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Visible interactions: all affected independent (normal) missing nothing (blank)

Visualization interactions

Powered by Cytoscape Web for: AF186110 is the fusion of parental proteins ALK, TPM4 (from a repository: Wed Nov 23 05:23:32 2016)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)109
The number (and %) of the onco-proteins40 (36.70 %)
The number (and %) of the tumor suppressors15 (13.76 %)
Total number of binary PPIs (saturation %)781 (13.27 %)
The number (and %) of affected PPIs108 (13.83 %)
The number of possible different fusions30
PPI diameter2
PPI radius1
The average degree of PPI13.468
Assortativity coefficient-0.2066
The network average Clustering coefficient0.558
The number (and %) of a zero Clustering coefficients4 (3.67 %)
The number (and %) of a zero Betweenness Centrality15 (13.76 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: ALK,TPM4 All fusions
: AF186110;
Proteins found in more fusions PSMC2 (see 1 fusions); SRSF2 (see 1 fusions); TPM1 (see 2 fusions); G3BP1 (see 1 fusions); TPM2/TPM3 (see 1 fusions); HSP90AA1 (see 2 fusions); MAPK1 (see 1 fusions); TPM2/MYH9 (see 1 fusions); JAK2 (see 3 fusions); TPM2/TPM1 (see 1 fusions); ACTN1 (see 3 fusions); GRB2 (see 1 fusions); CENPF (see 1 fusions); SP1 (see 1 fusions); NTRK1/TPM3 (see 3 fusions); STAT3 (see 2 fusions); TPM2 (see 1 fusions); MAPRE1 (see 1 fusions); ACTB (see 3 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); PIK3R1 (see 1 fusions); ACTN2 (see 1 fusions); RACK1 (see 3 fusions); EPHB2 (see 1 fusions); SHC1 (see 1 fusions); MYO6 (see 3 fusions); TP53 (see 3 fusions); ATP1A1/MAPK1 (see 1 fusions);

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AF186110chimera1080.1086305.318Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SlyX (PF04102, IPR007236): SlyX
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
2 ACTBoncoprotein170.55020.558Actin (PF00022, IPR004000, SM00268): Actin
3 ACTN1protein found in more fusions250.46766.860CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Dak2 (PF02734, IPR004007, SM01120): DAK2 domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
4 ACTN2protein found in more fusions80.7625.000CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
5 ACTN4interactor240.51151.003CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand
Spectrin (PF00435, IPR002017): Spectrin repeat
EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
Uds1 (PF15456, IPR029191): Up-regulated During Septation
6 ADD1interactor70.7141.508Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
7 AKT1oncoprotein190.31454.836PH (PF00169, IPR001849, SM00233): PH domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
8 ANLNoncoprotein160.8083.839Anillin (PF08174, IPR012966): Cell division protein anillin
PH (PF00169, IPR001849, SM00233): PH domain
Anillin_N (PF16018, IPR031970): Anillin N-terminus
9 ARRB1interactor140.34127.071Arrestin_C (PF02752, IPR011022, SM01017): Arrestin (or S-antigen), C-terminal domain
Arrestin_N (PF00339, IPR011021): Arrestin (or S-antigen), N-terminal domain
10 ATF2oncoprotein110.28914.040bZIP_1 (PF00170, IPR004827): bZIP transcription factor
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
11 ATP1A1protein found in more fusions80.5363.922Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus
Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus
E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase
Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase
Tetraspannin (PF00335, IPR018499): Tetraspanin family
Cation_ATPase (PF13246): Cation transport ATPase (P-type)
12 ATP5F1interactor80.6792.709Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B)
DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
13 CAP1interactor100.6674.808CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal
CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
14 CAPZA2interactor230.59729.831F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
15 CDH2interactor40.6671.500Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region
Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like
Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
