Statistic of PPI	Value(s)
The number of interactors (fusion and proteins)	93
The number (and %) of the onco-proteins	55 (59.14 %)
The number (and %) of the tumor suppressors	10 (10.75 %)
Total number of binary PPIs (saturation %)	574 (13.42 %)
The number (and %) of affected PPIs	92 (16.03 %)
The number of possible different fusions	27
PPI diameter	2
PPI radius	1
The average degree of PPI	11.398
Assortativity coefficient	-0.2277
The network average Clustering coefficient	0.532
The number (and %) of a zero Clustering coefficients	9 (9.68 %)
The number (and %) of a zero Betweenness Centrality	19 (20.43 %)

ACTIVE INTERACTORS

List of the fusions
PPI for parental proteins: BCR,FGFR1	All fusions : AB742170;
Proteins found in more fusions	AP2M1 (see 3 fusions); GRK5 (see 2 fusions); GAB2 (see 2 fusions); HSP90AA1 (see 2 fusions); CBL (see 1 fusions); CTPS2 (see 1 fusions); JAK2 (see 3 fusions); KPNB1 (see 2 fusions); FRS3 (see 1 fusions); GRB2 (see 1 fusions); RAC1 (see 1 fusions); MYC (see 1 fusions); ERBB3 (see 1 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); CDH1 (see 3 fusions); ERBIN (see 4 fusions); PIK3R1 (see 1 fusions); STUB1 (see 1 fusions); SHC1 (see 1 fusions); RAC1/PKM (see 1 fusions); UBC (see 1 fusions); NEDD4 (see 1 fusions); TP53 (see 3 fusions); HSPA8/HSPD1 (see 1 fusions); CDK9 (see 2 fusions);

List of the fusions

PPI for parental proteins: BCR,FGFR1

All fusions

: AB742170;

Proteins found in more fusions

AP2M1 (see 3 fusions); GRK5 (see 2 fusions); GAB2 (see 2 fusions); HSP90AA1 (see 2 fusions); CBL (see 1 fusions); CTPS2 (see 1 fusions); JAK2 (see 3 fusions); KPNB1 (see 2 fusions); FRS3 (see 1 fusions); GRB2 (see 1 fusions); RAC1 (see 1 fusions); MYC (see 1 fusions); ERBB3 (see 1 fusions); CREBBP (see 5 fusions); STAT3 (see 2 fusions); CDH1 (see 3 fusions); ERBIN (see 4 fusions); PIK3R1 (see 1 fusions); STUB1 (see 1 fusions); SHC1 (see 1 fusions); RAC1/PKM (see 1 fusions); UBC (see 1 fusions); NEDD4 (see 1 fusions); TP53 (see 3 fusions); HSPA8/HSPD1 (see 1 fusions); CDK9 (see 2 fusions);

