	0.333	Pro_isomerase (PF00160, IPR002130): Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
84	PPME1	protein found in more fusions	8	0.429	10.167	Abhydrolase_6 (PF12697, IPR000073): Alpha/beta hydrolase family
85	PPP1R15A	interactor	2	1.000	0	FSAP_sig_propep (PF03032, IPR004275): Frog skin active peptide family signal and propeptide Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family EF-1_beta_acid (PF10587, IPR018940): Eukaryotic elongation factor 1 beta central acidic region PP1c_bdg (PF10488, IPR019523): Phosphatase-1 catalytic subunit binding region SCHIP-1 (PF10148, IPR015649): Schwannomin-interacting protein 1 CAF1A (PF12253, IPR022043): Chromatin assembly factor 1 subunit A
86	PRKAG2	interactor	1	0	0	CBS (PF00571, IPR000644, SM00116): CBS domain
87	PSIP1	oncoprotein	2	1.000	0	AT_hook (PF02178, IPR017956, SM00384): AT hook motif BEX (PF04538, IPR021156): Brain expressed X-linked like family DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510) PGA2 (PF07543, IPR011431): Protein trafficking PGA2 PWWP (PF00855, IPR000313, SM00293): PWWP domain LEDGF (PF11467, IPR021567): Lens epithelium-derived growth factor (LEDGF) TERB2 (PF15101, IPR028065): Telomere-associated protein TERB2
88	PSMD5	interactor	4	0.667	1.067	Proteasom_PSMB (PF10508, IPR019538): Proteasome non-ATPase 26S subunit
89	RAB1A	oncoprotein	4	0.833	0.667	Ras (PF00071, IPR001806, SM00173): Ras family
90	RAN	oncoprotein	12	0.288	30.849	Ras (PF00071, IPR001806, SM00173): Ras family
91	RBBP4	oncoprotein	23	0.458	49.137	eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
92	RBBP5	oncoprotein	18	0.301	54.038	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457) ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
93	RBBP7	suppressor	20	0.532	37.385	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat Capsid_NCLDV (PF04451, IPR007542): Large eukaryotic DNA virus major capsid protein CAF1C_H4-bd (PF12265, IPR022052): Histone-binding protein RBBP4 or subunit C of CAF1 complex
94	RCN1	interactor	8	0.536	10.487	EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
95	RNF2	interactor	31	0.283	164.605	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
96	RPIA	interactor	2	0	0	Rib_5-P_isom_A (PF06026, IPR004788): Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Sugar-bind (PF04198, IPR007324): Putative sugar-binding domain
97	RUNX1	suppressor	9	0.643	3.277	Runt (PF00853, IPR013524): Runt domain RunxI (PF08504, IPR013711): Runx inhibition domain DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
98	SAP30	interactor	8	1.000	0	Titin_Z (PF09042, IPR015129): Titin Z zf-SAP30 (PF13866, IPR025717): SAP30 zinc-finger SAP30_Sin3_bdg (PF13867, IPR025718): Sin3 binding region of histone deacetylase complex subunit SAP30
99	SBF1	interactor	4	0.667	0.451	dDENN (PF03455, IPR005112, SM00801): dDENN domain DENN (PF02141, IPR001194, SM00799): DENN (AEX-3) domain GRAM (PF02893, IPR004182, SM00568): GRAM domain Myotub-related (PF06602, IPR010569): Myotubularin-like phosphatase domain PH (PF00169, IPR001849, SM00233): PH domain uDENN (PF03456, IPR005113, SM00800): uDENN domain T2SSJ (PF11612, IPR010055): Type II secretion system (T2SS), protein J SBF2 (PF12335, IPR022096): Myotubularin protein
100	SET	oncoprotein	8	0.476	1.975	NAP (PF00956, IPR002164): Nucleosome assembly protein (NAP) Nop14 (PF04147, IPR007276): Nop14-like family DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
101	SIN3A	oncoprotein	25	0.407	78.669	Sin3_corepress (PF08295, IPR013194, SM00761): Sin3 family co-repressor PAH (PF02671, IPR003822, SM00309): Paired amphipathic helix repeat Sin3a_C (PF16879, IPR031693): C-terminal domain of Sin3a protein
102	SIRT7	interactor	24	0.275	98.021	DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563) SIR2 (PF02146, IPR003000): Sir2 family
103	SKP2	suppressor	6	0.400	7.667	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat LRR_2 (PF07723, IPR013101): Leucine Rich Repeat LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) F-box-like (PF12937, IPR001810): F-box-like LRR_6 (PF13516, IPR001611): Leucine Rich repeat LRR_8 (PF13855, IPR001611): Leucine rich repeat