Cadherin_3 (PF16184): Cadherin-like
16 CDK2suppressor390.302230.377Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family
Pkinase (PF00069, IPR000719): Protein kinase domain
17 CENPEinteractor31.0000bZIP_1 (PF00170, IPR004827): bZIP transcription factor
VIT1 (PF01988, IPR008217): VIT family
DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515)
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
Fez1 (PF06818): Fez1
FUSC (PF04632, IPR006726): Fusaric acid resistance protein family
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
IncA (PF04156, IPR007285): IncA protein
NPV_P10 (PF05531, IPR008702): Nucleopolyhedrovirus P10 protein
OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like)
Pepsin-I3 (PF06394, IPR010480): Pepsin inhibitor-3-like repeated domain
Pox_A_type_inc (PF04508, IPR007596): Viral A-type inclusion protein repeat
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
SlyX (PF04102, IPR007236): SlyX
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
TrbI_Ftype (PF09677, IPR014115): Type-F conjugative transfer system protein (TrbI_Ftype)
TSC22 (PF01166, IPR000580): TSC-22/dip/bun family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain
ADIP (PF11559, IPR021622): Afadin- and alpha -actinin-Binding
AAA_13 (PF13166, IPR026866): AAA domain
DUF4023 (PF13215, IPR025097): Protein of unknown function (DUF4023)
HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
HMMR_N (PF15905, IPR031787): Hyaluronan mediated motility receptor N-terminal
T3SSipB (PF16535, IPR032391): Type III cell invasion protein SipB
18 CENPFoncoprotein31.0000APG6 (PF04111, IPR007243): Autophagy protein Apg6
ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16)
Bap31 (PF05529, IPR008417): B-cell receptor-associated protein 31-like
bZIP_1 (PF00170, IPR004827): bZIP transcription factor
DivIC (PF04977, IPR007060): Septum formation initiator
DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664)
ZapB (PF06005, IPR009252): Cell division protein ZapB
DUF972 (PF06156, IPR010377): Protein of unknown function (DUF972)
Fez1 (PF06818): Fez1
Filament (PF00038, IPR001664): Intermediate filament protein
HALZ (PF02183, IPR003106, SM00340): Homeobox associated leucine zipper
HrpB7 (PF09486, IPR013392): Bacterial type III secretion protein (HrpB7)
IncA (PF04156, IPR007285): IncA protein
Propep_M14 (PF02244, IPR003146): Carboxypeptidase activation peptide
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
Usp (PF00582, IPR006016): Universal stress protein family
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
CENP-F_N (PF10481, IPR018463): Cenp-F N-terminal domain
CENP-F_C_Rb_bdg (PF10490, IPR018302): Rb-binding domain of kinetochore protein Cenp-F/LEK1
DUF3450 (PF11932, IPR016866): Protein of unknown function (DUF3450)
DUF4140 (PF13600, IPR025554): N-terminal domain of unknown function (DUF4140)
DUF4239 (PF14023, IPR025333): Protein of unknown function (DUF4239)
TolA_bind_tri (PF16331, IPR032519): TolA binding protein trimerisation
GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
19 CFAP97interactor40.5002.154DUF755 (PF05501, IPR008474): Domain of unknown function (DUF755)
KIAA1430 (PF13879, IPR029488): KIAA1430 homologue
GH97_C (PF14509, IPR029483): Glycosyl-hydrolase 97 C-terminal, oligomerisation
20 CKBinteractor100.6225.545ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain
ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
21 CORO1Concoprotein160.7337.051DUF1899 (PF08953, IPR015048, SM01166): Domain of unknown function (DUF1899)
WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
WD40_4 (PF16300): Type of WD40 repeat
22 COX4I1interactor60.6674.167COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
23 COX5Ainteractor50.7001.900COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
24 DBN1oncoprotein260.52660.846Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Cofilin_ADF (PF00241, IPR002108, SM00102): Cofilin/tropomyosin-type actin-binding protein
CAF-1_p150 (PF11600): Chromatin assembly factor 1 complex p150 subunit, N-terminal
MSA-2c (PF12238, IPR021060): Merozoite surface antigen 2c
25 DCTN2interactor130.51515.184Dynamitin (PF04912): Dynamitin
