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Fusion ID: Protein names:	AB795243
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Visualization interactions

Cytoscape Web for: AB795243 is the fusion of parental proteins SLC34A2, ROS1 (from a repository: Tue Feb 14 21:23:20 2017)

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Statistics and Network structure information

Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	6
The number (and %) of the onco-proteins	3 (50.00 %)
The number (and %) of the tumor suppressors	2 (33.33 %)
Total number of binary PPIs (saturation %)	11 (73.33 %)
The number (and %) of affected PPIs	5 (45.45 %)
The number of possible different fusions	3
PPI diameter	2
PPI radius	1
The average degree of PPI	2.667
Assortativity coefficient	0.1240
The network average Clustering coefficient	0.633
The number (and %) of a zero Clustering coefficients	1 (16.67 %)
The number (and %) of a zero Betweenness Centrality	4 (66.67 %)

ACTIVE INTERACTORS

MISSING INTERACTORS

List of the fusions
PPI for parental proteins: ROS1,SLC34A2	All fusions : AB795243;
Proteins found in more fusions	GRB2 (see 1 fusions); PTPN11 (see 1 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AB795243	chimera	5	0.300	11.000	DUF805 (PF05656, IPR008523): Protein of unknown function (DUF805) Na_Pi_cotrans (PF02690, IPR003841): Na+/Pi-cotransporter Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)
2	GRB2	oncoprotein	5	0.500	3.000	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
3	IKBKG	interactor	2	0	0	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
4	PTPN11	suppressor	3	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
5	PTPN6	suppressor	2	1.000	0	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
6	VAV3	oncoprotein	2	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326) C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain PH_10 (PF15411): Pleckstrin homology domain

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	NUDCD1	interactor	CS (PF04969, IPR007052): CS domain
2	ROS1	parental protein	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
3	SLC34A2	parental protein	TMEM43 (PF07787, IPR012430): Transmembrane protein 43 Na_Pi_cotrans (PF02690, IPR003841): Na+/Pi-cotransporter SKG6 (PF08693, IPR014805): Transmembrane alpha-helix domain DUF2207 (PF09972, IPR018702): Predicted membrane protein (DUF2207)

B a c k t o T o p ⇑