List of active interactors

#	Name	Type	Number of PPI (degree)	Clustering Coefficient	Betweenness Centrality	Domains (Pfam, InterPro, SMART): description
1	AB742170	chimera	92	0.105	5107.875	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain
2	ABL1	oncoprotein	35	0.353	163.196	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain F_actin_bind (PF08919, IPR015015, SM00808): F-actin binding SH3_1 (PF00018, IPR001452, SM00326): SH3 domain FRG2 (PF15315, IPR026245): Facioscapulohumeral muscular dystrophy candidate 2
3	AFDN	oncoprotein	3	1.000	0	DIL (PF01843, IPR018444, SM01132): DIL domain DUF1777 (PF08648, IPR013957): Protein of unknown function (DUF1777) FHA (PF00498, IPR000253, SM00240): FHA domain MAP7 (PF05672, IPR008604): MAP7 (E-MAP-115) family MAS20 (PF02064, IPR002056): MAS20 protein import receptor Pap_E4 (PF02711, IPR003861): E4 protein PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) Peptidase_S49_N (PF08496, IPR013703): Peptidase family S49 N-terminal Pex14_N (PF04695, IPR006785): Peroxisomal membrane anchor protein (Pex14p) conserved region RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain ARGLU (PF15346): Arginine and glutamate-rich 1
4	AP2M1	protein found in more fusions	11	0.689	4.249	Adap_comp_sub (PF00928, IPR008968): Adaptor complexes medium subunit family Clat_adaptor_s (PF01217, IPR022775): Clathrin adaptor complex small chain
5	BNIP2	interactor	4	0.667	0.500	BNIP2 (PF12496, IPR022181): Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 CRAL_TRIO_2 (PF13716, IPR001251): Divergent CRAL/TRIO domain
6	CBL	oncoprotein	36	0.292	239.104	Cbl_N (PF02262, IPR003153): CBL proto-oncogene N-terminal domain 1 Cbl_N2 (PF02761, IPR014741): CBL proto-oncogene N-terminus, EF hand-like domain Cbl_N3 (PF02762, IPR014742): CBL proto-oncogene N-terminus, SH2-like domain UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain Prok-RING_4 (PF14447): Prokaryotic RING finger family 4 zf-RING_4 (PF14570): RING/Ubox like zinc-binding domain
7	CCDC183	interactor	1	0	0	MRP-63 (PF14978, IPR016576): Mitochondrial ribosome protein 63
8	CDC20	oncoprotein	9	0.393	9.034	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain
9	CDC42	oncoprotein	12	0.327	28.108	Ras (PF00071, IPR001806, SM00173): Ras family
10	CDH1	oncoprotein	11	0.444	10.374	Cadherin_C (PF01049, IPR000233): Cadherin cytoplasmic region Cadherin_pro (PF08758, IPR014868, SM01055): Cadherin prodomain like Cadherin (PF00028, IPR002126, SM00112): Cadherin domain
11	CDK9	protein found in more fusions	8	0.667	2.162	Pkinase (PF00069, IPR000719): Protein kinase domain
12	CEACAM21	interactor	2	1.000	0	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_2 (PF13895, IPR007110): Immunoglobulin domain
13	CEP128	interactor	7	0.524	4.672	DUF1129 (PF06570, IPR009214): Protein of unknown function (DUF1129) DUF1664 (PF07889, IPR012458): Protein of unknown function (DUF1664) ERM (PF00769, IPR011259): Ezrin/radixin/moesin family Reo_sigmaC (PF04582, IPR007662): Reovirus sigma C capsid protein SpoOE-like (PF09388, IPR018540): Spo0E like sporulation regulatory protein DUF2968 (PF11180, IPR021350): Protein of unknown function (DUF2968) TraF_2 (PF13729, IPR032811): F plasmid transfer operon, TraF, protein GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding DUF4200 (PF13863, IPR025252): Domain of unknown function (DUF4200) DUF4404 (PF14357, IPR025516): Domain of unknown function (DUF4404) HAUS6_N (PF14661, IPR028163): HAUS augmin-like complex subunit 6 N-terminus HIP1_clath_bdg (PF16515, IPR032422): Clathrin-binding domain of Huntingtin-interacting protein 1
14	CFTR	suppressor	15	0.363	31.773	ABC_membrane (PF00664, IPR001140): ABC transporter transmembrane region ABC_tran (PF00005, IPR003439): ABC transporter Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase SMC_N (PF02463, IPR003395): RecF/RecN/SMC N terminal domain Rotamase_2 (PF13145, IPR000297): PPIC-type PPIASE domain CFTR_R (PF14396, IPR025837): Cystic fibrosis TM conductance regulator (CFTR), regulator domain
