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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AF289510 is the fusion of parental proteins NR4A3, TCF12 (from a repository: Tue Dec 6 05:24:09 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)61
The number (and %) of the onco-proteins19 (31.15 %)
The number (and %) of the tumor suppressors11 (18.03 %)
Total number of binary PPIs (saturation %)209 (11.42 %)
The number (and %) of affected PPIs60 (28.71 %)
The number of possible different fusions14
PPI diameter2
PPI radius1
The average degree of PPI6.000
Assortativity coefficient-0.3532
The network average Clustering coefficient0.594
The number (and %) of a zero Clustering coefficients11 (18.03 %)
The number (and %) of a zero Betweenness Centrality32 (52.46 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: NR4A3,TCF12 All fusions
: AF289510;
Proteins found in more fusions RUNX1 (see 1 fusions); CREBBP (see 6 fusions); TAF4 (see 4 fusions); COPS5 (see 1 fusions); EP300 (see 1 fusions); RUNX1T1 (see 1 fusions); RUNX1/RUNX1T1 (see 41 fusions); TCF3 (see 4 fusions); TRIM28 (see 1 fusions); TRIM33 (see 1 fusions); ID3 (see 1 fusions); MYC (see 1 fusions); SMAD3 (see 3 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AF289510chimera600.0692693.776SelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Mei5 (PF10376, IPR018468): Double-strand recombination repair protein
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
2 ARMC8interactor40.5001.833Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat
DUF383 (PF04063, IPR007205): Domain of unknown function (DUF383)
HEAT (PF02985, IPR000357): HEAT repeat
IFRD (PF05004, IPR007701): Interferon-related developmental regulator (IFRD)
Uso1_p115_head (PF04869, IPR006953): Uso1 / p115 like vesicle tethering protein, head region
V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H
UNC45-central (PF11701, IPR024660): Myosin-binding striated muscle assembly central
HEAT_EZ (PF13513): HEAT-like repeat
3 ASCL4interactor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
4 CDKN2Csuppressor21.0000Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
5 CFAP206interactor200THP2 (PF09432, IPR018557): Tho complex subunit THP2
DUF3508 (PF12018, IPR021897): Domain of unknown function (DUF3508)
6 COPS5protein found in more fusions80.4767.300JAB (PF01398, IPR000555, SM00232): JAB1/Mov34/MPN/PAD-1 ubiquitin protease
7 CRCPinteractor40.5002.167RNA_pol_Rpb4 (PF03874, IPR005574): RNA polymerase Rpb4
Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
8 CREBBPsuppressor110.6447.438Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
MAS20 (PF02064, IPR002056): MAS20 protein import receptor
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
9 EDRF1oncoprotein100TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat
TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
DUF2315 (PF10231, IPR018796): Uncharacterised conserved protein (DUF2315)
10 ELAVL1oncoprotein170.33363.238RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
11 EP300oncoprotein140.43632.052Creb_binding (PF09030, IPR014744): Creb binding
DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902)
Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region
KIX (PF02172, IPR003101): KIX domain
RR_TM4-6 (PF06459, IPR009460): Ryanodine Receptor TM 4-6
TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2)
zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger
HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type
12 FOXH1interactor40.6670.619Forkhead (PF00250, IPR001766, SM00339): Forkhead domain
13 FRMD6interactor100FERM_C (PF09380, IPR018980): FERM C-terminal PH-like domain
FERM_M (PF00373, IPR019748): FERM central domain
FERM_N (PF09379, IPR018979): FERM N-terminal domain
HTH_24 (PF13412, IPR011991): Winged helix-turn-helix DNA-binding
14 HEXIM2interactor40.6670.400bZIP_2 (PF07716, IPR004827, SM00338): Basic region leucine zipper
HEXIM (PF15313, IPR024872): Hexamethylene bis-acetamide-inducible protein
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
15 HOPXsuppressor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
16 ID1interactor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
17 ID2oncoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
18 ID3oncoprotein41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
19 KDM5Binteractor31.0000ARID (PF01388, IPR001606, SM00501): ARID/BRIGHT DNA binding domain
JmjC (PF02373, IPR003347, SM00558): JmjC domain, hydroxylase
JmjN (PF02375, IPR003349, SM00545): jmjN domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
PLU-1 (PF08429, IPR013637): PLU-1-like protein