104	SMARCA2	suppressor	24	0.395	69.376	DUF1168 (PF06658, IPR009548): Protein of unknown function (DUF1168) DUF1840 (PF08895, IPR014991): Domain of unknown function (DUF1840) HSA (PF07529, IPR014012, SM00573): HSA QLQ (PF08880, IPR014978, SM00951): QLQ SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain YL1 (PF05764, IPR008895): YL1 nuclear protein BRK (PF07533, IPR006576, SM00592): BRK domain DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Bromodomain (PF00439, IPR001487, SM00297): Bromodomain Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain SnAC (PF14619, IPR029295): Snf2-ATP coupling, chromatin remodelling complex WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
105	SMARCC1	suppressor	16	0.495	16.979	SWIRM (PF04433, IPR007526): SWIRM domain Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain DUF2618 (PF10940, IPR021237): Protein of unknown function (DUF2618) PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
106	SMARCC2	interactor	14	0.604	8.624	GHMP_kinases_N (PF00288, IPR006204): GHMP kinases N terminal domain SWIRM (PF04433, IPR007526): SWIRM domain DUF2360 (PF10152, IPR019309): Predicted coiled-coil domain-containing protein (DUF2360) Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain SWIRM-assoc_1 (PF16495, IPR032451): SWIRM-associated region 1 SWIRM-assoc_2 (PF16496, IPR032450): SWIRM-associated domain at the N-terminal SWIRM-assoc_3 (PF16498, IPR032448): SWIRM-associated domain at the C-terminal
107	SNW1	protein found in more fusions	27	0.298	127.460	SKIP_SNW (PF02731, IPR004015): SKIP/SNW domain PRP38_assoc (PF12871, IPR024767): Pre-mRNA-splicing factor 38-associated hydrophilic C-term SIR4_SID (PF16991, IPR031556): Sir4 SID domain
108	SVIL	interactor	4	0.500	2.333	Gelsolin (PF00626, IPR007123): Gelsolin repeat VHP (PF02209, IPR003128, SM00153): Villin headpiece domain DUF4695 (PF15766, IPR031521): Domain of unknown function (DUF4695)
109	SYMPK	interactor	8	0.571	5.427	HEAT (PF02985, IPR000357): HEAT repeat DUF3453 (PF11935, IPR021850): Domain of unknown function (DUF3453) Symplekin_C (PF12295, IPR022075): Symplekin tight junction protein C terminal Cohesin_HEAT (PF12765, IPR026003): HEAT repeat associated with sister chromatid cohesion
110	TAF1	oncoprotein	13	0.423	26.526	Exonuc_VII_L (PF02601, IPR020579): Exonuclease VII, large subunit LcrG (PF07216, IPR009863): LcrG protein Opi1 (PF08618, IPR013927): Transcription factor Opi1 Pinin_SDK_N (PF04697, IPR006787): pinin/SDK conserved region PRP1_N (PF06424, IPR010491): PRP1 splicing factor, N-terminal TBP-binding (PF09247, IPR009067): TATA box-binding protein binding U3_snoRNA_assoc (PF08297, IPR013268): U3 snoRNA associated Bromodomain (PF00439, IPR001487, SM00297): Bromodomain DUF3591 (PF12157, IPR022591): Protein of unknown function (DUF3591) zf-CCHC_6 (PF15288): Zinc knuckle
111	TAF6	interactor	19	0.573	23.155	CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal TAF6_C (PF07571, IPR011442): TAF6 C-terminal HEAT repeat domain Spo0A_C (PF08769, IPR014879): Sporulation initiation factor Spo0A C terminal TAF (PF02969, IPR004823, SM00803): TATA box binding protein associated factor (TAF)
112	TAF9	interactor	8	0.893	0.374	TFIID-31kDa (PF02291, IPR003162): Transcription initiation factor IID, 31kD subunit DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
113	TBP	interactor	17	0.475	30.909	TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP) EPL1 (PF10513, IPR019542): Enhancer of polycomb-like Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
114	TCEAL1	interactor	4	0.667	1.667	BEX (PF04538, IPR021156): Brain expressed X-linked like family
115	TCEB1	oncoprotein	7	0.476	8.500	Skp1_POZ (PF03931, IPR016073): Skp1 family, tetramerisation domain
116	TCEB2	interactor	7	0.476	6.273	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