26 EGFRoncoprotein300.286171.303Furin-like (PF00757, IPR006211): Furin-like cysteine rich region
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Recep_L_domain (PF01030, IPR000494): Receptor L domain
GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT)
GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
27 EPHA1suppressor30.6670.222fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
28 EPHB2suppressor41.0000EGF_2 (PF07974, IPR013111): EGF-like domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif)
Ephrin_lbd (PF01404, IPR001090, SM00615): Ephrin receptor ligand binding domain
cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
EphA2_TM (PF14575, IPR027936): Ephrin type-A receptor 2 transmembrane domain
29 FASNinteractor130.54511.296Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain
ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase
ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain
Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain
KR (PF08659, IPR013968, SM00130): KR domain
L27 (PF02828, IPR014775, SM00569): L27 domain
Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain
PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site
Thioesterase (PF00975, IPR001031): Thioesterase domain
YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus
ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase
PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase
KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
30 FLIIoncoprotein170.60323.256Gelsolin (PF00626, IPR007123): Gelsolin repeat
SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies)
LRR_8 (PF13855, IPR001611): Leucine rich repeat
31 FLNAsuppressor300.47484.402CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
Filamin (PF00630, IPR017868): Filamin/ABP280 repeat
32 G3BP1protein found in more fusions90.42910.358NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain
RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
PTPRCAP (PF15713, IPR016553): Protein tyrosine phosphatase receptor type C-associated
33 GAKoncoprotein50.9000.182DnaJ (PF00226, IPR001623, SM00271): DnaJ domain
DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
Pkinase (PF00069, IPR000719): Protein kinase domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
34 GRB2oncoprotein290.307145.158SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
35 HDAC8interactor40.8330.154DNase-RNase (PF02577, IPR003729): Bifunctional nuclease
Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
36 HNRNPKoncoprotein130.39419.266ROKNT (PF08067, IPR012987): ROKNT (NUC014) domain
KH_1 (PF00013, IPR004088, SM00322): KH domain
37 HSP90AA1oncoprotein350.267235.220HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
HSP90 (PF00183, IPR001404): Hsp90 protein
38 HSPD1suppressor110.41811.625Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
39 IKBKGinteractor160.35239.669CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H)
DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725)
NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO
LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein
CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
40 ILF2interactor80.6436.417DZF (PF07528, IPR006561, SM00572): DZF domain
41 ILF3oncoprotein150.37141.618dsrm (PF00035, IPR014720, SM00358): Double-stranded RNA binding motif
DZF (PF07528, IPR006561, SM00572): DZF domain
42 IQGAP1interactor300.47479.525CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
DUF87 (PF01935, IPR002789): Domain of unknown function DUF87
IDEAL (PF08858, IPR014957, SM00914): IDEAL domain
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase
RasGAP_C (PF03836, IPR000593): RasGAP C-terminus
WW (PF00397, IPR001202, SM00456): WW domain
43 IRS1interactor90.6116.458CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
PH (PF00169, IPR001849, SM00233): PH domain
44 JAK2oncoprotein150.53818.182FERM_M (PF00373, IPR019748): FERM central domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
45 JAK3oncoprotein70.4297.700Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
46 KRT18interactor90.32110.013Filament (PF00038, IPR001664): Intermediate filament protein
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