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
Rubredoxin (PF00301, IPR024935): Rubredoxin
zf-C5HC2 (PF02928, IPR004198): C5HC2 zinc finger
Lipoprotein_20 (PF13942, IPR025262): YfhG lipoprotein
20 LYSMD1interactor100LysM (PF01476, IPR018392, SM00257): LysM domain
21 MAPKBP1interactor21.0000eIF2A (PF08662, IPR013979): Eukaryotic translation initiation factor eIF2A
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
WD40_like (PF17005, IPR031544): WD40-like domain
22 MESP2interactor31.0000DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
23 MLLT6oncoprotein30.6670.400DUF572 (PF04502, IPR007590): Family of unknown function (DUF572)
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
SpoIIIAH (PF12685, IPR024232): SpoIIIAH-like protein
zf-HC5HC2H (PF13771): PHD-like zinc-binding domain
PHD_2 (PF13831): PHD-finger
zf-HC5HC2H_2 (PF13832): PHD-zinc-finger like domain
SOBP (PF15279, IPR026092): Sine oculis-binding protein
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
24 MORN4interactor21.0000MORN (PF02493, IPR003409, SM00698): MORN repeat
25 MOV10interactor50.6002.500AAA_12 (PF13087): AAA domain
AAA_30 (PF13604): AAA domain
26 MYConcoprotein130.50019.386HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain
Myc_N (PF01056, IPR012682): Myc amino-terminal region
27 MYF6interactor21.0000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Myf5 (PF12232, IPR022032): Myogenic determination factor 5
28 MYOGinteractor31.0000Basic (PF01586, IPR002546, SM00520): Myogenic Basic domain
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
29 NEUROD1interactor41.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
YL1 (PF05764, IPR008895): YL1 nuclear protein
Neuro_bHLH (PF12533, IPR022575): Neuronal helix-loop-helix transcription factor
30 NEUROG3interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
Umbravirus_LDM (PF04817, IPR006902): Umbravirus long distance movement (LDM) family
31 NOTCH1suppressor70.5334.833Ank (PF00023, IPR002110, SM00248): Ankyrin repeat
EGF (PF00008, IPR000742, SM00181): EGF-like domain
EGF_2 (PF07974, IPR013111): EGF-like domain
EGF_alliinase (PF04863, IPR006947): Alliinase EGF-like domain
EGF_CA (PF07645, IPR001881, SM00179): Calcium-binding EGF domain
NOD (PF06816, IPR010660): NOTCH protein
NODP (PF07684, IPR011656): NOTCH protein
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
Notch (PF00066, IPR000800, SM00004): LNR domain
DUF3454 (PF11936, IPR024600): Domain of unknown function (DUF3454)
hEGF (PF12661, IPR013032): Human growth factor-like EGF
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
32 NTRK1oncoprotein130.36434.052I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
33 NXF1interactor60.4004.000NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding
TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain
LRR_8 (PF13855, IPR001611): Leucine rich repeat
34 OLIG3interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
35 PRSS23interactor21.0000Trypsin (PF00089, IPR001254, SM00020): Trypsin
36 QARSinteractor40.6671.000tRNA-synt_1c (PF00749, IPR020058): tRNA synthetases class I (E and Q), catalytic domain
tRNA-synt_1c_C (PF03950, IPR020059): tRNA synthetases class I (E and Q), anti-codon binding domain
tRNA_synt_1c_R1 (PF04558, IPR007639): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1
tRNA_synt_1c_R2 (PF04557, IPR007638): Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2
37 RNASELsuppressor100Pkinase (PF00069, IPR000719): Protein kinase domain
Ribonuc_2-5A (PF06479, IPR010513): Ribonuclease 2-5A
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
Ank_5 (PF13857): Ankyrin repeats (many copies)
38 RUNX1suppressor140.52620.243Runt (PF00853, IPR013524): Runt domain
RunxI (PF08504, IPR013711): Runx inhibition domain
DUF3037 (PF11236, IPR021398): Protein of unknown function (DUF3037)
39 RUNX1T1oncoprotein70.7332.667NHR2 (PF08788, IPR014896): NHR2 domain like
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
zf-MYND (PF01753, IPR002893): MYND finger
DUF3731 (PF12531, IPR021030): DNA-K related protein
40 SHMT2interactor30.6670.667SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
41 SIX3interactor100Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
SIX1_SD (PF16878, IPR031701): Transcriptional regulator, SIX1, N-terminal SD domain
42 SMAD2suppressor120.50918.924MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
43 SMAD3oncoprotein100.6396.538MH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
44 SOX2oncoprotein70.6673.333HMG_box (PF00505, IPR009071, SM00398): HMG (high mobility group) box
SOXp (PF12336, IPR022097): SOX transcription factor
