Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	118
The number (and %) of the onco-proteins	37 (31.36 %)
The number (and %) of the tumor suppressors	13 (11.02 %)
Total number of binary PPIs (saturation %)	737 (10.68 %)
The number (and %) of affected PPIs	117 (15.88 %)
The number of possible different fusions	28
PPI diameter	2
PPI radius	1
The average degree of PPI	11.644
Assortativity coefficient	-0.2564
The network average Clustering coefficient	0.534
The number (and %) of a zero Clustering coefficients	5 (4.24 %)
The number (and %) of a zero Betweenness Centrality	18 (15.25 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: TPM3,ROS1	All fusions : AB795239;
Proteins found in more fusions	HSPB1/OBSL1 (see 1 fusions); PTPN11 (see 1 fusions); TPM1 (see 2 fusions); HSP90AA1 (see 2 fusions); TPM2/MYH9 (see 1 fusions); TPM2/TPM1 (see 1 fusions); CUL7 (see 2 fusions); ACTN1 (see 3 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); GRB2 (see 1 fusions); SP1 (see 1 fusions); TPM2 (see 1 fusions); AHCYL1 (see 3 fusions); MAD1L1 (see 3 fusions); PRDX1 (see 1 fusions); EIF4A2 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); ACTN2 (see 1 fusions); TLK1 (see 1 fusions); HSPB1 (see 4 fusions); THOC1 (see 3 fusions); LRRK2 (see 1 fusions); DAPK1 (see 1 fusions); TNNT1 (see 1 fusions); TP53 (see 3 fusions);

List of the fusions

PPI for parental proteins: TPM3,ROS1

All fusions

: AB795239;

Proteins found in more fusions

HSPB1/OBSL1 (see 1 fusions); PTPN11 (see 1 fusions); TPM1 (see 2 fusions); HSP90AA1 (see 2 fusions); TPM2/MYH9 (see 1 fusions); TPM2/TPM1 (see 1 fusions); CUL7 (see 2 fusions); ACTN1 (see 3 fusions); CUL3 (see 1 fusions); HSP90AB1 (see 1 fusions); GRB2 (see 1 fusions); SP1 (see 1 fusions); TPM2 (see 1 fusions); AHCYL1 (see 3 fusions); MAD1L1 (see 3 fusions); PRDX1 (see 1 fusions); EIF4A2 (see 2 fusions); EGFR (see 2 fusions); MCM2 (see 1 fusions); ACTN2 (see 1 fusions); TLK1 (see 1 fusions); HSPB1 (see 4 fusions); THOC1 (see 3 fusions); LRRK2 (see 1 fusions); DAPK1 (see 1 fusions); TNNT1 (see 1 fusions); TP53 (see 3 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AB795239	chimera	117	0.084	8688.478	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
2	ACTN1	protein found in more fusions	25	0.489	60.965	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain Dak2 (PF02734, IPR004007, SM01120): DAK2 domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
3	ACTN2	protein found in more fusions	8	0.857	0.908	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Nsp1_C (PF05064, IPR007758): Nsp1-like C-terminal region Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair
4	ACTN4	interactor	27	0.447	79.033	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain EFhand_Ca_insen (PF08726, IPR014837): Ca2+ insensitive EF hand Spectrin (PF00435, IPR002017): Spectrin repeat EF-hand_7 (PF13499, IPR011992): EF-hand domain pair Uds1 (PF15456, IPR029191): Up-regulated During Septation
5	ADD1	interactor	6	0.867	0.382	Aldolase_II (PF00596, IPR001303, SM01007): Class II Aldolase and Adducin N-terminal domain CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal
6	AHCYL1	suppressor	9	0.393	9.819	AdoHcyase (PF05221, IPR000043, SM00996): S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD (PF00670, IPR015878, SM00997): S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF515 (PF04415, IPR007509): Protein of unknown function (DUF515) Big_3_5 (PF16640, IPR032109): Bacterial Ig-like domain (group 3)