47 LNX1interactor80.4765.771PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain
zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
48 MAP2K7interactor50.6001.404Pkinase (PF00069, IPR000719): Protein kinase domain
49 MAP3K1oncoprotein120.40016.287zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Pkinase (PF00069, IPR000719): Protein kinase domain
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Phostensin_N (PF13916, IPR025903): PP1-regulatory protein, Phostensin N-terminal
50 MAPK1oncoprotein170.28346.125Pkinase (PF00069, IPR000719): Protein kinase domain
51 MAPK8IP3interactor50.7001.400Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP)
Jnk-SapK_ap_N (PF09744, IPR019143): JNK_SAPK-associated protein-1
Rootletin (PF15035): Ciliary rootlet component, centrosome cohesion
UPF0449 (PF15136, IPR028227): Uncharacterised protein family UPF0449
JIP_LZII (PF16471, IPR032486): JNK-interacting protein leucine zipper II
52 MAPRE1oncoprotein130.47019.688CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain
EB1 (PF03271, IPR004953): EB1-like C-terminal motif
SUIM_assoc (PF16619): Unstructured region C-term to UIM in Ataxin3
53 MCM2oncoprotein290.307124.401AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA)
MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family
MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2
MCM_N (PF14551, IPR027925): MCM N-terminal domain
MCM_OB (PF17207): MCM OB domain
54 MYBPC2interactor100fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
55 MYH10interactor110.5456.698IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
56 MYH7Binteractor60.8670.686Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
57 MYH9suppressor310.52760.519IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
58 MYO18Ainteractor210.67616.098Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_tail_1 (PF01576, IPR002928): Myosin tail
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein
CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
59 MYO19interactor200.67414.995IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
60 MYO6protein found in more fusions170.59215.906BUD22 (PF09073, IPR015158): BUD22
IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif
Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain
Rad9 (PF04139, IPR007268): Rad9
Sec62 (PF03839, IPR004728): Translocation protein Sec62
XhlA (PF10779, IPR019715): Haemolysin XhlA
Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
DUF4887 (PF16228, IPR032615): Domain of unknown function (DUF4887)
Myosin-VI_CBD (PF16521, IPR032412): Myosin VI cargo binding domain
61 NDUFB10interactor41.0000NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
62 NTRK1oncoprotein570.169877.048I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
LRR_8 (PF13855, IPR001611): Leucine rich repeat
TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
63 OSTF1interactor40.5000.718SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
64 PACSIN1interactor200FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain
DUF2605 (PF10792, IPR019728): Protein of unknown function (DUF2605)
DUF4446 (PF14584, IPR027981): Protein of unknown function (DUF4446)
SH3_9 (PF14604, IPR001452): Variant SH3 domain
NPF (PF16601): Rabosyn-5 repeating NPF sequence-motif
65 PAN2interactor200.45842.865RNase_T (PF00929, IPR013520): Exonuclease
UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase
WD40_like (PF17005, IPR031544): WD40-like domain
66 PARK2suppressor210.26868.318IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain
ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
67 PCMT1interactor50.8000.254PCMT (PF01135, IPR000682): Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
68 PDLIM3interactor21.0000LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
69 PDLIM7interactor120.7736.083LIM (PF00412, IPR001781, SM00132): LIM domain
PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF)
zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein
DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
70 PIK3R1oncoprotein120.6556.890RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_2 (PF07653, IPR011511): Variant SH3 domain
PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
71 PLCG1oncoprotein110.52712.954C2 (PF00168, IPR000008, SM00239): C2 domain
PH (PF00169, IPR001849, SM00233): PH domain
SH2 (PF00017, IPR000980, SM00252): SH2 domain
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
PH_12 (PF16457, IPR001849): Pleckstrin homology domain
72 PPP1CBinteractor240.63028.186Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
73 PPP1CConcoprotein210.44350.208Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase
STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
74 PRKCDBPsuppressor50.5004.333A1_Propeptide (PF07966, IPR012848): A1 Propeptide
PTRF_SDPR (PF15237, IPR026752): PTRF/SDPR family
75 PRKCQinteractor51.0000Pkinase (PF00069, IPR000719): Protein kinase domain
Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain)
76 PSMA1interactor140.50017.185Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
77 PSMA6interactor100.6675.319Proteasome (PF00227, IPR001353): Proteasome subunit
Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
78 PSMC2protein found in more fusions100.7503.214AAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
79 PSMD1interactor100.7333.868PA26 (PF04636, IPR006730): PA26 p53-induced protein (sestrin)
PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
HEAT_2 (PF13646): HEAT repeats
80 PSMD2oncoprotein110.56412.286PC_rep (PF01851, IPR002015): Proteasome/cyclosome repeat
THAP (PF05485, IPR006612, SM00980): THAP domain
HEAT_2 (PF13646): HEAT repeats
81 PYCARDsuppressor200CARD (PF00619, IPR001315, SM00114): Caspase recruitment domain
PYRIN (PF02758, IPR004020): PAAD/DAPIN/Pyrin domain
82 RAB35oncoprotein21.0000Ras (PF00071, IPR001806, SM00173): Ras family
83 RACK1suppressor70.7331.702WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat
ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
84 SERPINH1interactor70.4764.240Serpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
85 SHC1oncoprotein180.44130.631PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
86 SHC3interactor31.0000PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID)
SH2 (PF00017, IPR000980, SM00252): SH2 domain
87 SHTN1interactor90.4647.462Asp-B-Hydro_N (PF05279, IPR007943): Aspartyl beta-hydroxylase N-terminal region
VIT1 (PF01988, IPR008217): VIT family
Pinin_SDK_memA (PF04696, IPR006786): pinin/SDK/memA/ protein conserved region
Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein
BLOC1_2 (PF10046, IPR019269): Biogenesis of lysosome-related organelles complex-1 subunit 2
Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
DUF3484 (PF11983, IPR021873): Membrane-attachment and polymerisation-promoting switch
Dscam_C (PF12355, IPR021012): Down syndrome cell adhesion molecule C terminal
PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
PRIMA1 (PF16101): Proline-rich membrane anchor 1
88 SIRT1suppressor140.32130.363DUF592 (PF04574, IPR007654): Protein of unknown function (DUF592)
SIR2 (PF02146, IPR003000): Sir2 family
TPP_enzyme_M (PF00205, IPR012000): Thiamine pyrophosphate enzyme, central domain
89 SLC33A1interactor100Acatn (PF13000, IPR024371): Acetyl-coenzyme A transporter 1
90 SMC6interactor31.0000SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain
91 SNRNP70interactor60.6003.054RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
MIP-T3 (PF10243): Microtubule-binding protein MIP-T3
U1snRNP70_N (PF12220, IPR022023): U1 small nuclear ribonucleoprotein of 70kDa MW N terminal
92 SOCS1suppressor70.8101.376SH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS_box (PF07525, IPR001496): SOCS box
93 SP1protein found in more fusions160.46726.063zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding
Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
Miga (PF10265, IPR019392): Mitoguardin
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain
FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
94 SRConcoprotein220.33385.562Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
SH2 (PF00017, IPR000980, SM00252): SH2 domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
95 SRSF2oncoprotein50.8330.125RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
TP2 (PF01254, IPR000678): Nuclear transition protein 2