15	CREBBP	oncoprotein	14	0.333	29.727	Creb_binding (PF09030, IPR014744): Creb binding DUF902 (PF06001, IPR010303): Domain of Unknown Function (DUF902) Forkhead_N (PF08430, IPR013638): Forkhead N-terminal region KIX (PF02172, IPR003101): KIX domain MAS20 (PF02064, IPR002056): MAS20 protein import receptor TPX2 (PF06886, IPR027329): Targeting protein for Xklp2 (TPX2) zf-TAZ (PF02135, IPR000197, SM00551): TAZ zinc finger ANAPC_CDC26 (PF10471, IPR018860): Anaphase-promoting complex APC subunit CDC26 HAT_KAT11 (PF08214, IPR013178): Histone acetylation protein Bromodomain (PF00439, IPR001487, SM00297): Bromodomain ZZ (PF00569, IPR000433, SM00291): Zinc finger, ZZ type DUF3729 (PF12526, IPR022202): Protein of unknown function (DUF3729) DUF4834 (PF16118, IPR032272): Domain of unknown function (DUF4834)
16	CRK	oncoprotein	23	0.443	56.404	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
17	CRKL	oncoprotein	16	0.583	21.826	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
18	CSNK2A2	interactor	7	0.571	3.641	Pkinase (PF00069, IPR000719): Protein kinase domain
19	CTNNB1	oncoprotein	14	0.418	24.665	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat Atx10homo_assoc (PF09759, IPR019156): Spinocerebellar ataxia type 10 protein domain DUF3361 (PF11841, IPR024574): Domain of unknown function (DUF3361) HEAT_EZ (PF13513): HEAT-like repeat
20	CTPS2	protein found in more fusions	4	1.000	0	CTP_synth_N (PF06418, IPR017456): CTP synthase N-terminus GATase (PF00117, IPR017926): Glutamine amidotransferase class-I
21	DLK1	tumor suppressor	1	0	0	EGF (PF00008, IPR000742, SM00181): EGF-like domain EGF_2 (PF07974, IPR013111): EGF-like domain cEGF (PF12662, IPR026823): Complement Clr-like EGF-like
22	DOK1	suppressor	17	0.508	22.126	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type) PH (PF00169, IPR001849, SM00233): PH domain
23	ERBB3	oncoprotein	20	0.474	33.748	Furin-like (PF00757, IPR006211): Furin-like cysteine rich region Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Recep_L_domain (PF01030, IPR000494): Receptor L domain GF_recep_IV (PF14843, IPR032778): Growth factor receptor domain IV
24	ERBIN	oncoprotein	8	0.619	2.660	LRR_1 (PF00560, IPR001611): Leucine Rich Repeat Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat
25	ERCC3	oncoprotein	4	0.833	0.500	ResIII (PF04851, IPR006935): Type III restriction enzyme, res subunit DUF2748 (PF10871, IPR020183): Protein of unknown function (DUF2748) Helicase_C_3 (PF13625, IPR032830): Helicase conserved C-terminal domain PBP1_TM (PF14812, IPR032730): Transmembrane domain of transglycosylase PBP1 at N-terminal ERCC3_RAD25_C (PF16203, IPR032438): ERCC3/RAD25/XPB C-terminal helicase
26	FES	oncoprotein	8	0.476	4.251	FCH (PF00611, IPR001060, SM00055): Fes/CIP4, and EFC/F-BAR homology domain OmpH (PF03938, IPR005632, SM00935): Outer membrane protein (OmpH-like) Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Remorin_C (PF03763, IPR005516): Remorin, C-terminal region SH2 (PF00017, IPR000980, SM00252): SH2 domain Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein
27	FGF8	oncoprotein	1	0	0	FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor TraC_F_IV (PF11130, IPR025955): F pilus assembly Type-IV secretion system for plasmid transfer
28	FRS2	interactor	6	0.933	0.143	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
29	FRS3	suppressor	5	0.833	0.667	IRS (PF02174, IPR002404, SM00310): PTB domain (IRS-1 type)
30	GAB2	oncoprotein	15	0.538	11.192	PH (PF00169, IPR001849, SM00233): PH domain Pheromone (PF08015, IPR012597): Fungal mating-type pheromone
31	GABRR1	interactor	2	0	0	Neur_chan_LBD (PF02931, IPR006202): Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb (PF02932, IPR006029): Neurotransmitter-gated ion-channel transmembrane region
32	GOLGA7B	interactor	1	0	0	Serglycin (PF04360, IPR007455): Serglycin Erf4 (PF10256, IPR019383): Golgin subfamily A member 7/ERF4 family
33	GRB14	interactor	3	1.000	0	BPS (PF08947, IPR015042): BPS (Between PH and SH2) PH (PF00169, IPR001849, SM00233): PH domain RA (PF00788, IPR000159, SM00314): Ras association (RalGDS/AF-6) domain SH2 (PF00017, IPR000980, SM00252): SH2 domain
34	GRB2	oncoprotein	38	0.332	221.550	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain DUF5093 (PF17011, IPR031533): Domain of unknown function (DUF5093)