7	ANLN	oncoprotein	13	0.808	8.410	Anillin (PF08174, IPR012966): Cell division protein anillin PH (PF00169, IPR001849, SM00233): PH domain Anillin_N (PF16018, IPR031970): Anillin N-terminus
8	ATP1A1	interactor	10	0.400	11.892	Cation_ATPase_C (PF00689, IPR006068): Cation transporting ATPase, C-terminus Cation_ATPase_N (PF00690, IPR004014, SM00831): Cation transporter/ATPase, N-terminus E1-E2_ATPase (PF00122, IPR008250): E1-E2 ATPase Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase Tetraspannin (PF00335, IPR018499): Tetraspanin family Cation_ATPase (PF13246): Cation transport ATPase (P-type)
9	ATP5F1	interactor	10	0.422	11.522	Mt_ATP-synt_B (PF05405, IPR008688): Mitochondrial ATP synthase B chain precursor (ATP-synt_B) DUF2105 (PF09878, IPR019212): Predicted membrane protein (DUF2105)
10	BLOC1S6	interactor	5	0.500	3.000	BRE1 (PF08647, IPR013956): BRE1 E3 ubiquitin ligase Snapin_Pallidin (PF14712, IPR028119): Snapin/Pallidin
11	BRCA1	suppressor	14	0.372	32.492	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain zf-C3HC4 (PF00097, IPR018957): Zinc finger, C3HC4 type (RING finger) BRCT_assoc (PF12820, IPR025994): Serine-rich domain associated with BRCT
12	C1orf216	interactor	3	0.667	1.000	DUF4653 (PF15546, IPR027812): Domain of unknown function (DUF4653)
13	CAP1	interactor	11	0.733	3.351	CAP_C (PF08603, IPR013912): Adenylate cyclase associated (CAP) C terminal CAP_N (PF01213, IPR013992): Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg (PF05308, IPR007972): Mitochondrial fission regulator
14	CAPZA2	interactor	22	0.537	41.897	F-actin_cap_A (PF01267, IPR002189): F-actin capping protein alpha subunit
15	CCDC102B	interactor	6	0.700	2.000	Filament (PF00038, IPR001664): Intermediate filament protein Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Myosin_tail_1 (PF01576, IPR002928): Myosin tail PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
16	CCDC114	interactor	2	1.000	0	FlaC_arch (PF05377, IPR008039): Flagella accessory protein C (FlaC) Histone_HNS (PF00816, IPR001801): H-NS histone family Hydantoinase_B (PF02538, IPR003692): Hydantoinase B/oxoprolinase DUF2353 (PF09789, IPR019179): Uncharacterized coiled-coil protein (DUF2353) PLAC9 (PF15205, IPR027941): Placenta-specific protein 9
17	CCDC146	interactor	3	0.667	1.000	ATG16 (PF08614, IPR013923): Autophagy protein 16 (ATG16) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) DUF724 (PF05266, IPR007930): Protein of unknown function (DUF724) DUF745 (PF05335, IPR007999): Protein of unknown function (DUF745) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Med21 (PF11221, IPR021384): Subunit 21 of Mediator complex Kinetocho_Slk19 (PF12709, IPR024312): Central kinetochore-associated FOXP-CC (PF16159, IPR032354): FOXP coiled-coil domain BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
18	CCHCR1	interactor	8	0.333	12.067	HCR (PF07111, IPR009800): Alpha helical coiled-coil rod protein (HCR)
19	CDC123	interactor	2	1.000	0	D123 (PF07065, IPR009772): D123
20	CDK2	suppressor	29	0.349	117.038	Kdo (PF06293, IPR010440): Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase (PF00069, IPR000719): Protein kinase domain
21	CKB	interactor	13	0.487	14.631	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
22	CKMT1A	interactor	3	0.667	0.500	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
23	CKMT1B	interactor	4	0.667	0.682	ATP-gua_Ptrans (PF00217, IPR022414): ATP:guanido phosphotransferase, C-terminal catalytic domain ATP-gua_PtransN (PF02807, IPR022413): ATP:guanido phosphotransferase, N-terminal domain
24	COX4I1	interactor	6	0.733	2.333	COX4 (PF02936, IPR004203): Cytochrome c oxidase subunit IV