Transformer (PF06495, IPR010519): Fruit fly transformer protein
Apt1 (PF10351, IPR019443): Golgi-body localisation protein domain
DUF2457 (PF10446, IPR018853): Protein of unknown function (DUF2457)
96 SRXN1interactor60.6003.533ParBc (PF02195, IPR003115): ParB-like nuclease domain
97 STAT3suppressor130.47019.333SH2 (PF00017, IPR000980, SM00252): SH2 domain
STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain
STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain
STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
98 SULT1A1interactor60.6672.086Sulfotransfer_1 (PF00685, IPR000863): Sulfotransferase domain
99 TBCDinteractor40.8330.333HEAT (PF02985, IPR000357): HEAT repeat
HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat
TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal
HEAT_EZ (PF13513): HEAT-like repeat
100 TCERG1interactor41.0000FF (PF01846, IPR002713, SM00441): FF domain
WW (PF00397, IPR001202, SM00456): WW domain
Folliculin (PF11704, IPR021713): Vesicle coat protein involved in Golgi to plasma membrane transport
DUF3807 (PF12720, IPR024526): Protein of unknown function (DUF3807)
DUF3886 (PF13025, IPR024980): Protein of unknown function (DUF3886)
Spore_coat_CotO (PF14153, IPR025439): Spore coat protein CotO
FAM150 (PF15129, IPR029364): FAM150 family
101 TELO2interactor31.0000Telomere_reg-2 (PF10193, IPR019337): Telomere length regulation protein
HEAT_2 (PF13646): HEAT repeats
102 TP53suppressor280.325112.510DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
P53 (PF00870, IPR011615): P53 DNA-binding domain
P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
103 TPM1protein found in more fusions360.304243.293Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
104 TPM2protein found in more fusions250.44973.160DASH_Spc19 (PF08287, IPR013251): Spc19
Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
105 TPM3oncoprotein400.275312.567Tropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
106 TRIP6interactor90.30617.767DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region
LIM (PF00412, IPR001781, SM00132): LIM domain
107 TUBB4Binteractor130.55110.014Tubulin (PF00091, IPR003008, SM00864): Tubulin/FtsZ family, GTPase domain
Tubulin_C (PF03953, IPR018316, SM00865): Tubulin C-terminal domain
108 TXN2interactor60.5334.833Thioredoxin (PF00085, IPR013766): Thioredoxin
109 ZYXsuppressor50.5002.233DUF1180 (PF06679, IPR009565): Protein of unknown function (DUF1180)
LIM (PF00412, IPR001781, SM00132): LIM domain
DUF2757 (PF10955, IPR020115): Protein of unknown function (DUF2757)

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 ALKparental proteinMAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A
Gly_rich (PF12810): Glycine rich protein
FXa_inhibition (PF14670): Coagulation Factor Xa inhibitory site
2 BCAR1oncoproteinSerine_rich (PF08824, IPR014928): Serine rich protein interaction domain
SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
DUF3513 (PF12026, IPR021901): Domain of unknown function (DUF3513)
Caskin1-CID (PF16600): Caskin1 CASK-interaction domain
3 BICD2interactorBicD (PF09730, IPR018477): Microtubule-associated protein Bicaudal-D
4 CDK13interactorK_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain
Pkinase (PF00069, IPR000719): Protein kinase domain
Macoilin (PF09726, IPR019130): Transmembrane protein
THRAP3_BCLAF1 (PF15440, IPR029199): THRAP3/BCLAF1 family
5 EIF4BinteractorRRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
DUF3774 (PF12609, IPR022251): Wound-induced protein
PROL5-SMR (PF15621, IPR026288): Proline-rich submaxillary gland androgen-regulated family
6 ERRFI1suppressorGTPase_binding (PF09027, IPR015116): GTPase binding
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
7 IRF7interactorIRF (PF00605, IPR001346, SM00348): Interferon regulatory factor transcription factor
IRF-3 (PF10401, IPR019471): Interferon-regulatory factor 3
8 IRS4interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
TAT_signal (PF10518, IPR019546): TAT (twin-arginine translocation) pathway signal sequence
PH_11 (PF15413): Pleckstrin homology domain
9 KRT74interactorFilament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