35	GRK5	protein found in more fusions	5	0.667	0.686	Pkinase (PF00069, IPR000719): Protein kinase domain RGS (PF00615, IPR000342, SM00315): Regulator of G protein signaling domain
36	HCK	oncoprotein	13	0.397	33.229	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
37	HIF1A	suppressor	15	0.438	25.051	Dicty_REP (PF05086, IPR007778): Dictyostelium (Slime Mold) REP protein HIF-1a_CTAD (PF08778, IPR014887): HIF-1 alpha C terminal transactivation domain HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain PAS (PF00989, IPR013767, SM00091): PAS fold PAS_3 (PF08447, IPR013655): PAS fold HIF-1 (PF11413, IPR021537): Hypoxia-inducible factor-1
38	HOXA9	oncoprotein	3	1.000	0	Hox9_act (PF04617, IPR006711): Hox9 activation region Homeobox (PF00046, IPR001356, SM00389): Homeobox domain
39	HSP90AA1	oncoprotein	32	0.265	206.808	HATPase_c (PF02518, IPR003594, SM00387): Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 (PF00183, IPR001404): Hsp90 protein
40	HSPA4	interactor	13	0.551	15.484	Herpes_ICP4_N (PF03584, IPR005206): Herpesvirus ICP4-like protein N-terminal region HSP70 (PF00012, IPR013126): Hsp70 protein TP53IP5 (PF15331, IPR029290): Cellular tumour antigen p53-inducible 5
41	HSPA8	oncoprotein	24	0.428	66.430	HSP70 (PF00012, IPR013126): Hsp70 protein
42	HSPD1	oncoprotein	13	0.500	16.102	Cpn60_TCP1 (PF00118, IPR002423): TCP-1/cpn60 chaperonin family
43	IGSF21	interactor	1	0	0	C2-set_2 (PF08205, IPR013162): CD80-like C2-set immunoglobulin domain V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain
44	IL20RB	interactor	1	0	0	Interfer-bind (PF09294, IPR015373): Interferon-alpha/beta receptor, fibronectin type III Tissue_fac (PF01108, IPR003961): Tissue factor
45	IL3	oncoprotein	1	0	0	IL3 (PF02059, IPR002183): Interleukin-3
46	INPP5D	interactor	11	0.709	4.986	Exo_endo_phos (PF03372, IPR005135): Endonuclease/Exonuclease/phosphatase family SH2 (PF00017, IPR000980, SM00252): SH2 domain
47	ITK	oncoprotein	9	0.786	1.015	BTK (PF00779, IPR001562, SM00107): BTK motif PH (PF00169, IPR001849, SM00233): PH domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
48	JAK2	oncoprotein	16	0.486	26.494	FERM_M (PF00373, IPR019748): FERM central domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain
49	KIT	oncoprotein	14	0.582	18.464	ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
50	KPNB1	protein found in more fusions	10	0.361	11.794	Arm (PF00514, IPR000225, SM00185): Armadillo/beta-catenin-like repeat HEAT (PF02985, IPR000357): HEAT repeat IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain V-ATPase_H_C (PF11698, IPR011987): V-ATPase subunit H CLASP_N (PF12348, IPR024395): CLASP N terminal Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 HEAT_EZ (PF13513): HEAT-like repeat
51	LNX1	interactor	6	0.800	0.900	PDZ (PF00595, IPR001478, SM00228): PDZ domain (Also known as DHR or GLGF) zf-rbx1 (PF12678, IPR024766): RING-H2 zinc finger domain zf-C3HC4_2 (PF13923): Zinc finger, C3HC4 type (RING finger)
52	LRRK1	interactor	9	0.643	3.710	Roc (PF08477, IPR013684): Ras of Complex, Roc, domain of DAPkinase Pkinase (PF00069, IPR000719): Protein kinase domain TniB (PF05621, IPR008868): Bacterial TniB protein Ank_2 (PF12796, IPR020683): Ankyrin repeats (3 copies) LRR_4 (PF12799, IPR025875): Leucine Rich repeats (2 copies) LRR_8 (PF13855, IPR001611): Leucine rich repeat COR (PF16095, IPR032171): C-terminal of Roc, COR, domain
53	LTBR	oncoprotein	3	1.000	0	Ephrin_rec_like (PF07699, IPR011641): Putative ephrin-receptor like TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region TMEM252 (PF15664, IPR031363): Transmembrane protein 252 family
54	MYC	oncoprotein	17	0.342	46.815	HLH (PF00010, IPR011598, SM00353): Helix-loop-helix DNA-binding domain Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain Myc_N (PF01056, IPR012682): Myc amino-terminal region
55	NCAM1	interactor	3	1.000	0	fn3 (PF00041, IPR003961, SM00060): Fibronectin type III domain I-set (PF07679, IPR013098): Immunoglobulin I-set domain Syndecan (PF01034, IPR027789): Syndecan domain Trypan_PARP (PF05887, IPR008882): Procyclic acidic repetitive protein (PARP) Ig_2 (PF13895, IPR007110): Immunoglobulin domain Ig_3 (PF13927): Immunoglobulin domain
