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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AF295078 is the fusion of parental proteins ALK, MSN (from a repository: Thu Feb 16 06:10:20 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)156
The number (and %) of the onco-proteins51 (32.69 %)
The number (and %) of the tumor suppressors27 (17.31 %)
Total number of binary PPIs (saturation %)1140 (9.43 %)
The number (and %) of affected PPIs155 (13.60 %)
The number of possible different fusions31
PPI diameter2
PPI radius1
The average degree of PPI13.872
Assortativity coefficient-0.2057
The network average Clustering coefficient0.490
The number (and %) of a zero Clustering coefficients10 (6.41 %)
The number (and %) of a zero Betweenness Centrality22 (14.10 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ALK,MSN All fusions
: AF295078;
Proteins found in more fusions HLA-B (see 2 fusions); MAPK1 (see 1 fusions); U2AF2 (see 2 fusions); GRB2 (see 1 fusions); SLC9A3R1 (see 2 fusions); CENPF (see 1 fusions); MAP3K1 (see 1 fusions); TNFRSF1A (see 2 fusions); EWSR1 (see 2 fusions); FAXC (see 2 fusions); ACTB (see 3 fusions); GSS (see 1 fusions); PIK3R1 (see 1 fusions); PAFAH1B1 (see 1 fusions); VCL (see 2 fusions); RACK1/FN1 (see 1 fusions); TKT (see 5 fusions); HSP90AA1 (see 2 fusions); JAK2 (see 3 fusions); CALR (see 6 fusions); STAT3 (see 2 fusions); CD2AP (see 1 fusions); SELPLG (see 2 fusions); EZR (see 2 fusions); MCM2 (see 1 fusions); RACK1 (see 3 fusions); EPHB2 (see 1 fusions); HSPB1 (see 4 fusions); SHC1 (see 1 fusions); JUP/MYH9 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AF295078chimera1550.07815378.744DUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
2 ABCE1interactor170.25057.188ABC_tran (PF00005, IPR003439): ABC transporter
Fer4 (PF00037, IPR001450): 4Fe-4S binding domain
RLI (PF04068, IPR007209): Possible Fer4-like domain in RNase L inhibitor, RLI
SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
Fer4_7 (PF12838, IPR001450): 4Fe-4S dicluster domain
AAA_29 (PF13555): P-loop containing region of AAA domain
3 ACAA2interactor140.56015.912Thiolase_C (PF02803, IPR020617): Thiolase, C-terminal domain
Thiolase_N (PF00108, IPR020616): Thiolase, N-terminal domain
4 ACTBoncoprotein200.32269.787Actin (PF00022, IPR004000, SM00268): Actin
5 ACTN4interactor160.35835.624CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
6 AHCYinteractor130.43919.506AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase
AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain
7 AKR1B1suppressor110.7455.172Aldo_ket_red (PF00248, IPR023210): Aldo/keto reductase family
8 ARHGDIAinteractor290.299178.281Rho_GDI (PF02115, IPR000406): RHO protein GDP dissociation inhibitor
9 ASNSoncoprotein170.36852.490Asn_synthase (PF00733, IPR001962): Asparagine synthase
GATase_7 (PF13537, IPR000583): Glutamine amidotransferase domain
10 ATIConcoprotein150.45727.912AICARFT_IMPCHas (PF01808, IPR002695, SM00798): AICARFT/IMPCHase bienzyme
MGS (PF02142, IPR011607, SM00851): MGS-like domain
11 BCAR1oncoprotein100.37818.300Serine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
12 BIDoncoprotein140.85910.333BID (PF06393, IPR010479): BH3 interacting domain (BID)
13 BRCA1suppressor190.29459.242BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
14 CALRoncoprotein180.50720.579Calreticulin (PF00262, IPR001580): Calreticulin family
DDHD (PF02862, IPR004177, SM01127): DDHD domain
15 CALUinteractor80.7142.141EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
16 CAPN2interactor140.41839.451Calpain_III (PF01067, IPR022682, SM00720): Calpain large subunit, domain III
Peptidase_C2 (PF00648, IPR001300, SM00230): Calpain family cysteine protease
EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_6 (PF13405, IPR002048): EF-hand domain
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
17 CASP10interactor131.0000DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
18 CASP8suppressor140.8725.733DED (PF01335, IPR001875, SM00031): Death effector domain
Peptidase_C14 (PF00656, IPR011600): Caspase domain
19 CD2APprotein found in more fusions70.7332.167SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
betaPIX_CC (PF16523, IPR032409): betaPIX coiled coil
20 CD44suppressor90.4449.538VP4_2 (PF08935, IPR015031): Viral protein VP4 subunit
Xlink (PF00193, IPR000538, SM00445): Extracellular link domain
S36_mt (PF10937, IPR020373): Ribosomal protein S36, mitochondrial