Keratin_2_head (PF16208, IPR032444): Keratin type II head
10 MAP3K4suppressorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Pkinase (PF00069, IPR000719): Protein kinase domain
PLU-1 (PF08429, IPR013637): PLU-1-like protein
Radial_spoke_3 (PF06098, IPR009290): Radial spoke protein 3
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
DUF3958 (PF13125, IPR025014): Protein of unknown function (DUF3958)
11 MAP3K5oncoproteinPkinase (PF00069, IPR000719): Protein kinase domain
DUF4071 (PF13281, IPR025136): Domain of unknown function (DUF4071)
12 MEP1BinteractorAstacin (PF01400, IPR001506): Astacin (Peptidase family M12A)
EGF (PF00008, IPR000742, SM00181): EGF-like domain
MAM (PF00629, IPR000998, SM00137): MAM domain, meprin/A5/mu
LRRC37AB_C (PF14914, IPR029423): LRRC37A/B like protein 1 C-terminal domain
13 MTIF2interactorGTP_EFTU (PF00009, IPR000795): Elongation factor Tu GTP binding domain
Dynamin_N (PF00350, IPR001401, SM00053): Dynamin family
IF-2 (PF11987, IPR023115): Translation-initiation factor 2
14 MYLKinteractorAmelogenin (PF02948, IPR004116, SM00818): Amelogenin
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E
I-set (PF07679, IPR013098): Immunoglobulin I-set domain
Pkinase (PF00069, IPR000719): Protein kinase domain
23ISL (PF16620): Unstructured linker between I-set domains 2 and 3 on MYLCK
15 PDX1suppressorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
TMEM171 (PF15471, IPR029173): Transmembrane protein family 171
16 PIK3CBoncoproteinPI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2
PI3K_p85B (PF02192, IPR003113, SM00143): PI3-kinase family, p85-binding domain
PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain
PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain)
RWD (PF05773, IPR006575, SM00591): RWD domain
PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase
Tom37_C (PF11801, IPR019564): Tom37 C-terminal domain
DUF4381 (PF14316, IPR025489): Domain of unknown function (DUF4381)
17 PLCB2oncoproteinC2 (PF00168, IPR000008, SM00239): C2 domain
DUF1154 (PF06631, IPR009535): Protein of unknown function (DUF1154)
EF-hand_like (PF09279, IPR015359): Phosphoinositide-specific phospholipase C, efhand-like
PLC-beta_C (PF08703, IPR014815): PLC-beta C terminal
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain
DUF3682 (PF12446, IPR022152): Protein of unknown function (DUF3682)
FlgT_N (PF16548, IPR032370): Flagellar assembly protein T, N-terminal domain
18 PTNoncoproteinPTN_MK_C (PF01091, IPR020090): PTN/MK heparin-binding protein family, C-terminal domain
PTN_MK_N (PF05196, IPR020089): PTN/MK heparin-binding protein family, N-terminal domain
19 PXNoncoproteinLIM (PF00412, IPR001781, SM00132): LIM domain
Paxillin (PF03535): Paxillin family
20 RAD17interactorMvb12 (PF09452, IPR019014): ESCRT-I subunit Mvb12
Rad17 (PF03215): Rad17 cell cycle checkpoint protein
21 SOCS5interactorSH2 (PF00017, IPR000980, SM00252): SH2 domain
SOCS (PF12610, IPR001496, SM00253): Suppressor of cytokine signalling
SOCS_box (PF07525, IPR001496): SOCS box
22 TNK2interactorCAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
GTPase_binding (PF09027, IPR015116): GTPase binding
Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
Inhibitor_Mig-6 (PF11555, IPR021619): EGFR receptor inhibitor Mig-6
UBA_4 (PF14555): UBA-like domain
SH3_9 (PF14604, IPR001452): Variant SH3 domain
23 TPM3P4interactorNA
24 TPM4parental proteinTropomyosin (PF00261, IPR000533): Tropomyosin
Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
25 TUBGCP2interactorSpc97_Spc98 (PF04130, IPR007259): Spc97 / Spc98 family
zf-Tim10_DDP (PF02953, IPR004217): Tim10/DDP family zinc finger
26 UBASH3AinteractorHis_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1)
UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain
Ste5 (PF11610, IPR021651): Scaffold protein Ste5-Fus5 binding region
SH3_9 (PF14604, IPR001452): Variant SH3 domain
27 VIMsuppressorFilament (PF00038, IPR001664): Intermediate filament protein
Filament_head (PF04732, IPR006821): Intermediate filament head (DNA binding) region
28 ZC3HC1interactorRsm1 (PF08600, IPR013909): Rsm1-like
zf-C3HC (PF07967, IPR012935): C3HC zinc finger-like

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