56	NCK1	oncoprotein	12	0.606	6.358	SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain
57	NEDD4	suppressor	13	0.348	23.302	Rota_NS26 (PF01525, IPR002512): Rotavirus NS26 WW (PF00397, IPR001202, SM00456): WW domain HECT (PF00632, IPR000569, SM00119): HECT-domain (ubiquitin-transferase)
58	NINL	interactor	5	0.600	2.667	PD40 (PF07676, IPR011659): WD40-like Beta Propeller Repeat TBCA (PF02970, IPR004226): Tubulin binding cofactor A DUF2389 (PF09493, IPR012663): Tryptophan-rich protein (DUF2389) Golgin_A5 (PF09787, IPR019177): Golgin subfamily A member 5 EF-hand_1 (PF00036, IPR002048, SM00054): EF hand EF-hand_6 (PF13405, IPR002048): EF-hand domain EF-hand_7 (PF13499, IPR011992): EF-hand domain pair GAS (PF13851, IPR025593): Growth-arrest specific micro-tubule binding Muted (PF14942, IPR017243): Organelle biogenesis, Muted-like protein FAM184 (PF15665): Family with sequence similarity 184, A and B TRAF_BIRC3_bd (PF16673, IPR032070): TNF receptor-associated factor BIRC3 binding domain
59	NTRK1	oncoprotein	34	0.275	234.429	I-set (PF07679, IPR013098): Immunoglobulin I-set domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase LRR_8 (PF13855, IPR001611): Leucine rich repeat TPKR_C2 (PF16920, IPR031635): Tyrosine-protein kinase receptor C2 Ig-like domain
60	PIK3CG	oncoprotein	2	1.000	0	Myc-LZ (PF02344, IPR003327): Myc leucine zipper domain PI3K_C2 (PF00792, IPR002420, SM00142): Phosphoinositide 3-kinase C2 PI3K_rbd (PF00794, IPR000341, SM00144): PI3-kinase family, ras-binding domain PI3Ka (PF00613, IPR001263, SM00145): Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase (PF00454, IPR000403, SM00146): Phosphatidylinositol 3- and 4-kinase DUF3244 (PF11589, IPR021638): Domain of unknown function (DUF3244) DUF4135 (PF13575, IPR025410): Domain of unknown function (DUF4135)
61	PIK3R1	oncoprotein	27	0.449	73.581	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_2 (PF07653, IPR011511): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
62	PIK3R2	oncoprotein	15	0.657	10.916	RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_9 (PF14604, IPR001452): Variant SH3 domain PI3K_P85_iSH2 (PF16454, IPR032498): Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
63	PKM	oncoprotein	6	0.533	3.748	PK (PF00224, IPR015793): Pyruvate kinase, barrel domain PK_C (PF02887, IPR015795): Pyruvate kinase, alpha/beta domain
64	PLCG1	oncoprotein	18	0.477	39.282	C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain SH2 (PF00017, IPR000980, SM00252): SH2 domain PI-PLC-X (PF00388, IPR000909, SM00148): Phosphatidylinositol-specific phospholipase C, X domain PI-PLC-Y (PF00387, IPR001711, SM00149): Phosphatidylinositol-specific phospholipase C, Y domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain PH_12 (PF16457, IPR001849): Pleckstrin homology domain
65	PPP2R1B	suppressor	5	0.667	0.800	HEAT (PF02985, IPR000357): HEAT repeat Cnd1 (PF12717, IPR032682): non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region HEAT_2 (PF13646): HEAT repeats
66	PTGES3	interactor	8	0.667	2.348	CS (PF04969, IPR007052): CS domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
67	PTK6	interactor	5	0.667	0.393	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
68	PTPN6	oncoprotein	10	0.711	3.051	SH2 (PF00017, IPR000980, SM00252): SH2 domain Y_phosphatase (PF00102, IPR000242, SM00194): Protein-tyrosine phosphatase PolyA_pol_arg_C (PF12626, IPR025866): Polymerase A arginine-rich C-terminus
69	PXN	oncoprotein	9	0.722	2.261	LIM (PF00412, IPR001781, SM00132): LIM domain Paxillin (PF03535): Paxillin family
70	RAC1	oncoprotein	8	0.381	7.100	Ras (PF00071, IPR001806, SM00173): Ras family
71	RB1	oncoprotein	9	0.583	4.205	RB_A (PF01858, IPR002720): Retinoblastoma-associated protein A domain RB_B (PF01857, IPR002719): Retinoblastoma-associated protein B domain Rb_C (PF08934, IPR015030): Rb C-terminal domain DUF3452 (PF11934, IPR024599): Domain of unknown function (DUF3452) DUF4592 (PF15262, IPR028030): Domain of unknown function (DUF4592)
72	RHOA	oncoprotein	4	0.500	1.667	Ras (PF00071, IPR001806, SM00173): Ras family
73	RPS6KA3	interactor	6	0.600	1.974	Pkinase (PF00069, IPR000719): Protein kinase domain Pkinase_C (PF00433, IPR017892): Protein kinase C terminal domain