25	COX5A	interactor	6	0.533	3.347	COX5A (PF02284, IPR003204): Cytochrome c oxidase subunit Va
26	CUL3	protein found in more fusions	27	0.191	175.282	Cullin (PF00888, IPR001373, SM00182): Cullin family Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain WAC_Acf1_DNA_bd (PF10537, IPR013136): ATP-utilising chromatin assembly and remodelling N-terminal
27	CUL7	protein found in more fusions	21	0.289	62.266	ANAPC10 (PF03256, IPR004939): Anaphase-promoting complex, subunit 10 (APC10) Cullin (PF00888, IPR001373, SM00182): Cullin family DUF1918 (PF08940, IPR015035): Domain of unknown function (DUF1918) Cullin_Nedd8 (PF10557, IPR019559, SM00884): Cullin protein neddylation domain Cul7 (PF11515, IPR021097): Mouse development and cellular proliferation protein Cullin-7
28	CYC1	interactor	9	0.389	11.733	Cytochrom_C1 (PF02167, IPR002326): Cytochrome C1 family
29	DAPK1	suppressor	8	0.524	3.587	ABC_tran (PF00005, IPR003439): ABC transporter Death (PF00531, IPR000488, SM00005): Death domain Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) AAA_23 (PF13476): AAA domain Ank_5 (PF13857): Ankyrin repeats (many copies) COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
30	DVL2	interactor	8	0.571	4.706	DEP (PF00610, IPR000591, SM00049): Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Dishevelled (PF02377, IPR003351): Dishevelled specific domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) DIX (PF00778, IPR001158, SM00021): DIX domain Dsh_C (PF12316, IPR024580): Segment polarity protein dishevelled (Dsh) C terminal
31	EGFR	oncoprotein	23	0.316	91.106	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GAPT (PF11770, IPR021082): GRB2-binding adapter (GAPT) GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
32	EIF4A2	oncoprotein	6	0.500	3.800	DEAD (PF00270, IPR011545): DEAD/DEAH box helicase Helicase_C (PF00271, IPR001650, SM00490): Helicase conserved C-terminal domain
33	ELAVL1	oncoprotein	29	0.212	203.425	RRM_1 (PF00076, IPR000504, SM00361): RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
34	FAM9C	interactor	1	0	0	Cor1 (PF04803, IPR006888): Cor1/Xlr/Xmr conserved region DUF3391 (PF11871, IPR021812): Domain of unknown function (DUF3391)
35	FASN	interactor	16	0.457	24.776	Acyl_transf_1 (PF00698, IPR014043): Acyl transferase domain ADH_zinc_N (PF00107, IPR013149): Zinc-binding dehydrogenase ketoacyl-synt (PF00109, IPR014030): Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C (PF02801, IPR014031): Beta-ketoacyl synthase, C-terminal domain KR (PF08659, IPR013968, SM00130): KR domain L27 (PF02828, IPR014775, SM00569): L27 domain Methyltransf_12 (PF08242, IPR013217): Methyltransferase domain PP-binding (PF00550, IPR009081): Phosphopantetheine attachment site Thioesterase (PF00975, IPR001031): Thioesterase domain YjeF_N (PF03853, IPR004443): YjeF-related protein N-terminus ADH_zinc_N_2 (PF13602): Zinc-binding dehydrogenase PS-DH (PF14765, IPR020807): Polyketide synthase dehydratase KAsynt_C_assoc (PF16197, IPR032821): Ketoacyl-synthetase C-terminal extension
36	FBXO5	oncoprotein	5	0.400	3.233	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain F-box (PF00646, IPR001810, SM00256): F-box domain
37	FKBP4	interactor	11	0.655	5.875	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat
38	FKBP5	interactor	10	0.556	11.741	FKBP_C (PF00254, IPR001179): FKBP-type peptidyl-prolyl cis-trans isomerase TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat NuDC (PF16273, IPR032572): Nuclear distribution C domain