21 CD46oncoprotein30.6670.667Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
DUF3188 (PF11384, IPR021524): Protein of unknown function (DUF3188)
ECSCR (PF15820, IPR026247): Endothelial cell-specific chemotaxis regulator
22 CD81interactor140.32132.996Tetraspannin (PF00335, IPR018499): Tetraspanin family
23 CDK11Boncoprotein41.0000DDHD (PF02862, IPR004177, SM01127): DDHD domain
DivIC (PF04977, IPR007060): Septum formation initiator
Pkinase (PF00069, IPR000719): Protein kinase domain
DUF4748 (PF15932, IPR031833): Domain of unknown function (DUF4748)
24 CDK2suppressor430.206378.545Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
25 CENPFoncoprotein40.6670.286APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
IncA (PF04156, IPR007285): IncA protein
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Usp (PF00582, IPR006016): Universal stress protein family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
CENP-F_N (PF10481, IPR018463): Cenp-F N-terminal domain
CENP-F_C_Rb_bdg (PF10490, IPR018302): Rb-binding domain of kinetochore protein Cenp-F/LEK1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
26 CTNNB1oncoprotein160.33345.496Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361)
HEAT_EZ (PF13513): HEAT-like repeat
27 DCPSinteractor120.47018.815DcpS (PF05652, IPR008594): Scavenger mRNA decapping enzyme (DcpS) N-terminal
DcpS_C (PF11969): Scavenger mRNA decapping enzyme C-term binding
28 DHX15interactor160.42533.144DEAD (PF00270, IPR011545): DEAD/DEAH box helicase
OB_NTP_bind (PF07717, IPR011709): Oligonucleotide/oligosaccharide-binding (OB)-fold
DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777)
HA2 (PF04408, IPR007502, SM00847): Helicase associated domain (HA2)
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
AAA_29 (PF13555): P-loop containing region of AAA domain
29 DUTinteractor140.44021.392dUTPase (PF00692, IPR008180): dUTPase
30 EIF5AL1interactor40.6670.297EFP_N (PF08207, IPR013185): Elongation factor P (EF-P) KOW-like domain
eIF-5a (PF01287, IPR020189): Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold
31 ELAVL1oncoprotein280.251147.973RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
32 ENO1oncoprotein320.335156.236Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
33 ENO2interactor210.48637.428Enolase_C (PF00113, IPR020810): Enolase, C-terminal TIM barrel domain
Enolase_N (PF03952, IPR020811): Enolase, N-terminal domain
34 EPHA1suppressor30.6670.333fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
35 EPHB2suppressor41.0000EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
36 EWSR1oncoprotein270.326102.927RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
SVS_QK (PF10578, IPR018942): Seminal vesicle protein repeat
zf-RanBP (PF00641, IPR001876, SM00547): Zn-finger in Ran binding protein and others
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
Keratin_2_head (PF16208, IPR032444): Keratin type II head
37 EZRprotein found in more fusions590.1661062.942DUF106 (PF01956, IPR002809): Integral membrane protein DUF106
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
38 FABP5interactor150.58121.236Lipocalin (PF00061, IPR000566): Lipocalin / cytosolic fatty-acid binding protein family
39 FADDsuppressor130.8973.067Death (PF00531, IPR000488, SM00005): Death domain
DED (PF01335, IPR001875, SM00031): Death effector domain
Hpt (PF01627, IPR008207, SM00073): Hpt domain
40 FASsuppressor150.76914.300Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
Stn1_C (PF12659, IPR024263): Telomere capping C-terminal wHTH
41 FASLGinteractor170.58835.742PAP_PilO (PF06864, IPR009663): Pilin accessory protein (PilO)
TNF (PF00229, IPR006052, SM00207): TNF(Tumour Necrosis Factor) family
PRIMA1 (PF16101): Proline-rich membrane anchor 1
42 FAXCprotein found in more fusions200GST_C_6 (PF17171): Glutathione S-transferase, C-terminal domain
GST_N_4 (PF17172): Glutathione S-transferase N-terminal domain
43 FHsuppressor160.43335.323Lyase_1 (PF00206, IPR022761): Lyase
FumaraseC_C (PF10415, IPR018951): Fumarase C C-terminus
44 FKBP2interactor70.7621.797FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase
45 FLIIoncoprotein70.5715.027Gelsolin (PF00626, IPR007123): Gelsolin repeat
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
46 FN1oncoprotein350.289195.371fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
47 GAKoncoprotein21.0000DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