74	RSPH9	interactor	1	0	0	Radial_spoke (PF04712, IPR006802): Radial spokehead-like protein
75	SEC13	interactor	3	1.000	0	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat ANAPC4_WD40 (PF12894, IPR024977): Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 (PF16529, IPR032401): WD40 region of Ge1, enhancer of mRNA-decapping protein
76	SHB	interactor	8	0.857	0.750	Herpes_capsid (PF06112, IPR009299): Gammaherpesvirus capsid protein SH2 (PF00017, IPR000980, SM00252): SH2 domain Period_C (PF12114, IPR022728): Period protein 2/3C-terminal region
77	SHC1	oncoprotein	24	0.506	42.940	PID (PF00640, IPR006020, SM00462): Phosphotyrosine interaction domain (PTB/PID) SH2 (PF00017, IPR000980, SM00252): SH2 domain
78	SOS1	oncoprotein	14	0.648	9.460	Histone (PF00125, IPR007125): Core histone H2A/H2B/H3/H4 PH (PF00169, IPR001849, SM00233): PH domain RasGEF (PF00617, IPR001895, SM00147): RasGEF domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain RasGEF_N (PF00618, IPR000651, SM00229): RasGEF N-terminal motif
79	SRC	oncoprotein	28	0.348	123.945	Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase SH2 (PF00017, IPR000980, SM00252): SH2 domain SH3_1 (PF00018, IPR001452, SM00326): SH3 domain
80	STAT3	oncoprotein	18	0.338	53.284	SH2 (PF00017, IPR000980, SM00252): SH2 domain STAT_alpha (PF01017, IPR013800): STAT protein, all-alpha domain STAT_bind (PF02864, IPR013801): STAT protein, DNA binding domain STAT_int (PF02865, IPR013799, SM00964): STAT protein, protein interaction domain
81	STUB1	suppressor	14	0.628	9.179	U-box (PF04564, IPR003613, SM00504): U-box domain ANAPC3 (PF12895): Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 (PF13414, IPR011990): TPR repeat TPR_20 (PF14561): Tetratricopeptide repeat
82	TGFBR2	oncoprotein	7	0.571	2.873	ecTbetaR2 (PF08917, IPR015013): Transforming growth factor beta receptor 2 ectodomain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
83	TNFRSF10B	suppressor	5	0.400	5.500	Death (PF00531, IPR000488, SM00005): Death domain RskA (PF10099, IPR018764): Anti-sigma-K factor rskA TNFR_c6 (PF00020, IPR001368, SM00208): TNFR/NGFR cysteine-rich region
84	TP53	oncoprotein	23	0.294	107.156	DEC-1_N (PF04625, IPR006719): DEC-1 protein, N-terminal region P53 (PF00870, IPR011615): P53 DNA-binding domain P53_tetramer (PF07710, IPR010991): P53 tetramerisation motif
85	TSG101	oncoprotein	9	0.571	4.632	APG6 (PF04111, IPR007243): Autophagy protein Apg6 Laminin_II (PF06009, IPR010307): Laminin Domain II UEV (PF05743, IPR008883): UEV domain Vps23_core (PF09454, IPR017916): Vps23 core domain
86	TSPAN3	interactor	2	1.000	0	Hum_adeno_E3A (PF05393, IPR008652): Human adenovirus early E3A glycoprotein Tetraspannin (PF00335, IPR018499): Tetraspanin family
87	UBASH3B	interactor	12	0.745	4.125	His_Phos_1 (PF00300, IPR013078, SM00855): Histidine phosphatase superfamily (branch 1) UBA (PF00627, IPR000449, SM00165): UBA/TS-N domain 2_5_RNA_ligase2 (PF13563): 2'-5' RNA ligase superfamily SH3_9 (PF14604, IPR001452): Variant SH3 domain
88	UBC	protein found in more fusions	23	0.325	98.255	ubiquitin (PF00240, IPR000626, SM00213): Ubiquitin family
89	UNC119	interactor	3	0.667	0.667	GMP_PDE_delta (PF05351, IPR008015): GMP-PDE, delta subunit
90	VAV1	oncoprotein	13	0.564	16.095	PH (PF00169, IPR001849, SM00233): PH domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain SH2 (PF00017, IPR000980, SM00252): SH2 domain C1_1 (PF00130, IPR002219, SM00109): Phorbol esters/diacylglycerol binding domain (C1 domain) SH3_1 (PF00018, IPR001452, SM00326): SH3 domain CAMSAP_CH (PF11971, IPR022613): CAMSAP CH domain
91	VPS28	interactor	4	0.833	0.200	VPS28 (PF03997, IPR007143): VPS28 protein
92	WDR48	suppressor	5	0.800	0.567	WD40 (PF00400, IPR001680, SM00320): WD domain, G-beta repeat DUF3337 (PF11816, IPR021772): Domain of unknown function (DUF3337)
93	XPO1	interactor	20	0.295	86.179	CRM1_C (PF08767, IPR014877, SM01102): CRM1 C terminal Hydrolase_3 (PF08282, IPR023214): haloacid dehalogenase-like hydrolase IBN_N (PF03810, IPR001494, SM00913): Importin-beta N-terminal domain Xpo1 (PF08389, IPR013598): Exportin 1-like protein Vac14_Fab1_bd (PF12755, IPR032878): Vacuolar 14 Fab1-binding region