39	FN1	oncoprotein	20	0.342	51.487	fn1 (PF00039, IPR000083, SM00058): Fibronectin type I domain fn2 (PF00040, IPR000562, SM00059): Fibronectin type II domain fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
40	GRB2	oncoprotein	18	0.404	47.057	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
41	HDAC8	interactor	5	0.500	1.829	DNase-RNase (PF02577, IPR003729): Bifunctional nuclease Hist_deacetyl (PF00850, IPR023801): Histone deacetylase domain
42	HDDC3	interactor	1	0	0	HD_4 (PF13328, IPR003607): HD domain
43	HOOK2	interactor	4	0.667	0.222	HOOK (PF05622, IPR008636): HOOK protein
44	HSF2	interactor	2	1.000	0	HAP1_N (PF04849, IPR006933): HAP1 N-terminal conserved region Vert_HS_TF (PF06546, IPR010542): Vertebrate heat shock transcription factor HSF_DNA-bind (PF00447, IPR000232, SM00415): HSF-type DNA-binding HMMR_C (PF15908, IPR031794): Hyaluronan mediated motility receptor C-terminal
45	HSP90AA1	oncoprotein	32	0.312	155.960	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
46	HSP90AB1	oncoprotein	32	0.316	147.143	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
47	HSPB1	oncoprotein	21	0.337	82.619	HSP20 (PF00011, IPR002068): Hsp20/alpha crystallin family
48	IFIT3	interactor	3	1.000	0	TPR_1 (PF00515, IPR001440): Tetratricopeptide repeat TPR_2 (PF07719, IPR013105): Tetratricopeptide repeat TPR_10 (PF13374, IPR011990): Tetratricopeptide repeat TPR_12 (PF13424): Tetratricopeptide repeat TPR_17 (PF13431): Tetratricopeptide repeat TPR_19 (PF14559): Tetratricopeptide repeat
49	IKBIP	interactor	2	1.000	0	Fez1 (PF06818): Fez1 Occludin_ELL (PF07303, IPR010844): Occludin homology domain GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) SesA (PF17107, IPR031352): N-terminal domain on NACHT_NTPase and P-loop NTPases
50	IKBKG	interactor	14	0.346	29.990	CENP-H (PF05837, IPR008426): Centromere protein H (CENP-H) DUF725 (PF05267, IPR007931): Protein of unknown function (DUF725) NEMO (PF11577, IPR021063): NF-kappa-B essential modulator NEMO LLC1 (PF14945, IPR020339): Normal lung function maintenance, Low in Lung Cancer 1 protein CC2-LZ (PF16516, IPR032419): Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator
51	IQGAP1	interactor	29	0.419	98.434	CH (PF00307, IPR001715, SM00033): Calponin homology (CH) domain DUF87 (PF01935, IPR002789): Domain of unknown function DUF87 IDEAL (PF08858, IPR014957, SM00914): IDEAL domain IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif RasGAP (PF00616, IPR001936, SM00323): GTPase-activator protein for Ras-like GTPase RasGAP_C (PF03836, IPR000593): RasGAP C-terminus WW (PF00397, IPR001202, SM00456): WW domain
52	KCNE1	interactor	1	0	0	ISK_Channel (PF02060, IPR000369): Slow voltage-gated potassium channel
53	KIFC3	oncoprotein	5	0.833	0.667	Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein KxDL (PF10241, IPR019371): Uncharacterized conserved protein Kinesin (PF00225, IPR001752, SM00129): Kinesin motor domain DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
54	KXD1	interactor	2	1.000	0	KxDL (PF10241, IPR019371): Uncharacterized conserved protein
55	KYNU	interactor	3	0.667	1.000	Aminotran_5 (PF00266, IPR000192): Aminotransferase class-V CaKB (PF03185, IPR003930): Calcium-activated potassium channel, beta subunit
56	LCA5L	interactor	1	0	0	DUF1515 (PF07439, IPR010889): Protein of unknown function (DUF1515) Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease PRKG1_interact (PF15898, IPR031775): cGMP-dependent protein kinase interacting domain