48 GDI1interactor90.41713.299GDI (PF00996, IPR018203): GDP dissociation inhibitor
49 GINS3interactor90.52810.119Sld5 (PF05916, IPR021151): GINS complex protein
50 GRB2oncoprotein330.244249.403SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
51 GSSprotein found in more fusions100.6397.271GSH_synth_ATP (PF03917, IPR005615): Eukaryotic glutathione synthase, ATP binding domain
52 GTF3C4interactor40.6671.167TFIIIC_delta (PF12657, IPR024761): Transcription factor IIIC subunit delta N-term
zf-TFIIIC (PF12660, IPR024764): Putative zinc-finger of transcription factor IIIC complex
53 H2AFXsuppressor170.44926.446Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4
Histone_H2A_C (PF16211, IPR032454): C-terminus of histone H2A
54 HADHAinteractor70.6671.9293HCDH (PF00725, IPR006108): 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain
3HCDH_N (PF02737, IPR006176): 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain
ECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
55 HLA-Boncoprotein80.3819.400MHC_I (PF00129, IPR001039): Class I Histocompatibility antigen, domains alpha 1 and 2
MHC_I_C (PF06623, IPR010579): MHC_I C-terminus
C1-set (PF07654, IPR003597, SM00407): Immunoglobulin C1-set domain
56 HNRNPA1interactor310.356130.028RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
HnRNPA1 (PF11627, IPR021662): Nuclear factor hnRNPA1
57 HSD17B10interactor230.41970.036adh_short (PF00106, IPR002198): short chain dehydrogenase
58 HSP90AA1oncoprotein350.267247.182HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
59 HSPA4interactor180.36641.017Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region
HSP70 (PF00012, IPR013126): Hsp70 protein
TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
60 HSPA4Linteractor90.6114.314HSP70 (PF00012, IPR013126): Hsp70 protein
61 HSPA5oncoprotein320.295184.768HSP70 (PF00012, IPR013126): Hsp70 protein
62 HSPB1oncoprotein200.40937.719HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
63 HSPD1suppressor160.50014.651Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
64 HSPE1interactor260.348104.425Cpn10 (PF00166, IPR020818, SM00883): Chaperonin 10 Kd subunit
65 HSPH1oncoprotein120.7423.398HSP70 (PF00012, IPR013126): Hsp70 protein
SICA_alpha (PF12887, IPR024290): SICA extracellular alpha domain
66 ICAM1oncoprotein50.5001.069Adhes-Ig_like (PF09085, IPR015169): Adhesion molecule, immunoglobulin-like
C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
67 ICAM2interactor21.0000ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
SecE (PF00584, IPR001901): SecE/Sec61-gamma subunits of protein translocation complex
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
68 ICAM3interactor30.6670.286C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain
ICAM_N (PF03921, IPR013768): Intercellular adhesion molecule (ICAM), N-terminal domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
69 IGSF8oncoprotein50.8000.417V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_2 (PF13895, IPR007110): Immunoglobulin domain
Ig_3 (PF13927): Immunoglobulin domain
70 IKBKGinteractor150.34144.291CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
71 IMPA2interactor50.6670.500Inositol_P (PF00459, IPR000760): Inositol monophosphatase family
72 IRS1interactor80.5716.233CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
73 ISG15suppressor210.26269.103ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
74 ISYNA1interactor90.5838.805NAD_binding_5 (PF07994, IPR002587): Myo-inositol-1-phosphate synthase
75 ITGA4interactor280.36295.638FG-GAP (PF01839, IPR013517): FG-GAP repeat
Integrin_alpha (PF00357, IPR018184): Integrin alpha cytoplasmic region
Integrin_alpha2 (PF08441, IPR013649): Integrin alpha
76 JAK2oncoprotein170.40841.112FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
77 JAK3oncoprotein70.4299.400Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
78 JUPsuppressor100.5337.078Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain
HEAT_EZ (PF13513): HEAT-like repeat
HEAT_2 (PF13646): HEAT repeats
79 KRT18interactor110.5339.377Filament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
80 KRT74interactor100Filament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
81 LCP1oncoprotein50.8000.311CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
82 MAP2K7interactor80.4298.884Pkinase (PF00069, IPR000719): Protein kinase domain
83 MAP3K1oncoprotein110.37816.862zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