B a c k t o T o p ⇑

List of missing interactors

#	Name	Type	Domains (Pfam, InterPro, SMART): description	Fusion(s)
1	BCR	parental protein	Bcr-Abl_Oligo (PF09036, IPR015123): Bcr-Abl oncoprotein oligomerisation domain C2 (PF00168, IPR000008, SM00239): C2 domain PH (PF00169, IPR001849, SM00233): PH domain RhoGAP (PF00620, IPR000198, SM00324): RhoGAP domain RhoGEF (PF00621, IPR000219, SM00325): RhoGEF domain IQ_SEC7_PH (PF16453, IPR001849): PH domain
2	EVI2A	interactor	EVI2A (PF05399, IPR008608): Ectropic viral integration site 2A protein (EVI2A)
3	FDPS	interactor	polyprenyl_synt (PF00348, IPR000092): Polyprenyl synthetase
4	FGF1	oncoprotein	FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
5	FGF2	interactor	FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
6	FGF23	interactor	FGF (PF00167, IPR002209, SM00442): Fibroblast growth factor
7	FGFR1	parental protein	I-set (PF07679, IPR013098): Immunoglobulin I-set domain ig (PF00047, IPR013151, SM00409): Immunoglobulin domain Pkinase_Tyr (PF07714, IPR001245): Protein tyrosine kinase
8	GINM1	interactor	NA
9	HEPACAM2	interactor	V-set (PF07686, IPR013106): Immunoglobulin V-set domain Ig_3 (PF13927): Immunoglobulin domain PgaD (PF13994, IPR023829): PgaD-like protein
10	LDLRAD4	interactor	Ldl_recept_a (PF00057, IPR002172, SM00192): Low-density lipoprotein receptor domain class A DUF2615 (PF11027, IPR020309): Protein of unknown function (DUF2615)
11	LGALS8	interactor	Gal-bind_lectin (PF00337, IPR001079, SM00908): Galactoside-binding lectin
12	MREG	interactor	MREG (PF15812, IPR031638): Melanoregulin

B a c k t o T o p ⇑

Fusion ID: Protein names:	AB742170
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Statistics and Network structure information

List of the fusions

List of active interactors

List of missing interactors