57	LRRK2	oncoprotein	11	0.511	8.996	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat ATP-synt_ab (PF00006, IPR000194): ATP synthase alpha/beta family, nucleotide-binding domain DUF1043 (PF06295, IPR009386): Protein of unknown function (DUF1043) T2SSE (PF00437, IPR001482): Type II/IV secretion system protein Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) PQQ_2 (PF13360, IPR002372): PQQ-like domain LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
58	LURAP1	interactor	2	1.000	0	LURAP (PF14854): Leucine rich adaptor protein DUF4530 (PF15039, IPR029202): Domain of unknown function (DUF4530)
59	MAD1L1	suppressor	5	0.500	1.487	MAD (PF05557, IPR008672): Mitotic checkpoint protein Atg14 (PF10186, IPR018791): Vacuolar sorting 38 and autophagy-related subunit 14
60	MAGEA11	interactor	6	0.400	5.400	MAGE (PF01454, IPR002190): MAGE family MAGE_N (PF12440, IPR021072): Melanoma associated antigen family N terminal
61	MAGED2	interactor	11	0.564	9.098	CDC27 (PF09507, IPR019038): DNA polymerase subunit Cdc27 MAGE (PF01454, IPR002190): MAGE family SRP-alpha_N (PF04086, IPR007222): Signal recognition particle, alpha subunit, N-terminal DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
62	MCC	suppressor	2	1.000	0	ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IFP_35_N (PF07334, IPR009938): Interferon-induced 35 kDa protein (IFP 35) N-terminus K_channel_TID (PF07941, IPR012897): Potassium channel Kv1.4 tandem inactivation domain Mod_r (PF07200, IPR009851): Modifier of rudimentary (Mod(r)) protein Spc7 (PF08317, IPR013253, SM00787): Spc7 kinetochore protein TPR_MLP1_2 (PF07926, IPR012929): TPR/MLP1/MLP2-like protein MCC-bdg_PDZ (PF10506, IPR019536): PDZ domain of MCC-2 bdg protein for Usher syndrome TMF_DNA_bd (PF12329, IPR022092): TATA element modulatory factor 1 DNA binding EF-hand_7 (PF13499, IPR011992): EF-hand domain pair FAM76 (PF16046, IPR032017): FAM76 protein
63	MCM2	oncoprotein	25	0.438	64.444	AAA_3 (PF07726, IPR011703): ATPase family associated with various cellular activities (AAA) MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family MCM2_N (PF12619, IPR008045): Mini-chromosome maintenance protein 2 MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
64	MCM3	interactor	13	0.526	11.143	MCM (PF00493, IPR001208, SM00350): MCM2/3/5 family CPSF100_C (PF13299, IPR025069): Cleavage and polyadenylation factor 2 C-terminal MCM_N (PF14551, IPR027925): MCM N-terminal domain MCM_OB (PF17207): MCM OB domain
65	MDC1	suppressor	9	0.528	10.164	FHA (PF00498, IPR000253, SM00240): FHA domain DUF3274 (PF11678, IPR021692): Protein of unknown function (DUF3274) Yop-YscD_cpl (PF16697, IPR032030): Inner membrane component of T3SS, cytoplasmic domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
66	MGEA5	oncoprotein	11	0.509	14.935	NAGidase (PF07555, IPR011496): beta-N-acetylglucosaminidase
67	MOV10	interactor	12	0.258	33.456	AAA_12 (PF13087): AAA domain AAA_30 (PF13604): AAA domain
68	MTCH1	interactor	4	0.500	0.952	YdjM (PF04307, IPR007404): LexA-binding, inner membrane-associated putative hydrolase Mito_carr (PF00153, IPR018108): Mitochondrial carrier protein
69	MYH7B	interactor	7	0.714	2.650	Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail YkuI_C (PF10388, IPR018842): EAL-domain associated signalling protein domain Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
70	MYH9	suppressor	25	0.550	39.858	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Myosin_tail_1 (PF01576, IPR002928): Myosin tail Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