117	TNRC6B	interactor	5	0.700	1.500	DUF1421 (PF07223, IPR010820): Protein of unknown function (DUF1421) Totivirus_coat (PF05518, IPR008871): Totivirus coat protein Ago_hook (PF10427, IPR019486): Argonaute hook DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TNRC6-PABC_bdg (PF16608, IPR032226): TNRC6-PABC binding domain RRM_occluded (PF16842, IPR031766): Occluded RNA-recognition motif
118	TOP1	oncoprotein	14	0.495	16.887	DUF1764 (PF08576, IPR013885): Eukaryotic protein of unknown function (DUF1764) Topoisom_I (PF01028, IPR013500): Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N (PF02919, IPR008336): Eukaryotic DNA topoisomerase I, DNA binding fragment MCM_bind (PF09739, IPR019140): Mini-chromosome maintenance replisome factor Sox_N (PF12444, IPR022151): Sox developmental protein N terminal Topo_C_assoc (PF14370, IPR025834): C-terminal topoisomerase domain DUF4614 (PF15391, IPR027884): Domain of unknown function (DUF4614) TonB_N (PF16031): TonB N-terminal region
119	TP53	suppressor	39	0.220	325.320	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
120	TRIM21	interactor	6	0.400	3.383	DUF313 (PF03754, IPR005508): Domain of unknown function (DUF313) SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain Prok-RING_1 (PF14446): Prokaryotic RING finger family 1 zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
121	TSTA3	interactor	6	0.533	6.167	Epimerase (PF01370, IPR001509): NAD dependent epimerase/dehydratase family NICE-3 (PF07406, IPR010876): NICE-3 protein Polysacc_synt_2 (PF02719, IPR003869): Polysaccharide biosynthesis protein
122	USP7	oncoprotein	15	0.385	39.643	MATH (PF00917, IPR002083, SM00061): MATH domain UCH (PF00443, IPR001394): Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg (PF12436, IPR024729): ICP0-binding domain of Ubiquitin-specific protease 7 USP7_C2 (PF14533, IPR029346): Ubiquitin-specific protease C-terminal
123	VCAM1	interactor	13	0.385	18.054	C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
124	WDR5	interactor	23	0.312	96.838	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
125	WDR61	interactor	7	0.810	1.619	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ASH2L	interactor	SPRY (PF00622, IPR003877, SM00449): SPRY domain PHD20L1_u1 (PF16660): PHD finger protein 20-like protein 1
2	CBFB	suppressor	CBF_beta (PF02312, IPR003417): Core binding factor beta subunit
3	GMPS	parental protein	GATase (PF00117, IPR017926): Glutamine amidotransferase class-I GMP_synt_C (PF00958, IPR001674): GMP synthase C terminal domain NAD_synthase (PF02540, IPR022310): NAD synthase
4	INS	interactor	Insulin (PF00049, IPR016179, SM00078): Insulin/IGF/Relaxin family
5	KMT2A	parental protein	AT_hook (PF02178, IPR017956, SM00384): AT hook motif DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FYRC (PF05965, IPR003889, SM00542): F/Y rich C-terminus FYRN (PF05964, IPR003888, SM00541): F/Y-rich N-terminus Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal PHD (PF00628, IPR019787, SM00249): PHD-finger Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein RNA_pol_Rpc4 (PF05132, IPR007811): RNA polymerase III RPC4 SET (PF00856, IPR001214, SM00317): SET domain zf-CXXC (PF02008, IPR002857): CXXC zinc finger domain SR-25 (PF10500, IPR019532): Nuclear RNA-splicing-associated protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain zf-HC5HC2H (PF13771): PHD-like zinc-binding domain DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
6	MEN1	suppressor	Menin (PF05053, IPR007747): Menin
7	PIH1D1	interactor	PIH1 (PF08190, IPR012981): pre-RNA processing PIH1/Nop17
8	SENP3	interactor	Nop53 (PF07767, IPR011687): Nop53 (60S ribosomal biogenesis) Peptidase_C48 (PF02902, IPR003653): Ulp1 protease family, C-terminal catalytic domain
9	SMARCB1	suppressor	SNF5 (PF04855, IPR006939): SNF5 / SMARCB1 / INI1
10	TASP1	interactor	Asparaginase_2 (PF01112, IPR000246): Asparaginase

B a c k t o T o p ⇑

Fusion ID: Protein names:	AF297748
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List of the fusions

List of active interactors

List of missing interactors