45 SRIoncoprotein31.0000EF-hand_1 (PF00036, IPR002048, SM00054): EF hand
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
EF-hand_8 (PF13833, IPR002048): EF-hand domain pair
46 STAT5Asuppressor31.0000SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
47 STK16interactor31.0000Pkinase (PF00069, IPR000719): Protein kinase domain
48 STRN3interactor41.0000Striatin (PF08232, IPR013258): Striatin family
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
Nup160 (PF11715, IPR021717): Nucleoporin Nup120/160
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
49 TAF4protein found in more fusions41.0000TAF4 (PF05236, IPR007900): Transcription initiation factor TFIID component TAF4 family
TAFH (PF07531, IPR003894, SM00549): NHR1 homology to TAF
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729)
50 TAL1oncoprotein70.8670.619HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
SelK_SelG (PF10961, IPR024491): Selenoprotein SelK_SelG
51 TAL2oncoprotein31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
52 TBPinteractor70.7332.619TBP (PF00352, IPR000814): Transcription factor TFIID (or TATA-binding protein, TBP)
EPL1 (PF10513, IPR019542): Enhancer of polycomb-like
Med3 (PF11593, IPR020998): Mediator complex subunit 3 fungal
53 TCF21interactor31.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
54 TCF23interactor100HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
55 TCF3suppressor210.253110.671CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
56 TCF4suppressor240.145212.752CDC45 (PF02724, IPR003874): CDC45-like protein
HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
57 TRIM28protein found in more fusions70.5334.200ASFV_J13L (PF05568, IPR008385): African swine fever virus J13L protein
K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
PHD (PF00628, IPR019787, SM00249): PHD-finger
FYVE_2 (PF02318, IPR010911): FYVE-type zinc finger
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain
SKA2 (PF16740, IPR026762): Spindle and kinetochore-associated protein 2
58 TRIM33oncoprotein130.50017.186PHD (PF00628, IPR019787, SM00249): PHD-finger
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
Siva (PF05458, IPR022773): Cd27 binding protein (Siva)
Spectrin (PF00435, IPR002017): Spectrin repeat
TFIIA (PF03153, IPR004855): Transcription factor IIA, alpha/beta subunit
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
Bromodomain (PF00439, IPR001487, SM00297): Bromodomain
zf-RING_UBOX (PF13445, IPR027370): RING-type zinc-finger
59 TRIM72interactor100HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
SPRY (PF00622, IPR003877, SM00449): SPRY domain
zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger
PRY (PF13765, IPR006574, SM00589): SPRY-associated domain
zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING
60 TWIST2suppressor21.0000HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
61 XPO1interactor100.44418.586CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain
Xpo1 (PF08389, IPR013598): Exportin 1-like protein
Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 BMFsuppressorBMF (PF15185, IPR028192): Bcl-2-modifying factor, apoptosis
2 C16orf45interactorDUF3585 (PF12130, IPR022735): Protein of unknown function (DUF3585)
PurL_C (PF16904, IPR031652): Phosphoribosylformylglycinamidine synthase II C-terminus
3 C1orf109interactorCK2S (PF15011, IPR029159): Casein Kinase 2 substrate
4 DGCR6interactorDGCR6 (PF07324, IPR010849): DiGeorge syndrome critical region 6 (DGCR6) protein
5 NAGKinteractorBcrAD_BadFG (PF01869, IPR002731): BadF/BadG/BcrA/BcrD ATPase family
6 NR4A3parental proteinSelP_N (PF04592, IPR007671): Selenoprotein P, N terminal region
zf-C4 (PF00105, IPR001628, SM00399): Zinc finger, C4 type (two domains)
Hormone_recep (PF00104, IPR000536, SM00430): Ligand-binding domain of nuclear hormone receptor
Nucleoporin_FG2 (PF15967): Nucleoporin FG repeated region
7 OSGIN1suppressorPyr_redox_2 (PF07992, IPR023753): Pyridine nucleotide-disulphide oxidoreductase
Pyr_redox_3 (PF13738): Pyridine nucleotide-disulphide oxidoreductase
8 PSMA1interactorProteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
9 SGF29interactorDUF1325 (PF07039, IPR010750): SGF29 tudor-like domain
Filament (PF00038, IPR001664): Intermediate filament protein
10 SPG21interactorAbhydrolase_1 (PF00561, IPR000073): alpha/beta hydrolase fold
11 TCF12parental proteinHLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain
12 TSNAXinteractorTranslin (PF01997, IPR002848): Translin family
13 VPS28interactorVPS28 (PF03997, IPR007143): VPS28 protein
14 ZWINTinteractorZwint (PF15556, IPR029092): ZW10 interactor

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