71	MYO18A	interactor	18	0.549	30.994	Vfa1 (PF08432, IPR013640): AAA-ATPase Vps4-associated protein 1 IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_tail_1 (PF01576, IPR002928): Myosin tail PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein CENP-F_leu_zip (PF10473, IPR019513): Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) BST2 (PF16716, IPR024886): Bone marrow stromal antigen 2
72	MYO19	interactor	15	0.781	5.501	IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain)
73	MYO5C	interactor	14	0.670	9.499	DIL (PF01843, IPR018444, SM01132): DIL domain DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family IQ (PF00612, IPR000048, SM00015): IQ calmodulin-binding motif Myosin_N (PF02736, IPR004009): Myosin N-terminal SH3-like domain Pilus_CpaD (PF09476, IPR019027): Pilus biogenesis CpaD protein (pilus_cpaD) Myosin_head (PF00063, IPR001609, SM00242): Myosin head (motor domain) YtxH (PF12732, IPR024623): YtxH-like protein Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
74	NDUFB10	interactor	5	0.700	1.083	NDUFB10 (PF10249, IPR019377): NADH-ubiquinone oxidoreductase subunit 10
75	NEK2	interactor	6	0.400	5.400	Pkinase (PF00069, IPR000719): Protein kinase domain
76	NTRK1	oncoprotein	44	0.213	455.695	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
77	NXF1	interactor	14	0.321	33.012	NTF2 (PF02136, IPR002075): Nuclear transport factor 2 (NTF2) domain Tap-RNA_bind (PF09162, IPR015245): Tap, RNA-binding TAP_C (PF03943, IPR005637, SM00804): TAP C-terminal domain LRR_8 (PF13855, IPR001611): Leucine rich repeat
78	OBSL1	protein found in more fusions	24	0.316	85.480	BiPBP_C (PF06832, IPR009647): Penicillin-Binding Protein C-terminus Family fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Herpes_gE (PF02480, IPR003404): Alphaherpesvirus glycoprotein E I-set (PF07679, IPR013098): Immunoglobulin I-set domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain Ig_4 (PF16680, IPR032052): T-cell surface glycoprotein CD3 delta chain Izumo-Ig (PF16706, IPR032699): Izumo-like Immunoglobulin domain
79	OIP5	interactor	3	0.667	0.500	Yippee-Mis18 (PF03226, IPR004910): Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
80	OSTF1	interactor	3	0.667	0.182	SH3_1 (PF00018, IPR001452, SM00326): SH3 domain Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies)
81	PAN2	interactor	14	0.505	18.397	RNase_T (PF00929, IPR013520): Exonuclease UCH_1 (PF13423, IPR001394): Ubiquitin carboxyl-terminal hydrolase WD40_like (PF17005, IPR031544): WD40-like domain
82	PARK2	suppressor	14	0.385	24.865	IBR (PF01485, IPR002867, SM00647): IBR domain, a half RING-finger domain ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
83	PAXIP1	interactor	6	0.533	3.686	BRCT (PF00533, IPR001357, SM00292): BRCA1 C Terminus (BRCT) domain IPT (PF01745, IPR002648, SM00429): Isopentenyl transferase SURF6 (PF04935, IPR007019): Surfeit locus protein 6 DUF2052 (PF09747, IPR018613): Coiled-coil domain containing protein (DUF2052) CYSTM (PF12734, IPR028144): Cysteine-rich TM module stress tolerance PTCB-BRCT (PF12738, IPR001357): twin BRCT domain BRCT_2 (PF16589, IPR001357): BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT (PF16759, IPR031916): DNA ligase 3 BRCT domain RTT107_BRCT_5 (PF16770, IPR001357): Regulator of Ty1 transposition protein 107 BRCT domain
84	PBX3	interactor	1	0	0	Homeobox_KN (PF05920, IPR008422): Homeobox KN domain PBC (PF03792, IPR005542): PBC domain Ribosomal_60s (PF00428, IPR001813): 60s Acidic ribosomal protein Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