84 MAPK1oncoprotein120.27324.451Pkinase (PF00069, IPR000719): Protein kinase domain
85 MAPK10suppressor40.6670.667Pkinase (PF00069, IPR000719): Protein kinase domain
86 MAPK8oncoprotein220.39592.968DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
87 MAPK8IP3interactor60.5335.333Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
88 MCM2oncoprotein440.287318.230AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
89 ME1interactor21.0000malic (PF00390, IPR012301): Malic enzyme, N-terminal domain
Malic_M (PF03949, IPR012302, SM00919): Malic enzyme, NAD binding domain
90 MYBPC2interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
91 MYH10interactor100.5115.853IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
92 MYH9suppressor240.37379.842IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
93 MYO19interactor80.4647.036IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
94 NAE1interactor110.60010.355ThiF (PF00899, IPR000594): ThiF family
95 NCF1interactor50.5002.500p47_phox_C (PF08944, IPR015039): NADPH oxidase subunit p47Phox, C terminal domain
PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
NECFESHC (PF16621, IPR032136): SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1
96 NCF4interactor21.0000PX (PF00787, IPR001683, SM00312): PX domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
97 NOTCH2suppressor100Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
98 NSFL1Cinteractor120.56117.005SEP (PF08059, IPR012989, SM00553): SEP domain
UBX (PF00789, IPR001012, SM00166): UBX domain
UBA_4 (PF14555): UBA-like domain
99 P4HBinteractor230.45946.734Glycos_trans_3N (PF02885, IPR017459): Glycosyl transferase family, helical bundle domain
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
100 PAFAH1B1suppressor130.53014.764LisH (PF08513, IPR013720, SM00667): LisH
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
101 PAFAH1B2oncoprotein120.40923.802Lipase_GDSL_2 (PF13472, IPR013830): GDSL-like Lipase/Acylhydrolase family
102 PAPSS1interactor130.55118.584APS_kinase (PF01583, IPR002891): Adenylylsulphate kinase
ATP-sulfurylase (PF01747, IPR024951): ATP-sulfurylase
DUF258 (PF03193, IPR004881): Protein of unknown function, DUF258
PUA_2 (PF14306, IPR025980): PUA-like domain
103 PDHA1interactor80.5366.334E1_dh (PF00676, IPR001017): Dehydrogenase E1 component
104 PDIA4interactor190.40954.108Calsequestrin (PF01216, IPR001393): Calsequestrin
Thioredoxin (PF00085, IPR013766): Thioredoxin
Thioredoxin_6 (PF13848): Thioredoxin-like domain
FAM176 (PF14851): FAM176 family
105 PDLIM3interactor100LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
106 PFASinteractor70.6195.300AIRS_C (PF02769, IPR010918): AIR synthase related protein, C-terminal domain
GATase_5 (PF13507): CobB/CobQ-like glutamine amidotransferase domain
107 PGDoncoprotein110.43612.6236PGD (PF00393, IPR006114): 6-phosphogluconate dehydrogenase, C-terminal domain
NAD_binding_2 (PF03446, IPR006115): NAD binding domain of 6-phosphogluconate dehydrogenase
108 PGK1interactor200.48428.424PGK (PF00162, IPR001576): Phosphoglycerate kinase
109 PGK2interactor40.8330.143PGK (PF00162, IPR001576): Phosphoglycerate kinase
110 PIK3R1oncoprotein160.38138.563RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
111 PLCG1oncoprotein90.44414.305C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
112 PLS1interactor60.6003.917CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
GlutR_dimer (PF00745, IPR015896): Glutamyl-tRNAGlu reductase, dimerisation domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
113 PLS3interactor120.51515.473CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EF-hand_5 (PF13202, IPR002048): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
114 PPP1R2interactor110.52715.186IPP-2 (PF04979, IPR007062): Protein phosphatase inhibitor 2 (IPP-2)
115 PRKCQinteractor50.6671.667Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
116 PTMAoncoprotein130.51317.024Prothymosin (PF03247, IPR004931): Prothymosin/parathymosin family
117 PTPN1suppressor80.5715.086Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
118 RAB35oncoprotein40.5001.417Ras (PF00071, IPR001806, SM00173): Ras family
119 RACK1suppressor170.32536.753WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
120 RAP1GDS1oncoprotein160.46734.843Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
WAPL (PF07814, IPR022771): Wings apart-like protein regulation of heterochromatin
Vps39_1 (PF10366, IPR019452): Vacuolar sorting protein 39 domain 1
