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Visible interactions: all affected independent (normal) missing nothing (blank)
Chimeric state: ordinary fusion big fusion

Visualization interactions

Powered by Cytoscape Web for: AF121182 is the fusion of parental proteins SERPINA1, AGXT2 (from a repository: Sat May 6 06:48:02 2017)
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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)3
The number (and %) of the onco-proteins1 (33.33 %)
The number (and %) of the tumor suppressors0 (0.00 %)
Total number of binary PPIs (saturation %)2 (66.67 %)
The number (and %) of affected PPIs2 (100.00 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI1.333
Assortativity coefficient0
The network average Clustering coefficient0.000
The number (and %) of a zero Clustering coefficients3 (100.00 %)
The number (and %) of a zero Betweenness Centrality2 (66.67 %)

ACTIVE INTERACTORS
MISSING INTERACTORS


List of the fusions

PPI for parental proteins: AGXT2,SERPINA1 All fusions
: AF121182;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Coefficient
Betweenness
Centrality
Domains (Pfam, InterPro, SMART): description
1 AF121182chimera202.000Aminotran_3 (PF00202, IPR005814): Aminotransferase class-III
2 CYP2E1interactor100p450 (PF00067, IPR001128): Cytochrome P450
3 FBXO2interactor100FBA (PF04300, IPR007397): F-box associated region
F-box (PF00646, IPR001810, SM00256): F-box domain

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 AGXT2parental proteinAminotran_3 (PF00202, IPR005814): Aminotransferase class-III
2 ALDH2oncoproteinAldedh (PF00171, IPR015590): Aldehyde dehydrogenase family
DUF1235 (PF06822, IPR009641): Protein of unknown function (DUF1235)
3 ALDOBoncoproteinGlycolytic (PF00274, IPR000741): Fructose-bisphosphate aldolase class-I
4 ATP5C1interactorATP-synt (PF00231, IPR000131): ATP synthase
ACT_4 (PF13291, IPR002912): ACT domain
5 CA8interactorCarb_anhydrase (PF00194, IPR001148, SM01057): Eukaryotic-type carbonic anhydrase
6 CANXinteractorCalreticulin (PF00262, IPR001580): Calreticulin family
DUF1510 (PF07423, IPR009988): Protein of unknown function (DUF1510)
TRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
7 DDX19BinteractorDEAD (PF00270, IPR011545): DEAD/DEAH box helicase
Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
8 DERL1interactorDER1 (PF04511, IPR007599): Der1-like family
9 DERL2interactorDER1 (PF04511, IPR007599): Der1-like family
10 ECHS1interactorECH_1 (PF00378, IPR001753): Enoyl-CoA hydratase/isomerase
11 ELANEinteractorTrypsin (PF00089, IPR001254, SM00020): Trypsin
12 ERLEC1interactorPRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
13 FN1oncoproteinfn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain
fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain
fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain
DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
14 GDPD1interactorGDPD (PF03009, IPR004129): Glycerophosphoryl diester phosphodiesterase family
PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain
15 GSDMBinteractorGasdermin (PF04598, IPR007677): Gasdermin family
16 HSPA5oncoproteinHSP70 (PF00012, IPR013126): Hsp70 protein
17 ICE2interactorNARG2_C (PF10505, IPR019535): NMDA receptor-regulated gene protein 2 C-terminus
CLAMP (PF14769, IPR032727): Flagellar C1a complex subunit C1a-32
18 KLK3interactorTrypsin (PF00089, IPR001254, SM00020): Trypsin
19 LAMTOR5interactorLAMTOR5 (PF16672, IPR024135): Ragulator complex protein LAMTOR5
20 MIS12interactorDUF349 (PF03993, IPR007139): Domain of Unknown Function (DUF349)
Mis12 (PF05859, IPR008685): Mis12 protein
21 OS9interactorDNA_pol_phi (PF04931, IPR007015): DNA polymerase phi
Nucleo_P87 (PF07267, IPR009893): Nucleopolyhedrovirus capsid protein P87
PRKCSH (PF07915, IPR012913): Glucosidase II beta subunit-like protein
Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein
PRKCSH_1 (PF13015, IPR009011): Glucosidase II beta subunit-like protein
22 PLK2suppressorPkinase (PF00069, IPR000719): Protein kinase domain
POLO_box (PF00659, IPR000959): POLO box duplicated region
G_path_suppress (PF15991, IPR026094): G-protein pathway suppressor
23 PRTN3interactorTrypsin (PF00089, IPR001254, SM00020): Trypsin
24 RAP2AoncoproteinRas (PF00071, IPR001806, SM00173): Ras family
25 RCHY1suppressorC1_2 (PF03107, IPR004146): C1 domain
zf-CHY (PF05495, IPR008913): CHY zinc finger
zf-RING_2 (PF13639, IPR001841, SM00184): Ring finger domain
Prok-RING_4 (PF14447): Prokaryotic RING finger family 4
zinc_ribbon_6 (PF14599): Zinc-ribbon
26 SDC2interactorGlycophorin_A (PF01102, IPR001195): Glycophorin A
Syndecan (PF01034, IPR027789): Syndecan domain
DUF3275 (PF11679, IPR021693): Protein of unknown function (DUF3275)
27 SERPINA1parental proteinSerpin (PF00079, IPR023796, SM00093): Serpin (serine protease inhibitor)
28 SMAD4suppressorMH1 (PF03165, IPR003619, SM00523): MH1 domain
MH2 (PF03166, IPR001132, SM00524): MH2 domain
29 SSR1interactorTRAP_alpha (PF03896, IPR005595): Translocon-associated protein (TRAP), alpha subunit
30 VCPinteractorAAA (PF00004, IPR003959, SM00382): ATPase family associated with various cellular activities (AAA)
CDC48_2 (PF02933, IPR004201, SM01072): Cell division protein 48 (CDC48), domain 2
CDC48_N (PF02359, IPR003338, SM01073): Cell division protein 48 (CDC48), N-terminal domain
TniB (PF05621, IPR008868): Bacterial TniB protein
Vps4_C (PF09336, IPR015415): Vps4 C terminal oligomerisation domain
DUF3944 (PF13099, IPR025217): Domain of unknown function (DUF3944)
31 VKORC1interactorVKOR (PF07884, IPR012932, SM00756): Vitamin K epoxide reductase family
32 ZNF558interactorKRAB (PF01352, IPR001909, SM00349): KRAB box
zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type
zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain

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