85	PDLIM7	interactor	15	0.581	18.532	LIM (PF00412, IPR001781, SM00132): LIM domain PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zinc_ribbon_10 (PF10058, IPR019273): Predicted integral membrane zinc-ribbon metal-binding protein DUF4749 (PF15936, IPR031847): Domain of unknown function (DUF4749)
86	PPP1CB	interactor	20	0.605	25.031	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
87	PPP1CC	oncoprotein	15	0.400	35.254	Metallophos (PF00149, IPR004843): Calcineurin-like phosphoesterase STPPase_N (PF16891, IPR031675): Serine-threonine protein phosphatase N-terminal domain
88	PRDX1	oncoprotein	11	0.422	6.182	AhpC-TSA (PF00578, IPR000866): AhpC/TSA family 1-cysPrx_C (PF10417, IPR019479): C-terminal domain of 1-Cys peroxiredoxin
89	PSMA2	interactor	7	0.733	0.863	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
90	PSMA6	interactor	12	0.379	20.212	Proteasome (PF00227, IPR001353): Proteasome subunit Proteasome_A_N (PF10584, IPR000426, SM00948): Proteasome subunit A N-terminal signature
91	PTPN11	suppressor	7	0.733	1.044	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase
92	PTPN6	suppressor	4	0.667	1.667	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
93	RAD21	oncoprotein	10	0.533	9.375	Rad21_Rec8 (PF04824, IPR006909): Conserved region of Rad21 / Rec8 like protein Rad21_Rec8_N (PF04825, IPR006910): N terminus of Rad21 / Rec8 like protein FAM176 (PF14851): FAM176 family WRNPLPNID (PF15017): Putative WW-binding domain and destruction box
94	RNF2	interactor	12	0.273	23.345	zf-C4_Topoisom (PF01396, IPR013498): Topoisomerase DNA binding C4 zinc finger zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger) RAWUL (PF16207, IPR032443): RAWUL domain RING finger- and WD40-associated ubiquitin-like
95	SEC23IP	interactor	3	0.667	1.000	DDHD (PF02862, IPR004177, SM01127): DDHD domain SAM_1 (PF00536, IPR021129, SM00454): SAM domain (Sterile alpha motif) WWE (PF02825, IPR004170, SM00678): WWE domain
96	SEPT9	oncoprotein	6	0.333	3.443	Septin (PF00735, IPR000038): Septin DUF3306 (PF11748, IPR021735): Protein of unknown function (DUF3306)
97	SF3A2	interactor	7	0.667	2.652	Cytadhesin_P30 (PF07271, IPR009896): Cytadhesin P30/P32 PRP4 (PF08799, IPR014906): pre-mRNA processing factor 4 (PRP4) like Totivirus_coat (PF05518, IPR008871): Totivirus coat protein zf-met (PF12874): Zinc-finger of C2H2 type ARL6IP6 (PF15062, IPR029383): Haemopoietic lineage transmembrane helix SF3A2 (PF16835, IPR031781): Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11)
98	SHMT2	interactor	9	0.333	11.138	SHMT (PF00464, IPR001085): Serine hydroxymethyltransferase
99	SP1	protein found in more fusions	12	0.618	8.642	zf-Di19 (PF05605, IPR008598): Drought induced 19 protein (Di19), zinc-binding Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein zf-C2H2 (PF00096, IPR007087, SM00355): Zinc finger, C2H2 type Miga (PF10265, IPR019392): Mitoguardin zf-H2C2_2 (PF13465, IPR007087): Zinc-finger double domain FoP_duplication (PF13865, IPR025715): C-terminal duplication domain of Friend of PRMT1
100	STMN1	interactor	7	0.429	5.004	Stathmin (PF00836, IPR000956): Stathmin family
101	SYCE1	interactor	5	0.500	3.952	CENP-Q (PF13094, IPR025212): CENP-Q, a CENPA-CAD centromere complex subunit SYCE1 (PF15233, IPR026676): Synaptonemal complex central element protein 1
102	TBCD	interactor	4	0.833	0.286	HEAT (PF02985, IPR000357): HEAT repeat HEAT_PBS (PF03130, IPR004155, SM00567): PBS lyase HEAT-like repeat TFCD_C (PF12612, IPR022577): Tubulin folding cofactor D C terminal HEAT_EZ (PF13513): HEAT-like repeat
103	TFPT	oncoprotein	3	1.000	0	GIT_CC (PF16559, IPR032352): GIT coiled-coil Rho guanine nucleotide exchange factor