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
HEAT_2 (PF13646): HEAT repeats
Nitr_red_bet_C (PF14711, IPR029263): Respiratory nitrate reductase beta C-terminal
SIL1 (PF16782, IPR031884): Nucleotide exchange factor SIL1
121 RCN1interactor110.52710.735EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_4 (PF12763, IPR000261): Cytoskeletal-regulatory complex EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
122 RHOAsuppressor190.48064.833Ras (PF00071, IPR001806, SM00173): Ras family
123 S100A16interactor100S_100 (PF01023, IPR013787): S-100/ICaBP type calcium binding domain
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
124 SELLinteractor40.5001.821EGF (PF00008, IPR000742, SM00181): EGF-like domain
Sushi (PF00084, IPR000436, SM00032): Sushi repeat (SCR repeat)
Lectin_C (PF00059, IPR001304, SM00034): Lectin C-type domain
MWFE (PF15879, IPR017384): NADH-ubiquinone oxidoreductase MWFE subunit
125 SELPLGprotein found in more fusions31.0000EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF4689 (PF15755, IPR031499): Domain of unknown function (DUF4689)
126 SHC1oncoprotein180.29460.488PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
127 SHC3interactor100PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
128 SIRT7interactor290.209182.253DUF563 (PF04577, IPR007657): Protein of unknown function (DUF563)
SIR2 (PF02146, IPR003000): Sir2 family
129 SLC9A3R1suppressor60.7000.783EBP50_C (PF09007, IPR015098): EBP50, C-terminal
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
130 SMC6interactor200SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
131 SOCS1suppressor51.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
132 SPNinteractor21.0000BatA (PF07584, IPR024163): Aerotolerance regulator N-terminal
MAGUK_N_PEST (PF10608, IPR019590): Polyubiquitination (PEST) N-terminal domain of MAGUK
133 SPTAN1oncoprotein140.41830.903EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Tetrabrachion (PF11401, IPR021535): Tetrabrachion
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
E2F_CC-MB (PF16421, IPR032198): E2F transcription factor CC-MB domain
134 SRConcoprotein210.258102.436Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
135 SRCAPinteractor100AT_hook (PF02178, IPR017956, SM00384): AT hook motif
HSA (PF07529, IPR014012, SM00573): HSA
RXT2_N (PF08595, IPR013904): RXT2-like, N-terminal
SNF2_N (PF00176, IPR000330): SNF2 family N-terminal domain
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
DBINO (PF13892, IPR020838): DNA-binding domain
PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal
136 STAT3suppressor130.31825.653SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
137 STIP1interactor260.45270.389TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
TPR_9 (PF13371, IPR011990): Tetratricopeptide repeat
TPR_11 (PF13414, IPR011990): TPR repeat
TPR_12 (PF13424): Tetratricopeptide repeat
TPR_17 (PF13431): Tetratricopeptide repeat
Wtap (PF17098, IPR029732): Pre-mRNA-splicing regulator WTAP
138 STK24interactor70.6003.867DUF1241 (PF06840, IPR009652): Protein of unknown function (DUF1241)
Pkinase (PF00069, IPR000719): Protein kinase domain
139 TAGLN2interactor270.41682.182Calponin (PF00402, IPR000557): Calponin family repeat
CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
140 TATDN1interactor130.62811.679TatD_DNase (PF01026, IPR001130): TatD related DNase
141 TERF1interactor200.24074.954TRF (PF08558, IPR013867): Telomere repeat binding factor (TRF)
Myb_DNA-binding (PF00249, IPR001005, SM00717): Myb-like DNA-binding domain
142 TKTprotein found in more fusions300.40489.544Transket_pyr (PF02779, IPR005475, SM00861): Transketolase, pyrimidine binding domain
Transketolase_C (PF02780, IPR005476): Transketolase, C-terminal domain
Transketolase_N (PF00456, IPR005474): Transketolase, thiamine diphosphate binding domain
143 TNFRSF10Bsuppressor121.0000Death (PF00531, IPR000488, SM00005): Death domain
RskA (PF10099, IPR018764): Anti-sigma-K factor rskA
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
144 TNFRSF1Aoncoprotein200.53243.275Death (PF00531, IPR000488, SM00005): Death domain
TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
145 TRIM15suppressor60.5002.305Fib_alpha (PF08702, IPR012290): Fibrinogen alpha/beta chain family
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger)
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
zf-C4pol (PF14260, IPR025687): C4-type zinc-finger of DNA polymerase delta
146 TSC1suppressor31.0000Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
Hamartin (PF04388, IPR007483): Hamartin protein
147 TSPAN33interactor100Tetraspannin (PF00335, IPR018499): Tetraspanin family
148 TUBB3interactor90.25014.188Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
149 TUBB4Binteractor140.46221.888Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
150 TUBGCP2interactor50.6002.111Spc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
151 U2AF2protein found in more fusions300.337114.829RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
Transformer (PF06495, IPR010519): Fruit fly transformer protein
152 UCHL3interactor140.61510.319Peptidase_C12 (PF01088, IPR001578): Ubiquitin carboxyl-terminal hydrolase, family 1
153 VCAM1interactor260.34871.563C2-set (PF05790, IPR008424): Immunoglobulin C2-set domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
ig (PF00047, IPR013151, SM00409): Immunoglobulin domain
V-set (PF07686, IPR013106): Immunoglobulin V-set domain
Ig_3 (PF13927): Immunoglobulin domain
154 VCLoncoprotein240.292108.613Vinculin (PF01044, IPR006077): Vinculin family
155 VPS11interactor30.6670.500DUF1086 (PF06461, IPR009462, SM01146): Domain of Unknown Function (DUF1086)
Vps39_2 (PF10367, IPR019453): Vacuolar sorting protein 39 domain 2
Clathrin (PF00637, IPR000547, SM00299): Region in Clathrin and VPS
VPS11_C (PF12451, IPR024763): Vacuolar protein sorting protein 11 C terminal
TPR_11 (PF13414, IPR011990): TPR repeat
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
156 WDR1interactor140.48419.223eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
PQQ (PF01011, IPR002372, SM00564): PQQ enzyme repeat
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain

B a c k    t o    T o p ⇑


List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALKparental proteinMAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
2 BICD2interactorBicD (PF09730, IPR018477): Microtubule-associated protein Bicaudal-D
3 CDK13interactorK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Macoilin (PF09726, IPR019130): Transmembrane protein
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
4 CORO1ConcoproteinDUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
5 EIF4BinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
6 ERRFI1suppressorGTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
7 IRF7interactorIRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
8 IRS4interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
9 MAP3K4suppressorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
10 MAP3K5oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
11 MEP1BinteractorAstacin (PF01400, IPR001506): Astacin (Peptidase family M12A)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
12 MSNparental proteinDUF883 (PF05957, IPR010279): Bacterial protein of unknown function (DUF883)
ERM (PF00769, IPR011259): Ezrin/radixin/moesin family
FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
13 MTIF2interactorGTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
IF-2 (PF11987, IPR023115): Translation-initiation factor 2
14 MYLKinteractorAmelogenin (PF02948, IPR004116, SM00818): Amelogenin
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
15 MYO6interactorBUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
16 PDX1suppressorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
17 PIK3CBoncoproteinPI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
RWD (PF05773, IPR006575, SM00591): RWD domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
18 PLCB2oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
19 PTNoncoproteinPTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
20 PXNoncoproteinLIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
21 RAD17interactorMvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
22 SOCS5interactorSH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
23 TNK2interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
24 UBASH3AinteractorHis_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Ste5 (PF11610, IPR021651): Scaffold protein Ste5-Fus5 binding region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
25 VIMsuppressorFilament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
26 ZC3HC1interactorRsm1 (PF08600, IPR013909): Rsm1-like
zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like

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