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Visualization interactions

Powered by Cytoscape Web for: AF014118 is the fusion of parental proteins PAQR4, PKMYT1 (from a repository: Sun Mar 11 18:24:31 2018)

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Statistics and Network structure information

Statistic of PPI Value(s)
The number of interactors (fusion and proteins)13
The number (and %) of the onco-proteins5 (38.46 %)
The number (and %) of the tumor suppressors3 (23.08 %)
Total number of binary PPIs (saturation %)22 (28.21 %)
The number (and %) of affected PPIs12 (54.55 %)
The number of possible different fusions1
PPI diameter2
PPI radius1
The average degree of PPI2.615
Assortativity coefficient-0.5963
The network average Clustering coefficient0.442
The number (and %) of a zero Clustering coefficients6 (46.15 %)
The number (and %) of a zero Betweenness Centrality11 (84.62 %)


List of the fusions

PPI for parental proteins: PKMYT1,PAQR4 All fusions
: AF014118;
Proteins found in more fusions

List of active interactors

# Name Type Number of PPI (degree) Clustering
Domains (Pfam, InterPro, SMART): description
1 AF014118chimera120.076120.000Pkinase (PF00069, IPR000719): Protein kinase domain
2 CCNA2oncoprotein31.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
Cyclin_N2 (PF16500, IPR032447): N-terminal region of cyclin_N
3 CCNB1oncoprotein31.0000Adeno_E1A (PF02703, IPR003853): Early E1A protein
Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
4 CCNB2interactor31.0000Cyclin_C (PF02984, IPR004367): Cyclin, C-terminal domain
Cyclin_N (PF00134, IPR006671): Cyclin, N-terminal domain
5 CDK1oncoprotein50.6672.000Pkinase (PF00069, IPR000719): Protein kinase domain
6 MAPK10suppressor200Pkinase (PF00069, IPR000719): Protein kinase domain
7 MAPK8oncoprotein200DUF530 (PF04409, IPR007503): Protein of unknown function (DUF530)
Pkinase (PF00069, IPR000719): Protein kinase domain
8 PIN1suppressor100Rotamase (PF00639, IPR000297): PPIC-type PPIASE domain
WW (PF00397, IPR001202, SM00456): WW domain
9 PLIN3interactor200Perilipin (PF03036, IPR004279): Perilipin family
10 PTENsuppressor100DSPc (PF00782, IPR020422, SM00195): Dual specificity phosphatase, catalytic domain
PTEN_C2 (PF10409, IPR014020): C2 domain of PTEN tumour-suppressor protein
11 STEAP3interactor21.0000DUF781 (PF05612, IPR008499): Mouse protein of unknown function (DUF781)
F420_oxidored (PF03807, IPR028939): NADP oxidoreductase coenzyme F420-dependent
Ferric_reduct (PF01794, IPR013130): Ferric reductase like transmembrane component
12 THOC2interactor100Sec62 (PF03839, IPR004728): Translocation protein Sec62
Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2
Thoc2 (PF11732, IPR021726): Transcription- and export-related complex subunit
DUF3915 (PF13054, IPR025026): Protein of unknown function (DUF3915)
THOC2_N (PF16134, IPR032302): THO complex subunit 2 N-terminus
13 TMEM216interactor21.0000Transmemb_17 (PF09799, IPR019184): Predicted membrane protein

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List of missing interactors

# Name Type Domains (Pfam, InterPro, SMART): description Fusion(s)
1 PAQR4interactorHlyIII (PF03006, IPR004254): Haemolysin-III related
2 PKMYT1parental proteinPkinase (PF00069, IPR000719): Protein kinase domain
3 SPINT2suppressorKunitz_BPTI (PF00014, IPR002223, SM00131): Kunitz/Bovine pancreatic trypsin inhibitor domain

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