104	THAP1	interactor	4	1.000	0	THAP (PF05485, IPR006612, SM00980): THAP domain Tho2 (PF11262, IPR021418): Transcription factor/nuclear export subunit protein 2 Cep57_CLD (PF14073, IPR025913): Centrosome localisation domain of Cep57
105	THOC1	protein found in more fusions	5	0.500	0.915	Death (PF00531, IPR000488, SM00005): Death domain efThoc1 (PF11957, IPR021861): THO complex subunit 1 transcription elongation factor
106	TLK1	protein found in more fusions	3	1.000	0	Pkinase (PF00069, IPR000719): Protein kinase domain Vir_act_alpha_C (PF10400, IPR018309): Virulence activator alpha C-term
107	TNNT1	protein found in more fusions	4	0.667	0.154	Troponin (PF00992, IPR001978): Troponin DUF4050 (PF13259, IPR025124): Protein of unknown function (DUF4050)
108	TP53	suppressor	28	0.288	145.193	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
109	TP73	suppressor	5	1.000	0	P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif SAM_2 (PF07647, IPR011510): SAM domain (Sterile alpha motif)
110	TPM1	protein found in more fusions	41	0.221	418.833	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
111	TPM2	protein found in more fusions	28	0.362	135.421	DASH_Spc19 (PF08287, IPR013251): Spc19 Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
112	TPM4	oncoprotein	38	0.270	300.287	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
113	TRAP1	oncoprotein	12	0.424	15.323	HSP90 (PF00183, IPR001404): Hsp90 protein HATPase_c_3 (PF13589): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
114	TRIM27	oncoprotein	9	0.357	16.056	IncA (PF04156, IPR007285): IncA protein SPRY (PF00622, IPR003877, SM00449): SPRY domain zf-B_box (PF00643, IPR000315, SM00336): B-box zinc finger PRY (PF13765, IPR006574, SM00589): SPRY-associated domain zf-C2H2_4 (PF13894): C2H2-type zinc finger zf-RING_5 (PF14634, IPR001841): zinc-RING finger domain zf-C3HC4_4 (PF15227): zinc finger of C3HC4-type, RING Lebercilin (PF15619, IPR028933): Ciliary protein causing Leber congenital amaurosis disease
115	TRIP6	interactor	8	0.357	13.633	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region LIM (PF00412, IPR001781, SM00132): LIM domain
116	UQCRC2	oncoprotein	8	0.571	6.003	Peptidase_M16 (PF00675, IPR011765): Insulinase (Peptidase family M16) Peptidase_M16_C (PF05193, IPR007863): Peptidase M16 inactive domain
117	VAV3	oncoprotein	3	1.000	0	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain DUF2326 (PF10088, IPR018760): Uncharacterised protein conserved in bacteria (DUF2326) C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain PH_10 (PF15411): Pleckstrin homology domain
118	VPS52	interactor	4	0.667	1.000	Vps52 (PF04129, IPR007258): Vps52 / Sac2 family COG5 (PF10392, IPR019465): Golgi transport complex subunit 5 Sec3_C (PF09763, IPR019160): Exocyst complex component Sec3

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	ROS1	parental protein	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase DUF2369 (PF10179, IPR019326): Uncharacterised conserved protein (DUF2369)
2	TPM3	parental protein	Tropomyosin (PF00261, IPR000533): Tropomyosin Tropomyosin_1 (PF12718, IPR000533): Tropomyosin like
3	WASH3P	interactor	NA

B a c k t o T o p ⇑

Fusion ID: Protein names:	AB795239
Level of PPIs:	or Upload text file:	Update repository

Examples	Cytoscape Web will replace the contents your graph	PPI Properties: Click on nodes or edges
Layout Tree Circle Radial Force Directed Preset
Export graph PDF file SVG file SIF file XML file GraphML file

Find Fusion Network

Visualization interactions

Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors